Listening to Individuals with Differences in Sex Development or Intersex and Their Families: “Not Doing Surgery Does Not Mean Doing Nothing”
Informed decision-making and considerations of the child ’s best interest offer a starting place for building informed and lifelong discussions that promote the long-term interests and the well-being of individuals experiencing differences in sex development (DSD) or intersex traits. Parents require sufficient information and support to understand what “doing something and doing nothing” really means when learning about nonsurgical options. This may take the form of health literacy support, asking how parents are given access to meaningful and understandable information, as well as psychosocial support and psychologi...
Source: Hormone Research in Paediatrics - June 10, 2022 Category: Endocrinology Source Type: research
Listening to individuals with differences in sex development or intersex and their families:
‘not doing surgery doesn’t mean doing nothing’
Informed decision-making and considerations of the child ’s best interest offer a starting place for building informed and lifelong discussions that promote the long-term interests and the wellbeing of individuals experiencing differences in sex development (DSD) or intersex traits. Parents require sufficient information and support to understand what ‘ doing something and doing nothing’ really means when learning about non-surgical options. This may take the form of health literacy support, asking how parents are given access to meaningful and understandable information, as well as psychosocial support and psycholog...
Source: Hormone Research in Paediatrics - June 10, 2022 Category: Endocrinology Source Type: research
The decision-making process regarding ovarian tissue cryopreservation in girls with Turner syndrome by patients, parents, and healthcare providers: a mixed-methods study
Discussion and conclusion: Offering young girls with TS the possibility of fertility preservation in an experimental setting raised high hopes and led to challenges for healthcare providers in ensuring a considered decision. The appropriate moment for counselling should be tailored to the individual and discussed with patient, parents and paediatrician. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - June 7, 2022 Category: Endocrinology Source Type: research
Do all patients with congenital adrenal hyperplasia need to be on hydrocortisone three times a day in order to have normal growth?
Conclusions: Less than half of our patients with CAH were receiving TID HC. Reassuringly, growth parameters and other indices of disease control were equivalent between patients on conventional HC dosing and other therapeutic approaches. These results suggest that a range of glucocorticoid treatment regimens may be equally viable in children with CAH. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - June 1, 2022 Category: Endocrinology Source Type: research
New-Onset Primary Adrenal Insufficiency and Autoimmune Hypothyroidism in a Pediatric Patient Presenting with MIS-C
Conclusion: This is the first pediatric report, to our knowledge, of primary adrenal insufficiency and hypothyroidism following COVID-19, leading to a unique presentation of autoimmune polyglandular syndrome type 2. The initial presentation was attributed to MIS-C, but the subsequent clinical course suggests the possibility of adrenal crisis. It remains unknown if COVID-19 had a causal relationship in triggering the autoimmune adrenal insufficiency and hypothyroidism.Horm Res Paediatr (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - May 24, 2022 Category: Endocrinology Source Type: research
New onset Primary Adrenal Insufficiency and Autoimmune Hypothyroidism in a Pediatric Patient presenting with MIS-C
Conclusion: This is the first pediatric report, to our knowledge, of primary adrenal insufficiency and hypothyroidism following COVID-19, leading to a unique presentation of autoimmune polyglandular syndrome type 2. The initial presentation was attributed to MIS-C, but the subsequent clinical course suggests the possibility of adrenal crisis. It remains unknown if COVID-19 had a causal relationship in triggering the autoimmune adrenal insufficiency and hypothyroidism. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - May 24, 2022 Category: Endocrinology Source Type: research
Outcome of Dopamine Agonist Therapy Withdrawal in Children with Prolactinomas
Conclusions: Less than half of our patients were eligible for DA treatment withdrawal and less than one fourth achieved remission of hyperprolactinemia following cessation of therapy. This suggests that the overall recurrence rate of prolactinomas in pediatric patients may be higher than has been reported in adults. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - May 24, 2022 Category: Endocrinology Source Type: research
Gut hormones secretion across clusters of Metabolic Syndrome in prepubertal children with obesity
Conclusion Components of MetS and GH concentrations are impaired in prepubertal children with obesity compared to controls. The close association between progressive alterations in GH levels and increasing number of components of the MetS might indicate a role of these hormones in the determination of metabolic risk. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - May 17, 2022 Category: Endocrinology Source Type: research
Management of Acute Adrenal Insufficiency-Related Adverse Events in Children with Congenital Adrenal Hyperplasia: Results of an International Survey of Specialist Centres
Conclusion: Although there is variation in the definition and management of AI-related adverse events in children amongst centres, there is also a good level of consensus on specific aspects that can lead to greater benchmarking of care. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - May 13, 2022 Category: Endocrinology Source Type: research
Management Of Acute Adrenal Insufficiency Related Adverse Events In Children With Congenital Adrenal Hyperplasia - Results Of An International Survey Of Specialist Centres
Conclusion
Although there is variation in the definition and management of AI related adverse events in children amongst centres, there is also a good level of consensus on specific aspects that can lead to greater benchmarking of care. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - May 13, 2022 Category: Endocrinology Source Type: research
Treatment practices and confidence in the management of pediatric metabolic bone disorders
Discussion/conclusion: Dedicated training, knowledge acquisition and education resources are needed to increase confidence and standardize the use of bone-targeted therapies. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - May 13, 2022 Category: Endocrinology Source Type: research
Erratum
Horm Res Paediatr (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - May 10, 2022 Category: Endocrinology Source Type: research
Recent Advances in Immune-based Therapies for Type 1 Diabetes
Background: Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by progressive destruction of the pancreatic beta-cells leading to a lifelong dependence on insulin. It is associated with an increased morbidity and mortality from diabetes-related complications and a significant treatment burden. However, there has been a substantial progress in therapeutic strategies that can affect the course of the disease. Summary: This review addresses advances in immunotherapy aimed at preserving residual beta-cell function in individuals with a recent onset of T1D, and arresting the disease in pre-symptomatic stages. R...
Source: Hormone Research in Paediatrics - May 9, 2022 Category: Endocrinology Source Type: research
Erratum
Horm Res Paediatr (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - May 6, 2022 Category: Endocrinology Source Type: research
Histopathological Criteria for Paediatric Adrenocortical Carcinoma
Conclusion: The Wieneke classification showed the best accuracy but was not sufficiently precise to establish reliable prognosis for ACC in the paediatric population. The Wieneke classification had approximately 95% sensitivity and negative predictive value.Horm Res Paediatr (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - May 4, 2022 Category: Endocrinology Source Type: research
