Alcohol mixed with energy drink (AMED): A critical review and meta ‐analysis
In conclusion, when compared to AO consumption, mixing alcohol with energy drink does not affect subjective intoxication and seems unlikely to increase total alcohol consumption, associated risk‐taking behavior, nor other negative alcohol‐related consequences. Further research may be necessary to fully reveal the effects of AMED. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2018 Category: Psychiatry Authors: Joris C. Verster, Sarah Benson, Sean J. Johnson, Chris Alford, Samuel Benrejeb Godefroy, Andrew Scholey Tags: REVIEW ARTICLE Source Type: research

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Human Psychopharmacology: Clinical and Experimental,Volume 33, Issue 1, January 2018. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - December 21, 2017 Category: Psychiatry Source Type: research

Learning and memory performance following acute intranasal insulin administration in abstinent smokers
Abstract The highest incidence of relapse to smoking occurs within the first 2 weeks of a cessation attempt. In addition to enhanced nicotine craving, this phase of smoking cessation is also marked by learning and memory dysfunction. Many smokers are not able to overcome these symptoms, and they relapse to smoking shortly after trying to quit. In two clinical studies, we evaluated intranasal insulin for efficacy in improving learning and memory function during nicotine withdrawal. Our first study was a crossover evaluation (N = 19) following 20 hr of smoking abstinence. Study 2 was a parallel design stu...
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2017 Category: Psychiatry Authors: Ajna Hamidovic, Lionel Candelaria, Ihsan Rodriguez, Mikiko Yamada, James Nawarskas, Mark R. Burge Tags: RESEARCH ARTICLE Source Type: research

Consensus statements on the clinical understanding and use of milnacipran in Hong Kong
ConclusionsThe present consensus statements were developed as general recommendations for medical practitioners and psychiatrists to be practically referred to in clinical settings. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2017 Category: Psychiatry Authors: Wing King Lee, Kwok Leung Au Yeung, Ho Bun Lam, Chi Keung Wong, Ming Kai Au, Hoi Yee Karina Chan, Yat Wo Eric Cheung, Wing Ho Chui, Ting Chi Vanessa Wong, Chi Kin Fu, Shiu Kow Sham, Ki Yan Mak Tags: REVIEW ARTICLE Source Type: research

Relative short ‐term efficacy and acceptability of agomelatine versus vortioxetine in adult patients suffering from major depressive disorder
The objective of this present analysis is to determine the relative efficacy and acceptability of agomelatine (25–50 mg) compared to vortioxetine (10–15–20 mg) in adult patients with major depressive disorder. We performed an adjusted indirect comparison using placebo as a common control. The main outcomes were efficacy (response to treatment by Montgomery‐Åsberg depression rating scale/Hamilton Rating Scale for Depression) and acceptability (withdrawal rate for any reason or due to adverse events). 10 agomelatine and 11 vortioxetine studies were included in the analysis. For efficacy, n...
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2017 Category: Psychiatry Authors: Sidney H. Kennedy, Jean ‐Marie Grouin, Stéphanie Cadour, Véronique Robert, Françoise Picarel‐Blanchot Tags: RESEARCH ARTICLE Source Type: research

Gender ‐specific risk factors for low bone mineral density in patients taking antipsychotics for psychosis
ConclusionManaging the risk factors associated with low BMD among patients with psychotic disorder should be done gender‐specifically. Psychotropic agents should be prescribed mindful of their effects on bone, as use of these medications is a modifiable risk factor for osteoporosis in women with psychotic disorders. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2017 Category: Psychiatry Authors: Min Jhon, Taeyoung Yoo, Ju ‐Yeon Lee, Seon‐Young Kim, Jae‐Min Kim, Il‐Seon Shin, Lana Williams, Michael Berk, Jin‐Sang Yoon, Sung‐Wan Kim Tags: RESEARCH ARTICLE Source Type: research

Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV ‐positive, methamphetamine‐using men who have sex with men
This study examined if methamphetamine use alone (METH + HIV−) and methamphetamine use in combination with HIV (METH + HIV+) were associated with hypothalamic‐pituitary‐adrenal (HPA) axis dysregulation as well as insulin resistance relative to a nonmethamphetamine‐using, HIV‐negative comparison group (METH‐HIV−). MethodsUsing an intact groups design, serum levels of HPA axis hormones in 46 METH + HIV− and 127 METH + HIV+ men who have sex with men (MSM) were compared to 136 METH‐HIV− men. ResultsThere were no group differences in prevailing adrenoco...
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2017 Category: Psychiatry Authors: Adam W. Carrico, Violeta J. Rodriguez, Deborah L. Jones, Mahendra Kumar Tags: RESEARCH ARTICLE Source Type: research

Psychiatrists' treatment preferences for generalized anxiety disorder
ConclusionsTreatment preferences for GAD by psychiatrists in the 3 West Balkan countries were mostly in accordance with treatment guidelines and treatment preferences for patients and for psychiatrists as patients were mostly concordant. However, some psychiatrists were more likely to choose pharmacotherapy for patients and psychotherapy for themselves as patients. These findings have implications for education of psychiatrists and for efforts to improve treatment guidelines and mental health services. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2017 Category: Psychiatry Authors: Milan Latas, Goran Trajkovi ć, Dimitar Bonevski, Andromahi Naumovska, Dušanka Vučinić Latas, Zoran Bukumirić, Vladan Starčević Tags: RESEARCH ARTICLE Source Type: research

ABCB1 and CYP2D6 polymorphisms and treatment response of psychotic patients in a naturalistic setting
ConclusionWe have detected a possible interaction between ABCB1 and CYP2D6 in affecting response of psychotic patients to drug treatment, in a naturalistic setting. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2017 Category: Psychiatry Authors: Georgios Papazisis, Antonios Goulas, Alexios Sarrigiannidis, Stavroula Bargiota, Diomidis Antoniadis, Nikolaos Raikos, Emmanouela Basgiouraki, Vasileios P. Bozikas, Georgios Garyfallos Tags: RESEARCH ARTICLE Source Type: research

Higher serotonin transporter availability in early ‐onset obsessive–compulsive disorder patients undergoing escitalopram treatment: A [11C]DASB PET study
ConclusionsThese findings indicate that the earlier the age of onset of OCD, the less serotonergic pathology there is and that this difference remains even after long‐term serotonin reuptake inhibitor treatment. Clinically, it might suggest that nonserotonergic treatments would be a better option for EOCD patients. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2017 Category: Psychiatry Authors: Junhee Lee, Bo ‐Hyung Kim, Euitae Kim, Oliver D. Howes, Kang Ik Kevin Cho, Youngwoo Bryan Yoon, Jun Soo Kwon Tags: SHORT COMMUNICATION Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2017 Category: Psychiatry Tags: ISSUE INFORMATION Source Type: research

C ‐reactive protein levels and treatment resistance in schizophrenia—A Danish population‐based cohort study
ConclusionsC‐reactive protein, as a single inflammatory marker, appears insufficient to detect treatment‐resistant schizophrenia. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 26, 2017 Category: Psychiatry Authors: Henriette Thisted Horsdal, Theresa Wimberley, Michael Eriksen Benros, Christiane Gasse Tags: SHORT COMMUNICATION Source Type: research

Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met
ConclusionsThis study is the first to date examining the impact of AUDs/SUDs and COMT variants on FER in an epidemiologically representative sample of subjects with schizophrenia. Our findings do not suggest an additional impairment from comorbid AUDs/SUDs on FER among subjects with schizophrenia, whilst COMT Val158Met, though based on a limited sample, might have a role just among those without AUDs/SUDs. Based on our results, additional research is needed also exploring differential roles of various substances. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 15, 2017 Category: Psychiatry Authors: Giuseppe Carr à, Gabriella Nicolini, Annamaria Lax, Francesco Bartoli, Filippo Castellano, Alessia Chiorazzi, Giulia Gamba, Mattia Bava, Cristina Crocamo, Costanza Papagno Tags: RESEARCH ARTICLE Source Type: research

Effects of caffeinated alcoholic beverages with low alcohol and high caffeine content on cognitive and motor functions
ConclusionsCABs that contains a higher ratio of caffeine to alcohol did not counteract the motor function impairments induced by alcohol. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2017 Category: Psychiatry Authors: Wan ‐Ju Cheng, Chun‐Cheng Lin, Yawen Cheng, Ming‐Chyi Huang Tags: RESEARCH ARTICLE Source Type: research

Association between antipsychotic treatment and leptin levels across multiple psychiatric populations: An updated meta ‐analysis
ConclusionLeptin increases induced by APs are present across all diagnoses. More comprehensive research is needed to understand the relationship between AP use and leptin levels across multiple diagnoses. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2017 Category: Psychiatry Authors: Renee ‐Marie Ragguett, Margaret Hahn, Giovanni Messina, Sergio Chieffi, Marcellino Monda, Vincenzo De Luca Tags: RESEARCH ARTICLE Source Type: research

Italian prescribing patterns in obsessive –compulsive disorder
Abstract The aim of the present study was to investigate psychopharmacological prescribing patterns in a large sample (n = 1815) of patients suffering from obsessive–compulsive disorder (OCD) recruited in 4 Italian centers specialized in OCD, in comparison to available national and international guidelines. The centers were asked to complete a specific data sheet questionnaire on patients' therapeutic status. Statistical analyses were carried out by SPSS. The results showed that almost all patients referred to the centers of Milan, Pisa and Rome received psychotropic medications, whereas only 59.9% (313) di...
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2017 Category: Psychiatry Authors: Donatella Marazziti, Umberto Albert, Bernardo Dell'Osso, Antonio Tundo, Francesco Cuniberti, Giuseppe Maina, Ilenia Moroni, Beatrice Benatti, Federico Mucci, Gabriele Massimetti, Armando Piccinni, Vlasios Brakoulias Tags: RESEARCH ARTICLE Source Type: research

Does early antipsychotic response predict long ‐term treatment outcome?
ConclusionThese results demonstrate the long‐term prognostic value of early haloperidol response. The predictive value of early olanzapine response may be less robust. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2017 Category: Psychiatry Authors: Sean A. Rasmussen, Patricia I. Rosebush, Michael F. Mazurek Tags: RESEARCH ARTICLE Source Type: research

Human neutrophils show decreased survival upon long ‐term exposure to clozapine
ConclusionsThe effect of long‐term exposure to clozapine on neutrophil survival is plausibly associated with delayed onset of agranulocytosis after initial exposure. Our results suggest that human neutrophils are vulnerable to clozapine and its reactive metabolite in a concentration‐ and time‐dependent manner. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2017 Category: Psychiatry Authors: Aya Goto, Akira Yoshimi, Tomoko Nagai, Mako Ukigai, Akihiro Mouri, Norio Ozaki, Yukihiro Noda Tags: RESEARCH ARTICLE Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2017 Category: Psychiatry Tags: ISSUE INFORMATION Source Type: research

Multiple DSM ‐5 substance use disorders: A national study of US adults
ConclusionsAssessment, diagnosis, and treatment often focus on individual substance‐specific SUDs rather than multiple SUDs, despite evidence for substantial rates of polysubstance use in clinical and epidemiological studies. There are notable differences in the prevalence of multiple SUDs between alcohol use disorders and other nonalcohol SUDs that have important clinical implications; for example, multiple SUDs are more persistent than individual SUDs. These findings suggest that clinical assessment and diagnosis should screen for multiple SUDs, especially among adults with nonalcohol DSM‐5 SUDs. (Source: Human Psych...
Source: Human Psychopharmacology: Clinical and Experimental - July 27, 2017 Category: Psychiatry Authors: Sean Esteban McCabe, Brady T. West, Emily M. Jutkiewicz, Carol J. Boyd Tags: RESEARCH ARTICLE Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 19, 2017 Category: Psychiatry Tags: ISSUE INFORMATION Source Type: research

Current and potential pharmacological and psychosocial interventions for anxiety symptoms and disorders in patients with schizophrenia: structured review
ConclusionsThe presence of coexisting anxiety symptoms and co‐morbid anxiety disorders should be ascertained when assessing patients with schizophrenia or other psychoses as a range of pharmacological and psychosocial treatments are available. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2017 Category: Psychiatry Authors: Fleur M. Howells, David G. Kingdon, David S. Baldwin Tags: REVIEW ARTICLE Source Type: research

Drinking status but not acute alcohol consumption influences delay discounting
ConclusionsOur data suggest that heavier drinkers discount the value of delayed rewards more steeply than lighter drinkers. Delay discounting may therefore be a promising marker of heavy alcohol consumption in social drinkers. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2017 Category: Psychiatry Authors: Sally Adams, Angela S. Attwood, Marcus R. Munaf ò Tags: RESEARCH ARTICLE Source Type: research

Resting ‐state fMRI and social cognition: An opportunity to connect
Abstract Many psychiatric disorders are characterized by altered social cognition. The importance of social cognition has previously been recognized by the National Institute of Mental Health Research Domain Criteria project, in which it features as a core domain. Social task‐based functional magnetic resonance imaging (fMRI) currently offers the most direct insight into how the brain processes social information; however, resting‐state fMRI may be just as important in understanding the biology and network nature of social processing. Resting‐state fMRI allows researchers to investigate the functional relationships b...
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2017 Category: Psychiatry Authors: Alex Doruyter, Nynke A. Groenewold, Patrick Dupont, Dan J. Stein, James M. Warwick Tags: SHORT COMMUNICATION Source Type: research

The impact of alcohol hangover symptoms on cognitive and physical functioning, and mood
In conclusion, whereas severity and impact scores usually correspond well, some frequently reported symptoms with moderate to high severity scores had little impact on mood, and cognitive and physical functioning (i.e., reduced appetite, regret, and thirst). (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2017 Category: Psychiatry Authors: Marith Schrojenstein Lantman, Marlou Mackus, Aurora J.A.E. Loo, Joris C. Verster Tags: RESEARCH ARTICLE Source Type: research

Impairment due to combined sleep restriction and alcohol is not mitigated by decaying breath alcohol concentration or rest breaks
Abstract ObjectiveEpidemiological and laboratory‐based driving simulator studies have shown the detrimental impact of moderate, legal levels of alcohol consumption on driving performance in sleepy drivers. As less is known about the time course of decaying alcohol alongside performance impairment, our study examined impairment and recovery of performance alongside decaying levels of alcohol, with and without sleep restriction. MethodsSixteen healthy young males (18–27 years) underwent 4 counterbalanced conditions: Baseline, Alcohol (breath alcohol concentration [BrAC] 
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2017 Category: Psychiatry Authors: Jessica E. Manousakis, Clare Anderson Tags: RESEARCH ARTICLE Source Type: research

Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Tags: ERRATUM Source Type: research

Effectiveness of agomelatine on anhedonia in depressed patients: An outpatient, open ‐label, real‐world study
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Tags: CORRIGENDUM Source Type: research

Patterns of use and toxicity of new para ‐halogenated substituted cathinones: 4‐CMC (clephedrone), 4‐CEC (4‐chloroethcatinone) and 4‐BMC (brephedrone)
ConclusionSince the emergence of these substances could prove to be the next step to the cat‐and‐mouse game existing between drug producers and legislation, further clinical and epidemiological research should be carried out in order to build evidence to support policy for public health issues. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Authors: Marc Grifell, Mireia Ventura, Xo án Carbón, Pol Quintana, Liliana Galindo, Álvaro Palma, Ivan Fornis, Cristina Gil, Magi Farre, Marta Torrens Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Utility of Web search query data in testing theoretical assumptions about mephedrone
ConclusionsThe results might provide support for the hypothesis that mephedrone's popularity was highly correlated with its legal status as well as it functioned as a potential substitute for MDMA. Google Trends was found to be a useful tool for testing theoretical assumptions about NPS. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Authors: M áté Kapitány‐Fövény, Zsolt Demetrovics Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

The use of supplements and performance and image enhancing drugs in fitness settings: A exploratory cross ‐sectional investigation in the United Kingdom
ConclusionThis pilot study identified the emergence of a new drug trend in fitness settings and showed a potential relationship to exercise addiction, anxiety disorders and low self‐esteem. The Internet played a crucial role in disseminating often untested products, including PIEDs without medical supervision and unwanted side‐effects were reported. More studies in the field are required in order to safeguard public health and inform policy making. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Authors: Roisin Mooney, Pierluigi Simonato, Risha Ruparelia, Andres Roman ‐Urrestarazu, Giovanni Martinotti, Ornella Corazza Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Intended and unintended use of cathinone mixtures
ConclusionRaising awareness of NPS, education, and training of health care professionals are paramount in reducing harms related to cathinone use. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Authors: Amira Guirguis, John Martin Corkery, Jacqueline Leslie Stair, Stewart Brian Kirton, Mire Zloh, Fabrizio Schifano Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

4,4 ′‐Dimethylaminorex (“4,4′‐DMAR”; “Serotoni”) misuse: A Web‐based study
ConclusionsAlthough being characterized by a number of methodological limitations, the social networks' Web monitoring approach (netnography) may be helpful to better understand some of the clinical and psychopharmacological issues pertaining to a range of novel psychoactive substances, including 4,4′‐DMAR, for which only extremely little, if any, scientific knowledge is available. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Authors: Barbara Loi, Mire Zloh, Maria Antonietta De Luca, Nicholas Pintori, John Corkery, Fabrizio Schifano Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

An insight into the deep web; why it matters for addiction psychiatry?
ConclusionsThis paper represents a complete or systematical guideline about the deep web, specifically focusing on practical information on online drug marketplaces, useful for addiction's professionals. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Authors: Laura Orsolini, Duccio Papanti, John Corkery, Fabrizio Schifano Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Repeated subcutaneous administrations of krokodil causes skin necrosis and internal organs toxicity in Wistar rats: putative human implications
ConclusionsThese findings contribute notably to comprehension of the local and systemic toxicological impact of this complex drug mixture on major organs and will hopefully be useful for the development of appropriate treatment strategies towards the human toxicological effects of krokodil. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Authors: Emanuele Amorim Alves, Pedro Brand ão, João Filipe Neves, Sara Manuela Cravo, José Xavier Soares, Jean‐Paul C. Grund, José Alberto Duarte, Carlos M.M. Afonso, Annibal Duarte Pereira Netto, Félix Carvalho, Ricardo Jorge Dinis‐Oliveira Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

From concept(ion) to life after death/the grave: The ‘natural’ history and life cycle(s) of novel psychoactive substances (NPS)
Abstract A range of information needs should be met in order to better understand and predict the longevity/existence of novel psychoactive substances (NPS). This conceptual paper argues that one way of assessing how long a molecule may be around is to document how the life cycles or natural histories of ‘traditional’ drugs and NPS evolve. The earliest indication of the possible appearance of a new substance might be evidenced on the DeepWeb. However, this means they are less visible, in line with the clandestine nature of drug use and supply. Therefore, monitoring discussion groups/fora needs the development o...
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Authors: John Martin Corkery, Laura Orsolini, Duccio Papanti, Fabrizio Schifano Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

1 ‐cyclohexyl‐x‐methoxybenzene derivatives, novel psychoactive substances seized on the internet market. Synthesis and in vivo pharmacological studies in mice
ConclusionsFor the first time, this study demonstrates that systemic administration of 1‐cyclohexyl‐x‐methoxybenzene compounds markedly inhibit visual response, promote analgesia, and induce core temperature alterations in mice. This data, although obtained in animal model, suggest their possible hazard for human health (i.e., hyperthermia and sensorimotor alterations). In particular, these novel psychoactive substances may have a negative impact in many daily activities, greatly increasing the risk factors for workplace accidents and traffic injuries. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Authors: Anna Fantinati, Andrea Ossato, Sara Bianco, Isabella Canazza, Fabio De Giorgio, Claudio Trapella, Matteo Marti Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Novel psychoactive substances: Shedding new lights on the ever ‐changing drug scenario and the associated health risks
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Authors: Corazza O., Parrott A.C., Demetrovics Z. Tags: EDITORIAL Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 28, 2017 Category: Psychiatry Tags: ISSUE INFORMATION Source Type: research

Fentanyl novel derivative ‐related deaths
ConclusionsThis study provides a medical–legal and toxicological assessment of this phenomenon in order to understand the role of illegal fentanyl and its congeners in deaths from FENS overdose. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 21, 2017 Category: Psychiatry Authors: Arianna Giorgetti, Carmela Centola, Raffaele Giorgetti Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Impact of synthetic cannabinoids on the duration of opioid ‐related withdrawal and craving among patients of addiction clinics in Kazakhstan: A prospective case–control study
ObjectiveThe aim of the study was to prospectively assess whether regular use of synthetic cannabinoids (SCs) affects the duration of opioid‐related withdrawal and craving symptoms in patients undergoing drug detoxification treatments. MethodsPatients (n = 193) with opioid use disorder, among which 47 patients are regularly using SCs, underwent integrated drug detoxification therapies. The Clinical Opiate Withdrawal Scale and a specific visual analogue scale were used to assess opioid withdrawal and craving symptoms over time. ResultsSubjects using SCs had significantly longer duration of withdrawal and craving symptoms (p 
Source: Human Psychopharmacology: Clinical and Experimental - June 20, 2017 Category: Psychiatry Authors: Mariya Prilutskaya, Francesco Saverio Bersani, Ornella Corazza, Sergey Molchanov Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

The risk of violence associated with novel psychoactive substance misuse in patients presenting to acute mental health services
This report presents the initial findings of a continuing study looking into the impact of NPS misuse on admissions to an acute mental health facility in London. Violence preadmission and violence during admission have been found to be significant in NPS misusers compared to non‐NPS substance misusers. Our findings have important consequences for acute mental health, emergency, and public health services. NPS misusers require specific assessment and risk management to reduce the risk of violence towards others. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 19, 2017 Category: Psychiatry Authors: Abu Shafi, Paul Gallagher, Neil Stewart, Giovanni Martinotti, Ornella Corazza Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Updating of working memory in ecstasy polydrug users: Findings from fNIRS
DiscussionThe lack of a behavioural difference on both tasks but presence of blood oxygenation and deoxygenation changes in letter updating provides support for the notion that ecstasy‐polydrug users are investing more effort to achieve the same behavioural output. Total lifetime dose was high, and recency of use was significantly related to most changes, suggesting that heavy and recent use may be particularly detrimental. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 19, 2017 Category: Psychiatry Authors: Catharine Montgomery, John E. Fisk, Carl A. Roberts Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Novel psychoactive substance use among treatment ‐seeking opiate users: The role of life events and psychiatric symptoms
ConclusionSynthetic cathinones might still substitute amphetamine‐derivatives, although these NPS are no longer legal. There is a need for the regular screening of psychiatric symptoms and the use of family therapy among participants on opioid substitution programs. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 15, 2017 Category: Psychiatry Authors: M áté Kapitány‐Fövény, Judit Farkas, Patrícia Andrea Pataki, Anna Kiss, Janka Horváth, Róbert Urbán, Zsolt Demetrovics Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Pharmaco ‐toxicological effects of the novel third‐generation fluorinate synthetic cannabinoids, 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 in mice. In vitro and in vivo studies
ConclusionsFor the first time, the present study demonstrates the pharmaco‐toxicological effects induced by the administration of 5F‐ADBINACA, AB‐FUBINACA, and STS‐135 in mice and suggests their possible detrimental effects on human health. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 9, 2017 Category: Psychiatry Authors: Isabella Canazza, Andrea Ossato, Fabrizio Vincenzi, Adolfo Gregori, Fabiana Di Rosa, Federica Nigro, Alessandro Rimessi, Paolo Pinton, Katia Varani, Pier Andrea Borea, Matteo Marti Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research

Oral glucose tolerance test performance in olanzapine ‐treated schizophrenia‐spectrum patients is predicted by BMI and triglycerides but not olanzapine dose or duration
Abstract ObjectiveOlanzapine, an atypical antipsychotic, is associated with glucoregulatory abnormalities, but the nature of this link is not fully elucidated. This is the first olanzapine oral glucose tolerance test (oGTT) study to consider treatment dose and duration, and to compare complementary indices respectively assessing insulin sensitivity (Matsuda index) and resistance (homeostasis model assessment). MethodsBody mass index (BMI), body composition, plasma lipids, and oGTT were measured in olanzapine‐treated nondiabetic patients with DSM‐IV‐TR diagnosis of schizophrenia or schizoaffective disorder (n =&n...
Source: Human Psychopharmacology: Clinical and Experimental - June 1, 2017 Category: Psychiatry Authors: Jeffrey Guina, Sayon Roy, Ankur Gupta, Daniel D. Langleben, Igor Elman Tags: RESEARCH ARTICLE Source Type: research

Hair analysis for the detection of drug use —is there potential for evasion?
ConclusionFurther research is needed by way of chemical analysis and trial of the adulterant products sold online and their effects as well as the development of more sophisticated hair testing techniques. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 31, 2017 Category: Psychiatry Authors: Shanna Marrinan, Andres Roman ‐Urrestarazu, Declan Naughton, Emerlinda Levari, John Collins, Robert Chilcott, Giuseppe Bersani, Ornella Corazza Tags: SPECIAL ISSUE Source Type: research