Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 31, 2016 Category: Psychiatry Tags: Issue Information Source Type: research

Altruism, personal benefit, and anxieties: a phenomenological study of healthy volunteers' experiences in a placebo‐controlled trial of duloxetine
ConclusionsSmall changes to advertising/consent materials to reflect volunteers' motivations could improve recruitment rates to similar trials; “active” placebos might be particularly useful for maintaining blinding in healthy volunteer trials; and sensitive procedures are needed for un‐blinding participants to treatment allocation. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 4, 2016 Category: Psychiatry Authors: Isaac N. Kwakye, Matthew Garner, David S. Baldwin, Susan Bamford, Verity Pinkney, Felicity L. Bishop Tags: Research Article Source Type: research

Measuring the subjective: revisiting the psychometric properties of three rating scales that assess the acute effects of hallucinogens
ConclusionsIt is crucial that instruments of sufficiently precise measurement are utilized to make sense of the information obtained in the study of the subjective effects of psychedelic drugs. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 30, 2016 Category: Psychiatry Authors: Jos é Carlos Bouso, Eduardo José Pedrero‐Pérez, Sam Gandy, Miguel Ángel Alcázar‐Córcoles Tags: Research Article Source Type: research

Duloxetine in elderly major depression disorder: effectiveness and drug plasma level evaluation
ConclusionsThe levels of duloxetine in plasma do not correlate with a greater clinical improvement, indeed appear to adversely affect the improvement of the Beck Depression Inventory and Hamilton Rating Scales for Anxiety. This could be explained by an increase in side effects that may aggravate the discomfort felt by the patient. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 30, 2016 Category: Psychiatry Authors: Chiara Rovera, Massimo Carlo Mauri, Elena Bertin, Chiara Di Pace, Silvia Paletta, Alessandra Reggiori, Ilaria Francesca De Gaspari, Dario Cattaneo, Daniela Mari, Alfredo Carlo Altamura Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 30, 2016 Category: Psychiatry Tags: Issue Information Source Type: research

Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta ‐analysis
ObjectiveThe aim of this study was to examine the efficacy of huperzine A (HupA), an isolate of Huperzine serrata, in the treatment of cognitive deficits in schizophrenia spectrum disorders. MethodsPubMed, PsycINFO, Embase, Cochrane Library, Cochrane Controlled Trials Register, WanFang, Chinese Biomedical, and China Journal Net databases were searched from inception to 15 July 2015 for randomized controlled trials (RCTs) in English or Chinese of HupA augmentation of antipsychotic drug therapy versus placebo or ongoing antipsychotic treatment. ResultsTwelve RCTs (n = 1117) lasting 11.7 ± 6...
Source: Human Psychopharmacology: Clinical and Experimental - June 14, 2016 Category: Psychiatry Authors: Wei Zheng, Ying ‐Qiang Xiang, Xian‐Bin Li, Gabor S. Ungvari, Helen F. K. Chiu, Feng Sun, Carl D'Arcy, Xiangfei Meng, Yu‐Tao Xiang Tags: Research Article Source Type: research

Haloperidol versus second ‐generation antipsychotics in the long‐term treatment of schizophrenia
ObjectiveThe purpose of the study was to compare antipsychotic monotherapies in terms of time to discontinuation in a sample of schizophrenia patients followed‐up for 36 months. MethodsTwo hundred and twenty schizophrenia patients, treated with antipsychotic monotherapy and followed‐up in psychiatric outpatient clinics of Universities of Milan and Utrecht were included in the study. A survival analysis (Kaplan–Meier) of the 36‐month follow‐up period was performed to compare the single treatment groups. End‐point was considered as discontinuation of treatment for recurrence, side effects or non‐comp...
Source: Human Psychopharmacology: Clinical and Experimental - June 12, 2016 Category: Psychiatry Authors: Massimiliano Buoli, Ren é S. Kahn, Marta Serati, A. Carlo Altamura, Wiepke Cahn Tags: Research Article Source Type: research

Donepezil modulates the endogenous immune response: implications for Alzheimer's disease
ConclusionsDonepezil might modulate a T helper 2 bias via α7nAChR leading to increased expression of NAb. Further studies on the role of the modulation of the immune response against Aβ may pave the way to innovative therapeutic strategies for AD. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 12, 2016 Category: Psychiatry Authors: Elisa Conti, Lucio Tremolizzo, Marta Elena Santarone, Marco Tironi, Isabella Radice, Chiara Paola Zoia, Angelo Aliprandi, Andrea Salmaggi, Roberto Dominici, Marco Casati, Ildebrando Appollonio, Carlo Ferrarese Tags: Research Article Source Type: research

Post authorization safety study comparing quetiapine to risperidone and olanzapine
ConclusionsQuetiapine was associated with lower EPS, but higher failed suicide attempt rates compared to risperidone. Quetiapine was associated with lower EPS and DM rates compared to olanzapine. The results should be interpreted with caution because of possible channelling and residual confounding. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 12, 2016 Category: Psychiatry Authors: Edith M. Heintjes, Jetty A. Overbeek, Fernie J. A. Penning‐van Beest, Gunnar Brobert, Ron M. C. Herings Tags: Research Article Source Type: research

International prescribing practices in obsessive –compulsive disorder (OCD)
ConclusionsPharmacotherapy for OCD varied significantly across sites. Prospective studies are required to determine the cultural, pharmacoeconomic and pharmacogenomic factors that may play a role in the variation in prescribing practices internationally and whether these variations influence treatment outcomes. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 6, 2016 Category: Psychiatry Authors: Vlasios Brakoulias, Vladan Starcevic, Amparo Belloch, Liliana Dell'Osso, Ygor A. Ferr ão, Leonardo F. Fontenelle, Christine Lochner, Donatella Marazziti, Andrew Martin, Hisato Matsunaga, Euripedes C. Miguel, Y C Janardhan Reddy, Maria C. Rosário, Roseli Tags: Research Article Source Type: research

First ‐generation antipsychotics and QTc: any role for mediating variables?
ConclusionsOur findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 31, 2016 Category: Psychiatry Authors: Giuseppe Carr à, Cristina Crocamo, Francesco Bartoli, Annamaria Lax, Martina Tremolada, Claudio Lucii, Giovanni Martinotti, Michela Nosè, Irene Bighelli, Giovanni Ostuzzi, Mariasole Castellazzi, Massimo Clerici, Corrado Barbui, Tags: Research Article Source Type: research

A simple method for optimising transformation of non ‐parametric data: an illustration by reference to cortisol assays
Neuroendocrine data are typically positively skewed and rarely conform to the expectations of a Gaussian distribution. This can be a problem when attempting to analyse results within the framework of the general linear model, which relies on assumptions that residuals in the data are normally distributed. One frequently used method for handling violations of this assumption is to transform variables to bring residuals into closer alignment with assumptions (as residuals are not directly manipulated). This is often attempted through ad hoc traditional transformations such as square root, log and inverse. However, Box and Co...
Source: Human Psychopharmacology: Clinical and Experimental - May 26, 2016 Category: Psychiatry Authors: James E. Clark, Jason W. Osborne, Peter Gallagher, Stuart Watson Tags: Research Article Source Type: research

Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment – a randomized double‐blind placebo‐controlled trial
ConclusionWe observed indications for improved cognitive flexibility without changes in brain activation, suggesting increased processing efficiency with EGb761. Together with a trend for improved response inhibition results are compatible with mild enhancement of prefrontal dopamine. These conclusions on potential beneficial effect of EGb761 on prefrontal dopaminergic functions should be confirmed by direct measurements. © 2016 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 4, 2016 Category: Psychiatry Authors: Stefanie M. Beck, Hannes Ruge, Christoph Schindler, Martin Burkart, Robert Miller, Clemens Kirschbaum, Thomas Goschke Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 4, 2016 Category: Psychiatry Tags: Issue Information Source Type: research

Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta‐analysis
ObjectiveThe aim of this study was to examine the efficacy of huperzine A (HupA), an isolate of Huperzine serrata, in the treatment of cognitive deficits in schizophrenia spectrum disorders. MethodsPubMed, PsycINFO, Embase, Cochrane Library, Cochrane Controlled Trials Register, WanFang, Chinese Biomedical, and China Journal Net databases were searched from inception to 15 July 2015 for randomized controlled trials (RCTs) in English or Chinese of HupA augmentation of antipsychotic drug therapy versus placebo or ongoing antipsychotic treatment. ResultsTwelve RCTs (n = 1117) lasting 11.7 ± 6...
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: Wei Zheng, Ying‐Qiang Xiang, Xian‐Bin Li, Gabor S. Ungvari, Helen F. K. Chiu, Feng Sun, Carl D'Arcy, Xiangfei Meng, Yu‐Tao Xiang Tags: Research Article Source Type: research

Haloperidol versus second‐generation antipsychotics in the long‐term treatment of schizophrenia
ObjectiveThe purpose of the study was to compare antipsychotic monotherapies in terms of time to discontinuation in a sample of schizophrenia patients followed‐up for 36 months. MethodsTwo hundred and twenty schizophrenia patients, treated with antipsychotic monotherapy and followed‐up in psychiatric outpatient clinics of Universities of Milan and Utrecht were included in the study. A survival analysis (Kaplan–Meier) of the 36‐month follow‐up period was performed to compare the single treatment groups. End‐point was considered as discontinuation of treatment for recurrence, side effects or non‐comp...
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: Massimiliano Buoli, René S. Kahn, Marta Serati, A. Carlo Altamura, Wiepke Cahn Tags: Research Article Source Type: research

International prescribing practices in obsessive–compulsive disorder (OCD)
ConclusionsPharmacotherapy for OCD varied significantly across sites. Prospective studies are required to determine the cultural, pharmacoeconomic and pharmacogenomic factors that may play a role in the variation in prescribing practices internationally and whether these variations influence treatment outcomes. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: Vlasios Brakoulias, Vladan Starcevic, Amparo Belloch, Liliana Dell'Osso, Ygor A. Ferrão, Leonardo F. Fontenelle, Christine Lochner, Donatella Marazziti, Andrew Martin, Hisato Matsunaga, Euripedes C. Miguel, Y C Janardhan Reddy, Maria C. Rosário, Roseli Tags: Research Article Source Type: research

First‐generation antipsychotics and QTc: any role for mediating variables?
ConclusionsOur findings showed that FGAs, concurrent risky drugs, and alcohol use disorders prolonged QTc. FGAs had a direct effect on QTc, confirming the need for clinicians to monitor a risk that could lead to sudden unexplained death. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: Giuseppe Carrà, Cristina Crocamo, Francesco Bartoli, Annamaria Lax, Martina Tremolada, Claudio Lucii, Giovanni Martinotti, Michela Nosè, Irene Bighelli, Giovanni Ostuzzi, Mariasole Castellazzi, Massimo Clerici, Corrado Barbui, Tags: Research Article Source Type: research

A simple method for optimising transformation of non‐parametric data: an illustration by reference to cortisol assays
Neuroendocrine data are typically positively skewed and rarely conform to the expectations of a Gaussian distribution. This can be a problem when attempting to analyse results within the framework of the general linear model, which relies on assumptions that residuals in the data are normally distributed. One frequently used method for handling violations of this assumption is to transform variables to bring residuals into closer alignment with assumptions (as residuals are not directly manipulated). This is often attempted through ad hoc traditional transformations such as square root, log and inverse. However, Box and Co...
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: James E. Clark, Jason W. Osborne, Peter Gallagher, Stuart Watson Tags: Research Article Source Type: research

Pharmacological treatment of acute agitation associated with psychotic and bipolar disorder: a systematic review and meta‐analysis
ConclusionBecause of limitations of available research, firm conclusions could not be drawn regarding the efficacy and safety of any identified intervention. Based on our results, there is no evidence that one drug is more effective or preferred over any other and treatment decisions could be made based on individual patient needs or costs. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 30, 2016 Category: Psychiatry Authors: Yenal Dundar, Janette Greenhalgh, Marty Richardson, Kerry Dwan Tags: Research Article Source Type: research

Suicide risk and antipsychotic side effects in schizophrenia: nested case –control study
ConclusionsA lower suicide risk identified among patients with EPS could potentially reflect higher antipsychotic adherence, exposure to higher dosage, or polypharmacy among these patients. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 24, 2016 Category: Psychiatry Authors: Johan Reutfors, Eric Clapham, Shahram Bahmanyar, Lena Brandt, Erik G. J önsson, Anders Ekbom, Robert Bodén, Urban Ösby Tags: Short Communication Source Type: research

The sleep effects of lurasidone: a placebo‐controlled cross‐over study using a 4‐h phase‐advance model of transient insomnia
BackgroundLurasidone, an atypical antipsychotic, is a potent 5‐HT7 antagonist and D2, 5‐HT2A antagonist, and 5‐HT1A partial agonist. As such, lurasidone would be expected to modulate sleep and circadian function but there have been no human studies of the sleep effects of a 5‐HT7 antagonist. The purpose of this study was to assess effects of lurasidone on sleep. MethodsThis was a cross‐over, polysomnographic study involving 54 healthy volunteers who underwent two treatment periods (order randomized) each consisting of two nights in the laboratory: Night 1—lights out at usual bedtime; Night 2–4‐h adv...
Source: Human Psychopharmacology: Clinical and Experimental - April 24, 2016 Category: Psychiatry Authors: Andrew D. Krystal, Gary Zammit Tags: Research Article Source Type: research

The effects of alcohol mixed with energy drink (AMED) on subjective intoxication and alertness: results from a double‐blind placebo‐controlled clinical trial
ConclusionMixing alcohol with energy drink had no overall masking effect on subjective intoxication caused by alcohol, nor had a relevant effect on subjective alertness‐sleepiness ratings. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 5, 2016 Category: Psychiatry Authors: Aurora J. A. E. Loo, Nienke Andel, Charlotte A. G. H. Gelder, Boris S. G. Janssen, Joep Titulaer, Jimmy Jansen, Joris C. Verster Tags: Research Article Source Type: research

Genetic mechanisms of electroconvulsive therapy response in depression
Electroconvulsive therapy (ECT) is known to be one of the most effective treatments for managing depression and other severe mental illnesses. Nevertheless, the exact mechanisms underlying response to ECT remain uncertain. This mini‐review presents clinical findings regarding the role of genetic factors in the aetiology of the ECT response. Studies on the role of variation in the catechol‐O‐methyltransferase (COMT) gene; other dopamine‐, serotonin‐, and G‐protein‐related genes; brain‐derived neurotrophic factor (BDNF); apolipoprotein E (APOE); angiotensin I‐converting enzyme (ACE) and vascular endothelial...
Source: Human Psychopharmacology: Clinical and Experimental - April 5, 2016 Category: Psychiatry Authors: Janine J. Benson‐Martin, Dan J. Stein, David S. Baldwin, Katharina Domschke Tags: Short Communication Source Type: research

Evaluation of interleukin‐6 and serotonin as biomarkers to predict response to fluoxetine
ObjectiveOnly 30% of major depressive disorder (MDD) patients achieve complete remission with a serotonergic antidepressant (selective serotonin reuptake inhibitor). We investigated the potential of serotonin (5‐HT) and interleukin‐6 (IL‐6) to serve as functional biomarkers of fluoxetine response. MethodsSerum IL‐6 and 5‐HT were measured in 73 MDD patients (39 responders and 34 non‐responders) pre‐ and 6 weeks post‐treatment and in 44 normal controls with ELISA. Fluoxetine and norfluoxetine were measured using LC MS/MS. ResultsIL‐6 levels were significantly higher in MDD patients when compared with controls (p 
Source: Human Psychopharmacology: Clinical and Experimental - March 26, 2016 Category: Psychiatry Authors: Aarthi Manoharan, Ravi Philip Rajkumar, Deepak Gopal Shewade, Rajan Sundaram, Avin Muthuramalingam, Abialbon Paul Tags: Research Article Source Type: research

A simulated car‐driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers
ConclusionsLevocetirizine and fexofenadine did not impair psychomotor performance in subjects performing simulated car‐driving tasks, while diphenhydramine did impair psychomotor performance in the subjects. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 21, 2016 Category: Psychiatry Authors: Akie Inami, Rin Matsuda, Thomas Grobosch, Hiroshi Komamura, Kazuko Takeda, Yusuke Yamada, Masayasu Miyake, Kotaro Hiraoka, Marcus Maurer, Kazuhiko Yanai, Manabu Tashiro Tags: Research Article Source Type: research

Access and latency to first antipsychotic treatment in Italian patients with schizophrenia and other schizophrenic spectrum disorders across different epochs
BackgroundThe duration of untreated illness (DUI) is a measure to express the latency to first psychopharmacological treatment: it differs among psychiatric disorders, being influenced by several illness‐intrinsic and environmental factors. The present study aimed to assess differences in DUI and related variables in patients with schizophrenia (SKZ) versus other schizophrenic spectrum disorders (SSDs) across different epochs. Methods101 SKZ or SSD patients were assessed with respect to DUI and related variables through clinical interview and questionnaire. ResultsPatients with SKZ showed earlier ages of onset, first dia...
Source: Human Psychopharmacology: Clinical and Experimental - March 6, 2016 Category: Psychiatry Authors: Maria Carlotta Palazzo, Chiara Arici, Bernardo Dell'Osso, Laura Cremaschi, Benedetta Grancini, Giulia Camuri, Beatrice Benatti, Lucio Oldani, Cristina Dobrea, Alma Cattaneo, Alfredo Carlo Altamura Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 6, 2016 Category: Psychiatry Tags: Issue Information Source Type: research

Validation of the 17‐item Hamilton Depression Rating Scale definition of response for adults with major depressive disorder using equipercentile linking to Clinical Global Impression scale ratings: analysis of Pharmacogenomic Research Network Antidepressant Medication Pharmacogenomic Study (PGRN‐AMPS) data
ConclusionsOur results support the consensus definition of response based on HDRS‐17 scores (>50% decrease from baseline). A similar definition of response may apply to the HDRS‐7 and Bech‐6. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2016 Category: Psychiatry Authors: William V. Bobo, Gabriela C. Angleró, Gregory Jenkins, Daniel K. Hall‐Flavin, Richard Weinshilboum, Joanna M. Biernacka Tags: Research Article Source Type: research

Suicide risk and antipsychotic side effects in schizophrenia: nested case–control study
ConclusionsA lower suicide risk identified among patients with EPS could potentially reflect higher antipsychotic adherence, exposure to higher dosage, or polypharmacy among these patients. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 29, 2016 Category: Psychiatry Authors: Johan Reutfors, Eric Clapham, Shahram Bahmanyar, Lena Brandt, Erik G. Jönsson, Anders Ekbom, Robert Bodén, Urban Ösby Tags: Short Communication Source Type: research

SSRI‐antipsychotic combination in psychotic depression: sertraline pharmacokinetics in the presence of olanzapine, a brief report from the STOP‐PD study
ObjectiveWe recently reported an unexpected interaction between olanzapine and sertraline in a population being treated for psychotic depression. Contrary to knowledge of cytochrome p450 interactions sertraline increased apparent clearance of olanzapine by 30%. Here we examined the pharmacokinetics of sertraline in the same population. Existing studies suggest that sertraline apparent clearance is significantly increased in male subjects and suggested an age/sex interaction. MethodsWe studied subjects undergoing combination of sertraline/olanzapine treatment for psychotic depression in the Study of the Pharmacotherapy of P...
Source: Human Psychopharmacology: Clinical and Experimental - February 29, 2016 Category: Psychiatry Authors: Simon J. C. Davies, Benoit H. Mulsant, Alastair J. Flint, Barnett S. Meyers, Anthony J. Rothschild, Ellen M. Whyte, Margaret M. Kirshner, Denise Sorisio, Bruce G. Pollock, Robert R. Bies, Tags: Short Communication Source Type: research

Next‐day residual effects of gabapentin, diphenhydramine, and triazolam on simulated driving performance in healthy volunteers: a phase 3, randomized, double‐blind, placebo‐controlled, crossover trial
ObjectiveNext‐day residual effects of a nighttime dose of gabapentin 250 mg were evaluated on simulated driving performance in healthy participants in a randomized, placebo‐controlled, double‐blind, multicenter, four‐period crossover study that included diphenhydramine citrate 76 mg and triazolam 0.5 mg. MethodsAt treatment visits, participants (n = 59) were dosed at ~23:30, went to bed immediately, and awakened 6.5 h postdose for evaluation. The primary endpoint was the standard deviation of lateral position for the 100‐km driving scenario. Additional measures of driving...
Source: Human Psychopharmacology: Clinical and Experimental - February 29, 2016 Category: Psychiatry Authors: Gary G. Kay, Howard I. Schwartz, Mark A. Wingertzahn, Shyamalie Jayawardena, Russell P. Rosenberg Tags: Research Article Source Type: research

Association study of polymorphism in the serotonin transporter gene promoter, methylation profiles, and expression in patients with major depressive disorder
We examined the association of 5HTT gene methylation, which influences gene expression, and the 5HTTLPR genotype before antidepressant treatment and expression before and after treatment. The aims of this study were (1) to investigate the association between 5HTT methylation or expression in leukocytes and depression and (2) to investigate a possible effect of 5HTT methylation, expression, and genotype on clinical symptoms in MDD. The 5HTTLPR genotype was significantly associated with mean methylation levels in patients only (patients: r = 0.40, p = 0.035, controls: p = 0.96). The ...
Source: Human Psychopharmacology: Clinical and Experimental - February 29, 2016 Category: Psychiatry Authors: Jun‐ichi Iga, Shin‐ya Watanabe, Shusuke Numata, Hidehiro Umehara, Akira Nishi, Makoto Kinoshita, Masatoshi Inoshita, Shinji Shimodera, Hirokazu Fujita, Tetsuro Ohmori Tags: Research Article Source Type: research

Genetic association analysis of N‐methyl‐d‐aspartate receptor subunit gene GRIN2B and clinical response to clozapine
ConclusionsOur findings do not support a role for these GRIN2B variants in altering response to clozapine in our sample. Investigation of additional glutamate variants in clozapine response is warranted. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 15, 2016 Category: Psychiatry Authors: Danielle L. Taylor, Arun K. Tiwari, Jeffrey A. Lieberman, Steven G. Potkin, Herbert Y. Meltzer, Jo Knight, Gary Remington, Daniel J. Müller, James L. Kennedy Tags: Research Article Source Type: research

The effects of pioglitazone adjuvant therapy on negative symptoms of patients with chronic schizophrenia: a double‐blind and placebo‐controlled trial
In this study, we evaluated the efficacy of pioglitazone as an adjunct to risperidone for reduction of negative symptoms in schizophrenia. MethodsIn this randomized, double‐blind, placebo‐controlled trial, 40 patients with chronic schizophrenia and a minimum score of 20 on the negative subscale of Positive and Negative Syndrome Scale (PANSS) were randomly allocated to receive risperidone plus either pioglitazone (30 mg/day) or placebo for 8 weeks. Patients' symptoms and adverse events were rated at baseline and weeks 2, 4, 6, and 8. The difference between the two groups in decline of PANSS negative subsca...
Source: Human Psychopharmacology: Clinical and Experimental - February 8, 2016 Category: Psychiatry Authors: Negar Iranpour, Atefeh Zandifar, Mehdi Farokhnia, Amirhossein Goguol, Habibeh Yekehtaz, Mohammad‐Reza Khodaie‐Ardakani, Bahman Salehi, Sophia Esalatmanesh, Atefeh Zeionoddini, Payam Mohammadinejad, Arefeh Zeinoddini, Shahin Akhondzadeh Tags: Research Article Source Type: research

Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5
ConclusionsIndividual differences in metabolic clearance of risperidone under the present conditions were not significantly influenced by the genotypes of CYP2D6 or CYP3A5. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 8, 2016 Category: Psychiatry Authors: Maho Okubo, Shoko Morita, Norie Murayama, Youichi Akimoto, Akiko Goto, Hiroshi Yamazaki Tags: Research Article Source Type: research

Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non‐smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3
ConclusionsOlanzapine clearance was not affected by CYP2D6 or FMO3 genotypes or smoking behavior as a single factor under the present conditions because olanzapine clearance is mediated by multiple enzymes involved in two major and one minor pathways. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 8, 2016 Category: Psychiatry Authors: Maho Okubo, Momoko Narita, Norie Murayama, Youichi Akimoto, Akiko Goto, Hiroshi Yamazaki Tags: Research Article Source Type: research

Mixing alcohol with energy drink (AMED) and total alcohol consumption: a systematic review and meta‐analysis
In conclusion, between‐group comparisons suggest that heavy alcohol consumption is one of the several phenotypical differences between AMED and AO consumers. Within‐subject comparisons revealed, however, that AMED consumption does not increase the total amount of alcohol consumed on a single drinking episode. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 19, 2016 Category: Psychiatry Authors: Joris C. Verster, Sarah Benson, Sean J. Johnson, Andrew Scholey, Chris Alford Tags: Review Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 19, 2016 Category: Psychiatry Tags: Issue Information Source Type: research

Does elevated peripheral benzodiazepine receptor gene expression relate to cognitive deficits in methamphetamine dependence?
ConclusionThe results suggest that systemic inflammatory effects can be associated with chronic METH abuse, and this may relate to the cognitive deficits seen in METH dependence. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2016 Category: Psychiatry Authors: Siriluk Veerasakul, Samur Thanoi, Paritat Watiktinkorn, Gavin P. Reynolds, Sutisa Nudmamud‐Thanoi Tags: Short Communication Source Type: research

Amygdala responses to quetiapine XR and citalopram treatment in major depression: the role of 5‐HTTLPR‐S/Lg polymorphisms
ConclusionsThese preliminary data suggest that pharmacological mechanisms and genetics need to be considered in the development of neuroimaging markers for the evaluation of antidepressant treatments. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2016 Category: Psychiatry Authors: Rajamannar Ramasubbu, Ashley Burgess, Ismael Gaxiola‐Valdez, Filomeno Cortese, Darren Clark, Anne Kemp, Bradley Goodyear, Glenda Macqueen, N. Torben Bech‐Hansen, Jane Foster, Vaibhav A. Diwadkar Tags: Research Article Source Type: research

A randomized, double‐blind, placebo controlled, parallel group, efficacy study of alpha BRAIN® administered orally
ConclusionsThe use of Alpha BRAIN® for 6 weeks significantly improved recent verbal memory when compared with controls, in a group of healthy adults. While the outcome of the study is encouraging, this is the first randomized controlled trial of Alpha BRAIN®, and the results merit further study. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2016 Category: Psychiatry Authors: Todd M. Solomon, Jarrett Leech, Guy B. deBros, Cynthia A. Murphy, Andrew E. Budson, Elizabeth A. Vassey, Paul R. Solomon Tags: Research Article Source Type: research

Pharmacology for sleep disturbance in PTSD
Symptoms of sleep disturbance, particularly nightmares and insomnia, are a central feature of post‐traumatic stress disorder (PTSD). Emerging evidence suggests that specific treatment of PTSD‐related sleep disturbance improves other symptoms of the disorder, which in turn suggests that such disturbance may be fundamental to development and maintenance of the disorder. This mini‐review focuses on pharmacological treatment of sleep disturbance in adult PTSD (specifically, studies testing the efficacy of antidepressants, adrenergic inhibiting agents, antipsychotics and benzodiazepine and non‐benzodiazepine hypnotics)....
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2016 Category: Psychiatry Authors: Gosia Lipinska, David S. Baldwin, Kevin G. F. Thomas Tags: Short Communication Source Type: research

Effect of polymorphisms on the pharmacokinetics, pharmacodynamics, and safety of risperidone in healthy volunteers
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 6, 2015 Category: Psychiatry Tags: Erratum Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 6, 2015 Category: Psychiatry Tags: Issue Information Source Type: research

New psychoactive substances as part of polydrug abuse within opioid maintenance treatment revealed by comprehensive high‐resolution mass spectrometric urine drug screening
ConclusionsA widespread occurrence of abused substances beyond the ordinary was revealed. Identifying these patients is essential as polydrug abuse is a safety risk to the patient and may cause attrition from OMT. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2015 Category: Psychiatry Authors: Pertti Heikman, Mira Sundström, Anna Pelander, Ilkka Ojanperä Tags: Research Article Source Type: research

Effects of methylphenidate on body index and physical fitness in Korean children with attention deficit hyperactivity disorder
This study aimed to investigate the effect of MPH on clinical symptoms, growth, and physical fitness in Korean children. MethodsFifty male children with attention deficit hyperactivity disorder (ADHD) treated with methylphenidate (MPH‐ADHD), 69 MPH‐naïve male children with ADHD (Naïve‐ADHD), and 60 age‐matched and sex‐matched healthy control subjects were recruited. Intelligence quotient (IQ), clinical symptoms of ADHD, body index (height, weight, and body mass index [BMI]), and physical fitness (muscular strength, endurance, flexibility, agility, speed, and balance) were assessed. ResultsTotal IQ and p...
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2015 Category: Psychiatry Authors: Kyoung Doo Kang, Sin Weon Yun, Unsun Chung, Tae Ho Kim, Jeong Ha Park, In Hui Park, Doug Hyun Han Tags: Research Article Source Type: research

Acute personalized habitual caffeine doses improve attention and have selective effects when considering the fractionation of executive functions
Caffeine is widely used, often consumed with food, and improves simple and complex/executive attention under fasting conditions. We investigated whether these cognitive effects are observed when personalized habitual doses of caffeine are ingested by caffeine consumers, whether they are influenced by nutriments and if various executive domains are susceptible to improvement. This was a double‐blind, placebo‐controlled study including 60 young, healthy, rested males randomly assigned to one of four treatments: placebo fasting, caffeine fasting, placebo meal and caffeine meal. Caffeine doses were individualized for each ...
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2015 Category: Psychiatry Authors: Juliana Lanini, José Carlos Fernandes Galduróz, Sabine Pompéia Tags: Research Article Source Type: research

Potential neuroprotective effect of lithium in bipolar patients evaluated by neuropsychological assessment: preliminary results
ConclusionsThis study is the first to our knowledge to have demonstrated, by means of a highly sensitive test of visual memory, a potential hippocampus neuroprotective effect of lithium in patients with bipolar disorder. Besides, it confirms prior findings of cognitive deficits in euthymic bipolar patients. Copyright © 2015 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2015 Category: Psychiatry Authors: Giuseppe Bersani, Adele Quartini, Daiana Zullo, Angela Iannitelli Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 9, 2015 Category: Psychiatry Tags: Issue Information Source Type: research