Evaluation of the efficacy of the four tests (p16 immunochemistry, PCR, DNA and RNA In situ Hybridization) to evaluate a Human Papillomavirus infection in head and neck cancers: a cohort of 348 French squamous cell carcinomas
In this study, using 348 HNSCCs (126 OP SCCs and 222 non-OP SCCs), we evaluated diagnostic performances of different HPV tests in OP and non-OP SCCs: PCR, p16 immunostaining, in situ hybridization targeting DNA (DNA-CISH) and RNA (RNA-CISH), combined p16 + DNA-CISH, and combined p16 + RNA-CISH. (Source: Human Pathology)
Source: Human Pathology - April 20, 2018 Category: Pathology Authors: J érémy Augustin, Sophie Outh-Gauer, Marion Mandavit, Cassandre Gasne, Ophélie Grard, Thomas Denize, Marine Nervo, Haïtham Mirghani, Ollivier Laccourreye, Pierre Bonfils, Patrick Bruneval, David Veyer, Hélène Péré, Eric Tartour, Cécile Badoual Source Type: research
MET amplification, expression, and exon 14 mutations in colorectal adenocarcinoma
MET amplification, expression, and splice mutations at exon 14 result in dysregulation of the MET signaling pathway. The aim of this study was to identify the relationship between MET amplification, protein or mRNA expression, and mutations in colorectal cancer (CRC). MET immunohistochemistry (IHC) was used for MET protein expression analysis and fluorescence in situ hybridization (FISH) was used for MET amplification detection. Both analyses were performed in tissue microarrays (TMA) containing 294 of colorectal adenocarcinoma tissue samples and 131 samples of adjacent normal epithelial tissue. (Source: Human Pathology)
Source: Human Pathology - April 8, 2018 Category: Pathology Authors: Meng Zhang, Guichao Li, Xiangjie Sun, Shujuan Ni, Cong Tan, Midie Xu, Dan Huang, Fei Ren, Dawei Li, Ping Wei, Xiang Du Tags: Original contribution Source Type: research
Comparison of thyroid transcription factor-1 expression by 2 monoclonal antibodies in schwannomas: the chosen clone matters
We have read with great interest the recently published study by Wang et al [1] on aberrant expression of thyroid transcription factor-1 (TTF-1) in schwannomas. The authors described nuclear TTF-1 in 109 (67.7%) schwannomas, including 102 of 132 (77.9%) conventional, 1 of 20 (5%) cellular, and 6 of 10 (60%) plexiform schwannomas. Nuclear staining was not identified in normal peripheral nerves and nonschwannoma peripheral nervous system lesions. (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: David Creytens, Mieke Van Bockstal, Liesbeth Ferdinande, Jo Van Dorpe Tags: Correspondence Source Type: research
Comparison of thyroid transcription factor-1 expression by 2 monoclonal antibodies in schwannomas: the chosen clone matters —reply
We thank Dr Creytens and colleagues for their interest in our manuscript on expression of thyroid transcription factor-1 (TTF-1) in schwannomas and comparison of TTF-1 expression by 2 monoclonal antibodies. We appreciate the opportunity to reply and further explain some of our observations. (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Dai-Zhong Wang, Li Yao, Xian-Bin Tang Tags: Correspondence Source Type: research
Comparison of thyroid transcription factor-1 expression by two monoclonal antibodies in schwannomas: the chosen clone matters
To the editor: (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: David Creytens, Mieke Van Bockstal, Liesbeth Ferdinande, Jo Van Dorpe Tags: Correspondence Source Type: research
Somatic polymerase epsilon mutations as another route leading to loss of DNA MMR protein expression in endometrial carcinoma
To the editor, (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Pieter J. Westenend, Winand N. Dinjens Source Type: research
High expression of synthesis of cytochrome c oxidase 2 and TP53-induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma
Synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR) are two p53-mediated proteins that can play a regulatory role in cancer energy metabolism. However, no study has examined the association of SCO2 and TIGAR with the prognosis of patients with lung adenocarcinoma (AC). In our study, the expression of SCO2 and TIGAR proteins in lung AC was detected, and the potential relation to prognosis was evaluated, aiming to take a further view of lung AC progression. (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Jiabin Liu, Funian Lu, Yan Gong, Chen Zhao, Qi Pan, Stephanie Ballantyne, Xianda Zhao, Sufang Tian, Honglei Chen Tags: Original contribution Source Type: research
The clinicopathological significance of micropapillary pattern in colorectal cancers
The aim of the present study is to elucidate the clinicopathological significance and prognostic role of micropapillary pattern (MPP) in colorectal cancer (CRC). We investigated the correlation between the presence of MPP and clinicopathological characteristics and prognosis in 266 CRCs. In addition, the clinicopathological significance of MPP in mucin pools was investigated and compared to pure MPP, which is not associated with mucin pools. MPP, regardless of its proportion in the overall tumor, was found in 74 of 266 CRCs (27.8%). (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Jung-Soo Pyo, Mee Ja Park, Dong-Wook Kang Tags: Original contribution Source Type: research
Clinical implication of programmed death-ligand 1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition
Programmed death-ligand 1 (PD-L1), essential for immune evasion, is a potential candidate for pathogenesis and therapeutic target of human papillomavirus (HPV)-positive tonsillar squamous cell carcinomas (TSCCs). MET/hepatocyte growth factor (HGF) signaling and transcription factors involved in epithelial-to-mesenchymal transition (EMT) upregulate PD-L1, which can contribute to clinical outcome. Intratumoral heterogeneity of PD-L1 expression is of clinical importance in selection bias due to false-negative patient enrollment. (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Mi Jung Kwon, Young-Soo Rho, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Eun Soo Kim, Bumjung Park, Mineui Hong, Kyueng-Whan Min Tags: Original contribution Source Type: research
Comparison of thyroid transcription factor-1 expression by two monoclonal antibodies in Scotchwoman: the chosen clone matters —reply
Dear Editor: (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Dai-Zhong Wang, Li Yao, Xian-Bin Tang Source Type: research
Genomic Profile of Appendiceal Goblet Cell Carcinoid Is Distinct Compared to Appendiceal Neuroendocrine Tumor and Conventional Adenocarcinoma
Goblet cell carcinoid (GCC) is a rare appendiceal tumor with unique morphologic features that shows glandular and neuroendocrine differentiation on immunohistochemistry. An additional component of adenocarcinoma (AC) can be present (GCC-AC). Both GCC and GCC-AC are staged and treated like AC. The histogenesis and genetic alterations underlying GCC and GCC-AC are unclear. Capture-based next-generation DNA sequencing targeting 479 cancer genes was performed on 19 appendiceal tumors: 4 GCC, 9 GCC-AC, 3 neuroendocrine tumors (NET), and 3AC (2 conventional, 1 mucinous). (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Kwun Wah Wen, James P. Grenert, Nancy M. Joseph, Nafis Shafizadeh, Anne Huang, Mojgan Hosseini, Sanjay Kakar Tags: Original contribution Source Type: research
Comparison of thyroid transcription factor-1 expression by two monoclonal antibodies in schwannomas: the chosen clone matters
To the editor: (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: David Creytens, Mieke Van Bockstal, Liesbeth Ferdinande, Jo Van Dorpe Tags: Correspondence Source Type: research
Somatic polymerase epsilon mutations as another route leading to loss of DNA MMR protein expression in endometrial carcinoma
To the editor, (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Pieter J. Westenend, Winand N. Dinjens Source Type: research
High expression of synthesis of cytochrome c oxidase 2 and TP53-induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma
Synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR) are two p53-mediated proteins that can play a regulatory role in cancer energy metabolism. However, no study has examined the association of SCO2 and TIGAR with the prognosis of patients with lung adenocarcinoma (AC). In our study, the expression of SCO2 and TIGAR proteins in lung AC was detected, and the potential relation to prognosis was evaluated, aiming to take a further view of lung AC progression. (Source: Human Pathology)
Source: Human Pathology - April 7, 2018 Category: Pathology Authors: Jiabin Liu, Funian Lu, Yan Gong, Chen Zhao, Qi Pan, Stephanie Ballantyne, Xianda Zhao, Sufang Tian, Honglei Chen Tags: Original contribution Source Type: research
