Increased plasma levels of soluble TNF receptors 1 and 2 in bipolar depression and impact of lithium treatment
ConclusionThese results reinforce the involvement of an activated immune response system in the pathophysiology of bipolar disorder, with no impact of lithium treatment on the related biomarkers. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 9, 2015 Category: Psychiatry Authors: Antonio L. Teixeira, Rafael T. Souza, Marcus V. Zanetti, Andre R. Brunoni, Geraldo F. Busatto, Carlos A. Zarate, Wagner F. Gattaz, Rodrigo Machado‐Vieira Tags: Research Article Source Type: research

Serotonin reuptake inhibitors and breastfeeding: a systematic review
ConclusionsLiterature review clearly indicates paroxetine and sertraline as the drugs that should be preferred as first line choice in nursing women who need an antidepressant treatment. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 9, 2015 Category: Psychiatry Authors: Laura Orsolini, Cesario Bellantuono Tags: Review Article Source Type: research

Adult separation anxiety disorder: accepted but little understood
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 9, 2015 Category: Psychiatry Authors: Jo Rochester, David S. Baldwin Tags: Editorial Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 9, 2015 Category: Psychiatry Tags: Issue Information Source Type: research

Rate and predictors of non‐response to first‐line antipsychotic treatment in first‐episode schizophrenia
ConclusionsResults are consistent with a lower rate of refractoriness to treatment in first‐episode schizophrenia compared with multi‐episode samples. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2015 Category: Psychiatry Authors: Bonginkosi Chiliza, Laila Asmal, Sanja Kilian, Lebogang Phahladira, Robin Emsley Tags: Research Article Source Type: research

Psychopharmacologic treatment of children prenatally exposed to drugs of abuse
ConclusionsThese results suggest that in utero drug‐exposed children may be more treatment‐refractory to or experience greater side effects from the pharmacologic treatment of psychiatric disorders than controls, although we cannot determine if early environment or drugs exposure drives these findings. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2015 Category: Psychiatry Authors: Leslie A. Hulvershorn, Kristen M. Schroeder, Logan K. Wink, Craig A. Erickson, Christopher J. McDougle Tags: Research Article Source Type: research

Association of angiotensin‐converting enzyme gene polymorphism with schizophrenia and depressive symptom severity in a Chinese population
BackgroundDepressive symptoms are frequently observed in schizophrenia patients. Angiotensin‐converting enzyme (ACE), a key enzyme of renin‐angiotensin system, can catalyze the degradation of neuropeptides and modulate dopaminergic and serotonergic neurotransmission. Previous studies have revealed the association of the ACE gene insertion/deletion polymorphism with depressive disorder and its treatment response but not with the depressive symptoms in schizophrenia. ObjectiveThe aim of this study is to examine whether this polymorphism was associated with susceptibility to schizophrenia and with its psychopathological s...
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2015 Category: Psychiatry Authors: Li Hui, Jing Qin Wu, Min Jie Ye, Ke Zheng, Jin Cai He, Xuan Zhang, Jia Hong Liu, Hai Jia Tian, Ben Hong Gong, Da Chun Chen, Meng Han Lv, Jair C. Soares, Xiang Yang Zhang Tags: Research Article Source Type: research

Is pindolol augmentation effective in depressed patients resistant to selective serotonin reuptake inhibitors? A systematic review and meta‐analysis
ConclusionsPindolol augmentation may not be suitable for treatment‐resistant depression patients with SSRI‐resistant depression. However, once‐daily high‐dose pindolol (7.5 mg qd) appears to show a promising benefit in these patients. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2015 Category: Psychiatry Authors: Yiyun Liu, Xinyu Zhou, Dan Zhu, Jianjun Chen, Bin Qin, Yuqing Zhang, Xiao Wang, Deyu Yang, Huaqing Meng, Qinghua Luo, Peng Xie Tags: Review Article Source Type: research

Are 5‐HT3 antagonists effective in obsessive–compulsive disorder? A systematic review of literature
ConclusionsOverall, results indicate some utility, but the available literature is too scanty to allow for valid conclusions to be drawn. The mismatch between animal models of obsessive–compulsive disorder and clinical data with 5‐HT3 antagonists needs more clinical data to ensure that it is not an artefact. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2015 Category: Psychiatry Authors: Daniele Serata, Georgios D. Kotzalidis, Chiara Rapinesi, Delfina Janiri, Simone Di Pietro, Gemma Callovini, Daria Piacentino, Carlotta Gasperoni, Roberto Brugnoli, Vittoria Rachele Ferri, Nicoletta Girardi, Roberto Tatarelli, Stefano Ferracuti, Gloria Ang Tags: Review Article Source Type: research

Lithium and sexual dysfunction: an under‐researched area
ConclusionThe findings of this systematic review reveal the paucity of information about the incidence, associated factors and management of sexual dysfunction with lithium treatment and highlight the need for well‐designed studies in this area. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2015 Category: Psychiatry Authors: Hesham Y. Elnazer, Anthony Sampson, David Baldwin Tags: Review Article Source Type: research

QTc prolongation in schizophrenia patients in Asia: clinical correlates and trends between 2004 and 2008/2009
This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008/2009 and its independent demographic and clinical correlates. MethodData on 3482 hospitalized schizophrenia patients (2004 = 1826 and 2008/2009 = 1656) in six Asian countries and territories were collected by either chart review or interviews during a 1‐month period. Patients' sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure. ResultsThe...
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2015 Category: Psychiatry Authors: Yu‐Tao Xiang, Helen F. K. Chiu, Gabor S. Ungvari, Christoph U. Correll, Kelly Y. C. Lai, Chuan‐Yue Wang, Tian‐Mei Si, Edwin H. M. Lee, Yan‐Ling He, Shu‐Yu Yang, Mian‐Yoon Chong, Ee‐Heok Kua, Senta Fujii, Kang Sim, Michael K. H. Yong, Jitendr Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 11, 2014 Category: Psychiatry Tags: Research Article Source Type: research

Effects of endogenous and exogenous progesterone on emotional intelligence in cocaine‐dependent men and women who also abuse alcohol
ConclusionsCDA women may be vulnerable to difficulties managing and regulating emotions. Gonadal hormones may contribute to this gender effect, as increases in both endogenous and exogenous progesterone improved selective aspects of EI. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 3, 2014 Category: Psychiatry Authors: Verica Milivojevic, Rajita Sinha, Peter T. Morgan, Mehmet Sofuoglu, Helen C. Fox Tags: Research Article Source Type: research

The impact of chronic benzodiazepine use on cognitive evolution in nursing home residents
ObjectiveChronic use of benzodiazepines and Z‐drugs (BZD/Zs) has been linked to cognitive decline. In this one‐year prospective cohort study, we explored the impact of chronic BZD/Z use on cognitive decline compared to nonusers. MethodsIn cognitively capable BZD/Z users and nonusers in 10 Belgian nursing homes, we investigated cognition with the MiniMentalStateExamination(MMSE) at baseline and one year. A decrease of ≥4 points on the MMSE (clinically relevant decrease) was used in multiple logistic regression. We collected baseline demographics, functional, psychometric and social characteristics potentially influen...
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2014 Category: Psychiatry Authors: Jolyce Bourgeois, Monique M. Elseviers, Luc Van Bortel, Mirko Petrovic, Robert H. Vander Stichele Tags: Research Article Source Type: research

Frontal lobe function and social adjustment in patients with schizophrenia: near‐infrared spectroscopy
ObjectiveThe study evaluated relationships between frontal lobe function in patients with schizophrenia and both their social adjustment and medication, using 22‐channel near‐infrared spectroscopy (NIRS). MethodsOne hundred ninety‐nine stable patients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision schizophrenia, whose medication had not been changed within the preceding 3 months and who were able to visit our clinics for NIRS, were the study subjects. As a comparator, 144 healthy volunteers who underwent a physical examination and the Mini‐International Neuropsychia...
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2014 Category: Psychiatry Authors: Yoshinori Watanabe, Takahiro Urakami, Seiji Hongo, Tenpei Ohtsubo Tags: Research Article Source Type: research

Are antidepressants equally effective in the long‐term treatment of major depressive disorder?
ConclusionsBupropion and fluvoxamine appear less effective in long‐term treatment of MDD. These results should be confirmed by randomized placebo‐controlled prospective studies with larger samples. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2014 Category: Psychiatry Authors: Massimiliano Buoli, Claudia Cumerlato Melter, Alice Caldiroli, A. Carlo Altamura Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 8, 2014 Category: Psychiatry Tags: Issue Information Source Type: research

Simultaneous co‐ingestion of prescription stimulants, alcohol and other drugs: a multi‐cohort national study of US adolescents
ConclusionsThe majority of past‐year nonmedical users of prescription stimulants reported simultaneous co‐ingestion of prescription stimulants and other substances. The findings indicate that co‐ingestion of prescription stimulants and other substances is a pervasive behavior among US adolescents who engage in nonmedical use of prescription stimulants and should be carefully considered in future clinical practice and research. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Sean Esteban McCabe, Brady T. West, Ty S. Schepis, Christian J. Teter Tags: Research Article Source Type: research

Pharmacotherapy in bipolar disorders during hospitalization and at discharge predicts clinical and psychosocial functioning at follow‐up
ConclusionsHaving been prescribed anxiolytics and atypical antipsychotics during hospitalization predicted reduced psychosocial functioning, whereas prescription of lithium at discharge was associated with better psychosocial functioning at follow‐up. Future studies are needed in order to investigate how psychosocial functioning may be related in the long‐term to pharmacological treatment in patients after discharge. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Maurizio Pompili, Marco Innamorati, Xenia Gonda, Gianluca Serafini, Denise Erbuto, Federica Ricci, Kostas N. Fountoulakis, David Lester, Gustavo Vazquez, Zoltan Rihmer, Mario Amore, Paolo Girardi Tags: Research Article Source Type: research

Benefit of slow titration of paroxetine to treat depression in the elderly
ObjectiveParoxetine is commonly used to treat depression in the elderly; however, titration issues have been raised. Rapid titration may lead to increased anxiety and early dropout. The aim of this cost–utility analysis was to compare the potential benefit of standard (10 mg the first day) versus slow titration (2.5 mg gradually increased). MethodsClinical analysis was based on a naturalistic trial integrated with a decision‐analytic model representing second treatments for those who initially did not respond and for dropout cases. Treatment setting was a public outpatient center for mental disorders ...
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Paolo Olgiati, Emanuele Bajo, Alessandro Serretti, Tags: Research Article Source Type: research

Addition of an NK1 receptor antagonist to an SSRI did not enhance the antidepressant effects of SSRI monotherapy: results from a randomized clinical trial in patients with major depressive disorder
ConclusionConcomitant use of aprepitant + paroxetine for 6 weeks did not provide greater antidepressant benefit compared with paroxetine + placebo in patients with major depression. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: William A. Ball, Duane B. Snavely, Richard J. Hargreaves, Armin Szegedi, Christopher Lines, Scott A. Reines Tags: Research Article Source Type: research

Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population
ConclusionThese results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Yutaka Mizuki, Manabu Takaki, Yuko Okahisa, Shinji Sakamoto, Masafumi Kodama, Hiroshi Ujike, Yosuke Uchitomi Tags: Research Article Source Type: research

Arousal and the attentional network in panic disorder
Although a great deal of information about the neurobiology of panic disorder is now available, there is a need for an updated etiological model integrating recent findings on the neurobiology of the arousal system and its relationship with higher cortical functions in panic disorder. The current mini‐review presents psychophysiological, molecular biological/genetic and functional neuroimaging evidence for dysfunction in major arousal systems of the brain. Such dysfunction may influence the development of panic disorder by precipitating autonomic bodily symptoms and at the same time increasing vigilance to these sensatio...
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Maximilian J. Geiger, Susanne Neufang, Dan J. Stein, Katharina Domschke Tags: Short Communication Source Type: research

Use of antidepressant medication and suicidal ideation—the Northern Finland Birth Cohort 1966
ConclusionIn a large unselected cohort, antidepressant medication was not associated with increased suicidal ideation when other symptoms of depression and anxiety were taken into account. The assessment of insomnia might be useful for identifying individuals liable to have increased suicidal ideation while on antidepressant medication. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Ina Rissanen, Erika Jääskeläinen, Matti Isohanni, Hannu Koponen, Matti Joukamaa, Antti Alaräisänen, Jouko Miettunen Tags: Research Article Source Type: research

How well do clinicians and patients agree on depression treatment outcomes? Implications for personalized medicine
ConclusionThe levels of disagreement for response and remission were too high for CR and SR scales to be considered interchangeable for research on patient‐level outcomes. Anxiety does not meaningfully impact SR–CR agreement. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Boadie W. Dunlop, Bhrett McCabe, James M. Eudicone, John J. Sheehan, Ross A. Baker Tags: Research Article Source Type: research

Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action
ConclusionsResearch conducted so far provides initial support for the use of saffron for the treatment of mild‐to‐moderate depression. Further research is required to expand our understanding of the role and actions of saffron in major depression. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2014 Category: Psychiatry Authors: Adrian L. Lopresti, Peter D. Drummond Tags: Review Article Source Type: research

Anticonvulsants to treat post‐traumatic stress disorder
ConclusionsFuture long‐term studies with larger sample sizes are needed to investigate the clinical utility of anticonvulsants for post‐traumatic stress disorder treatment. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 11, 2014 Category: Psychiatry Authors: Hee Ryung Wang, Young Sup Woo, Won‐Myong Bahk Tags: Review Article Source Type: research

The effect of desvenlafaxine 50 mg/day on a subpopulation of anxious/depressed patients: a pooled analysis of seven randomized, placebo‐controlled studies
BackgroundDesvenlafaxine (administered as desvenlafaxine succinate) for anxious depression was assessed in a post hoc analysis. MethodsData were pooled from patients randomly assigned to desvenlafaxine 50 mg/day or placebo in seven double‐blind, fixed‐dose studies in adults with major depressive disorder. Patients with “anxious depression” had baseline 17‐item Hamilton Rating Scale for Depression, anxiety–somatization factor (HAM‐D17 A/S) scores ≥7. Primary end point was change in HAM‐D17 scores from baseline at week 8 (last observation carried forward), evaluated using analysis of cov...
Source: Human Psychopharmacology: Clinical and Experimental - August 11, 2014 Category: Psychiatry Authors: Susan G. Kornstein, Christine J. Guico‐Pabia, Rana S. Fayyad Tags: Research Article Source Type: research

Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: a systematic review and meta‐analysis of randomized controlled trials
ConclusionsMinocycline may improve the psychopathology of schizophrenia, especially the negative symptoms, and seems to be well tolerated. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 4, 2014 Category: Psychiatry Authors: Kazuto Oya, Taro Kishi, Nakao Iwata Tags: Research Article Source Type: research

A randomised, double‐blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin–noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine
ObjectiveThis randomised, double‐blind, 12‐week study compared efficacy and tolerability of flexible‐dose treatment with vortioxetine (10–20 mg/day) versus agomelatine (25–50 mg/day) in major depressive disorder patients with inadequate response to selective serotonin reuptake inhibitor (SSRI)/serotonin–noradrenaline reuptake inhibitor (SNRI) monotherapy. MethodsPatients were switched directly from SSRI/SNRI to vortioxetine or agomelatine. Primary endpoint was change from baseline to week 8 in the Montgomery–Åsberg Depression Rating Scale (MADRS) total score analysed by mix...
Source: Human Psychopharmacology: Clinical and Experimental - August 3, 2014 Category: Psychiatry Authors: Stuart A. Montgomery, Rebecca Z. Nielsen, Lis H. Poulsen, Lars Häggström Tags: Research Article Source Type: research

Modulation of auditory deviance detection by acute nicotine is baseline and deviant dependent in healthy nonsmokers: a mismatch negativity study
ConclusionsThese findings provide preliminary support for the role of nicotinic neurotransmission in sensory memory processing of auditory change and suggest that nicotinic receptor modulation can both enhance and diminish change detection, depending on baseline MMN and its eliciting stimulus feature. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 9, 2014 Category: Psychiatry Authors: Verner Knott, Danielle Impey, Tristan Philippe, Dylan Smith, Joelle Choueiry, Sara Salle, Heather Dort Tags: Research Article Source Type: research

The potential role of atypical antipsychotics in the treatment of panic disorder
ConclusionsAlthough the majority of the evidence regarding the efficacy of atypical antipsychotics in the treatment of panic disorder comes from small, open‐label studies, this review suggests the potential role of atypical antipsychotics in treating panic disorder. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 9, 2014 Category: Psychiatry Authors: Hee Ryung Wang, Young Sup Woo, Won‐Myong Bahk Tags: Review Article Source Type: research

Administration of exogenous melatonin increases spreading activation in lexical memory networks
ObjectiveSeveral studies have examined the effect of exogenous melatonin on memory and cognitive functioning. Many of these investigations have reported improvement in recall and recognition as well as performance on various other indices of neuropsychological functioning. However, there have been no investigations reported that have examined the effects of exogenous melatonin administration on spreading activation in lexical and semantic memory networks. Hence, the purpose of this investigation was to determine the effects of melatonin on spreading activation. MethodsParticipants were randomly assigned to either a 3‐mg ...
Source: Human Psychopharmacology: Clinical and Experimental - July 8, 2014 Category: Psychiatry Authors: Paul S. Foster, Ransom W. Campbell, Megan R. Williams, Kaylei K. Branch, Katelyn M. Roosa, Caitlin Orman, Valeria Drago Tags: Short Communication Source Type: research

Is environmental temperature related to renal symptoms, serum lithium levels, and other laboratory test results in current lithium users?
ConclusionsThe association of temperature with lithium levels, renal symptoms, and laboratory tests appears to be of relatively little clinical importance in lithium users in temperate climates. However, future research should re‐examine patients living in climates with extreme temperatures (e.g.,>40°C), who may theoretically be at higher risk. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 8, 2014 Category: Psychiatry Authors: Soham Rej, Bandar AlAqeel, Marilyn Segal, Nancy C.P. Low, Istvan Mucsi, Christina Holcroft, Karl Looper Tags: Short Communication Source Type: research

Effects of alcohol and energy drink on mood and subjective intoxication: a double‐blind, placebo‐controlled, crossover study
ConclusionsThe co‐ingestion of an energy drink with alcohol does not differently influence blood alcohol content recordings or subjective intoxication compared with alcohol alone, although some mood items are differentially affected. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 8, 2014 Category: Psychiatry Authors: Sarah Benson, Andrew Scholey Tags: Research Article Source Type: research

Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double‐blind randomized clinical trial
ConclusionsIn addition to its favorable safety profile, 1‐year administration of saffron extract capsules showed to be comparable with memantine in reducing cognitive decline in patients with moderate to severe AD. Confirmatory studies with larger sample sizes and longer follow‐up periods are warranted. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 8, 2014 Category: Psychiatry Authors: Mehdi Farokhnia, Mehdi Shafiee Sabet, Negar Iranpour, Amirhossein Gougol, Habibeh Yekehtaz, Roozbeh Alimardani, Farzaneh Farsad, Maryam Kamalipour, Shahin Akhondzadeh Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 8, 2014 Category: Psychiatry Tags: Issue Information Source Type: research

New insights on the antidepressant discontinuation syndrome
ConclusionsThis review raises awareness of the long‐term negative aspects of non‐compliance and inappropriate antidepressant discontinuation, and suggests possible approaches to “design‐out” a risk for ADS. It reveals intuitive and rational ideas for antidepressant drug design, and provides new thoughts on antidepressant pharmacology, ADS risk and how these affect long‐term outcome. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2014 Category: Psychiatry Authors: Brian H. Harvey, Francois N. Slabbert Tags: Review Article Source Type: research

Total antioxidant capacity is significantly lower in cocaine‐dependent and methamphetamine‐dependent patients relative to normal controls: results from a preliminary study
ConclusionStimulant‐dependent patients had significantly lower antioxidant capacity relative to controls, suggesting that they may be at greater risk for oxidative damage to the brain and other organs. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2014 Category: Psychiatry Authors: Jessica Walker, Theresa Winhusen, Jayne M. Storkson, Daniel Lewis, Michael W. Pariza, Eugene Somoza, Veronika Somoza Tags: Research Article Source Type: research

Effects of two doses of glucose and a caffeine–glucose combination on cognitive performance and mood during multi‐tasking
ConclusionThese data suggest that co‐administration of glucose and caffeine allows greater allocation of attentional resources than placebo or glucose alone. At present, we cannot rule out the possibility that the effects are due to caffeine alone Future studies should aim at disentangling caffeine and glucose effects. © 2014 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2014 Category: Psychiatry Authors: Andrew Scholey, Karen Savage, Barry V. O'Neill, Lauren Owen, Con Stough, Caroline Priestley, Mark Wetherell Tags: Research Article Source Type: research

A review on schizophrenia and relapse—a quest for user‐friendly psychopharmacotherapy
ConclusionsBearing in mind that suboptimal adherence and withdrawal from antipsychotics are an established and unequivocal risk factor for relapse, further investigations are certainly needed to explore user‐friendly manner of psychopharmacotherapy to prevent relapse in schizophrenia. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2014 Category: Psychiatry Authors: Takefumi Suzuki, Hiroyuki Uchida, Hiroyoshi Takeuchi, Takashi Tsuboi, Jinichi Hirano, Masaru Mimura Tags: Review Article Source Type: research

Effect of polymorphisms on the pharmacokinetics, pharmacodynamics, and safety of risperidone in healthy volunteers
ConclusionsDifferences in the pharmacokinetics of risperidone are due to polymorphisms in CYP2D6, COMT, and VKORC1. Differences in adverse reactions can be explained by gender and polymorphisms in CYP2C19, AGTR1, and NAT2. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2014 Category: Psychiatry Authors: Teresa Cabaleiro, Dolores Ochoa, Rosario López‐Rodríguez, Manuel Román, Jesús Novalbos, Carmen Ayuso, Francisco Abad‐Santos Tags: Research Article Source Type: research

Relationship between intranasal cocaine self‐administration and subject‐rated effects: predictors of cocaine taking on progressive‐ratio schedules
ConclusionsThe present findings suggest that, at least under certain conditions with intranasal cocaine, some, but not all, positive subject‐rated effects may predict drug self‐administration. These findings will be useful in guiding future examinations of putative interventions for cocaine‐use disorders. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 19, 2014 Category: Psychiatry Authors: Justin C. Strickland, Joshua A. Lile, Craig R. Rush, William W. Stoops Tags: Research Article Source Type: research

The effects of moderate alcohol concentrations on driving and cognitive performance during ascending and descending blood alcohol concentrations
ConclusionsParticipants’ estimates of their level of intoxication were poorly related to their actual BAC levels (and hence degree of impairment), and various aspects of driving and cognitive performance worsened during descending BACs. This indicates that drivers are not good at judging their fitness to drive after drinking only moderate amounts of alcohol and suggests an important focus for public education regarding alcohol and driving. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2014 Category: Psychiatry Authors: Nicola J. Starkey, Samuel G. Charlton Tags: Research Article Source Type: research

Genes involved in neuroplasticity and stressful life events act on the short‐term response to antidepressant treatment: a complex interplay between genetics and environment
ConclusionsThough our results are limited by the small sample size, variants in BDNF and ST8SIA may slow down the early response to antidepressants in subjects non‐exposed to stressors at the illness onset, with a remarkable gene–environment interaction. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2014 Category: Psychiatry Authors: Laura Mandelli, Roberta Emiliani, Stefano Porcelli, Chiara Fabbri, Diego Albani, Alessandro Serretti Tags: Short Communication Source Type: research

Polymorphism in alpha 2A adrenergic receptor gene is associated with sialorrhea in schizophrenia patients on clozapine treatment
ConclusionsADRA2A genotype was associated with CIS. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2014 Category: Psychiatry Authors: Anssi Solismaa, Olli Kampman, Niko Seppälä, Merja Viikki, Kari‐Matti Mäkelä, Nina Mononen, Terho Lehtimäki, Esa Leinonen Tags: Research Article Source Type: research

Excursions out‐of‐lane versus standard deviation of lateral position as outcome measure of the on‐the‐road driving test
BackgroundThe traditional outcome measure of the Dutch on‐the‐road driving test is the standard deviation of lateral position (SDLP), the weaving of the car. This paper explores whether excursions out‐of‐lane are a suitable additional outcome measure to index driving impairment. MethodsA literature search was conducted to search for driving tests that used both SDLP and excursions out‐of‐lane as outcome measures. The analyses were limited to studies examining hypnotic drugs because several of these drugs have been shown to produce next‐morning sedation. ResultsStandard deviation of lateral position was more s...
Source: Human Psychopharmacology: Clinical and Experimental - April 23, 2014 Category: Psychiatry Authors: Joris C. Verster, Thomas Roth Tags: Research Article Source Type: research

Protein kinase cAMP‐dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic‐induced weight gain
ConclusionsBecause of limited power, PRKAR2B's role in antipsychotic‐induced weight gain is unclear, but biological evidence suggests that PRKAR2B may be involved. Further research in larger sample sizes is warranted. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 17, 2014 Category: Psychiatry Authors: Sarah A. Gagliano, Arun K. Tiwari, Natalie Freeman, Jeffrey A. Lieberman, Herbert Y. Meltzer, James L. Kennedy, Jo Knight, Daniel J. Müller Tags: Research Article Source Type: research

Gender moderates the effect of oxytocin on social judgments
ConclusionsThese findings contribute to a small but growing body of research demonstrating differential effects of oxytocin in men and women. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 15, 2014 Category: Psychiatry Authors: Elizabeth A. Hoge, Eric Anderson, Elizabeth A. Lawson, Eric Bui, Laura E. Fischer, Shradha D. Khadge, Lisa Feldman Barrett, Naomi M. Simon Tags: Short Communication Source Type: research

A single‐dose, randomized, double‐blind, double dummy, placebo and positive‐controlled, five‐way cross‐over study to assess the pharmacodynamic effects of lorediplon in a phase advance model of insomnia in healthy Caucasian adult male subjects
ConclusionsLorediplon demonstrated a dose‐dependent improvement in sleep, whereas zolpidem showed a more sustained WASO effect. No next‐day hangover effects were observed. These sleep effects are also consistent with the pharmacokinetic profile of lorediplon. These results warrant clinical trials in patients with insomnia. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 15, 2014 Category: Psychiatry Authors: Lucy Horoszok, Thais Baleeiro, Fabiana D'Aniello, Savion Gropper, Benjamin Santos, Antonio Guglietta, Thomas Roth Tags: Research Article Source Type: research