The clinicopathological significance of micropapillary pattern in colorectal cancers
The aim of the present study is to elucidate the clinicopathological significance and prognostic role of micropapillary pattern (MPP) in colorectal cancer (CRC). We investigated the correlation between the presence of MPP and clinicopathological characteristics and prognosis in 266 CRCs. In addition, the clinicopathological significance of MPP in mucin pools was investigated and compared to pure MPP, which is not associated with mucin pools. MPP, regardless of its proportion in the overall tumor, was found in 74 of 266 CRCs (27.8%). (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Jung-Soo Pyo, Mee Ja Park, Dong-Wook Kang Tags: Original contribution Source Type: research

Clinical implication of programmed death-ligand 1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition
Programmed death-ligand 1 (PD-L1), essential for immune evasion, is a potential candidate for pathogenesis and therapeutic target of human papillomavirus (HPV)-positive tonsillar squamous cell carcinomas (TSCCs). MET/hepatocyte growth factor (HGF) signaling and transcription factors involved in epithelial-to-mesenchymal transition (EMT) upregulate PD-L1, which can contribute to clinical outcome. Intratumoral heterogeneity of PD-L1 expression is of clinical importance in selection bias due to false-negative patient enrollment. (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Mi Jung Kwon, Young-Soo Rho, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Eun Soo Kim, Bumjung Park, Mineui Hong, Kyueng-Whan Min Tags: Original contribution Source Type: research

Comparison of thyroid transcription factor-1 expression by two monoclonal antibodies in Scotchwoman: the chosen clone matters —reply
Dear Editor: (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Dai-Zhong Wang, Li Yao, Xian-Bin Tang Source Type: research

Genomic Profile of Appendiceal Goblet Cell Carcinoid Is Distinct Compared to Appendiceal Neuroendocrine Tumor and Conventional Adenocarcinoma
Goblet cell carcinoid (GCC) is a rare appendiceal tumor with unique morphologic features that shows glandular and neuroendocrine differentiation on immunohistochemistry. An additional component of adenocarcinoma (AC) can be present (GCC-AC). Both GCC and GCC-AC are staged and treated like AC. The histogenesis and genetic alterations underlying GCC and GCC-AC are unclear. Capture-based next-generation DNA sequencing targeting 479 cancer genes was performed on 19 appendiceal tumors: 4 GCC, 9 GCC-AC, 3 neuroendocrine tumors (NET), and 3AC (2 conventional, 1 mucinous). (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Kwun Wah Wen, James P. Grenert, Nancy M. Joseph, Nafis Shafizadeh, Anne Huang, Mojgan Hosseini, Sanjay Kakar Tags: Original contribution Source Type: research

Somatic polymerase epsilon mutations as another route leading to loss of DNA MMR protein expression in endometrial carcinoma —reply
We thank Westenend and Dinjens for sharing their case that illustrates how mutations in polymerase epsilon (POLE) and polymerase delta (POLD1) can be an alternative mechanism for loss of MMR protein expression and a likely explanation for a number of patients that fall into the “Lynch-like syndrome” category with negative germline testing results for MMR genes. Although the etiology of “Lynch-like syndrome” was largely uncertain in the past, recent genomic discoveries and expanded sequence panels have revealed that the vast majority of these patients have 1, 2, or more somatic mutations in MMR genes, POLE/POLD1 or,...
Source: Human Pathology - April 6, 2018 Category: Pathology Authors: Laura J. Tafe Tags: Correspondence Source Type: research

Somatic polymerase epsilo mutations as another route leading to loss of DNA MMR protein expression in endometrial carcinoma —reply
Laura J. Tafe MD laura.j.tafe@hitchcock.org (Source: Human Pathology)
Source: Human Pathology - April 6, 2018 Category: Pathology Tags: Correspondence Source Type: research

Transcriptome analyses reveal FOXA1 dysregulation in mammary and extramammary Paget's disease
Paget's disease (PD) is an uncommon intraepithelial adenocarcinoma with unknown pathogenesis. There are two anatomic subtypes: mammary (MPD) and extramammary (EMPD). Little is known about their molecular characteristics. Our objective was to discover novel molecular markers for PD and its subtypes. In the discovery phase, we used transcriptome analyses to uncover the most differentially expressed genes and pathways in EMPD biopsies compared with normal skin. In the validation phase, we performed immunohistochemistry analyses on the most promising marker (FOXA1) and other markers selected from a literature review (GATA3, es...
Source: Human Pathology - April 6, 2018 Category: Pathology Authors: Ruiqin Mai, Songxia Zhou, Shuqin Zhou, Weixiang Zhong, Liangli Hong, Yuanyuan Wang, Shanming Lu, Jikai Pan, Yuansheng Huang, Mingwan Su, Richard Crawford, Youwen Zhou, Guohong Zhang Tags: Original contribution Source Type: research

Somatic polymerase epsilo mutations as another route leading to loss of DNA MMR protein expression in endometrial carcinoma —reply
Laura J. Tafe MD laura.j.tafe@hitchcock.org (Source: Human Pathology)
Source: Human Pathology - April 6, 2018 Category: Pathology Tags: Correspondence Source Type: research

Transcriptome analyses reveal FOXA1 dysregulation in mammary and extramammary Paget's disease
Paget's disease (PD) is an uncommon intraepithelial adenocarcinoma with unknown pathogenesis. There are two anatomic subtypes: mammary (MPD) and extramammary (EMPD). Little is known about their molecular characteristics. Our objective was to discover novel molecular markers for PD and its subtypes. In the discovery phase, we used transcriptome analyses to uncover the most differentially expressed genes and pathways in EMPD biopsies compared with normal skin. In the validation phase, we performed immunohistochemistry analyses on the most promising marker (FOXA1) and other markers selected from a literature review (GATA3, es...
Source: Human Pathology - April 6, 2018 Category: Pathology Authors: Ruiqin Mai, Songxia Zhou, Shuqin Zhou, Weixiang Zhong, Liangli Hong, Yuanyuan Wang, Shanming Lu, Jikai Pan, Yuansheng Huang, Mingwan Su, Richard Crawford, Youwen Zhou, Guohong Zhang Tags: Original contribution Source Type: research

EWSR1-NFATC2 Gene Fusion in a Soft Tissue Tumor with Epithelioid Round Cell Morphology and Abundant Stroma: A Case Report and Review of the Literature
We present a case of a tumor harboring the EWSR1-NFATC2 gene fusion arising in the subcutaneous tissue of a young woman. (Source: Human Pathology)
Source: Human Pathology - April 4, 2018 Category: Pathology Authors: Jarish N. Cohen, Amit J. Sabnis, Gregor Krings, Soo-Jin Cho, Andrew E. Horvai, Jessica L. Davis Tags: Case study Source Type: research

Renal histology in a patient with TAFRO Syndrome: A case report
An 84-year-old Japanese man was admitted due to anasarca, thrombocytopenia, systemic inflammation, and progressive renal insufficiency, resistant to diuretics, glucocorticoid therapy and plasma exchange. Renal biopsy showed diffuse endocapillary proliferation and mesangiolysis without any immune deposits. Tocilizumab suppressed systemic inflammation, resulting in improvement of anasarca and renal dysfunction, but thrombocytopenia persisted and platelet-associated IgG antibody was elevated. Though romiplostim was effective for thrombocytopenia, the patient died of aspiration pneumonia after cerebral hemorrhage. (Source: Human Pathology)
Source: Human Pathology - April 4, 2018 Category: Pathology Authors: Hiroki Mizuno, Akinari Sekine, Masahiko Oguro, Yoichi Oshima, Masahiro Kawada, Keiichi Sumida, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Rikako Hiramatsu, Eiko Hasegawa, Junichi Hoshino, Naoki Sawa, Takashi Fujii, Kenmei Takaichi, Kenichi Ohashi Tags: Case study Source Type: research

Placentas from women with pregnancy-associated venous insufficiency show villi damage with evidence of hypoxic cellular stress
Lower extremity venous insufficiency (VI) is a complication of pregnancy. The potential association of this venous disease with structural damage of the placenta has not been described. We analyzed the pattern of histopathological lesions and the gene and protein expression of HIF1- α and apoptosis regulatory proteins. A prospective study was carried out on placenta samples from 43 women with pregnancy-associated VI and 24 age-matched pregnant healthy controls (HC). Women with VI showed a significant increase in the number of villi (150.77±42.55 VI versus 122.13±27.74 HC) an d in syncytial knots compared to those found ...
Source: Human Pathology - April 4, 2018 Category: Pathology Authors: Natalio Garc ía-Honduvilla, Miguel A Ortega, Ángel Asúnsolo, María J Álvarez-Rocha, Beatriz Romero, Juan De León-Luis, Melchor Álvarez- Mon, Julia Buján Tags: Original contribution Source Type: research

Expanding the Histomorphologic Spectrum of TFE3 Rearranged PEComas
Perivascular epithelioid tumors (PEComas) are a family of mesenchymal neoplasms that have smooth muscle and melanocytic differentiation. They can be sporadic or associated with Tuberous Sclerosis Complex and commonly present in the kidney as angiomyolipoma or in the lung as pulmonary clear cell sugar tumors or lymphangioleiomyomatosis. However, they can present at any visceral or soft tissue site. They usually have a benign clinical course, but rarely can behave in a malignant fashion. Most PEComas demonstrate abnormalities of TSC2, but a recently described subset harbor TFE3 rearrangements that appear to be mutually exclu...
Source: Human Pathology - April 4, 2018 Category: Pathology Authors: Nolan Maloney, Krinio Giannikou, Joel Lefferts, Julia A. Bridge, Konstantinos Linos Tags: Case study Source Type: research

EWSR1-NFATC2 Gene Fusion in a Soft Tissue Tumor with Epithelioid Round Cell Morphology and Abundant Stroma: A Case Report and Review of the Literature
We present a case of a tumor harboring the EWSR1-NFATC2 gene fusion arising in the subcutaneous tissue of a young woman. (Source: Human Pathology)
Source: Human Pathology - April 4, 2018 Category: Pathology Authors: Jarish N. Cohen, Amit J. Sabnis, Gregor Krings, Soo-Jin Cho, Andrew E. Horvai, Jessica L. Davis Tags: Case study Source Type: research

Renal histology in a patient with TAFRO Syndrome: A case report
An 84-year-old Japanese man was admitted due to anasarca, thrombocytopenia, systemic inflammation, and progressive renal insufficiency, resistant to diuretics, glucocorticoid therapy and plasma exchange. Renal biopsy showed diffuse endocapillary proliferation and mesangiolysis without any immune deposits. Tocilizumab suppressed systemic inflammation, resulting in improvement of anasarca and renal dysfunction, but thrombocytopenia persisted and platelet-associated IgG antibody was elevated. Though romiplostim was effective for thrombocytopenia, the patient died of aspiration pneumonia after cerebral hemorrhage. (Source: Human Pathology)
Source: Human Pathology - April 4, 2018 Category: Pathology Authors: Hiroki Mizuno, Akinari Sekine, Masahiko Oguro, Yoichi Oshima, Masahiro Kawada, Keiichi Sumida, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Rikako Hiramatsu, Eiko Hasegawa, Junichi Hoshino, Naoki Sawa, Takashi Fujii, Kenmei Takaichi, Kenichi Ohashi Tags: Case study Source Type: research