Identification of LETM1 as a marker of cancer stem-like cells and predictor of poor prognosis in esophageal squamous cell carcinoma
This study discusses the expression of LETM1 in esophageal squamous carcinoma (ESCC) and its association with cancer stem-like cells (CSC). We used immunohistochemistry in 166 ESCC tissue samples, as well as western blot, and immunofluorescent methods in ESCC cell lines to study the role of LETM1 and its association with CSC in ESCC. The expression of LETM1 was significantly higher in ESCC, and it was closely related to the primary tumor (pT) stage and clinical stage. (Source: Human Pathology)
Source: Human Pathology - July 18, 2018 Category: Pathology Authors: Zhaoting Yang, Weidong Ni, Chunai Cui, Wenbo Qi, Longzhen Piao, Yanhua Xuan Tags: Original Contributions Source Type: research
IMP3 as a prognostic biomarker in patients with malignant peritoneal mesothelioma
Malignant peritoneal mesothelioma (MPeM) is an incurable cancer with poor prognosis and several biomarkers have been suggested for screening of MPeM. The aim of our study was to evaluate the prognostic significanceas of IMP3 and Fli-1 in MPeM. Diagnostic biopsies of 44 MPeM patients were centrally collected and were immunohistochemically analyzed for expression of IMP3, Fli-1, and Ki-67. Labelling was assessed by two pathologists. Complete clinical information and follow up were obtained from patients' records. (Source: Human Pathology)
Source: Human Pathology - July 18, 2018 Category: Pathology Authors: S Hui, Z Guo-qi, G Xiao-Zhong, L Chun-Rong, L Yu-Fei, Y Dong-Liang Tags: Original Contributions Source Type: research
TFE3 is a diagnostic marker for solid pseudopapillary neoplasms of the pancreas
Aberrant Wnt signaling is a hallmark of solid pseudopapillary neoplasms of the pancreas (SPN). Transcription factor E3 (TFE3) plays a critical role in activation and regulation of the Wnt pathway, and is predicted to be a candidate gene implicated in SPN by gene regulatory network analysis. The aim of this study was to evaluate TFE3 as a marker for SPN. Paraffin embedded tissues of SPN (n = 75) and other primary pancreatic tumors were analyzed, including pancreatic neuroendocrine tumors (PanNET) (n = 17), pancreatic ductal adenocarcinomas (PDAC) (n = 14), pancreatic neuroendocrine carcinomas (PanNEC) (n = 4) and acinar cel...
Source: Human Pathology - July 18, 2018 Category: Pathology Authors: Yina Jiang, Juan Xie, Bo Wang, Yudong Mu, Peijun Liu Tags: Original contribution Source Type: research
PD-1, PD-L1 and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications
Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC), a variant of pancreatic ductal adenocarcinoma (PDAC), has striking genetic similarity to PDAC but a significantly improved overall survival. We hypothesize that this difference could be due to the immune response to the tumor, and as such, we investigated the expression of PD-1, PD-L1 and CD163 in a series of UCOGC. To this aim, 27 pancreatic UCOGCs (11 pure and 16 PDAC-associated), 5 extra-pancreatic tumors with osteoclast-like giant cells and 10 pancreatic anaplastic carcinomas (ACs) were immunostained using antibodies against PD-1, PD-L1 and CD163. (So...
Source: Human Pathology - July 18, 2018 Category: Pathology Authors: Claudio Luchini, Jerome Cros, Antonio Pea, Camilla Pilati, Nicola Veronese, Borislav Rusev, Paola Capelli, Andrea Mafficini, Alessia Nottegar, Lodewijk A.A. Brosens, Micha ël Noë, G. Johan A. Offerhaus, Peter Chianchiano, Giulio Riva, Paola Piccoli, Cla Tags: Original contribution Source Type: research
Histomorphometric Evaluation of the Ki-67 Proliferation Rate and CD34 Microvascular and D2-40 Lymphovascular Densities Drives the Pulmonary Typical Carcinoid Outcome
In this study, we sought to validate the importance of Ki-67 and study the relationships between Ki-67 and other stromal biomarkers of vascular density. We examined Ki-67, CD34 and D2-40 in tumor tissues from 128 patients with surgically excised typical carcinoid of the lung. We used immunohistochemistry and morphometry to evaluate the amount of tumor staining for cellular proliferation (Ki-67), microvascular density (CD34-MVD) and lymphovascular density (D2-40-LVD). (Source: Human Pathology)
Source: Human Pathology - July 18, 2018 Category: Pathology Authors: Alyne Fonseca de Vilhena, Jo ão Carlos das Neves Pereira, Edwin Roger Parra, Marcelo Luiz Balancin, Alexandre A'b Saber, Vanessa Martins, Cecilia Farhat, Marcelo Militao Abrantes, Jose Ribas Milanez de Campos, Miguel Lia Tedde, Teresa Takagaki, Vera Luiz Tags: Original contribution Source Type: research
Role of complement system in patients with biopsy-proven IgG4 related kidney disease
Hypocomplementaemia has been frequently reported in IgG4 related kidney disease (IgG4-RKD). However, studies on the role of complement system in IgG4-RKD are lacking. A total of 40429 renal biopsies from January 2010 to January 2018 were re-examined in the present study, and 17 patients were confirmed to meet the criteria of IgG4-RKD. According to the serum C3 levels, they were divided into two groups: the low C3 group (C3 (Source: Human Pathology)
Source: Human Pathology - July 18, 2018 Category: Pathology Authors: Rong Wang, Dafeng He, Lili Zhao, Shaoshan Liang, Dandan Liang, Feng Xu, Mingchao Zhang, Xiaodong Zhu, Huiping Chen, Honglang Xie, Caihong Zeng, Zheng Tang, Zhihong Liu Tags: Original Contributions Source Type: research
Immunohistochemical characteristics of Renomedullary interstitial cell tumor: a study of 41 tumors with emphasis on differential diagnosis of mesenchymal neoplasms
Renomedullary interstitial cell tumors (RMICT) are almost always incidentally identified either at autopsy or resection of the kidney for other reasons. However, rare cases have been reported which are large, resulting in a clinical mass. The immunohistochemical phenotype of usual, incidental RMICT using modern soft tissue tumor markers in is largely unknown, however, providing little information to aid in classification of larger or atypical tumors. We retrieved 41 RMICTs from 36 patients, and studied pathologic characteristics including morphology, immunohistochemistry (S100, keratin AE1/AE3, smooth muscle actin, desmin,...
Source: Human Pathology - July 18, 2018 Category: Pathology Authors: Zhichun Lu, Khaleel Al-Obaidy, Liang Cheng, Kyle D Perry, David J Grignon, Sean R Williamson Tags: Original Contributions Source Type: research
Metastatic breast Cancer simulating well-differentiated neuroendocrine neoplasms of visceral organs
A series of metastatic breast carcinoma (MBC) mimicking visceral well-differentiated neuroendocrine neoplasms has not previously been reported. We identified five consultation cases originally submitted as neuroendocrine neoplasms in females but which were found to be MBC on subsequent review. All 5 neoplasms demonstrated nested architecture and relatively uniform nuclei. Four patients had a known history of breast cancer (remote in 3 and concurrent in 1), but the metastases (3 liver, 1 lung) labeled for chromogranin and/or synaptophysin, prompting misdiagnosis as neuroendocrine neoplasm. (Source: Human Pathology)
Source: Human Pathology - July 18, 2018 Category: Pathology Authors: Jeffrey Cloutier, Elizabeth D. Thompson, Ashley Cimino-Mathews, Lisa M. Rooper, Andres Matoso, Pedram Argani Tags: Original Contributions Source Type: research
Roles of human epidermal growth factor receptor family in pulmonary lymphangioleiomyomatosis
Lymphangioleiomyomatosis (LAM) is a rare and refractory disease that affects women of reproductive age. Several target therapies are used to manage LAM but no curative modes of treatment have been reported yet. Therefore, in this study, we focused on targeting human epidermal growth factor receptor (HER) family proteins as a treatment strategy for LAM. In antibody array analysis, HER signaling was detected in the proteins extracted from LAM tissues. We then evaluated the expression of HER family members in 34 pulmonary LAM specimens using both immunohistochemistry and quantitative reverse transcription polymerase chain rea...
Source: Human Pathology - July 17, 2018 Category: Pathology Authors: Kazuma Kobayashi, Yasuhiro Miki, Ryoko Saito, Koko Adachi, Kuniaki Seyama, Yoshinori Okada, Hironobu Sasano Tags: Original contribution Source Type: research
Tumor-infiltrating lymphocytes associate with outcome in non-endemic nasopharyngeal carcinoma: a multicenter study
The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been studied recently in many cancers. For the first time in a non-endemic region, we have evaluated the prognostic value of TILs in a whole population-based nationwide cohort of nasopharyngeal carcinoma (NPC) in Finland. A total of 115 cases from Finnish hospitals were included. TILs were analyzed using hematoxylin and eosin stained slides according to the criteria of the International Immuno-Oncology Biomarker Working Group. (Source: Human Pathology)
Source: Human Pathology - July 17, 2018 Category: Pathology Authors: Alhadi Almangush, Miia Ruuskanen, Jaana Hagstr öm, Pasi Hirvikoski, Satu Tommola, Veli-Matti Kosma, Pentti Nieminen, Antti Mäkitie, Ilmo Leivo Tags: Original Contributions Source Type: research
The clinical significance of PINX1 expression in papillary thyroid carcinoma
PIN2/TERF1 interacting telomerase inhibitor 1 (PINX1) is a telomerase inhibitor located on human chromosome 8p23, and also act as a tumor suppressor in several types of cancers, including breast, gastric, ovarian and bladder cancer; However, the role of PINX1 expression in papillary thyroid carcinoma (PTC) has not been defined. Therefore, we investigated the role of PINX1 expression in PTC by analyzing the correlation between PINX1 expression and various clinicopathological factors. Immunohistochemistry for PINX1 was performed using a tissue microarray of samples taken from the 160 patients with PTC. (Source: Human Pathology)
Source: Human Pathology - July 16, 2018 Category: Pathology Authors: JiHoon Kang, Kanghee Han, Hyeon Jin Kim, Ju Hui Park, Jun Suk Kong, Sunhoo Park, Jae Kyung Myung Tags: Original Contributions Source Type: research
TPL2, a therapeutic potential target for cancer
Dear Editor, (Source: Human Pathology)
Source: Human Pathology - July 6, 2018 Category: Pathology Authors: Qianqian Wang, Hongfeng Dai Tags: Correspondence Source Type: research
Immune checkpoint blockade as a potential therapeutic strategy for undifferentiated malignancies
Undifferentiated malignancies (UMs) encompass a diverse set of aggressive tumors that pose not only a diagnostic challenge but also a challenge for clinical management. Most tumors in this category are currently treated empirically with nonspecific chemotherapeutic agents that yield extremely poor clinical responses. Given that UMs are inherently genetically unstable neoplasms with the potential for immune dysregulation and increased neoantigen production, they are likely to be particularly amenable to immune checkpoint inhibitors, which target programmed cell death protein 1 (PD-1) or its ligands, PD-L1 and PD-L2, to prom...
Source: Human Pathology - July 6, 2018 Category: Pathology Authors: Kelly A. Devereaux, Vivek Charu, Shuchun Zhao, Gregory W. Charville, Charles D. Bangs, Matt van de Rijn, Athena M. Cherry, Yasodha Natkunam Tags: Original contribution Source Type: research
Telocytes as possible precursors of PDGFRA-mutant gastrointestinal mesenchymal tumors —reply
We are pleased that Ricci et al. have provided supporting evidence for our hypothesis that the telocyte, the only CD34- and PDGFRA-positive cell of the stomach and intestines [1], is the cell of origin of inflammatory fibroid polyps (IFPs). IFPs arising sporadically or syndromically predominantly have a gain-of-function mutation within the PDGFRA gene and are CD34 and PDGFRA positive. (Source: Human Pathology)
Source: Human Pathology - July 5, 2018 Category: Pathology Authors: Paul Manley, Jagdeep S Walia, Richard Kirsch, Robert Riddell Tags: Correspondence Source Type: research
Telocytes as possible precursors of PDGFRA-mutant gastrointestinal mesenchymal tumors
(See Fig..) (Source: Human Pathology)
Source: Human Pathology - July 5, 2018 Category: Pathology Authors: Maria C. Giustiniani, Paola Lanza, Riccardo Ricci Tags: Correspondence Source Type: research
