Stress Management Methods in Children and Adolescents – Past, Present, and Future
Background: Stress is a natural automatic reaction of organisms to challenging or threatening stimuli. Prevalence rates reveal an increasing number of students both in elementary and secondary education suffering from anxiety and stress-related disorders and illnesses. Literature shows a plethora of stress management techniques being used with children and adults to achieve stress reduction and inner peace. This review primarily aims in summarizing evidence-based relaxation techniques in use by minors in the present, contrasting them with data from the past, and directions for the future.
Summary: Literature research rev...
Source: Hormone Research in Paediatrics - September 12, 2022 Category: Endocrinology Source Type: research
60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE)
Horm Res Paediatr 2022;95:1 –616 (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - September 8, 2022 Category: Endocrinology Source Type: research
The effect of a nutritional supplement on growth and body composition in short and lean preadolescent boys following one-year of intervention
Introduction: Adequate nutrition plays an important role in linear growth throughout childhood, including puberty. However, not all children are willing or able to consume an adequate balanced diet daily. We aimed to evaluate the 1-year effectiveness and safety of nutritional supplementation on linear growth, weight gain, and changes in body composition in short and lean peripubertal boys.
Methods: A one-year, 2-phase multicenter interventional study comprising 1-6 months of a double-blinded intervention with nutritional formula or placebo, followed by 6-12 months of an open-label extension with the nutritional formula fo...
Source: Hormone Research in Paediatrics - September 5, 2022 Category: Endocrinology Source Type: research
Cell therapy for type 1 diabetes: from islet transplantation to stem cells
Background. The field of cell therapy of type 1 diabetes is a particularly interesting example in the scenario of regenerative medicine. In fact, β cell replacement has its roots in the experience of islet transplantation, which began 40 years ago, and is currently a rapidly accelerating field, with several ongoing clinical trials using β cells derived from stem cells.
Summary. Type 1 diabetes is particularly suitable for cell therapy as i t is a disease due to the deficiency of only one cell type, the insulin-producing β cell, and this endocrine cell does not need to be positioned inside the pancreas to perform its fu...
Source: Hormone Research in Paediatrics - August 30, 2022 Category: Endocrinology Source Type: research
A case of peripheral precocious puberty may be caused by a diet containing phytosterols in a 20-month-old boy
Conclusion: This phytosterol-containing diet may be responsible for the sexual development of this patient. However, the mechanism of how phytosterols affect the process of development in children needs to be further explored. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - August 30, 2022 Category: Endocrinology Source Type: research
Vitamin D toxicity from an unusual and unexpected source: a report of 2 cases
We present 2 cases of hypervitaminosis D caused by a manufacturing error of a natural health product which did not claim t o contain vitamin D. The use of dietary supplements is highly prevalent; their use should be incorporated in anamnesis and considered a potential source of toxicity when an alternative source cannot be found, regardless of the product label. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - August 26, 2022 Category: Endocrinology Source Type: research
Approaches to Identify Factors Associated with Pubertal Timing in Self-Limited Delayed Puberty
Introduction: Children with self-limited delayed puberty (constitutional delay) enter puberty after variable waiting times, and the factors associated with their eventual pubertal timing are not well understood.
Methods: We conducted a retrospective study of 99 girls and 228 boys with self-limited delayed puberty (DP) at an academic medical center between 2000 and 2015. To define features and potential subtypes of self-limited DP, we performed group-based trajectory modeling on childhood growth and latent-variable factor analysis on clinical characteristics. We then conducted time-to-event analyses to identify association...
Source: Hormone Research in Paediatrics - August 25, 2022 Category: Endocrinology Source Type: research
Can GH-therapy worsen a clinically silent Chiari malformation? A case report and systematic literature review.
We report the case of a patient with an unusual association of growth hormone deficiency (GHD) due to ectopic posterior pituitary and Chiari malformation type I (CM-1). Our patient developed headache and worsening of CM-1 after initiation of rhGH therapy. Following an atlo-occipital decompression surgery, the patient was able to resume therapy with a marked growth improvement. Based on this observation, we provide a systematic review of the current literature about these two pathologies. Key Messages: A careful follow-up of all patients with CM-1 treated with GH is mandatory, paying particular attention to the appearance o...
Source: Hormone Research in Paediatrics - August 24, 2022 Category: Endocrinology Source Type: research
Ethnic and National Differences in Congenital Adrenal Hyperplasia Incidence: A Systematic Review and Meta-analysis
Conclusions: This study highlights the at-risk population for CAH and regions that need monitoring for CAH. The highest CAH incidence could be attributed to higher consanguinity, less genetic diversity, or ot her genetic causes since CAH is an inherited genetic disorder. Cultural practices in some places regarding consanguineous unions or geographic isolation may directly affect the incidence. Newborn screening for CAH may be unavailable in many developing countries, thereby affecting the actual CAH inci dence. Therefore, healthcare workers should be trained to recognize CAH at an early stage to reduce its complications an...
Source: Hormone Research in Paediatrics - August 16, 2022 Category: Endocrinology Source Type: research
Salivary 17-hydroxyprogesterone levels in children with congenital adrenal hyperplasia – a retrospective longitudinal study considering auxological parameters
Conclusion.
The measurement of s17-OHP is an important sub-aspect in the overall assessment of treatment response in CAH. It can provide an indication of over-/undertreatment and allows the assessment of day profiles especially in phases of changing (e.g. puberty) steroid requirements. We present here observational data from a larger cohort with longitudinal multiple measurements of s17-OHP. The values do not allow a significant differentiation between normal and abnormal growth or pubertal status. Thus, relying solely on s17-OHP is not advisable. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - August 12, 2022 Category: Endocrinology Source Type: research
Mosaic GLUD1 mutations associated with hyperinsulinism hyperammonemia syndrome
Conclusion: The results suggest that low-level mosaic mutations in known HI genes may be the underlying molecular mechanism in some children with HI who have negative genetic testing in peripheral blood DNA. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - August 11, 2022 Category: Endocrinology Source Type: research
Erratum
Horm Res Paediatr (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - August 9, 2022 Category: Endocrinology Source Type: research
The influence of body mass index on the growth hormone peak response regarding growth hormone stimulation tests in children
Introduction: Several studies have analyzed the association between the maximal growth hormone serum level obtained during a growth hormone stimulation test (GH-Max) and the body mass index standard deviation score (BMI-SDS). However, as sample sizes were quite small, our study aimed to analyze the association between GH-Max and BMI-SDS within a large cohort of 991 children. Further, we investigated other influencing factors, like test type, age, sex, puberty and preterm birth. Methods: Children with short stature (height (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - July 29, 2022 Category: Endocrinology Source Type: research
A randomized trial of the effect of a GnRH analogue injection on ghrelin levels in girls
Introduction: Ghrelin concentrations decline during puberty by an unclear mechanism. Acylated ghrelin (AG) is unstable in sampling tubes, but no standardized sampling protocol exists. We hypothesized that ghrelin levels decrease as a consequence of increased gonadotropin releasing hormone (GnRH) signalling and that the addition of a protease inhibitor to sampling tubes preserves the AG levels.
Methods: In this randomized, placebo-controlled, cross-over study, 13 girls with suspected central precocious puberty were included. They performed an adjusted GnRH stimulation test twice and were given Relefact LHRH ® (100 g/m2...
Source: Hormone Research in Paediatrics - July 27, 2022 Category: Endocrinology Source Type: research
Indeterminate Thyroid Fine-Needle Aspirations in Pediatrics: Exploring the Clinicopathologic Features and Utility of Molecular Profiling
Abstract
Introduction: The diagnostic utility of molecular profiling for the evaluation of indeterminate pediatric thyroid nodules is unclear. We aimed to assess pediatric cases with indeterminate thyroid fine-needle aspiration (FNA) alongside clinicopathologic features and mutational analysis.
Methods: A retrospective review of 126 patients with indeterminate cytology who underwent FNA between January 2010 and December 2021 at the Children ’s Hospital of Philadelphia was performed. Indeterminate cases defined by The Bethesda System for Reporting Thyroid Cytopathology (AUS/FLUS or TBSRTC III; FN/SFN or TBSRTC IV; SM or...
Source: Hormone Research in Paediatrics - July 22, 2022 Category: Endocrinology Source Type: research
