Low-level clonal FGFR2 amplification defines a unique molecular subtype of intrahepatic cholangiocarcinoma in a Chinese population
Intrahepatic cholangiocarcinoma (ICC) is a subtype of primary liver cancer rarely curable by surgery that is increasing rapidly in incidence. Chromosomal translocations and amplifications of the fibroblast growth factor receptor 2 (FGFR2) locus are present in several kinds of tumors including ICC, but their incidence has not been assessed in Chinese patients. Using break-apart probes and by determining the ratios of FGFR2/chromosome enumeration probe (CEP) 10 double-color probes, we evaluated 122 ICCs for the presence of FGFR2 translocations and amplifications, respectively, by fluorescence in situ hybridization (FISH). (S...
Source: Human Pathology - March 4, 2018 Category: Pathology Authors: Xiao-Hong Pu, Qing Ye, Jun Yang, Hong-Yan Wu, Xi-Wei Ding, Jiong Shi, Liang Mao, Xiang-Shan Fan, Jun Chen, Yu-Dong Qiu, Qin Huang Tags: Original contribution Source Type: research
Propranolol prevents liver cirrhosis by inhibiting hepatic stellate cell activation mediated by the PDGFR/Akt pathway
In this study, a hepatic cirrhosis mouse model was induced by CCl4 administration for 6weeks. (Source: Human Pathology)
Source: Human Pathology - March 4, 2018 Category: Pathology Authors: Qian Ding, Zhen Li, Bin Liu, Liping Ling, Xiangguo Tian, Chunqing Zhang Tags: Original contribution Source Type: research
A case report of atypical Spitz tumor harboring a novel MLPH-ALK gene fusion with discordant ALK immunohistochemistry results
Frequent kinase fusions have been reported in spitzoid neoplasms, approximately 10% of which involve ALK rearrangements. Herein, we report a case of atypical Spitz tumour (AST) with a novel MLPH-ALK fusion, which has not been previously reported to contribute to cancer development. The tumour was detected in the right arm of a 40-year-old woman. The novel ALK fusion was identified by a 5 ′-rapid amplification of cDNA ends-based system optimised for formalin-fixed paraffin-embedded tissue. Initially, ALK expression was detected by immunohistochemistry (IHC) using 5A4 antibodies for both sensitive and conventional polymer ...
Source: Human Pathology - March 4, 2018 Category: Pathology Authors: Masakazu Fujimoto, Yuki Togashi, Ibu Matsuzaki, Satoko Baba, Kengo Takeuchi, Yutaka Inaba, Masatoshi Jinnin, Shin-ichi Murata Tags: Case report Source Type: research
Phosphaturic Mesenchymal Tumor Without Osteomalacia: Additional Confirmation of the “Non-Phosphaturic” Variant, with Emphasis on the Roles of FGF23 Chromogenic in situ Hybridization and FN1-FGFR1 Fluorescence in situ Hybridization
Phosphaturic Mesenchymal Tumor (PMT) is a rare, histologically distinctive neoplasm, which classically presents with phosphaturia and tumor-induced osteomalacia (TIO) (i.e., oncogenic osteomalacia). Both the phosphaturia and TIO are due to paraneoplastic production of FGF23 (a phosphatonin) by the neoplastic cells, which are genetically characterized by rearrangements of FN1 (most often with FGFR1 – and less frequently with FGF1). However, rare cases of PMT present without phosphaturia and TIO (i.e., the “non-phosphaturic” variant) – and are therefore much more challenging to diagnose. (Source: Human Pathology)
Source: Human Pathology - March 4, 2018 Category: Pathology Authors: Kimberley N Sent-Doux, Craig Mackinnon, Jen-Chieh Lee, Andrew L Folpe, Omar Habeeb Tags: Case Study Source Type: research
Low-level clonal FGFR2 amplification defines a unique molecular subtype of intrahepatic cholangiocarcinoma in a Chinese population
Intrahepatic cholangiocarcinoma (ICC) is a subtype of primary liver cancer rarely curable by surgery that is increasing rapidly in incidence. Chromosomal translocations and amplifications of the fibroblast growth factor receptor 2 (FGFR2) locus are present in several kinds of tumors including ICC, but their incidence has not been assessed in Chinese patients. Using break-apart probes and by determining the ratios of FGFR2/chromosome enumeration probe (CEP) 10 double-color probes, we evaluated 122 ICCs for the presence of FGFR2 translocations and amplifications, respectively, by fluorescence in situ hybridization (FISH). (S...
Source: Human Pathology - March 4, 2018 Category: Pathology Authors: Xiao-Hong Pu, Qing Ye, Jun Yang, Hong-Yan Wu, Xi-Wei Ding, Jiong Shi, Liang Mao, Xiang-Shan Fan, Jun Chen, Yu-Dong Qiu, Qin Huang Tags: Original contribution Source Type: research
Breast Pathology Masterclass
(Source: Human Pathology)
Source: Human Pathology - March 2, 2018 Category: Pathology Authors: Vincenzo Eusebi Source Type: research
A Case of Syphilitic Hepatitis in an HIV-Infected Patient
We present a case of a 51-year-old homosexual, HIV-positive male who presented with acute cholestatic hepatitis with a predominantly elevated alkaline phosphatase. After lab studies and imaging were unrevealing, a liver biopsy was performed that showed expanded portal tracts with a predominantly lymphoplasmacytic infiltrate and prominent bile ductular proliferation with periductal neutrophils. (Source: Human Pathology)
Source: Human Pathology - March 2, 2018 Category: Pathology Authors: Margarita N. German, Kristina A. Matkowskyj, Robert J. Hoffman, Parul D. Agarwal Source Type: research
KSHV/HHV8-Associated Extracavitary Primary Effusion Lymphoma Presenting as Multiple Lymphomatous Polyposis
Primary effusion lymphoma (PEL) is a distinct clinicopathologic entity usually characterized by presentation as a lymphomatous body cavity effusion in the absence of solid tumor mass or dissemination during its clinical course. PEL can also rarely occur as a solid lymphoma involving nodal and extranodal sites and is referred to as extracavitary PEL. Here we report a unique case of extracavitary PEL in a 49year-old HIV-seropositive patient, who presented with vague abdominal pain and 20 pound weight loss. (Source: Human Pathology)
Source: Human Pathology - March 2, 2018 Category: Pathology Authors: M.D Cyrus Oster, M.D Theodore Stein, M.D Sumire Kitahara, M.D Serhan Alkan, Qin Huang Tags: Case Study Source Type: research
Breast Pathology Masterclass
(Source: Human Pathology)
Source: Human Pathology - March 2, 2018 Category: Pathology Authors: Vincenzo Eusebi Source Type: research
A Case of Syphilitic Hepatitis in an HIV-Infected Patient
We present a case of a 51-year-old homosexual, HIV-positive male who presented with acute cholestatic hepatitis with a predominantly elevated alkaline phosphatase. After lab studies and imaging were unrevealing, a liver biopsy was performed that showed expanded portal tracts with a predominantly lymphoplasmacytic infiltrate and prominent bile ductular proliferation with periductal neutrophils. (Source: Human Pathology)
Source: Human Pathology - March 2, 2018 Category: Pathology Authors: Margarita N. German, Kristina A. Matkowskyj, Robert J. Hoffman, Parul D. Agarwal Source Type: research
KSHV/HHV8-Associated Extracavitary Primary Effusion Lymphoma Presenting as Multiple Lymphomatous Polyposis
Primary effusion lymphoma (PEL) is a distinct clinicopathologic entity usually characterized by presentation as a lymphomatous body cavity effusion in the absence of solid tumor mass or dissemination during its clinical course. PEL can also rarely occur as a solid lymphoma involving nodal and extranodal sites and is referred to as extracavitary PEL. Here we report a unique case of extracavitary PEL in a 49year-old HIV-seropositive patient, who presented with vague abdominal pain and 20 pound weight loss. (Source: Human Pathology)
Source: Human Pathology - March 2, 2018 Category: Pathology Authors: M.D Cyrus Oster, M.D Theodore Stein, M.D Sumire Kitahara, M.D Serhan Alkan, Qin Huang Tags: Case Study Source Type: research
Masthead
(Source: Human Pathology)
Source: Human Pathology - March 1, 2018 Category: Pathology Source Type: research
Table of Contents
(Source: Human Pathology)
Source: Human Pathology - March 1, 2018 Category: Pathology Source Type: research
Editorial Board
(Source: Human Pathology)
Source: Human Pathology - March 1, 2018 Category: Pathology Source Type: research
In This Issue
(Source: Human Pathology)
Source: Human Pathology - March 1, 2018 Category: Pathology Source Type: research
