Can mobile phone technology support a rapid sharing of information on novel psychoactive substances among health and other professionals internationally?
ConclusionsThis is the right time to use mobile phone technologies for rapid information sharing and prevention activities on NPSs. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 31, 2017 Category: Psychiatry Authors: Pierluigi Simonato, Francesco S. Bersani, Rita Santacroce, Eduardo Cinosi, Fabrizio Schifano, Giuseppe Bersani, Giovanni Martinotti, Ornella Corazza Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Next ‐day residual effects of flibanserin on simulated driving performance in premenopausal women
The objective of this study was to determine the next‐day residual effects of acute and steady‐state nighttime dosing of flibanserin on simulated driving performance and cognitive function in healthy premenopausal women. MethodsIn this randomized, double‐blind, placebo‐controlled, four‐way crossover study, 72 subjects were treated with either acute oral doses of placebo, zopiclone 7.5 mg (positive control) or flibanserin 100 mg at bedtime (indicated therapeutic dose), or after chronic nightly oral doses of flibanserin 100 mg for 1 week followed by a single bedtime dose of flibanserin 200 ...
Source: Human Psychopharmacology: Clinical and Experimental - May 31, 2017 Category: Psychiatry Authors: Gary G. Kay, Thomas Hochadel, Eric Sicard, Karthi K. Natarajan, Noel N. Kim Tags: RESEARCH ARTICLE Source Type: research

Substance ‐related psychopathology and aggressiveness in a nightlife holiday resort: Results from a pilot study in a psychiatric inpatient unit in Ibiza
Abstract ObjectivesWe aimed to describe a sample of subjects admitted to a psychiatric unit after the intake of psychoactive substances for recreational purposes. MethodsBetween June and September 2015, 49 subjects were included. Sociodemographic characteristics and psychopathological aspects were investigated, and urine samples for further analysis were collected. Three subgroups (cannabinoids, stimulants, and depressors users) were identified, according to the structured interview regarding substance use and urinalysis. ResultsLevel of aggressiveness was found to be significantly higher (p 
Source: Human Psychopharmacology: Clinical and Experimental - May 30, 2017 Category: Psychiatry Authors: Giovanni Martinotti, Eduardo Cinosi, Rita Santacroce, Duccio Papanti, Anna Pasquini, Valerio Mancini, Mariangela Corbo, Federica Fiori, Fabiola Sarchione, Daniela Marchetti, Maria Cristina Verrocchio, Massimo Di Giannantonio, Marta Torrens, Fabrizio Schif Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Novel psychoactive substance consumption is more represented in bipolar disorder than in psychotic disorders: A multicenter ‐observational study
ConclusionsThe use of NPS in a young psychiatric population appears to be frequent, and probably still underestimated. Bipolar disorder shows an association with NPS use. Careful and constant monitoring and an accurate evaluation of possible clinical effects related to NPS use are necessary. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 18, 2017 Category: Psychiatry Authors: Tiziano Acciavatti, Matteo Lupi, Rita Santacroce, Andrea Aguglia, Luigi Attademo, Laura Bandini, Paola Ciambrone, Giulia Lisi, Giovanni Migliarese, Federica Pinna, Diego Quattrone, Michele Ribolsi, Maria Salvina Signorelli, Salvatore Cal ò, Fabrizio Schi Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Genie in a blotter: A comparative study of LSD and LSD analogues' effects and user profile
ConclusionsLSD analogues were reported as similar in time to peak and duration as LSD but weaker in strength, pleasurable high, and comedown. Future studies should seek to replicate these findings with chemical confirmation and dose measurement. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 18, 2017 Category: Psychiatry Authors: Leigh D. Coney, Larissa J. Maier, Jason A. Ferris, Adam R. Winstock, Monica J. Barratt Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Is there a potential of misuse for Magnolia officinalis compounds/metabolites?
ConclusionsTo the best of our knowledge, this is the first paper commenting on the possible Magnolia derivatives' potential of misuse. Magnolia's recent increase in popularity, mainly as a sedative, may be arguably due to its peculiar pharmacological properties/acceptable affordability levels/virtually worldwide favorable legal status and customers' attraction to a product being perceived as “natural” and hence somehow “safe.” Future/potent/synthetic magnolol and honokiol structural analogues could however contribute to increasing the number of synthetic GABA‐ergic/cannabimimetic misusing compound...
Source: Human Psychopharmacology: Clinical and Experimental - May 18, 2017 Category: Psychiatry Authors: Fabrizio Schifano, Valentina Guarino, Duccio G. Papanti, Jacopo Baccarin, Laura Orsolini, John M. Corkery Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

The dose –effect relationship of baclofen in alcohol dependence: A 1‐year cohort study
ConclusionThe relationship between dose of baclofen and favorable drinking outcome was U‐shaped, that is, was increased at low and high doses compared to medium doses. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 18, 2017 Category: Psychiatry Authors: Baptiste Pignon, Julien Labreuche, Marine Auffret, Sophie Gautier, Sylvie Deheul, Nicolas Simioni, Olivier Cottencin, R égis Bordet, Alain Duhamel, Benjamin Rolland Tags: RESEARCH ARTICLE Source Type: research

A matter of life and death: substance ‐caused and substance‐related fatalities in Ibiza in 2015
ConclusionsAlthough the use of NPS is rapidly increasing in Europe, according to the results from our sample, alcohol and well‐known stimulants (MDMA and cocaine) are still the substances of abuse mainly involved in the cases of substance‐caused and substance‐related fatalities. The significant increase of fatalities in Ibiza in the last 5 years is an issue that must be taken into account and should be better investigated, as other theories besides NPS‐increased diffusion should be proposed, and therefore, targeted prevention strategies should be designed. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 18, 2017 Category: Psychiatry Authors: Rita Santacroce, Claudia Ruiz Bennasar, Juan Ramon Sancho Jaraiz, Federica Fiori, Fabiola Sarchione, Federica Angelini, Gabriella Catalano, Maria Luisa Carenti, John Martin Corkery, Fabrizio Schifano, Massimo Di Giannantonio, Giovanni Martinotti Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Novel psychoactive substances (NPS) use in severe mental illness (SMI) patients: Potential changes in the phenomenology of psychiatric diseases
ConclusionsNPS use could modify clinical features of SMI, but these conclusions cannot be generalizable. More evidence is needed to establish the causal and effective connection between NPS use and course of illness, type of psychiatric symptoms, and outcome of treatment in terms of adherence or response. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 18, 2017 Category: Psychiatry Authors: Giuseppe Bersani, Elisabeth Prevete Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

L ‐carnosine as an adjuvant to fluvoxamine in treatment of obsessive compulsive disorder: A randomized double‐blind study
Abstract BackgroundDysregulation of glutamate is implicated in the pathogenesis of obsessive‐compulsive disorder (OCD). Consistently, glutamate‐modulating agents, such as riluzole and memantine have been used in OCD treatment. Previous research has identified some neuroprotective role for L‐carnosine potentially via its modulatory effect on glutamate. Here, we assessed the efficacy of L‐carnosine as adjuvant to fluvoxamine in OCD treatment. MethodsForty‐four patients diagnosed with moderate to severe OCD were recruited in a randomized double‐blind trial. Patients received either L‐carnosine or placebo as adju...
Source: Human Psychopharmacology: Clinical and Experimental - May 8, 2017 Category: Psychiatry Authors: Somaye Arabzadeh, Maryam Shahhossenie, Bita Mesgarpour, Farzin Rezaei, Mohammad Reza Shalbafan, Zahra Ghiasi, Shahin Akhondzadeh Tags: RESEARCH ARTICLE Source Type: research

Biomarkers of the alcohol hangover state: Ethyl glucuronide (EtG) and ethyl sulfate (EtS)
ConclusionsAlthough urine EtG and EtS concentration did not significantly correlate to estimated peak blood alcohol concentrations or the number of alcoholic drinks consumed, a significant correlation was found with urine ethanol concentration. However, urine EtG and EtS concentrations did not significantly correlate with overall hangover severity. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2017 Category: Psychiatry Authors: Marlou Mackus, Aurora J. A. E. Loo, S. Jorinde Raasveld, Anna Hogewoning, Javier Sastre Tora ño, Frits M. Flesch, Gerdien A. H. Korte‐Bouws, Renier H. P. Neer, Xiaochun Wang, Thomas T. Nguyen, Karel A. Brookhuis, Aletta D. Kraneveld, Johan Garssen, Jor Tags: RESEARCH ARTICLE Source Type: research

Open ‐label, proof‐of‐concept study of brexanolone in the treatment of severe postpartum depression
ConclusionsBrexanolone was well tolerated and demonstrated activity in severe PPD. Larger, double‐blind trials are needed for further evaluation. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 30, 2017 Category: Psychiatry Authors: Stephen J. Kanes, Helen Colquhoun, James Doherty, Shane Raines, Ethan Hoffmann, David R. Rubinow, Samantha Meltzer ‐Brody Tags: SHORT COMMUNICATION Source Type: research

Prescribing in schizophrenia and psychosis: Increasing polypharmacy over time
Abstract IntroductionDiabetes, obesity, and metabolic syndrome are highly prevalent in patients with severe mental illness. Psychotropic polypharmacy is becoming increasingly prevalent within the UK. We determined the change in the number of psychotropic medications prescribed over time and trends in weight and fasting blood glucose. MethodsOne hundred ninety‐five individuals with schizophrenia and psychosis on the Severe Mental Illness Register in Cheshire, UK, were followed up between 2004 and 2012. Individuals were identified through a semianonymised search of general practitioner registers. ResultsThe total number of...
Source: Human Psychopharmacology: Clinical and Experimental - March 30, 2017 Category: Psychiatry Authors: Adrian Heald, Mark Livingston, Alison Yung, M.A. De Hert Tags: RESEARCH ARTICLE Source Type: research

Pharmacotherapy effectiveness for clinical subgroups among children and adolescents with early onset schizophrenia
ConclusionsRegardless of the specific constellation of symptoms and comorbid disorders targeted, the coprescription of multiple SGAs was not effective over time in stabilizing children and adolescents outside of acute care settings. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 30, 2017 Category: Psychiatry Authors: Jeanette M. Jerrell, Roger S. McIntyre, Chelsea B. Deroche Tags: RESEARCH ARTICLE Source Type: research

Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents
ConclusionSymptom patterns plus age of first diagnosis are important differentiators of EOS subgroups in this cohort. Earlier recognition of psychiatric symptom/syndrome patterns that frequently co‐occur may enable clinicians to stratify/tailor treatment interventions. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 30, 2017 Category: Psychiatry Authors: Jeanette M. Jerrell, Roger S. McIntyre, Chelsea B. Deroche Tags: RESEARCH ARTICLE Source Type: research

Long ‐term antipsychotic use and brain changes in schizophrenia – a systematic review and meta‐analysis
ConclusionsAntipsychotic medication may associate with brain structure changes. More long‐term follow‐up studies taking into account illness severity measures are needed to make definitive conclusions. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 30, 2017 Category: Psychiatry Authors: Sanna Huhtaniska, Erika J ääskeläinen, Noora Hirvonen, Jukka Remes, Graham K. Murray, Juha Veijola, Matti Isohanni, Jouko Miettunen Tags: REVIEW ARTICLE Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 30, 2017 Category: Psychiatry Tags: ISSUE INFORMATION Source Type: research

The detection and prevention of unintentional consumption of DOx and 25x ‐NBOMe at Portugal's Boom Festival
ConclusionsAlthough these results support the provision of integrated drug‐checking services in party settings, evidence of their utility and effectiveness would be improved through future research incorporating more robust measures of outcomes following provision of drug‐checking results. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Daniel Martins, Monica J. Barratt, Cristiana Vale Pires, Helena Carvalho, Mireia Ventura, Iv án Fornís, Helena Valente Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

The effects and toxicity of cathinones from the users' perspectives: A qualitative study
ConclusionsThe Internet discussion forums provide useful sources of information regarding the effects and toxicity of cathinones, which can be taken into account when assessing the safety of drugs. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Sulaf Assi, Nargilya Gulyamova, Paul Kneller, David Osselton Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Profile, effects, and toxicity of novel psychoactive substances: A systematic review of quantitative studies
ConclusionsDespite the unique subjective effects associated with the use of NPS, harmful effects could be severe and/or lethal. Therefore, there is a need to develop research in the area of NPS and promote awareness among healthcare professionals. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Sulaf Assi, Nargilya Gulyamova, Kinda Ibrahim, Paul Kneller, David Osselton Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

A market on both “sides” of the law: The use of the hidden web for the sale of new psychoactive substances
ConclusionsVendors selling and availability of NPS increased over the 12 months of data collection. Potential displacement from the visible Web to hidden Web should be taken into consideration. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Elle Wadsworth, Colin Drummond, Andreas Kimerg ård, Paolo Deluca Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

The challenge of complex drug use: Associated use of codeine ‐containing medicines and new psychoactive substances in a European cross‐sectional online population
ConclusionsAmongst NPS users, codeine is less likely to be used daily but more likely to be used for recreational purposes. Smaller populations engaging in high‐risk use exist who take multiple drugs in high doses. Combinations of misused codeine and NPS highlight the need for policy to respond to a more complex drug situation. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Andreas Kimerg ård, Michelle Foley, Zoe Davey, Elle Wadsworth, Colin Drummond, Paolo Deluca Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Altered serum levels of TNF ‐α, IL‐6, and IL‐18 in depressive disorder patients
ConclusionThese findings provided additional evidence that altered TNF‐α, IL‐6, and IL‐18 activities may contribute to the pathophysiology of depressive disorder. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Ni Fan, Yayan Luo, Yufen Ou, Hongbo He Tags: RESEARCH ARTICLE Source Type: research

Retraction: ‘Effect of blonanserin on cognitive function in antipsychotic‐naïve first‐episode schizophrenia’
The above article from Human Psychopharmacology, first published on 25 January 2012 in Wiley OnlineLibrary (onlinelibrary.wiley.com), and in Volume 90, pp. 90‐100, has been retracted by agreement between the authors, the journal Editor in Chief, David Baldwin, and John Wiley & Sons Ltd. The retraction has been agreed following an investigation by the St Marianna University Ethics Committee which determined that the paper was not as originally designed and approved. REFERENCESTenjin, T., Miyamoto, S., Miyake, N., Ogino, S., Kitajima, R., Ojima, K., … Yamaguchi, N. (2012). Effect of blonanserin on cognitive func...
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Tags: RETRACTION Source Type: research

Interventions for treatment and/or prevention of alcohol hangover: Systematic review
Abstract ObjectiveTo evaluate new research conducted over the past few years (2009–2016) assessing the effectiveness of potentially curative and/or preventive methods of alcohol hangover. MethodsData were retrieved by a 4‐stage systematic search process. A search of the online Pubmed and Scopus databases were performed, using a combination of keywords: “Alcohol,” “Ethanol,” and “C2H5OH,” in combination with the terms “Hangover,” “Treatment,” and “Prevention.” The search comprised studies listed between January 1, 2009 and June 30, 2016. Finding...
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Ranil Jayawardena, Thulasika Thejani, Priyanga Ranasinghe, Dinithi Fernando, Joris C. Verster Tags: REVIEW ARTICLE Source Type: research

Recreational stimulants, herbal, and spice cannabis: The core psychobiological processes that underlie their damaging effects
ConclusionsRecreational stimulants such as cocaine or MDMA (3.4‐methylenedioxymethamphetamine) and sedative drugs such as cannabis damage human homeostasis and well‐being through similar core psychobiological mechanisms. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Andrew C. Parrott, Amie C. Hayley, Luke A. Downey Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Changing trends in the use of kratom (Mitragyna speciosa) in Southeast Asia
ConclusionsLegal sanctions appear to have preceded serious scientific investigations into the claimed benefits of ketum. More objective‐controlled trials and experiments on humans need to be conducted to validate self‐report claims by kratom users in the community. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Darshan Singh, Suresh Narayanan, Balasingam Vicknasingam, Ornella Corazza, Rita Santacroce, Andres Roman ‐Urrestarazu Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

New psychoactive substances: Purchasing and supply patterns in Australia
ConclusionNBOMe consumers and those who nominated online markets as their main NPS source reported greater engagement with for‐profit supply; it is unclear if these individuals have “drifted” into dealing or if they were already engaged in such activities. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Rachel Sutherland, Raimondo Bruno, Amy Peacock, Paul Dietze, Courtney Breen, Lucinda Burns, Monica J. Barratt Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

An international survey on the awareness, use, preference, and health perception of novel psychoactive substances (NPS)
Abstract ObjectiveThis survey investigated the level of public awareness, preference, and motivation of novel psychoactive substances (NPS) use as well as knowledge of potential associated health risks. MethodsA Bristol Online Survey was advertised through social media and a drug forum “Bluelight” between January 7 and February 7, 2015. ResultsResponses were received from 17 countries, mainly from Europe. Most responses (83%) came from university educated students. Two‐thirds (65%) of the 168 respondents were aware of NPS. Awareness was significantly increased in those with bisexual or homosexual orientation (p 
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Elena Deligianni, John M. Corkery, Fabrizio Schifano, Lisa A. Lione Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Cilostazol adjunctive therapy in treatment of negative symptoms in chronic schizophrenia: Randomized, double ‐blind, placebo‐controlled study
Abstract ObjectiveTo evaluate the efficacy and safety of cilostazol, a selective inhibitor of phosphodiesterase III, as an adjunctive to risperidone in alleviating the negative symptoms of schizophrenia. MethodsEighty‐four in‐patients with diagnosis of chronic schizophrenia participated in a randomized, placebo‐controlled trial and underwent 8 weeks of treatment with either cilostazol (50 mg twice a day) or placebo as an adjuvant to risperidone. Participants were assessed using the positive and negative syndrome scale (PANSS) at baseline and at weeks 2, 4, 6, and 8. The primary outcome measure of the trial ...
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2017 Category: Psychiatry Authors: Farzin Rezaei, Bita Mesgarpour, Alireza Jeddian, Atefeh Zeionoddini, Payam Mohammadinejad, Elaheh Salardini, Mona Shahriari, Arefeh Zeinoddini, Shahin Akhondzadeh Tags: RESEARCH ARTICLE Source Type: research

The factor structure of the Mystical Experience Questionnaire (MEQ): Reply to Barrett & Griffiths (2016)
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 24, 2017 Category: Psychiatry Authors: Jos é Carlos Bouso, Eduardo José Pedrero‐Pérez, Sam Gandy, Miguel Ángel Alcázar‐Córcoles Tags: LETTER TO THE EDITOR Source Type: research

The factor structure of the Mystical Experience Questionnaire (MEQ): Reply to Bouso et al., 2016
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 24, 2017 Category: Psychiatry Authors: Frederick S. Barrett, Roland R. Griffiths Tags: LETTER TO THE EDITOR Source Type: research

Adjunctive antidepressant use in schizophrenia in China: A national survey (2002 –2012)
This study examined the pattern of adjunctive antidepressant use in schizophrenia patients and its demographic and clinical correlates in a nationwide survey in China. MethodsFourteen thousand and thirteen patients in 45 Chinese psychiatric hospitals or centers were interviewed (4,486 in 2002, 5,288 in 2006, and 4,239 in 2012). Patients' sociodemographic and clinical characteristics were recorded using a standardized protocol and data collection procedure. Chi‐square test, independent‐samples t test, Mann–Whitney U test, and multiple logistic regression analysis were used in data analyses. ResultsAntidepressant u...
Source: Human Psychopharmacology: Clinical and Experimental - January 24, 2017 Category: Psychiatry Authors: Qian Li, Yun ‐Ai Su, Yu‐Tao Xiang, Liang Shu, Xin Yu, Gabor S. Ungvari, Chee H. Ng, Helen F.K. Chiu, Yu‐Ping Ning, Gao‐Hua Wang, Ke‐Rang Zhang, Tao Li, Li‐Zhong Sun, Jian‐Guo Shi, Xian‐Sheng Chen, Qi‐Yi Mei, Ke‐Qing Li, Tian‐Mei Si Tags: RESEARCH ARTICLE Source Type: research

A phase I, randomized, proof ‐of‐clinical‐mechanism study assessing the pharmacokinetics and pharmacodynamics of the oral PDE9A inhibitor BI 409306 in healthy male volunteers
ConclusionsBI 409306 increased rapidly in plasma and was subsequently detected in CSF, resulting in dose‐dependent increases in cGMP levels in CSF. Results indicate BI 409306 efficiently crosses the blood‐CSF barrier, with an acceptable level of AEs. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 24, 2017 Category: Psychiatry Authors: Katja Boland, Viktoria Moschetti, Chantaratsamon Dansirikul, Solen Pichereau, Lien Gheyle, Frank Runge, Heike Zimdahl ‐Gelling, Michael Sand Tags: RESEARCH ARTICLE Source Type: research

Association study between the neurexin ‐1 gene and tardive dyskinesia
ConclusionsMore research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 24, 2017 Category: Psychiatry Authors: Rachel Lanning, Tristram A. Lett, Arun K. Tiwari, Eva J. Brandl, Vincenzo Luca, Aristotle N. Voineskos, Steven G. Potkin, Jeffrey A. Lieberman, Herbert Y. Meltzer, Daniel J. M üller, Gary Remington, James L. Kennedy, Clement C. Zai Tags: RESEARCH ARTICLE Source Type: research

Effects of acute buspirone administration on inhibitory control and sexual discounting in cocaine users
ConclusionsThese findings indicate that acutely administered buspirone has little impact on behavioral measures of inhibitory control and impulsive sexual decision‐making. Considering previous findings with chronic dosing, these findings highlight that the behavioral effects of buspirone differ as a function of dosing conditions. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 24, 2017 Category: Psychiatry Authors: Justin C. Strickland, B. Levi Bolin, Michael R. Romanelli, Craig R. Rush, William W. Stoops Tags: RESEARCH ARTICLE Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 24, 2017 Category: Psychiatry Tags: ISSUE INFORMATION Source Type: research

rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride
Abstract A recent genome‐wide pharmacogenomics study showed that the rs7968606 single‐nucleotide polymorphism (SNP) of the ankyrin repeat and sterile alpha motif domain‐containing protein 1B (ANKS1B) gene approached the threshold of statistical significance. The aim of this study was to determine the association between the rs7968606 SNP of ANKS1B and the treatment response to amisulpride in schizophrenia patients. In total, 154 participants were enrolled from six university hospitals in Korea. All the subjects were interviewed before and after 6 weeks of amisulpride treatment with the aid of the positive and ne...
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2017 Category: Psychiatry Authors: Seung ‐Gul Kang, Ik‐Seung Chee, Kwanghun Lee, Jonghun Lee Tags: RESEARCH ARTICLE Source Type: research

Association between overall rate of change in rising breath alcohol concentration and the magnitude of acute tolerance of subjective intoxication via the Mellanby method
This study explored whether acute tolerance magnitude varied as a function of the overall rate of increase in breath alcohol concentration (BrAC). MethodsTwenty‐nine young adult social drinkers (M age = 22.55, SD = 3.10; 62.1% women) consumed a moderate dose of alcohol (men: 0.86 g/kg, women: 0.75 g/kg) in a controlled laboratory setting. Subjective intoxication was assessed at matched BrACs (~0.060 g/dl) on each limb of the BrAC curve. ResultsHierarchical regression results indicated that faster overall increases in BrAC on the ascending limb were associated with greater acute toleranc...
Source: Human Psychopharmacology: Clinical and Experimental - December 6, 2016 Category: Psychiatry Authors: David H. Morris, Michael T. Amlung, Chia ‐Lin Tsai, Denis M. McCarthy Tags: RESEARCH ARTICLE Source Type: research

Seasonal variations in [3H] citalopram platelet binding between healthy controls and violent offenders in Finland
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 15, 2016 Category: Psychiatry Tags: CORRIGENDUM Source Type: research

Effectiveness of atomoxetine and methylphenidate for problematic online gaming in adolescents with attention deficit hyperactivity disorder
ConclusionsBoth MPH and ATM reduced the severity of Internet gaming disorder symptoms, and this reduction was correlated with impulsivity reduction, which also resulted from both ADHD medications. These findings suggest impulsivity plays a critical role in the development of problematic online gaming. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 15, 2016 Category: Psychiatry Authors: Jeong Ha Park, Young Sik Lee, Ji Hyun Sohn, Doug Hyun Han Tags: RESEARCH ARTICLE Source Type: research

The effects of olanzapine treatment on brain regional glucose metabolism in neuroleptic ‐naive first‐episode schizophrenic patients
ConclusionsThese findings provide evidence of the neural mechanisms underlying the effects of olanzapine on metabolism in the early stages of schizophrenia. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 15, 2016 Category: Psychiatry Authors: Hirofumi Yoshimuta, Masayuki Nakamura, Eisuke Kanda, Seigo Fujita, Kouzou Takeuchi, Toshiro Fujimoto, Yoshiaki Nakabeppu, Yasuaki Akasaki, Akira Sano Tags: RESEARCH ARTICLE Source Type: research

Effectiveness of agomelatine on anhedonia in depressed patients: an outpatient, open ‐label, real‐world study
Abstract ObjectiveThe aim of this real‐world study was to evaluate the effect of agomelatine on anhedonia as primary endpoint in outpatients under treatment of major depressive episodes. MethodsThe study was an open‐label, multicenter, 8‐week phase IV trial. Two hundred fifty‐seven (257) patients were recruited, and 143 patients were included in the analysis. Agomelatine was administered orally as a 25‐mg tablet. The dose could be increased to 50 mg after 2 weeks of treatment. ResultsAn improvement in the severity of anhedonia (Snaith‐Hamilton Pleasure Scale total score) was observed from 8.5 points a...
Source: Human Psychopharmacology: Clinical and Experimental - November 15, 2016 Category: Psychiatry Authors: Pedro Damian Gargoloff, Ricardo Corral, Luis Herbst, Miguel Marquez, Giovanni Martinotti, Pedro Rafael Gargoloff Tags: RESEARCH ARTICLE Source Type: research

Are deficits in cognition associated with psychotic ‐like experiences after cannabis?
ConclusionsThose who report psychotic/dysphoric experiences after cannabis have subtle inefficiencies in their cognitive processes. The multiple factors which predict vulnerability to psychotic‐like experiences after cannabis require further investigation. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 15, 2016 Category: Psychiatry Authors: Emma Barkus, Paul Morrison, Marta Di Forti, Robin M. Murray Tags: RESEARCH ARTICLE Source Type: research

Attentional biases in patients with alcohol dependence: influence of coexisting psychopathology
Abstract ObjectiveThe effects of coexisting psychopathology on disorder‐specific attentional biases in patients with alcohol dependence are uncertain. We undertook a cross‐sectional study assessing attentional biases to alcohol‐, depression‐, and anxiety‐ related stimuli using the visual probe task in patients with alcohol dependence, attending a community alcohol service. MethodsUsing the visual probe task, we presented disorder‐specific words (relating to alcohol, anxiety, and depression) for 500 ms and measured reaction times. ResultsParticipants demonstrated a significant attentional bias towards alcoh...
Source: Human Psychopharmacology: Clinical and Experimental - November 15, 2016 Category: Psychiatry Authors: Julia M.A. Sinclair, Matthew Garner, Sonja C. Pasche, Thomas B. Wood, David S. Baldwin Tags: RESEARCH ARTICLE Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 15, 2016 Category: Psychiatry Tags: Issue Information Source Type: research

Haloperidol increases false recognition memory of thematically related pictures in healthy volunteers
Abstract Dopamine can modulate long‐term episodic memory. Its potential role on the generation of false memories, however, is less well known. In a randomized, double‐blind, placebo‐controlled experiment, 24 young healthy volunteers ingested a 4‐mg oral dose of haloperidol, a dopamine D2‐receptor antagonist, or placebo, before taking part in a recognition memory task. Haloperidol was active during both study and test phases of the experiment. Participants in the haloperidol group produced more false recognition responses than those in the placebo group, despite similar levels of correct recognition. These finding...
Source: Human Psychopharmacology: Clinical and Experimental - October 31, 2016 Category: Psychiatry Authors: Regina V. Guarnieri, Luciano G. Buratto, Carlos F.A. Gomes, Rafaela L. Ribeiro, Altay A. Lino Souza, Lilian M. Stein, Jos é C. Galduróz, Orlando F.A. Bueno Tags: Short Communication Source Type: research

Lisdexamfetamine dimesylate in binge eating disorder: a placebo controlled trial
ConclusionLisdexamfetamine dimesylate may have clinical utility for BED but further studies of its efficacy, tolerability, and safety in this population are needed. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 19, 2016 Category: Psychiatry Authors: Anna I. Guerdjikova, Nicole Mori, Thomas J. Blom, Paul E. Keck, Stephanie L. Williams, Jeffrey A. Welge, Susan L. McElroy Tags: Research Article Source Type: research

Systematic review of blood transcriptome profiling in neuropsychiatric disorders: guidelines for biomarker discovery
ConclusionsDetailed consideration of statistical analysis in the early stages of experimental planning is critical to ensure blood‐based biomarker discovery and validation. Statistical guidelines are presented to enhance implementation and reproducibility of machine learning and gene network analyses across independent studies. Future studies capitalizing on larger sample sizes and emerging next‐generation technologies set the stage for moving the field forwards. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 19, 2016 Category: Psychiatry Authors: Michael S. Breen, Dan J. Stein, David S. Baldwin Tags: Review Article Source Type: research

Captagon: use and trade in the Middle East
ConclusionFurther investigations are needed on the role that psychoactive drugs play in terrorist attacks and civil war zones. Unless a comprehensive methodological strategy, inclusive of unconventional methods of research, is implemented, it will not be feasible to face such a threat to humanity. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 31, 2016 Category: Psychiatry Authors: Ahmed AL ‐Imam, Rita Santacroce, Andres Roman‐Urrestarazu, Robert Chilcott, Giuseppe Bersani, Giovanni Martinotti, Ornella Corazza Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research