The 5α‐reductase inhibitor finasteride is not associated with alterations in sleep spindles in men referred for polysomnography
ConclusionsContrary to our hypothesis, these findings demonstrate that finasteride is not associated with alterations in sleep spindle range activity or spindle morphology parameters. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2015 Category: Psychiatry Authors: Michael R. Goldstein, Jesse D. Cook, David T. Plante Tags: Short Communication Source Type: research

Erratum
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Tags: Erratum Source Type: research

A randomised, double‐blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin–noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine†
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Tags: Erratum Source Type: research

Detecting a signal in the noise: monitoring the global spread of novel psychoactive substances using media and other open‐source information
ConclusionsThe results of this study indicate that using media and other open‐source information can help monitor the presence, usage, local policy, law enforcement responses, and spread of NPS in a rapid effective way. Further, modifying GPHIN to actively track NPS would be relatively inexpensive to implement and would be highly complementary to current national and international monitoring efforts. © 2015 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Matthew M. Young, Chad Dubeau, Ornella Corazza Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Profiling online recreational/prescription drugs' customers and overview of drug vending virtual marketplaces
ConclusionsThe online availability of recreational/prescriptions drugs remains a public health concern. A more precise understanding of online vending sites' customers may well facilitate the drafting and implementation of proper prevention campaigns aimed at counteracting the increasing levels of online drug acquisition and hence intake activities. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Laura Orsolini, Giulia Francesconi, Duccio Papanti, Arianna Giorgetti, Fabrizio Schifano Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Novel psychoactive substances: use and knowledge among adolescents and young adults in urban and rural areas
In this study, we investigated knowledge and use of NPS in a sample of Italian youth in urban and rural areas. MethodsBetween December 2012 and October 2013, we administered a questionnaire to a sample of 3011 healthy subjects (44.7% men; 55.3% women), aged between 16 and 24 years and recruited in urban, intermediate and rural areas of Italy. ResultsOf the global sample, 53.3% declared to have some knowledge on NPS, with a higher knowledge in urban areas. Mephedrone (26%), desomorphine (22.6%) and methamphetamine (21.7%) were the most commonly known drugs. NPS use was reported by 4.7% of the sample, without signific...
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Giovanni Martinotti, Matteo Lupi, Leonardo Carlucci, Eduardo Cinosi, Rita Santacroce, Tiziano Acciavatti, Eleonora Chillemi, Ludovica Bonifaci, Luigi Janiri, Massimo Di Giannantonio Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Developmental outcomes of 3,4‐methylenedioxymethamphetamine (ecstasy)‐exposed infants in the UK
ConclusionsPrenatal MDMA exposure is related to fine and gross motor delays in the first 2 years of life. Follow‐up studies are needed to determine long‐term effects. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Lynn T. Singer, Derek G. Moore, Meeyoung O. Min, Julia Goodwin, John J. D. Turner, Sarah Fulton, Andrew C. Parrott Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Prenatal cocaine exposure and child outcomes: a conference report based on a prospective study from Cleveland
ConclusionsPrenatal exposure to cocaine was related to poorer perceptual organization IQ, visual–spatial information processing, attention, language, executive function, and behavior regulation through early adolescence. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Lynn T. Singer, Sonia Minnes, Meeyoung O. Min, Barbara A. Lewis, Elizabeth J. Short Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Enhancing sexual desire and experience: an investigation of the sexual correlates of gamma‐hydroxybutyrate (GHB) use
ConclusionGamma‐hydroxybutyrate seems to be a potential substitute for both stimulant and depressant substances. Increased sexual desire and disinhibition may lead to a more frequent and potentially more riskful sexual activity. Experienced blackouts need to be considered as risk factors for suffering sexual or acquisitory crimes. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Máté Kapitány‐Fövény, Barbara Mervó, Ornella Corazza, Gyöngyi Kökönyei, Judit Farkas, Róbert Urbán, Gábor Zacher, Zsolt Demetrovics Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Greater sexual risk‐taking in female and male recreational MDMA/ecstasy users compared with alcohol drinkers: a questionnaire study
ConclusionsThese findings indicate that both female and male ecstasy/MDMA users reported more risky sexual behaviours, than the non‐user controls. Further research into the sexual behaviour and sexual risk‐taking of heterosexual MDMA users should be conducted because much of the past literature has focused on homosexual participants. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Aimee L. May, Andrew C. Parrott Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Psyclones: a roller coaster of life? Hidden synthetic cannabinoids and stimulants in apparently harmless products
ConclusionsBeing sold as a legal product, Psyclone may appeal to recreational users, who remain unaware of its real content. This is a serious public health threat, which may lead to acute intoxications and fatalities. Further studies in the field, including Internet monitoring, are therefore required. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Rita Santacroce, Ornella Corazza, Giovanni Martinotti, Francesco Saverio Bersani, Giuseppe Valeriani, Massimo Di Giannantonio Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Injecting eye‐drops: a mini‐review on the non‐clinical use of tropicamide
ConclusionsTropicamide IV injections represent a serious health risk. Specific prevention programmes should be implemented for the general population as well as for the high‐risk population of polydrug abusers. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Francesco Saverio Bersani, Claudio Imperatori, Mariya Prilutskaya, Ramiz Kuliev, Ornella Corazza Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Venlafaxine as the ‘baby ecstasy’? Literature overview and analysis of web‐based misusers′ experiences
ConclusionsPhysicians should carefully evaluate patients for history of drug dependence and observe them for signs of venlafaxine misuse. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Giulia Francesconi, Laura Orsolini, Duccio Papanti, John M. Corkery, Fabrizio Schifano Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Olanzapine as the ideal “trip terminator”? Analysis of online reports relating to antipsychotics' use and misuse following occurrence of novel psychoactive substance‐related psychotic symptoms
ConclusionsOnly a few research studies have formally assessed the effectiveness of olanzapine and indeed of other second‐generation antipsychotics to treat NPS‐induced psychosis. Olanzapine was suggested here from a range of pro drug websites as being the “ideal” molecule to terminate “bad trips”. Health professionals should be informed about the risks related to olanzapine misuse. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Giuseppe Valeriani, Ornella Corazza, Francesco Saverio Bersani, Claudia Melcore, Antonio Metastasio, Giuseppe Bersani, Fabrizio Schifano Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Methoxetamine‐related deaths in the UK: an overview
ConclusionsMore research needs to be conducted into its health effects and toxicity potential. Health care professionals should be made aware of the potential health harms of MXE, in order to develop early intervention measures and minimise the number of MXE‐related poisonings and fatalities. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Stefania Chiappini, Hugh Claridge, John M. Corkery, Christine Goodair, Barbara Loi, Fabrizio Schifano Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Is there any difference in patterns of use and psychiatric symptom status between injectors and non‐injectors of mephedrone?
ConclusionsIntravenous mephedrone use is associated with a higher risk of harmful drug use, elevated psychiatric symptom profile and increased possibility of mephedrone being considered as an addictive substance. These findings might be important in efficient treatment planning. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Máté Kapitány‐Fövény, Barbara Mervó, Máté Kertész, Ornella Corazza, Judit Farkas, Gyöngyi Kökönyei, Róbert Urbán, Zsolt Demetrovics Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Deaths of individuals aged 16–24 years in the UK after using mephedrone
ConclusionsMephedrone use can have potentially fatal consequences, especially in combination with other substances. Deaths from its use in the 16–24 years' age group continue to occur in the UK, despite it being a controlled drug. Health professionals and potential consumers should be alert to this risk. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Barbara Loi, John Martin Corkery, Hugh Claridge, Christine Goodair, Stefania Chiappini, Carla Gimeno Clemente, Fabrizio Schifano Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Why all stimulant drugs are damaging to recreational users: an empirical overview and psychobiological explanation
ConclusionsRepetitive CNS stimulation is potentially damaging to the organism, both acutely and chronically. The review describes the various psychobiological systems through which recreational stimulant drugs impair human well‐being. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Authors: Andrew C. Parrott Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Novel psychoactive substances: second and third international conferences
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Tags: Editorial Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 28, 2015 Category: Psychiatry Tags: Issue Information Source Type: research

Assessment of functional outcomes by Sheehan Disability Scale in patients with major depressive disorder treated with duloxetine versus selective serotonin reuptake inhibitors
ObjectiveWe compared functional impairment outcomes assessed with Sheehan Disability Scale (SDS) after treatment with duloxetine versus selective serotonin reuptake inhibitors (SSRIs) in patients with major depressive disorder. MethodsData were pooled from four randomized studies comparing treatment with duloxetine and SSRIs (three double blind and one open label). Analysis of covariance, with last‐observation‐carried‐forward approach for missing data, explored treatment differences between duloxetine and SSRIs on SDS changes during 8 to 12 weeks of acute treatment for the intent‐to‐treat population. Logis...
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2015 Category: Psychiatry Authors: David V. Sheehan, Michele Mancini, Jianing Wang, Lovisa Berggren, Haijun Cao, Héctor José Dueñas, Li Yue Tags: Research Article Source Type: research

Aripiprazole for Tourette's syndrome: a systematic review and meta‐analysis
ConclusionThis review found that ARI has similar efficacy to TIA and HAL for TS, while extrapyramidal symptoms were significantly less with ARI than with HAL. ARI can be considered as an alternative treatment option for TS. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2015 Category: Psychiatry Authors: Wei Zheng, Xian‐Bin Li, Ying‐Qiang Xiang, Bao‐Liang Zhong, Helen F. K. Chiu, Gabor S. Ungvari, Chee H. Ng, Grace K. I. Lok, Yu‐Tao Xiang Tags: Research Article Source Type: research

Serial pharmacological prescribing practices for tic management in Tourette syndrome
We present this heterogeneous cohort in terms of the number of drugs they had tried, and as a proxy measure of some benefit of the last drug used, whether it had been prescribed under our supervision for ≥5 months. The most commonly prescribed medications were aripiprazole (64%), clonidine (40%), risperidone (30%) and sulpiride (29%) with changes in prescribing practises over the period examined. The number of different drugs tried were one (n = 155), two (n = 69), three (n = 36), four (n = 14), five (n = 15), six (n = 5), seven (...
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2015 Category: Psychiatry Authors: Mena Farag, Jeremy S. Stern, Helen Simmons, Mary M. Robertson Tags: Research Article Source Type: research

Can cognitive behaviour therapy beneficially influence arousal mechanisms in psychosis?
Cognitive behavioural therapy for psychosis (CBTp) is an approved adjunct therapy for patients with psychotic disorders; however, we do not fully understand the neurobiological effects that this therapy may exert. Arousal, as measured by electroencephalography (EEG), provides a useful electrophysiological marker for assessing psychotic disorders. EEG studies may therefore serve as a useful measure for assessing the underlying effects of CBTp in psychotic disorders. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2015 Category: Psychiatry Authors: Fleur M. Howells, David S. Baldwin, David G. Kingdon Tags: Short Communication Source Type: research

Possible role of a dysregulation of the endogenous opioid system in antisocial personality disorder
Around half the inmates in prison institutions have antisocial personality disorder (ASPD). A recent theory has proposed that a dysfunction of the endogenous opioid system (EOS) underlies the neurobiology of borderline personality disorder (BPD). In the present theoretical paper, based on a comprehensive database and hand search of the relevant literature, this hypothesis is extended to ASPD, which may be the predominant expression of EOS dysfunction in men, while the same pathology underlies BPD in women. According to evidence from human and animal studies, the problematic behaviours of persons with antisocial, callous, o...
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2015 Category: Psychiatry Authors: Borwin Bandelow, Dirk Wedekind Tags: Review Article Source Type: research

Explaining pharmacophobia and pharmacophilia in psychiatric patients: relationship with treatment adherence
ConclusionThe encouragement of psychiatric patients’ treatment adherence needs to include lack of coercion during prescription, a positive relationship with the prescriber, verbal persuasion, information containing vicarious experience, and the involvement of the patient in treatment decisions. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 25, 2015 Category: Psychiatry Authors: Carlos De las Cuevas, Wenceslao Peñate Tags: Research Article Source Type: research

Risky drug use and effects on sleep quality and daytime sleepiness
ConclusionsSocial drug users who report risky alcohol and cannabis use also report poor sleep. Poor sleep quality likely exacerbates any drug‐associated problems in non‐clinical populations. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 25, 2015 Category: Psychiatry Authors: Rowan P. Ogeil, James G. Phillips, Shantha M. W. Rajaratnam, Jillian H. Broadbear Tags: Research Article Source Type: research

Urine testing for antipsychotics: a pilot trial for a method to determine detection levels
ObjectiveThe goal of the present study was to demonstrate that the analytical assay of interest can detect antipsychotics in human urine specimens. MethodForty inpatients treated with haloperidol, quetiapine, risperidone, or olanzapine were recruited to participate in a one visit study. During the study visit, demographic and clinical information was collected as well as one urine sample that was forwarded to the Ameritox Laboratory and assayed for the presence of antipsychotic medications and/or metabolites. Urine samples were analyzed to determine detection sensitivity for four antipsychotic medications and their metabol...
Source: Human Psychopharmacology: Clinical and Experimental - May 25, 2015 Category: Psychiatry Authors: Jennifer Miller, Heidi Wehring, Robert P. McMahon, Bethany A. DiPaula, Raymond C. Love, Ayodele Antoinette Morris, Heather Raley, Stephanie Feldman, Deanna L. Kelly Tags: Research Article Source Type: research

Double‐blind, placebo‐controlled pilot study of adjunctive quetiapine SR in the treatment of PMS/PMDD
ConclusionThis small double‐blind study suggests that adjunctive treatment with quetiapine SR may be a useful addition to selective serotonin reuptake inhibitor therapy in women with PMS/PMDD by reducing symptoms and improving quality of life. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2015 Category: Psychiatry Authors: Christine Jackson, Brenda Pearson, Susan Girdler, Jacqueline Johnson, Robert M. Hamer, Susan Killenberg, Samantha Meltzer‐Brody Tags: Research Article Source Type: research

Decision‐making style, nicotine and caffeine use and dependence
ConclusionConfidence rather than defensive avoidance was a factor in reducing information‐seeking behaviours on the Internet. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2015 Category: Psychiatry Authors: James G. Phillips, Rowan P. Ogeil Tags: Research Article Source Type: research

Factors associated with self‐rated sexual function in Korean patients with schizophrenia receiving risperidone monotherapy
ConclusionsThe acknowledgement and management of sexual dysfunction in patients with schizophrenia by clinicians may be important for improvement of their quality of life and adherence to medication. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2015 Category: Psychiatry Authors: Ju‐Yeon Lee, Sung‐Wan Kim, Yo‐Han Lee, Hee‐Ju Kang, Seon‐Young Kim, Kyung‐Yeol Bae, Jae‐Min Kim, Il‐Seon Shin, Jin‐Sang Yoon Tags: Research Article Source Type: research

The effects of alcohol on the recognition of facial expressions and microexpressions of emotion: enhanced recognition of disgust and contempt
ConclusionAlcohol can increase sensitivity to expressions of disgust and contempt. Such effects are not dependent on stimulus duration up to 400 ms and may reflect contextual modulation of alcohol's effects on emotion recognition. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2015 Category: Psychiatry Authors: Fatima Felisberti, Philip Terry Tags: Research Article Source Type: research

Pharmacological, sensorimotor, and expectancy effects on tobacco withdrawal: a preliminary study
ConclusionResults provided initial validation of this novel three‐mechanism design. This design can be used in the future to advance understanding and treatment of tobacco withdrawal. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2015 Category: Psychiatry Authors: Casey R. Guillot, Matthew D. Stone, Bree A. Geary, Matthew G. Kirkpatrick, Jennifer W. Tidey, Jessica W. Cook, Adam M. Leventhal Tags: Research Article Source Type: research

No association between the COMT Val158Met polymorphism and the long‐term clinical response in obsessive–compulsive disorder in the Japanese population
ConclusionThe present case‐control/pharmacogenetic study did not provide clear evidence that the COMT Val158Met polymorphism is a predictor of OCD or of OCD patients' clinical responses. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2015 Category: Psychiatry Authors: Hidehiro Umehara, Shusuke Numata, Atsushi Tajima, Makoto Kinoshita, Shutaro Nakaaki, Issei Imoto, Satsuki Sumitani, Tetsuro Ohmori Tags: Research Article Source Type: research

Persistent benefits of slow titration of paroxetine in a six‐month follow‐up
ObjectiveParoxetine titration may be difficult in older individuals as they are more sensitive to side effects. The current study extends to 6 months our previously published report in which paroxetine was started at 2.5 mg/day and slowly increased by 2.5 mg on alternate days (slow titration) or rapidly titrated to target dose from 10 mg/day (standard titration) in a naturalistic setting. MethodsHere, the follow‐up period was extended to 26 weeks. We performed an intent‐to‐treat analysis of 47 subjects from the original sample (major depressive disorder and/or generalized anxiety di...
Source: Human Psychopharmacology: Clinical and Experimental - April 22, 2015 Category: Psychiatry Authors: Paolo Olgiati, Alessandro Serretti Tags: Research Article Source Type: research

Levodopa enhances explicit new‐word learning in healthy adults: a preliminary study
ConclusionsThese findings suggest that dopamine boosts initial lexical acquisition and enhances longer‐term consolidation of words learnt with semantic information, consistent with dopaminergic enhancement of semantic salience. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 21, 2015 Category: Psychiatry Authors: Leanne Shellshear, Anna D. MacDonald, Jeffrey Mahoney, Emma Finch, Katie McMahon, Peter Silburn, Pradeep J. Nathan, David A. Copland Tags: Research Article Source Type: research

Reduced memory skills and increased hair cortisol levels in recent Ecstasy/MDMA users: significant but independent neurocognitive and neurohormonal deficits
ConclusionsRecreational Ecstasy is associated with increased levels of the bio‐energetic stress hormone cortisol and significant memory impairments. No significant relationship between cortisol and the cognitive deficits was observed. Ecstasy users did display evidence of a metacognitive deficit, with the strength of the correlations between objective and subjective memory performances being significantly lower in the Ecstasy users. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 21, 2015 Category: Psychiatry Authors: Luke A. Downey, Helen Sands, Lewis Jones, Angela Clow, Phil Evans, Tobias Stalder, Andrew C. Parrott Tags: Research Article Source Type: research

The Substance Abuse Handbook (2nd Edn.). Edited by Pedro Ruiz and Eric C. Strain, Lippincott Williams & Wilkins, Philadelphia, PA 19103 USA, 2014 (p. 558). ISBN 978-1-4511-9196-7 (paperback)
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 21, 2015 Category: Psychiatry Authors: Sonja Pasche Tags: Book Review Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 21, 2015 Category: Psychiatry Tags: Issue Information Source Type: research

The use of ketamine as an antidepressant: a systematic review and meta‐analysis
ConclusionsSingle ketamine infusions elicit a significant antidepressant effect from 4 h to 7 days; the small number of studies at 12–14 days post infusion failed to reach significance. Results suggest a discrepancy in peak response time depending upon primary diagnosis — 24 h for MDD and 7 days for BD. The majority of published studies have used pre–post comparison; further placebo‐controlled studies would help to clarify the effect of ketamine over time. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 7, 2015 Category: Psychiatry Authors: Caoimhe M. Coyle, Keith R. Laws Tags: Review Article Source Type: research

4‐Methyl‐5‐(4‐methylphenyl)‐4,5‐dihydrooxazol‐2‐amine (4,4′‐DMAR, 4,4′‐dimethylaminorex): availability, prevalence of use, desired effects and acute toxicity
ConclusionsCurrently, there appears to limited availability of 4,4′‐DMAR; therefore, use is likely to be low. Its desired and unwanted effects appear similar to other sympathomimetic recreational drugs such as methylenedioxy‐methamphetamine or mephedrone. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 18, 2015 Category: Psychiatry Authors: Glanville James, Dargan Paul I., Wood David M. Tags: Research Article Source Type: research

The safety of serotonin–noradrenaline reuptake inhibitors (SNRIs) in pregnancy and breastfeeding: a comprehensive review
ConclusionsAvailable data suggest that venlafaxine is relatively safe during pregnancy, in particular as far as major malformations are concerned, whereas considering the small number of studies published, no definitive conclusions can be drawn on its safety during breastfeeding. Because of the few studies so far published, the safety of duloxetine during pregnancy and breastfeeding remains to be well established. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 18, 2015 Category: Psychiatry Authors: Cesario Bellantuono, Marianna Vargas, Gabriele Mandarelli, Bernardo Nardi, Maria Giulia Martini Tags: Review Article Source Type: research

Olanzapine: evaluation of the in vivo cytogenetic effect
Background/AimsOlanzapine (OLZ), an atypical antipsychotic, is licensed for use in the treatment of schizophrenia and other psychiatric disorders. MethodsOLZ cytogenetic effects were investigated by evaluating the frequency of Sister Chromatid Exchanges (SCEs) and Proliferation Rate Index (PRI) in cultured lymphocytes of schizophrenic patients who were under treatment of OLZ. SCE estimation is one of the most sensitive biomarkers of potential cytotoxicity, while PRI is used as a valuable marker of cytostatic activity. ResultsOur results showed a statistically significant increase of SCEs in the cultured lymphocytes of patients (p 
Source: Human Psychopharmacology: Clinical and Experimental - March 18, 2015 Category: Psychiatry Authors: Zampas Constantinos, Papadopoulou Eleni, Antonis Goulas, Zafiroula Iakovidou – Kritsi Tags: Research Article Source Type: research

Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle‐age adults
ConclusionsThese data confirm that P. quinquefolius can acutely benefit working memory and extend the age range of this effect to middle‐aged individuals. These changes are unlikely to be underpinned by modulation of blood glucose in this population. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 16, 2015 Category: Psychiatry Authors: Anastasia Ossoukhova, Lauren Owen, Karen Savage, Marjolaine Meyer, Alvin Ibarra, Marc Roller, Andrew Pipingas, Keith Wesnes, Andrew Scholey Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 16, 2015 Category: Psychiatry Tags: Issue Information Source Type: research

Changes in the Temperament and Character Inventory dimensions after paroxetine treatment in patients with major depressive disorder
Previous studies have reported changes in the dimensions of the Temperament and Character Inventory (TCI) after patients with major depressive disorder are treated. We aimed to investigate the changes in the TCI dimensions after paroxetine treatment in patients with major depressive disorder. Forty‐eight patients were enrolled in this study and were treated with 10–40 mg/day of paroxetine for 6 weeks. The TCI was completed twice, at weeks 0 and 6. We used the Montgomery–Asberg Depression Rating Scale (MADRS) to evaluate patients. The participants were divided into three groups (responders, non...
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2015 Category: Psychiatry Authors: Tetsu Tomita, Ayako Kaneda, Taku Nakagami, Sunao Kaneko, Norio Yasui‐Furukori Tags: Research Article Source Type: research

Influence of depression and anxiety on circulating endothelial progenitor cells in patients with acute coronary syndromes
ConclusionsThe current study indicates that EPCs circulate in decreased numbers in ACS patients with depression or anxiety and, therefore, contribute to explore new perspectives in the pathophysiology of the association between cardiovascular disorders and affective disorders. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2015 Category: Psychiatry Authors: Francesca Felice, Rossella Di Stefano, Stefano Pini, Gianfranco Mazzotta, Francesco M. Bovenzi, Daniele Bertoli, Marianna Abelli, Lucia Borelli, Alessandra Cardini, Lisa Lari, Camilla Gesi, Paola Michi, Doralisa Morrone, Luigi Gnudi, Alberto Balbarini Tags: Research Article Source Type: research

Drugged: The Science and Culture Behind Psychotropic Drugs Edited by Richard J. Miller. Oxford University Press USA, 2014. ISBN: 978‐0190235956 (US$39.95, pp. 359)
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 17, 2015 Category: Psychiatry Authors: Emma Brandish Tags: Book Review Source Type: research

The effect of self‐regulated caffeine use on cognition in young adults
ConclusionsThese data suggest that self‐regulated caffeine usage may not have a significant impact on reaction time, vigilance, response inhibition, or decision‐making in young adults, or that these effects are contingent upon other variables not accounted for in the current study. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 17, 2015 Category: Psychiatry Authors: Arit M. Harvanko, Katherine L. Derbyshire, Liana R. N. Schreiber, Jon E. Grant Tags: Research Article Source Type: research

Mn‐superoxide dismutase activity is associated with orofacial involuntary movements in schizophrenia patients with tardive dyskinesia
We examined the role of oxidative stress in relation to TD and TD subtypes in schizophrenia using manganese SOD (MnSOD) as the biomarker. MethodsWe recruited 152 male chronic patients with (n = 76) and without TD (n = 76) meeting Diagnostic and Statistical Manual of Mental Disorders‐IV criteria for schizophrenia and 75 male control subjects. We examined the MnSOD activity for all subjects. Positive and Negative Syndrome Scale and the Abnormal Involuntary Movement Scale (AIMS) were assessed in the patients. ResultsManganese SOD activity was lower in patients with TD than non‐TD (p 
Source: Human Psychopharmacology: Clinical and Experimental - January 9, 2015 Category: Psychiatry Authors: Jing Qin Wu, Da Chun Chen, Yun Long Tan, Jair C. Soares, Xiang Yang Zhang Tags: Research Article Source Type: research