Abstracts of the 2022 Pediatric Endocrine Society (PES) Annual Meeting
N/AHorm Res Paediatr 2022;95:1 –266 (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - July 21, 2022 Category: Endocrinology Source Type: research

The Evidence for Twice-Daily Hydrocortisone Dosing in Children with Congenital Adrenal Hyperplasia Is Lacking
Horm Res Paediatr (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - July 11, 2022 Category: Endocrinology Source Type: research

The Evidence for Twice Daily Hydrocortisone Dosing in Children with Congenital Adrenal Hyperplasia is Lacking
not applicable for a letter (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - July 11, 2022 Category: Endocrinology Source Type: research

Early post-natal use of glibenclamide in permanent neonatal diabetes secondary to antenatally diagnosed kjcn11 mutation
Conclusion: Ea rly post-natal glibenclamide treatment of insulin-naïve patients with KATP-dependent neonatal diabetes is safe, provides good metabolic control and has a potential protective effect on neurological function. The formulation of the medicine needs to be carefully considered in the context of the very small doses required in this age group. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - July 11, 2022 Category: Endocrinology Source Type: research

< b > < i > SLIT2 < /i > < /b > Rare Sequencing Variants Identified in Idiopathic Hypogonadotropic Hypogonadism
Conclusion: Our study suggestsSLIT2 as a new IHH-associated gene and expands the clinical and genetic spectrum of IHH. Furthermore,SLIT2 alone does not appear to be sufficient to cause the disorder, and it may interact with other IHH-associated genes to induce a clinical phenotype. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - July 7, 2022 Category: Endocrinology Source Type: research

SLIT2 rare sequencing variants identified in Idiopathic Hypogonadotropic Hypogonadism
Conclusion: Our study suggests SLIT2 as a new IHH-associated gene and expands the clinical and genetic spectrum of IHH. Furthermore, SLIT2 alone does not appear to be sufficient to cause the disorder, and it may interact with other IHH-associated genes to induce a clinical phenotype. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - July 7, 2022 Category: Endocrinology Source Type: research

Karyotyping of lymphocytes and epithelial cells of distinct embryonic origin doesn ’t help to predict the turner syndrome features
Background: In Turner syndrome (TS), fluorescent in situ hybridization (FISH) karyotyping offers an alternative to classical karyotyping. Objective: We tested the added value of FISH karyotyping from lymphocytes (mesodermal origin), buccal cells (ectodermal origin) and a rear-tongue smear (endodermal origin) to determine the 45,X cell line fraction and its impact on patient phenotype. Design and Patients: Classical karyotyping and three FISH assays were done in 153 girls and women previously diagnosed with TS in four university hospitals. The 45,X cell line fraction was determined for each method and correlated with the ...
Source: Hormone Research in Paediatrics - July 1, 2022 Category: Endocrinology Source Type: research

Screening of Islet Autoantibodies for Children in the General Population: a Position Statement endorsed by the European Society for Pediatric Endocrinology
Type 1 diabetes (T1D) is the most frequent chronic autoimmune disease in childhood and adolescence, its incidence is increasing particularly in toddlers and preschool children, and up to 60% of young patients present with diabetic ketoacidosis (DKA), a severe and life-threatening complication. So far, the majority of screening efforts have been performed in at risk group, i.e. relatives of people with T1D; anyhow, around 90% of young patients who eventually develop T1D do not have a family history. Some studies in Europe and the USA have clearly shown that a public health screening of children (with positive autoantibodies...
Source: Hormone Research in Paediatrics - July 1, 2022 Category: Endocrinology Source Type: research

Metabolic Changes across Tertiles of Delta Changes in Height SDS during Growth Hormone Therapy in Children with Growth Hormone Deficiency
Conclusions: GH therapy is associated with improvement of metabolic profile. Delta changes seem to be more evident in those children with a higher tertile of delta h-SDS after starting GH therapy. A tailored therapy aimed to reach a proper goal in h-SDS after GH treatment might be necessary in order to reduce cardiovascular risk in GHD children.Horm Res Paediatr (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - June 30, 2022 Category: Endocrinology Source Type: research

Metabolic changes across tertiles of delta changes in height-SDS during growth hormone therapy in children with Growth Hormone Deficiency (GHD)
Conclusions: GH therapy is associated with improvement of metabolic profile. Delta changes seem to be more evident in those children with a higher tertile of delta h-SDS after start GH therapy. A tailored therapy aimed to reach a proper goal in h-SDS after GH treatment might be necess ary in order to reduce cardiovascular risk in GHD children. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - June 30, 2022 Category: Endocrinology Source Type: research

The Half-Empty Glass of GH Treatment in Dyschondrosteosis
(Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - June 28, 2022 Category: Endocrinology Source Type: research

The half empty glass of GH treatment in dyschondrosteosis
The same glass can be said to be half full or half empty. This is now the case with the treatment of short stature caused by dyschondrosteosis with growth hormone alone. The recent article by Dantas et al adds to the studies by Blum et al [2,3], and Bennabad et al [4] to give a very coherent view of the results of this treatment. Dantas et al provide an interesting explanation for this mitigated result. Indeed, over the years of treatment, the annual growth rate, which reached 8.5 cm on average in the 1st year, progressively decreased to 5.3 cm in the 4th year. This decrease parallels that of the circulating IGF1. Almost a...
Source: Hormone Research in Paediatrics - June 28, 2022 Category: Endocrinology Source Type: research

Author- and Subject Index
Horm Res Paediatr 2022;95:204 (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - June 21, 2022 Category: Endocrinology Source Type: research

Preliminary Pages
Horm Res Paediatr 2022;95:101 –102 (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - June 21, 2022 Category: Endocrinology Source Type: research

The effect of pre-thyroidectomy calcitriol prophylaxis on post-thyroidectomy hypocalcaemia in children
The objective of this study was to evaluate the efficacy of this prophylactic calcitriol supplementation in preventing post-thyroidectomy hypocalcaemia in children. Methods: In a retrospective case study we included all children (age (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - June 20, 2022 Category: Endocrinology Source Type: research