Defining the Optimal Method for Reporting Prostate Cancer Grade and Tumor Extent on MR/US Fusion Targeted Biopsies
MR/ultrasound fusion targeted biopsy(TB) routinely samples multiple cores from each MR lesion of interest. Pathologists can evaluate the extent of cancer involvement and grade using an individual-core(IC) or aggregate(AG) method, which could potentially lead to differences in reporting. We reviewed patients who underwent TB followed by radical prostatectomy(RP). TB cores were evaluated for grade and tumor extent by two methods. IC method: grade for each TB lesion was based on the core with the highest Gleason score. (Source: Human Pathology)
Source: Human Pathology - March 15, 2018 Category: Pathology Authors: Jennifer B. Gordetsky, Luciana Schultz, Kristin K. Porter, Jeffrey W. Nix, John V. Thomas, Maria del Carmen Rodriguez Pena, Soroush Rais-Bahrami Source Type: research
Prognostication of superficial Barrett ’s carcinoma: a Japanese multicenter study
Endoscopic resection (ER) has become the standard therapy for superficial Barrett ’s carcinoma (BC) in Japan and other countries. Patients undergoing ER sometimes require additional treatment because of recurrence of lymph node metastasis (LNM). We attempted to clarify the histopathologic risk factors for LNM, and the difference between these risk factors for Japanese patients and the conventional risk factors documented for Western patients. This multi-center study included 12 leading institutions belonging to the Japan Research Society for Early Esophageal Cancer and Chromoendoscopy, and was based on a questionnaire de...
Source: Human Pathology - March 10, 2018 Category: Pathology Authors: Junko Aida, Tatsuro Ishizaki, Tomio Arai, Kaiyo Takubo, members of the Japan Research Society for Early Esophageal Cancer and Chromoendoscopy Tags: Original contribution Source Type: research
RARA and RARG Gene Downregulation Associated with EZH2 Mutation in Acute Promyelocytic-Like Morphology Leukemia
We report an Acute Myeloid Leukemia (AML) patient with morphology resembling APL without involvement of the RARA gene. Molecular and Fluorescent In Situ Hybridization (FISH) analyses excluded PML-RARA fusion and variant rearrangements involving RARA and RARG loci. (Source: Human Pathology)
Source: Human Pathology - March 10, 2018 Category: Pathology Authors: Nicoletta Coccaro, Antonella Zagaria, Paola Orsini, Luisa Anelli, Giuseppina Tota, Paola Casieri, Luciana Impera, Angela Minervini, Crescenzio F. Minervini, Cosimo Cumbo, Elisa Parciante, Anna Mestice, Mario Delia, Claudia Brunetti, Giorgina Specchia, Fra Tags: Case study Source Type: research
Prognostication of superficial Barrett's carcinoma: a Japanese multicenter study
Endoscopic resection (ER) has become the standard therapy for superficial Barrett's carcinoma (BC) in Japan and other countries. Patients undergoing ER sometimes require additional treatment because of recurrence of lymph node metastasis (LNM). We attempted to clarify the histopathologic risk factors for LNM, and the difference between these risk factors for Japanese patients and the conventional risk factors documented for Western patients. This multi-center study included 12 leading institutions belonging to the Japan Research Society for Early Esophageal Cancer and Chromoendoscopy, and was based on a questionnaire desig...
Source: Human Pathology - March 10, 2018 Category: Pathology Authors: Junko Aida, Tatsuro Ishizaki, Tomio Arai, Kaiyo Takubo Tags: Original contribution Source Type: research
RARA and RARG Gene Downregulation Associated with EZH2 Mutation in Acute Promyelocytic-Like Morphology Leukemia
We report an Acute Myeloid Leukemia (AML) patient with morphology resembling APL without involvement of the RARA gene. Molecular and Fluorescent In Situ Hybridization (FISH) analyses excluded PML-RARA fusion and variant rearrangements involving RARA and RARG loci. (Source: Human Pathology)
Source: Human Pathology - March 10, 2018 Category: Pathology Authors: Nicoletta Coccaro, Antonella Zagaria, Paola Orsini, Luisa Anelli, Giuseppina Tota, Paola Casieri, Luciana Impera, Angela Minervini, Crescenzio F. Minervini, Cosimo Cumbo, Elisa Parciante, Anna Mestice, Mario Delia, Claudia Brunetti, Giorgina Specchia, Fra Tags: Case study Source Type: research
Prognostication of superficial Barrett's carcinoma: a Japanese multicenter study
Endoscopic resection (ER) has become the standard therapy for superficial Barrett's carcinoma (BC) in Japan and other countries. Patients undergoing ER sometimes require additional treatment because of recurrence of lymph node metastasis (LNM). We attempted to clarify the histopathologic risk factors for LNM, and the difference between these risk factors for Japanese patients and the conventional risk factors documented for Western patients. This multi-center study included 12 leading institutions belonging to the Japan Research Society for Early Esophageal Cancer and Chromoendoscopy, and was based on a questionnaire desig...
Source: Human Pathology - March 10, 2018 Category: Pathology Authors: Junko Aida, Tatsuro Ishizaki, Tomio Arai, Kaiyo Takubo Tags: Original contribution Source Type: research
A unique evolution of the kidney phenotype in a patient with autosomal recessive Alport syndrome
We report a unique case of a 9-year-old boy who was biopsied for hematur ia and proteinuria, diagnosed as IgA nephropathy, with normal GBM appearance and thickness. Due to a family history of hematuria and chronic kidney disease, he subsequently underwent genetic evaluation and a mutation of α3 type IV collagen (COL4A3) was detected. (Source: Human Pathology)
Source: Human Pathology - March 9, 2018 Category: Pathology Authors: Gisella Vischini, Meghan E. Kapp, Ferrin C. Wheeler, Laszlo Hopp, Agnes B. Fogo Source Type: research
Autopsy-detected diagnostic errors over time in the intensive care unit
We evaluate the evolution over time of discrepancies between clinical diagnoses and post-mortem findings in critically ill patients, and to assess the factors associated with these discrepancies. We conducted a prospective study of all consecutive patients who underwent autopsy autopsies in a medical-surgical ICU between January 2008 and December 2015. Among 7.655 patients admitted to our ICU, 671 (8.8%) died. Clinical autopsy was performed in 215 (32%) patients. Major missed diagnoses were noted in 38 patients (17.7%). (Source: Human Pathology)
Source: Human Pathology - March 9, 2018 Category: Pathology Authors: Eva E. Tejerina, Rebeca Padilla, Elena Abril, Fernando Frutos-Vivar, Aida Ballen, Jos é María Rodríguez-Barbero, José Ángel Lorente, Andrés Esteban Tags: Original contribution Source Type: research
A unique evolution of the kidney phenotype in a patient with autosomal recessive Alport syndrome
We report a unique case of a 9-year-old boy who was biopsied for hematur ia and proteinuria, diagnosed as IgA nephropathy, with normal GBM appearance and thickness. Due to a family history of hematuria and chronic kidney disease, he subsequently underwent genetic evaluation and a mutation of α3 type IV collagen (COL4A3) was detected. (Source: Human Pathology)
Source: Human Pathology - March 9, 2018 Category: Pathology Authors: Gisella Vischini, Meghan E. Kapp, Ferrin C. Wheeler, Laszlo Hopp, Agnes B. Fogo Source Type: research
Autopsy-detected diagnostic errors over time in the intensive care unit
We evaluate the evolution over time of discrepancies between clinical diagnoses and post-mortem findings in critically ill patients, and to assess the factors associated with these discrepancies. We conducted a prospective study of all consecutive patients who underwent autopsy autopsies in a medical-surgical ICU between January 2008 and December 2015. Among 7.655 patients admitted to our ICU, 671 (8.8%) died. Clinical autopsy was performed in 215 (32%) patients. Major missed diagnoses were noted in 38 patients (17.7%). (Source: Human Pathology)
Source: Human Pathology - March 9, 2018 Category: Pathology Authors: Eva E. Tejerina, Rebeca Padilla, Elena Abril, Fernando Frutos-Vivar, Aida Ballen, Jos é María Rodríguez-Barbero, José Ángel Lorente, Andrés Esteban Tags: Original contribution Source Type: research
MicroRNA Signatures Discriminate Between Uterine and Ovarian Serous Carcinomas
Synchronous endometrial and ovarian malignancies occur in 5% of women presenting with endometrial cancer and 10% of patients presenting with ovarian malignancy. When a high-grade serous carcinoma concurrently involves both ovary and endometrium, pathological determination of whether they are synchronous primaries or metastatic tumors from one primary site can be challenging. MicroRNAs (miRNA) are 22-nucleotide noncoding RNAs that are aberrantly expressed in cancer cells and may inherit their cellular linage characteristics. (Source: Human Pathology)
Source: Human Pathology - March 5, 2018 Category: Pathology Authors: Pei Hui, Stefan M. Gysler, Mohamed Uduman, Taiwo A. Togun, Daniel E. Prado, Christine E. Richter, Sunitha Nallur, Peter E. Schwartz, Thomas J. Rutherford, Alessandro D. Santin, Joanne B. Weidhaas, Elena S. Ratner Tags: Original contribution Source Type: research
Propranolol prevents liver cirrhosis by inhibiting hepatic stellate cell activation mediated by the PDGFR/Akt pathway
In this study, a hepatic cirrhosis mouse model was induced by CCl4 administration for 6weeks. (Source: Human Pathology)
Source: Human Pathology - March 4, 2018 Category: Pathology Authors: Qian Ding, Zhen Li, Bin Liu, Liping Ling, Xiangguo Tian, Chunqing Zhang Tags: Original contribution Source Type: research
A case report of atypical Spitz tumor harboring a novel MLPH-ALK gene fusion with discordant ALK immunohistochemistry results
Frequent kinase fusions have been reported in spitzoid neoplasms, approximately 10% of which involve ALK rearrangements. Herein, we report a case of atypical Spitz tumour (AST) with a novel MLPH-ALK fusion, which has not been previously reported to contribute to cancer development. The tumour was detected in the right arm of a 40-year-old woman. The novel ALK fusion was identified by a 5 ′-rapid amplification of cDNA ends-based system optimised for formalin-fixed paraffin-embedded tissue. Initially, ALK expression was detected by immunohistochemistry (IHC) using 5A4 antibodies for both sensitive and conventional polymer ...
Source: Human Pathology - March 4, 2018 Category: Pathology Authors: Masakazu Fujimoto, Yuki Togashi, Ibu Matsuzaki, Satoko Baba, Kengo Takeuchi, Yutaka Inaba, Masatoshi Jinnin, Shin-ichi Murata Tags: Case report Source Type: research
Phosphaturic Mesenchymal Tumor Without Osteomalacia: Additional Confirmation of the “Non-Phosphaturic” Variant, with Emphasis on the Roles of FGF23 Chromogenic in situ Hybridization and FN1-FGFR1 Fluorescence in situ Hybridization
Phosphaturic Mesenchymal Tumor (PMT) is a rare, histologically distinctive neoplasm, which classically presents with phosphaturia and tumor-induced osteomalacia (TIO) (i.e., oncogenic osteomalacia). Both the phosphaturia and TIO are due to paraneoplastic production of FGF23 (a phosphatonin) by the neoplastic cells, which are genetically characterized by rearrangements of FN1 (most often with FGFR1 – and less frequently with FGF1). However, rare cases of PMT present without phosphaturia and TIO (i.e., the “non-phosphaturic” variant) – and are therefore much more challenging to diagnose. (Source: Human Pathology)
Source: Human Pathology - March 4, 2018 Category: Pathology Authors: Kimberley N Sent-Doux, Craig Mackinnon, Jen-Chieh Lee, Andrew L Folpe, Omar Habeeb Tags: Case Study Source Type: research
