Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 15, 2014 Category: Psychiatry Tags: Issue Information Source Type: research

Concurrent tobacco and khat use is associated with blunted cardiovascular stress response and enhanced negative mood: a cross‐sectional investigation
We examined for the first time associations of the concurrent use of tobacco and khat with psychophysiological responses to acute stress in two sites in Yemen. MethodsParticipants (N = 308; 135 women) included three groups: users of khat and tobacco, users of khat alone, and a control group (nonsmokers/nonusers of khat). These individuals completed a laboratory session in which blood pressures (BP), heart rate, and mood measures were assessed during rest and in response to acute stress. ResultsConcurrent use of khat and tobacco was associated with attenuated systolic BP, diastolic BP, and heart rate responses...
Source: Human Psychopharmacology: Clinical and Experimental - April 7, 2014 Category: Psychiatry Authors: Mustafa al'Absi, Motohiro Nakajima, Anisa Dokam, Abed Sameai, Mohamed Alsoofi, Najat Saem Khalil, Molham Al Habori Tags: Research Article Source Type: research

Nicotine administration in healthy non‐smokers reduces appetite but does not alter plasma ghrelin
ConclusionsThese results do not support a key role of peripheral ghrelin secretion in weight changes related to smoking or smoking cessation, but do not rule out that central nervous system ghrelin is involved. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 7, 2014 Category: Psychiatry Authors: Maximilian Pilhatsch, Hannah Scheuing, Nils Kroemer, Andrea Kobiella, Martin Bidlingmaier, Gisbert Farger, Michael N. Smolka, Ulrich S. Zimmermann Tags: Short Communication Source Type: research

Cardiovascular pharmacodynamics of donepezil hydrochloride on the PR and QT intervals in patients with dementia
ObjectiveAlthough several case reports suggested that donepezil hydrochloride can induce bradycardia or atrioventricular block, the details remain unclear. We implemented a study of the impact of donepezil hydrochloride administration on PR, RR, and QT intervals. MethodsThe subjects were 18 patients who were diagnosed with either dementia or cognitive disorder (DSM‐IV‐TR) and were hospitalized between January 2011 and December 2012. After hospitalization, they were treated with donepezil hydrochloride. Clinical parameters and electrocardiograms before and after the administration of donepezil hydrochloride were retriev...
Source: Human Psychopharmacology: Clinical and Experimental - March 11, 2014 Category: Psychiatry Authors: Hirofumi Igeta, Yutaro Suzuki, Misuzu Tajiri, Toshiyuki Someya Tags: Short Communication Source Type: research

Plasma dehydroepiandrosterone sulfate levels in patients with major depressive disorder correlate with remission during treatment with antidepressants
ConclusionsThese findings suggest that plasma DHEA‐S levels can be used as a putative indicator of the state of remission in patients with major depressive disorder. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 10, 2014 Category: Psychiatry Authors: Tokiko Morita, Koji Senzaki, Ryoko Ishihara, Kazunori Umeda, Nakao Iwata, Taku Nagai, Hirotake Hida, Toshitaka Nabeshima, Kazunori Yukawa, Norio Ozaki, Yukihiro Noda Tags: Research Article Source Type: research

Pharmacokinetics and tolerability of paliperidone palmitate injection in Chinese subjects
The objective of this study was to characterize the pharmacokinetics of 25, 100, and 150 mg equivalents (eq.) of paliperidone long‐acting injection in Chinese subjects with schizophrenia. MethodsThis was an open‐label, randomized, parallel group, multicenter study. A total of 48 patients were randomized in a 1:1:1 ratio to one of three groups. Sequential blood samples were collected immediately before injection on day 1 and up to 210 days after the first injection. The plasma paliperidone concentrations were determined by a validated high‐performance liquid chromatography/tandem mass spectrometry...
Source: Human Psychopharmacology: Clinical and Experimental - March 3, 2014 Category: Psychiatry Authors: Tianmei Si, Yun'ai Su, Yi Liu, Hongyan Zhang, Huafang Li, Qing Rui, Liang Shu Tags: Short Communication Source Type: research

MDMA is certainly damaging after 25 years of empirical research: a reply and refutation of Doblin et al. (2014)
Human Psychopharmacology recently published my review into the increase in empirical knowledge about the human psychobiology of MDMA over the past 25 years (Parrott, 2013a). Deficits have been demonstrated in retrospective memory, prospective memory, higher cognition, complex visual processing, sleep architecture, sleep apnoea, pain, neurohormonal activity, and psychiatric status. Neuroimaging studies have shown serotonergic deficits, which are associated with lifetime Ecstasy/MDMA usage, and degree of neurocognitive impairment. Basic psychological skills remain intact. Ecstasy/MDMA use by pregnant mothers leads to ...
Source: Human Psychopharmacology: Clinical and Experimental - March 3, 2014 Category: Psychiatry Authors: Andrew C. Parrott Tags: Review Article Source Type: research

A reconsideration and response to Parrott AC (2013) “Human psychobiology of MDMA or ‘Ecstasy’: an overview of 25 years of empirical research”
Abstract Parrott recently published a review of literature on MDMA/ecstasy. This commentary is a response to the content and tenor of his review, which mischaracterizes the literature through misstatement and omission of contrary findings, and fails to address the central controversies in the literature. The review makes several erroneous statements concerning MDMA‐assisted psychotherapy, such as incorrect statements about research design and other statements that are baseless or contradicted by the literature. Though it critiques an attempt by other authors to characterize the risks of MDMA, the review fails to produce ...
Source: Human Psychopharmacology: Clinical and Experimental - March 3, 2014 Category: Psychiatry Authors: Rick Doblin, George Greer, Julie Holland, Lisa Jerome, Michael C. Mithoefer, Ben Sessa Tags: Review Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 3, 2014 Category: Psychiatry Tags: Issue Information Source Type: research

Lack of influence of DAT1 and DRD2 gene variants on antidepressant response in generalized anxiety disorder
ConclusionsAlthough we detected no association in our sample, future studies using larger samples and more comprehensive gene coverage are needed to evaluate potential effects of dopaminergic variants on antidepressant treatment response in anxiety disorders. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2014 Category: Psychiatry Authors: Wint Thu Saung, Sneha Narasimhan, Falk W. Lohoff Tags: Research Article Source Type: research

Cortisol awakening response and spatial working memory in man: a U‐shaped relationship
ConclusionWe provide novel evidence supporting the existence of an inverted U‐shaped relationship between corticosteroid levels and cognitive function in humans. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2014 Category: Psychiatry Authors: Andrew S. Moriarty, Andrew J. Bradley, Kirstie N. Anderson, Stuart Watson, Peter Gallagher, R. Hamish McAllister‐Williams Tags: Short Communication Source Type: research

Health literacy and the pharmacological treatment of anxiety disorders: a systematic review
ConclusionThere have been few investigations of health literacy focused on psychotropic medications. Given the prevalence, burden and sub‐optimal recognition, and treatment of anxiety disorders, further work is needed to determine whether increased mental health literacy is associated with treatment‐seeking and medication adherence in patients with these disorders. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2014 Category: Psychiatry Authors: M. Carlotta Palazzo, Bernardo Dell'Osso, A Carlo Altamura, Dan J Stein, David S Baldwin Tags: Review Article Source Type: research

Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta‐analysis of randomized placebo‐controlled trials
ObjectiveThe aim of this research was to perform a systematic review to identify all randomized controlled trials (RCTs) evaluating the efficacy and safety of add‐on celecoxib for treatment of depressive mood episodes. MethodsFour electronic databases were systematically searched from their inception to 8 August 2013: PubMed, Cochrane Library (Cochrane Central Register of Controlled Trials), Scopus, and PsychINFO. Pooled difference in means of Hamilton Depression Rating Scale score, pooled odds ratio (OR) of treatment response, and pooled OR of remission were calculated as the main effect size. A random‐effects model w...
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2014 Category: Psychiatry Authors: Farhad Faridhosseini, Ramin Sadeghi, Layla Farid, Meysam Pourgholami Tags: Review Article Source Type: research

Evaluation of the safety, pharmacodynamic, and pharmacokinetic effects following oral coadministration of immediate‐release morphine with ethanol in healthy male participants
ConclusionsCoadministration of single doses of morphine and ethanol tested in this study did not affect the safety, pharmacodynamics, or pharmacokinetics of morphine or ethanol administered alone. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2014 Category: Psychiatry Authors: Beatrice Setnik, Marta Sokolowska, Franklin Johnson, John Oldenhof, Myroslava Romach Tags: Research Article Source Type: research

Association between the angiotensin‐converting enzyme gene insertion/deletion polymorphism and first‐episode patients with schizophrenia in a Chinese Han population
BackgroundAngiotensin‐converting enzyme (ACE), a key enzyme of the renin–angiotensin system, can modulate dopamine turnover in the midbrain. Previous studies have revealed an association between ACE gene insertion/deletion (I/D) polymorphism and chronic schizophrenia, yet results are conflicting. ObjectiveThe primary objective of this study was to examine whether the ACE gene I/D polymorphism is associated with first‐episode patients with schizophrenia (FEP) in a Chinese Han population. MethodsThe presence of the polymorphism was determined in 220 FEP and 538 healthy controls using a case–control design. We...
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2014 Category: Psychiatry Authors: Li Hui, Jing Qin Wu, Xuan Zhang, Jie Lv, Wei Li Du, Chang Gui Kou, Ya Qin Yu, Meng Han Lv, Da Chun Chen, Xiang Yang Zhang Tags: Research Article Source Type: research

Positive perception of pharmacogenetic testing for psychotropic medications
DiscussionTo our knowledge, this study is the first to survey a large sample for their attitude toward pharmacogenetic testing for psychotropic medications. Our results indicate that, although concerns remain and scientific advancements are required, respondents were in support of pharmacogenetic testing for medications used to treat schizophrenia. © 2014 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2014 Category: Psychiatry Authors: Matthew B. Lanktree, Gwyneth Zai, Laura E. VanderBeek, Daniel E. Giuffra, David S. Smithson, Lucas B. Kipp, Timothy R. Dalseg, Mark Speechley, James L. Kennedy Tags: Short Communication Source Type: research

Cognitive effects of pregabalin in the treatment of long‐term benzodiazepine‐use and dependence
ConclusionsAlthough preliminary, our findings suggest that successful treatment of long‐term BDZ use with PGB is associated with a substantial, though only partial, recovery of BDZ‐compromised neuropsychological functioning, at least at a 2‐month follow‐up. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 17, 2014 Category: Psychiatry Authors: Panagiotis Oulis, Stamatina Kalogerakou, Eleni Anyfandi, George Konstantakopoulos, Vassiliki‐Maria Papakosta, Vasilios Masdrakis, Eleftheria Tsaltas Tags: Research Article Source Type: research

A naturalistic comparison study of the efficacy and safety of intramuscular olanzapine, intramuscular haloperidol, and intramuscular levomepromazine in acute agitated patients with schizophrenia
ConclusionsThe results of this study suggest the possibility that the anti‐agitation effects of IM olanzapine and IM levomepromazine are more rapid than those of IM haloperidol. No worsening of EPS was observed. Our results also suggest that compared with IM levomepromazine, IM olanzapine is safer and affords greater improvement in symptoms. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 14, 2014 Category: Psychiatry Authors: Hidenobu Suzuki, Keishi Gen, Yuki Takahashi Tags: Research Article Source Type: research

Effects of multivitamin, mineral and herbal supplement on cognition in younger adults and the contribution of B group vitamins
ConclusionMultivitamin supplementation may be useful for maintaining levels of B vitamins. The effects of multivitamins on speeded attention such as the stroop task in young adults warrant further investigation. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 14, 2014 Category: Psychiatry Authors: Andrew Pipingas, David A. Camfield, Con Stough, Andrew B. Scholey, Katherine H.M. Cox, David White, Jerome Sarris, Avni Sali, Helen Macpherson Tags: Research Article Source Type: research

A randomized, double‐blind, fixed‐dose study comparing the efficacy and tolerability of vortioxetine 2.5 and 10 mg in acute treatment of adults with generalized anxiety disorder
ConclusionsVortioxetine 2.5 and 10 mg treatment did not significantly improve generalized anxiety disorder symptoms versus placebo. Vortioxetine was safe and well tolerated in this patient population. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 14, 2014 Category: Psychiatry Authors: Atul R. Mahableshwarkar, Paula L. Jacobsen, Michael Serenko, Yinzhong Chen Tags: Research Article Source Type: research

MDMA and heightened cortisol: a neurohormonal perspective on the pregnancy outcomes of mothers used ‘Ecstasy’ during pregnancy
ConclusionsIn terms of causation, the developmental problems may reflect a combination of neurotransmitter and neurohormonal effects on the hypothalamic–pituitary–adrenal axis, with serotonergic activity being influenced by the high levels of cortisol. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 14, 2014 Category: Psychiatry Authors: Andrew C. Parrott, Derek G. Moore, John J.D. Turner, Julia Goodwin, Meeyoung O. Min, Lynn T. Singer Tags: Review Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 14, 2014 Category: Psychiatry Tags: Issue Information Source Type: research

Switching antipsychotics to aripiprazole or blonanserin and plasma monoamine metabolites levels in patients with schizophrenia
ConclusionsThere were no differences between blonanserin and aripiprazole in the improvement of clinical symptoms. Our results suggest that pHVA may be useful indicator for the switching strategy to aripiprazole or blonanserin in schizophrenia. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 8, 2014 Category: Psychiatry Authors: Itaru Miura, Tetsuya Shiga, Akihiko Katsumi, Keiko Kanno‐Nozaki, Hirobumi Mashiko, Shin‐Ichi Niwa, Hirooki Yabe Tags: Short Communication Source Type: research

Microarray analysis of global gene expression in leukocytes following lithium treatment
ConclusionsOur investigation suggests that the molecular action of lithium is mediated in part by its effects on the cellular and immune response to stimulus and stress followed by the interleukin 6, inhibitor of differentiation, and methane metabolism pathways. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 7, 2014 Category: Psychiatry Authors: Shinya Watanabe, Junichi Iga, Akira Nishi, Shusuke Numata, Makoto Kinoshita, Kumiko Kikuchi, Masahito Nakataki, Tetsuro Ohmori Tags: Short Communication Source Type: research

Psychomotor and subjective effects of bilastine, hydroxyzine, and cetirizine, in combination with alcohol: a randomized, double‐blind, crossover, and positive‐controlled and placebo‐controlled Phase I clinical trials
ConclusionConcomitant administration of bilastine (at therapeutic dose) and alcohol does not produce greater central nervous system depressant effects than ACL alone. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 3, 2014 Category: Psychiatry Authors: Consuelo García‐Gea, Joan Martínez, Maria Rosa Ballester, Ignasi Gich, Román Valiente, Rosa Maria Antonijoan Tags: Research Article Source Type: research

Omega‐3 supplementation improves cognition and modifies brain activation in young adults
ConclusionsBy extending the theory of neural efficiency to the within‐subject neurocognitive effects of supplementation, we concluded that following the EPA‐rich supplementation, participants' brains worked ‘less hard’ and achieved a better cognitive performance than prior to supplementation. Conversely, the increase in functional activation and lack of improvement in time or accuracy of cognitive performance following DHA‐rich supplementation may indicate that DHA‐rich supplementation is less effective than EPA‐rich supplementation in enhancing neurocognitive functioning after a 30‐day supplementat...
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2014 Category: Psychiatry Authors: Isabelle Bauer, Matthew Hughes, Renee Rowsell, Robyn Cockerell, Andrew Pipingas, Sheila Crewther, David Crewther Tags: Research Article Source Type: research

Effects of antipsychotics on bone mineral density and prolactin levels in patients with schizophrenia: a 12‐month prospective study
ConclusionThe increase of PRL might be an important risk factor leading to a high prevalence of osteoporosis in patients with schizophrenia on long‐term conventional antipsychotic medication. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2014 Category: Psychiatry Authors: Mengxin Wang, Ruihua Hou, Jia Jian, Guolin Mi, Huimin Qiu, Bingyu Cao, Maoqin Tang Tags: Research Article Source Type: research

Temporal and visual source memory deficits among ecstasy/polydrug users
ConclusionsGiven the role that source memory plays in everyday cognition, those who use cocaine more frequently might have more difficulty in everyday tasks such as recalling the sources of crucial information or making use of contextual information as an aid to learning. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2014 Category: Psychiatry Authors: John E. Fisk, Denis T. Gallagher, Florentia Hadjiefthyvoulou, Catharine Montgomery Tags: Research Article Source Type: research

A randomised trial of the effect of the glycine reuptake inhibitor Org 25935 on cognitive performance in healthy male volunteers
ConclusionsA single dose of Org 25935 does not improve learning or memory in healthy male individuals. However, the drug was well tolerated, and it remains to be seen whether it would have a positive effect on cognition in patient groups with pre‐existing cognitive deficits. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2014 Category: Psychiatry Authors: David Christmas, Alison Diaper, Sue Wilson, Ann Rich, Suzanne Phillips, Joanna Udo de Haes, Magnus Sjogren, David Nutt Tags: Research Article Source Type: research

Psychological functioning 1 year after a brief intervention using micronutrients to treat stress and anxiety related to the 2011 Christchurch earthquakes: a naturalistic follow‐up
ConclusionsDisaster survivors improve psychologically over time regardless of receiving intervention; however, those taking micronutrients during the acute phase following a disaster show better outcomes, identifying micronutrients as a viable treatment for acute stress following a natural disaster with maintenance of benefits 1 year later. ACTRN 12611000460909 Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2014 Category: Psychiatry Authors: Julia J. Rucklidge, Neville Blampied, Brigette Gorman, Heather A. Gordon, Ellen Sole Tags: Research Article Source Type: research

Relationship between the plasma concentration of paliperidone and the clinical and drug‐induced extrapyramidal symptoms in elderly patients with schizophrenia
In this study, 15 patients with schizophrenia receiving risperidone were switched to PAL and treated for 12 weeks. Their clinical symptoms were assessed using the Positive and Negative Syndrome Scale and the Clinical Global Impression‐Severity of Illness Scale. Their EPS were assessed using the Drug‐induced EPS Scale, Abnormal Involuntary Movement Scale, and Barnes Akathisia Scale at baseline and 12 weeks. Plasma concentrations were measured by the liquid chromatography‐mass spectrometry/mass spectrometry method. ResultsThe results revealed that there were significant correlations between the plasma con...
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2014 Category: Psychiatry Authors: Hidenobu Suzuki, Keishi Gen, Masahiro Otomo, Yuichi Inoue, Hiroyuki Hibino, Ayako Mikami, Hideo Matsumoto, Katsunaka Mikami Tags: Research Article Source Type: research

Rimonabant effects on anxiety induced by simulated public speaking in healthy humans: a preliminary report
ConclusionsCannabinoid‐1 antagonism magnifies the responses to an anxiogenic stimulus without interfering with the prestress phase. These data suggest that the endocannabinoid system may work on‐demand to counteract the consequences of anxiogenic stimuli in healthy humans. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - December 3, 2013 Category: Psychiatry Authors: Mateus M. Bergamaschi, Regina H. C. Queiroz, Marcos H. N. Chagas, Ila M. P. Linares, Kátia C. Arrais, Danielle C. G. Oliveira, Maria E. Queiroz, Antonio E. Nardi, Marilyn A. Huestis, Jaime E. C. Hallak, Antonio W. Zuardi, Fabrício A. Moreira, José A. S Tags: Short Communication Source Type: research

Comorbidity of obsessive–compulsive disorder and substance use disorder: a new heuristic
Obsessive–compulsive disorder (OCD) and substance use disorder share several aspects of phenomenology and may be underpinned by a common mechanism with compulsivity at the core. Despite this overlap, the two disorders show a variable pattern of comorbidity. Here, we review the current evidence for comorbidity across clinical and epidemiological studies, and propose a new heuristic for substance use comorbidity in OCD, based on a hypothetical threshold of OCD severity. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 27, 2013 Category: Psychiatry Authors: Natalie L. Cuzen, Dan J. Stein, Christine Lochner, Naomi A. Fineberg Tags: Short Communication Source Type: research

Treatment Resistant Depression Edited by Siegfried Kasper and Stuart Mongomery. Wiley‐Blackwell, Chichester, U.K. ISBN: 978‐1‐119‐95290‐9: 2013. Price £29.99. pages 217. pbk.
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 4, 2013 Category: Psychiatry Authors: Brian E. Leonard Tags: Book Review Source Type: research

Novel markers of kidney injury in bipolar patients on long‐term lithium treatment
ConclusionsLithium treatment causes an impairment of kidney function reflected also by abnormal levels of novel markers of kidney injury. Of these, urinary β2‐MG, as a marker of tubular function seems to be better predictor than serum NGAL in lithium‐treated patients because it shows multiple clinical and biochemical correlations, especially in men. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 4, 2013 Category: Psychiatry Authors: Janusz K. Rybakowski, Maria Abramowicz, Maria Chłopocka‐Wozniak, Stanislaw Czekalski Tags: Short Communication Source Type: research

Methylphenidate‐osmotic‐controlled release oral delivery system treatment reduces parenting stress in parents of children and adolescents with attention‐deficit/hyperactivity disorder
ConclusionsWe suggest that the increased parenting stress and depression in parents of children and adolescents with ADHD can be improved following the treatment with MPH‐OROS. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 4, 2013 Category: Psychiatry Authors: Jun‐Won Hwang, Bongseog Kim, Yeni Kim, Tae‐Ho Kim, Wan‐Seok Seo, Dong‐Won Shin, Young‐Jae Woo, Heejeong Yoo, Jeong‐Seop Lee, Jong‐Hun Lee, Myung‐Ho Lim, Young‐Chul Chung, Chul‐Ho Jung, Hanik K. Yoo Tags: Research Article Source Type: research

Clinical evaluation of the efficacy and safety of tandospirone versus sertraline monotherapy for social anxiety disorder: a randomized open‐label trial
ObjectiveAlthough selective serotonin reuptake inhibitors are now established as first‐line pharmacotherapy for social anxiety disorder (SAD), other agents with different mechanisms have shown promise in treating SAD. The aim of this study was to examine the efficacy and safety of tandospirone in treating adolescents with SAD. MethodsAdolescent patients meeting the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM‐IV) criteria for SAD were randomly assigned (1:1) to open‐label treatment with either tandospirone or sertraline for 8 weeks. The primary outcome measures were changes from b...
Source: Human Psychopharmacology: Clinical and Experimental - November 4, 2013 Category: Psychiatry Authors: Xiao Huang, Chao Li, Wei‐hui Li, Yan‐li Luo, Biao Wang, Wei Zhang, Jian‐jun Gan, Jian‐lin Ji Tags: Research Article Source Type: research

On ‘cognitive dysfunction’ as a novel target for antidepressant treatment
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 4, 2013 Category: Psychiatry Authors: Bethan Impey, David S. Baldwin Tags: Editorial Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 4, 2013 Category: Psychiatry Tags: Issue Information Source Type: research

Cortisol levels decrease after acute tobacco abstinence in regular smokers
ConclusionAcute tobacco abstinence was associated with decreased cortisol levels. Cortisol dampening during acute tobacco abstinence may reflect nicotine‐mediated modulation of hypothalamic–pituitary–adrenal axis activity, which may be relevant to the maintenance of tobacco dependence. Tobacco‐withdrawal cortisol changes do not appear to be a cause or consequence of many manifestations of acute tobacco withdrawal with the possible exception of hunger. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2013 Category: Psychiatry Authors: Jordan A. Wong, Wallace B. Pickworth, Andrew J. Waters, Mustafa al'Absi, Adam M. Leventhal Tags: Research Article Source Type: research

Effects of antipsychotic drugs on cardiovascular variability in participants with bipolar disorder
ConclusionsCurrent antipsychotic use (particularly second‐generation antipsychotics with high affinities for the D2S receptor) is associated with reduced autonomic‐mediated variability of the HR. The absence of an association with cumulative exposure suggests that the effects are acute in onset and may therefore relate more to altered autonomic function than structural cardiovascular abnormalities. Future studies should prospectively examine effects of these antipsychotics on autonomic function. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2013 Category: Psychiatry Authors: Jonathan R. Linder, Simrit K. Sodhi, William G. Haynes, Jess G. Fiedorowicz Tags: Research Article Source Type: research

Effects of central nervous system drugs on driving: speed variability versus standard deviation of lateral position as outcome measure of the on‐the‐road driving test
ConclusionsStandard deviation of lateral position is a more sensitive outcome measure to detect driving impairment than speed variability. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2013 Category: Psychiatry Authors: Joris C. Verster, Thomas Roth Tags: Review Article Source Type: research

Association study of common variants within the G protein‐coupled receptor kinase 6 gene and schizophrenia susceptibility in Han Chinese
In this study, we examined whether common variants in the G protein‐coupled receptor kinase 6 gene (GRK6) confers susceptibility to schizophrenia in Chinese. We genotyped two common variants in 697 schizophrenia patients and 563 healthy control subjects. No significant difference in either allele or genotype comparisons between the case and control groups was found. Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2013 Category: Psychiatry Authors: Wenxin Tang, Jun Cai, Zhenghui Yi, Yi Zhang, Weihong Lu, Chen Zhang Tags: Short Communication Source Type: research

A meta‐analysis of inositol for depression and anxiety disorders
ConclusionsOur results suggest that inositol may be beneficial for depressed patients, especially those with PMDD. The main limitation of this report is that a small number of studies were included in this meta‐analysis. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2013 Category: Psychiatry Authors: Tomohiko Mukai, Taro Kishi, Yuki Matsuda, Nakao Iwata Tags: Research Article Source Type: research

Does omega‐3 fatty acid supplementation enhance neural efficiency? A review of the literature
ConclusionsWe conclude that, where comparison is available, an increase in EPA intake is more advantageous than DHA in reducing “brain effort” relative to cognitive performance. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2013 Category: Psychiatry Authors: Isabelle Bauer, Sheila Crewther, Andrew Pipingas, Laura Sellick, David Crewther Tags: Review Article Source Type: research

Association of ADRA2A and MTHFR gene polymorphisms with weight loss following antipsychotic switching to aripiprazole or ziprasidone
ConclusionThe study data indicated that carriage of the ADRA2A rs1800544 GG genotype and the MTHFR rs1801131 C allele are associated with BMI reduction in this population following switching of antipsychotics to aripiprazole and ziprasidone. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2013 Category: Psychiatry Authors: Siti Norsyuhada Roffeei, Gavin P. Reynolds, Nor Zuraida Zainal, Mas Ayu Said, Ahmad Hatim, Syarinaz Ahmad Aida, Zahurin Mohamed Tags: Research Article Source Type: research

The effect of attenuating noradrenergic neurotransmission by clonidine on brain activity measures of visuospatial attention
ConclusionClonidine attenuated the result of bias in a subsample and may have a modulating effect on disengagement. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2013 Category: Psychiatry Authors: H. N. Alexander Logemann, Koen B. E. Böcker, Peter K. H. Deschamps, Chantal Kemner, J. Leon Kenemans Tags: Research Article Source Type: research

Gender influences on efficacy and safety of sublingual zolpidem tartrate for middle‐of‐the‐night awakening in insomnia
ObjectiveEvaluate potential gender effects on efficacy and safety of a buffered zolpidem sublingual tablet (ZST) formulation. MethodsPost hoc analysis of the pivotal sleep laboratory and outpatient studies, per gender. ResultsIn the sleep laboratory study, polysomnography‐derived latency to persistent sleep after middle‐of‐the‐night was significantly improved for both genders at both 1.75 mg and 3.5 mg ZST (females: 15.7 and 8.6 min, respectively, vs. 27.7 min [placebo]; males: 19.0 and 12.7 min vs. 29.0 min [placebo]) with no significant gender differences. In the outpatie...
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2013 Category: Psychiatry Authors: Thomas Roth, Frank Steinberg, Nikhilesh N. Singh, Margaret Moline Tags: Research Article Source Type: research

Secondary nonmotor negative symptoms in healthy volunteers after single doses of haloperidol and risperidone: a double‐blind, crossover, placebo‐controlled trial
ConclusionsSingle doses of both haloperidol and risperidone induced nonmotor secondary negative symptoms in healthy volunteers. The clinical findings are especially relevant in view of the impact of negative symptoms on poor functioning. They may help to guide clinicians in their choice of APs (http://clinicaltrials.gov/ct2/show/NCT01259973). Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - October 7, 2013 Category: Psychiatry Authors: Sergi Mas, Patricia Gassó, Ramón Fernández de Bobadilla, Joan Albert Arnaiz, Miquel Bernardo, Amalia Lafuente Tags: Research Article Source Type: research

Equations for converting scores between depression scales (MÅDRS, SRS, PHQ‐9 and BDI‐II): good statistical, but weak idiographic, validity
ConclusionIt does appear that conversion equations for depression scores are precise enough to be of use when applied to averages; these might aid comparison of data across different studies, meta‐analysis or instrument selection for clinical trials. But regarding scale translation at the idiographic level, the variability we have observed is so great that severe doubt is cast on the validity of such an approach. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 23, 2013 Category: Psychiatry Authors: Chris J. Hawley, Tim M. Gale, Paul St John Smith, Sanjay Jain, Ako Farag, Raj Kondan, Cerian Avent, Juliet Graham Tags: Research Article Source Type: research