ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma
Acyl-CoA thioesterase 1 (ACOT1) is an important isoform of the ACOT family that catalyzes the reaction of fatty acyl-CoAs to CoA-SH and free fatty acids. Recent studies of gastrointestinal tumor metabolism suggest that there is abnormal metabolism of lipids and fatty acids during tumor progression. However, the function and contribution of ACOT1 in gastric cancer development are still poorly understood. Additionally, GLI3 is a major transcription factor in the regulation of hedgehog (Hh) signaling. (Source: Human Pathology)
Source: Human Pathology - March 17, 2018 Category: Pathology Authors: Fang Wang, Jingyi Wu, Zhichao Qiu, Xiaosong Ge, Xingxiang Liu, Chun Zhang, Wenhuan Xu, Fengming Wang, Dong Hua, Xiaowei Qi, Yong Mao Tags: Original contribution Source Type: research
P16-positive cystic squamous cell carcinoma in midline neck: metastasis from oropharynx or primary carcinoma arising from thyroglossal duct cyst?
In this study, we report a p16-positive cystic SCC located in the midline neck. (Source: Human Pathology)
Source: Human Pathology - March 16, 2018 Category: Pathology Authors: Songlin Zhang, Hong D. Xiao, Zhenjian Cai, Michael Covinsky, Karan Saluja, Maria O Patino, Xinmin Liu, Hui Zhu Source Type: research
Luminally-polarized mural and vascular remodeling in ileal strictures of Crohn's Disease
Intestinal stricture, a major complication of Crohn's disease (CD), results from fibromuscular remodeling and expansion of the intestinal wall. The corresponding microanatomical alterations have not been fully described, hindering progress toward understanding their pathogenesis and devising appropriate treatments. We used tissue-specific staining and quantitative digital histomorphometry for this purpose. Serial histological sections from 37 surgically-resected ileal strictures and adjacent non-strictured controls from patients with CD were evaluated after staining for smooth muscle actin, collagen (Sirius red) and collag...
Source: Human Pathology - March 16, 2018 Category: Pathology Authors: Xiaofei Zhang, Huaibin Mabel Ko, Joana Torres, Hinaben J. Panchal, Zhenjian Cai, Mathilde Wagner, Bruce E. Sands, Jean-Frederic Colombel, Judy Cho, Bachir Taouli, Noam Harpaz Source Type: research
Analysis of cancer-associated fibroblasts and the epithelial-mesenchymal transition in cutaneous basal cell carcinoma, squamous cell carcinoma and malignant melanoma
Activated cancer-associated fibroblasts (CAFs) and fibroblasts that have undergone the epithelial-mesenchymal transition (EMT) in cancer stroma contribute to tumor progression and metastasis. However, no reports have investigated the CAF phenotype and its clinicopathological relevance in cutaneous malignant tumors, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). Here, we investigated the CAF phenotype in cutaneous malignant tumors based on their histology and immunohistochemical expression of CAF-related markers, including adipocyte enhancer-binding protein 1 (AEBP1), podopl...
Source: Human Pathology - March 16, 2018 Category: Pathology Authors: Kousuke Sasaki, Tamotsu Sugai, Kazuyuki Ishida, Mitsumasa Osakabe, Hiroo Amano, Hiroaki Kimura, Minoru Sakuraba, Katsuhiko Kashiwa, Seiichiro Kobayashi Tags: Original article Source Type: research
Spectrum of Findings in Orchiectomy Specimens of Persons Undergoing Gender Confirmation Surgery
We describe changes seen in gonads from individuals seeking male to female physical adaptation. We studied 99 orchiectomies from 50 persons. The average age was 33years (range: 21 –63). Eighty six of 99 (86.8%) testes were normal in size with an average size of 3.87cm (range: 3.0–5.5). Thirteen of 99 (13.1%) testes were hypotrophic and measured up to 2.5cm. Seminiferous tubules were reduced in diameter compared to controls (0.237 mm vs. (Source: Human Pathology)
Source: Human Pathology - March 16, 2018 Category: Pathology Authors: Andres Matoso, Binny Khandakar, Songyang Yuan, Tony Wu, Li J. Wang, Kara A Lombardo, Shamlal Mangray, Abul Ala Syed Rifat Mannan, Evgeny Yakirevich Source Type: research
Aberrant high expression level of MORC2 is a common character in multiple cancers
In this study, we showed that MORC2 was widely expressed in human tissues while significantly up-regulated in most cancer types employing immunohistochemical staining and analysis of mRNA expression profile of more than 2000 human tissue samples from 15 different organs (lung, prostate, liver, breast, brain, stomach, colon/rectum, pancreas, ovary, endometrium, skin, nasopharynx, kidney, oesophagus and bladder). (Source: Human Pathology)
Source: Human Pathology - March 16, 2018 Category: Pathology Authors: Ding Qian-shan, Zhang Li, Wang Bi-cheng, Zeng Zhi, Zou Xian-qiong, Cao Peng-bo, M.S. Zhou Guang-ming, Tang Meng, Wu Lu, B.S. Wu Lian-lian, Yu Hong-gang, Guo Yong, Zhou Fu-xiang Tags: Original Contribution Source Type: research
P16-positive cystic squamous cell carcinoma in midline neck: metastasis from oropharynx or primary carcinoma arising from thyroglossal duct cyst?
In this study, we report a p16-positive cystic SCC located in the midline neck. (Source: Human Pathology)
Source: Human Pathology - March 16, 2018 Category: Pathology Authors: Songlin Zhang, Hong D. Xiao, Zhenjian Cai, Michael Covinsky, Karan Saluja, Maria O Patino, Xinmin Liu, Hui Zhu Source Type: research
Luminally-polarized mural and vascular remodeling in ileal strictures of Crohn's Disease
Intestinal stricture, a major complication of Crohn's disease (CD), results from fibromuscular remodeling and expansion of the intestinal wall. The corresponding microanatomical alterations have not been fully described, hindering progress toward understanding their pathogenesis and devising appropriate treatments. We used tissue-specific staining and quantitative digital histomorphometry for this purpose. Serial histological sections from 37 surgically-resected ileal strictures and adjacent non-strictured controls from patients with CD were evaluated after staining for smooth muscle actin, collagen (Sirius red) and collag...
Source: Human Pathology - March 16, 2018 Category: Pathology Authors: Xiaofei Zhang, Huaibin Mabel Ko, Joana Torres, Hinaben J. Panchal, Zhenjian Cai, Mathilde Wagner, Bruce E. Sands, Jean-Frederic Colombel, Judy Cho, Bachir Taouli, Noam Harpaz Source Type: research
Analysis of cancer-associated fibroblasts and the epithelial-mesenchymal transition in cutaneous basal cell carcinoma, squamous cell carcinoma and malignant melanoma
Activated cancer-associated fibroblasts (CAFs) and fibroblasts that have undergone the epithelial-mesenchymal transition (EMT) in cancer stroma contribute to tumor progression and metastasis. However, no reports have investigated the CAF phenotype and its clinicopathological relevance in cutaneous malignant tumors, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). Here, we investigated the CAF phenotype in cutaneous malignant tumors based on their histology and immunohistochemical expression of CAF-related markers, including adipocyte enhancer-binding protein 1 (AEBP1), podopl...
Source: Human Pathology - March 16, 2018 Category: Pathology Authors: Kousuke Sasaki, Tamotsu Sugai, Kazuyuki Ishida, Mitsumasa Osakabe, Hiroo Amano, Hiroaki Kimura, Minoru Sakuraba, Katsuhiko Kashiwa, Seiichiro Kobayashi Tags: Original article Source Type: research
Spectrum of Findings in Orchiectomy Specimens of Persons Undergoing Gender Confirmation Surgery
We describe changes seen in gonads from individuals seeking male to female physical adaptation. We studied 99 orchiectomies from 50 persons. The average age was 33years (range: 21 –63). Eighty six of 99 (86.8%) testes were normal in size with an average size of 3.87cm (range: 3.0–5.5). Thirteen of 99 (13.1%) testes were hypotrophic and measured up to 2.5cm. Seminiferous tubules were reduced in diameter compared to controls (0.237 mm vs. (Source: Human Pathology)
Source: Human Pathology - March 16, 2018 Category: Pathology Authors: Andres Matoso, Binny Khandakar, Songyang Yuan, Tony Wu, Li J. Wang, Kara A Lombardo, Shamlal Mangray, Abul Ala Syed Rifat Mannan, Evgeny Yakirevich Source Type: research
Aberrant high expression level of MORC2 is a common character in multiple cancers
In this study, we showed that MORC2 was widely expressed in human tissues while significantly up-regulated in most cancer types employing immunohistochemical staining and analysis of mRNA expression profile of more than 2000 human tissue samples from 15 different organs (lung, prostate, liver, breast, brain, stomach, colon/rectum, pancreas, ovary, endometrium, skin, nasopharynx, kidney, oesophagus and bladder). (Source: Human Pathology)
Source: Human Pathology - March 16, 2018 Category: Pathology Authors: Ding Qian-shan, Zhang Li, Wang Bi-cheng, Zeng Zhi, Zou Xian-qiong, Cao Peng-bo, M.S. Zhou Guang-ming, Tang Meng, Wu Lu, B.S. Wu Lian-lian, Yu Hong-gang, Guo Yong, Zhou Fu-xiang Tags: Original Contribution Source Type: research
Defining the optimal method for reporting prostate cancer grade and tumor extent on magnetic resonance/ultrasound fusion –targeted biopsies
Magnetic resonance (MR)/ultrasound fusion –targeted biopsy (TB) routinely samples multiple cores from each MR lesion of interest. Pathologists can evaluate the extent of cancer involvement and grade using an individual core (IC) or aggregate (AG) method, which could potentially lead to differences in reporting. We reviewed patients who un derwent TB followed by radical prostatectomy (RP). TB cores were evaluated for grade and tumor extent by 2 methods. In the IC method, the grade for each TB lesion was based on the core with the highest Gleason score. (Source: Human Pathology)
Source: Human Pathology - March 15, 2018 Category: Pathology Authors: Jennifer B. Gordetsky, Luciana Schultz, Kristin K. Porter, Jeffrey W. Nix, John V. Thomas, Maria del Carmen Rodriguez Pena, Soroush Rais-Bahrami Tags: Original contribution Source Type: research
Elevated Expression of IRS-1 Associates with p-Akt Expression and Predicts Poor Prognosis of Breast Invasive Ductal Carcinoma
Overexpression of Insulin Receptor Substrate 1 (IRS-1) has been reported to promote cell growth, atypical hyperplasia, and carcinogenesis. And phosphorylated Akt (p-Akt) is certified to be involved in many types of cancers such as breast invasive ductal carcinoma (BIDC). However, the relationship between IRS-1 and Akt, as well as the role of expression of IRS-1 in BIDC, has never been reported. The purpose of this research is to investigate the association between expression of IRS-1 and p-Akt proteins and clinicopathological features of BIDC by immunohistochemistry, as well as the survival status. (Source: Human Pathology)
Source: Human Pathology - March 15, 2018 Category: Pathology Authors: Jiadi Luo, Juan Feng, Qiuyuan Wen, Christopher Qoyawayma, Weiyuan Wang, Lingjiao Chen, Junmi Lu, Yuting Zhan, Lina Xu, Hongjing Zang, Songqing Fan, Shuzhou Chu Tags: Original contribution Source Type: research
Defining the Optimal Method for Reporting Prostate Cancer Grade and Tumor Extent on MR/US Fusion Targeted Biopsies
MR/ultrasound fusion targeted biopsy(TB) routinely samples multiple cores from each MR lesion of interest. Pathologists can evaluate the extent of cancer involvement and grade using an individual-core(IC) or aggregate(AG) method, which could potentially lead to differences in reporting. We reviewed patients who underwent TB followed by radical prostatectomy(RP). TB cores were evaluated for grade and tumor extent by two methods. IC method: grade for each TB lesion was based on the core with the highest Gleason score. (Source: Human Pathology)
Source: Human Pathology - March 15, 2018 Category: Pathology Authors: Jennifer B. Gordetsky, Luciana Schultz, Kristin K. Porter, Jeffrey W. Nix, John V. Thomas, Maria del Carmen Rodriguez Pena, Soroush Rais-Bahrami Source Type: research
Elevated Expression of IRS-1 Associates with p-Akt Expression and Predicts Poor Prognosis of Breast Invasive Ductal Carcinoma
Overexpression of Insulin Receptor Substrate 1 (IRS-1) has been reported to promote cell growth, atypical hyperplasia, and carcinogenesis. And phosphorylated Akt (p-Akt) is certified to be involved in many types of cancers such as breast invasive ductal carcinoma (BIDC). However, the relationship between IRS-1 and Akt, as well as the role of expression of IRS-1 in BIDC, has never been reported. The purpose of this research is to investigate the association between expression of IRS-1 and p-Akt proteins and clinicopathological features of BIDC by immunohistochemistry, as well as the survival status. (Source: Human Pathology)
Source: Human Pathology - March 15, 2018 Category: Pathology Authors: Jiadi Luo, Juan Feng, Qiuyuan Wen, Christopher Qoyawayma, Weiyuan Wang, Lingjiao Chen, Junmi Lu, Yuting Zhan, Lina Xu, Hongjing Zang, Songqing Fan, Shuzhou Chu Tags: Original contribution Source Type: research
