Sertraline can reduce the uremic pruritus in hemodialysis patient: A double blind randomized clinical trial from Southern Iran
Abstract Introduction: Uremic pruritus is an undesirable complication of end stage renal disease (ESRD). In spite of introduction of many treatments for this complication, it has no certain cure. The aim of this study was to assess sertraline effect on uremic pruritus. Methods: In the present clinical trial study, we randomly divided our patients into two groups; trial group that received sertraline and control group that consumed placebo. We measured the severity of pruritus by two scoring systems (visual analogue scale and DUO) at the beginning and during the study with a‐2‐week interval. Data were analyzed by SPSS 1...
Source: Hemodialysis International - December 31, 2016 Category: Hematology Authors: Maryam Pakfetrat, Leila Malekmakan, Noushin Hashemi, Taraneh Tadayon Tags: Original Article Source Type: research

Assessment of intradialysis calcium mass balance by single pool variable ‐volume calcium kinetic model
Discussion: The proposed single pool variable‐volume Calcium kinetic model is adequate for prediction and quantification of intradialysis calcium mass balance, it can evaluate the eventual calcium transfer outside the extracellular pool in clinical practice. (Source: Hemodialysis International)
Source: Hemodialysis International - December 31, 2016 Category: Hematology Authors: Salvatore di Filippo, Fabio Carfagna, Vincenzo la Milia, Antonio Bellasi, Giustina Casagrande, Camilla Bianchi, Domenico Vito, Maria Laura Costantino, Giuseppe Rombol à, Claudio Minoretti, Carlo Schönholzer, Giuseppe Pontoriero, Francesco Locatelli Tags: Original Article Source Type: research

Hypoproteinemia as a prognostic risk factor for arteriovenous fistula failure
Abstract Introduction: Any vascular access is of limited duration with many factors which influence survival in patients on chronic hemodialysis (HD). Hypoproteinemia as a marker of chronic illness is common among chronic HD patients. Our aim was to analyze the survival of the primary arteriovenous fistula (AVFs) and the risk factors which influence their patency and to test the hypothesis that patients with normal values of serum proteins have lower risk of AVF failure compared to patients with hypoproteinemia. Methods: Seven hundred thirty‐four consecutive patients were included who underwent creation of an AVF. The pa...
Source: Hemodialysis International - December 31, 2016 Category: Hematology Authors: Vedran Premuzic, Tvrtko Hudolin, Josip Pasini, Zoran Zimak, Dinko Hauptman, Bojan Jelakovic, Zeljko Kastelan Tags: Original Article Source Type: research

Can twice weekly hemodialysis expand patient access under resource constraints?
Abstract The convention of prescribing hemodialysis on a thrice weekly schedule began empirically when it seemed that this frequency was convenient and likely to treat symptoms for a majority of patients. Later, when urea was identified as the main target and marker of clearance, studies supported the prevailing notion that thrice weekly dialysis provided appropriate clearance of urea. Today, national guidelines on hemodialysis from most countries recommend patients receive at least thrice weekly therapy. However, resource constraints in low‐ and middle‐income countries (LMIC) have resulted in a substantial proportion ...
Source: Hemodialysis International - December 13, 2016 Category: Hematology Authors: Dipal Savla, Glenn M. Chertow, Timothy Meyer, Shuchi Anand Tags: Scholarly Review (solicited) Source Type: research

Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients
This study indicates that daily consumption of 6 g flaxseed oil reduces serum hepcidin and improves hematologic factors in HD patients. (Source: Hemodialysis International)
Source: Hemodialysis International - November 24, 2016 Category: Hematology Authors: Hadi Tabibi, Maryam Mirfatahi, Mehdi Hedayati, Alireza Nasrollahi Tags: Original Article Source Type: research

Unusual cause of hypercalcaemia in end stage renal failure patients
We present two cases of our dialysis patients, who were clinically unwell from hypercalcemia. We were initially uncertain of the cause of hypercalcemia as despite our attempts to adjust treatment based on their biochemical findings, we were unable to correct the hypercalcemia. We did not have appropriate bone turnover markers to guide us and out of desperation, anti‐resorptives—calcitonin and bisphosphonate were given with good clinical response. We concluded that the hypercalcemia was related to immobility‐induced hypercalcemia and the inappropriately low iPTH was a red herring. Immobility‐induced hypercalcaem...
Source: Hemodialysis International - November 19, 2016 Category: Hematology Authors: Hooi Khee Teo, Jiunn Wong Tags: Case Report Source Type: research

Potentially pathogenic circulating autoantibodies to cardiac troponin are present in hemodialysis patients
This study aimed to explore the possibility that analogous autoimmune processes might occur in hemodialysis (HD) patients, by initially investigating cTnAAb prevalence, and exploring potential links with HD‐induced myocardial stunning. Methods In 130 prevalent HD patients from two centers (Derby, UK; Turku, Finland), cTnAAb (immunoassay) and cardiac troponins were quantified. Sixty‐four patients underwent serial echocardiography to assess myocardial stunning. Findings cTnAAb were present in 7% of patients. Dual positivity to cTnAAb and elevated cTn occurred in 3% and 6% for cTnI and cTnT, respectively. Patients with cT...
Source: Hemodialysis International - November 19, 2016 Category: Hematology Authors: Helen J. Jefferies, Risto Tertti, Saara Wittfooth, James O. Burton, Kaj Mets ärinne, Kim Pettersson, Christopher W. McIntyre Tags: Original Article Source Type: research

Pulmonary artery hypertension in methylmalonic acidemia
In this report, we discuss the role of regular hemodialysis in MMA and the causal relationship between MMA and regular hemodialysis for PAH. (Source: Hemodialysis International)
Source: Hemodialysis International - October 31, 2016 Category: Hematology Authors: Jun Kido, Hiroshi Mitsubuchi, Mina Sakanashi, Junichi Matsubara, Shirou Matsumoto, Rieko Sakamoto, Fumio Endo, Kimitoshi Nakamura Tags: Case Report Source Type: research

Quality of life development during initial hemodialysis therapy and association with loss of residual renal function
Discussion Preservation of residual renal function seems to be important for HRQOL. In newly started HD patients, HRQOL showed little change after 12 months. HRQOL was negatively affected by comorbidity, especially diabetes, hospital admissions, female gender, and age. (Source: Hemodialysis International)
Source: Hemodialysis International - October 31, 2016 Category: Hematology Authors: Christina G. Poulsen, Krista D. Kjaergaard, Christian D. Peters, Bente Jespersen, Jens D. Jensen Tags: Original Article Source Type: research

Assessing the contact ‐activation of coagulation during hemodialysis with three different polysulfone filters: A prospective randomized cross‐over trial
This study aims to evaluate its amplitude, comparing dialyzers made of different polysulfone polymers, by measuring D‐dimers in the filter‐rinsing fluids (Frf) and to test whether Frf D‐dimers are suitable candidate markers to assess contact coagulation activation during HD. Methods In a prospective, cross‐over study 41 hemodialysis patients were randomly allocated to nine HD sessions with three types of polysulfone membranes: Filter A: Poliflux®RevaclearMAX; Filter B: Helixone®Fx80, Filter C: Polyflux®H210. Findings A total of 117 HD sessions were studied. The mean (SD) filter (Frf) D‐dimers were 0.1...
Source: Hemodialysis International - October 31, 2016 Category: Hematology Authors: Igor Salvad è, Rosaria Del Giorno, Donato Gaetano, Luca Gabutti Tags: Original Article Source Type: research

The Dialysis Outcomes and Practice Patterns Study (DOPPS) in Turkey
Discussion In this first DOPPS‐Turkey report, the DOPPS sample agrees well with national Turkish Registry data. Treatment and laboratory data, and patient‐reported outcomes, demonstrate similarities and previously unrecognized contrasts to DOPPS findings in Europe, Japan, and North America. Long‐term follow‐up of these patients will describe how these differences relate to clinical outcomes within Turkey. (Source: Hemodialysis International)
Source: Hemodialysis International - October 24, 2016 Category: Hematology Authors: Tevfik Ecder, Cengiz Utas, Kenan Ates, Brian Bieber, Bruce M. Robinson, Ronald L. Pisoni, G ültekin Süleymanlar Tags: Original Article Source Type: research

Issue information ‐ toc
(Source: Hemodialysis International)
Source: Hemodialysis International - October 2, 2016 Category: Hematology Tags: ISSUE INFORMATION ‐ TOC Source Type: research

HFE gene mutation is a risk factor for tissue iron accumulation in hemodialysis patients
Discussion: Serum iron parameters were not adequate to detect iron overload and HFE gene mutation was found to be an important risk factor for iron accumulation. (Source: Hemodialysis International)
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Ercan Turkmen, Tolga Yildirim, Rahmi Yilmaz, Tuncay Hazirolan, Gonca Eldem, Engin Yilmaz, Aysun Aybal Kutlugun, Mahmut Altindal, Bulent Altun Tags: Original Article Source Type: research

Management of coronary artery disease and acute coronary syndrome in the chronic kidney disease population —A review of the current literature
Abstract Coronary Artery Disease (CAD) is a large contributor to morbidity and mortality in the chronic kidney disease (CKD) and end‐stage renal disease (ESRD) population. Due to the fact that many large‐scale trials evaluating management for acute coronary syndromes (ACS) and CAD have excluded patients with CKD, there is a paucity of data investigating medical management of CAD and revascularization strategies of these patients. Further, while there have been many advances in the treatment for ACS and CAD, both medically and technologically, few studies have focused on the CKD population and many predate these advance...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Justin M. Lingel, Mukta C. Srivastava, Anuj Gupta Tags: Scholarly Review (solicited) Source Type: research

Biomarkers upon discontinuation of renal replacement therapy predict 60 ‐day survival and renal recovery in critically ill patients with acute kidney injury
This study aimed to explore the prognostic value of several biomarkers measured upon discontinuation of RRT for their value in predicting 60‐day survival and renal recovery in an effort to add knowledge to the decision‐making process regarding RRT withdrawal. Methods We prospectively enrolled 102 patients with AKI who required RRT from the intensive care unit. Serum osteopontin (sOPN), serum interleukin 6 (sIL‐6), serum cystatin C (sCysC), sIL‐18, serum neutrophil gelatinase‐associated lipocalin and urinary IL‐18 and urinary neutrophil gelatinase‐associated lipocalin were measured upon discontinuation of RRT....
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Tingting Yang, Si Sun, Yuliang Zhao, Qiang Liu, Mei Han, Liping Lin, Baihai Su, Songmin Huang, Lichuan Yang Tags: Original Article Source Type: research

Radio ‐cephalic fistula recovered with drainage to forearm basilic vein
Abstract Dysfunction problems with vascular access are a concern to patients and dialysis units. The vascular surgeon should analyse such dysfunction and perform a careful assessment of the vascular network in order to find new fistula layouts. We introduce and discuss the case of creation of a radio‐cephalic fistula with outflow into the forearm basilic vein through rotation of the forearm basilic vein toward the cephalic vein in the forearm of an 88‐year‐old hemodialysis male patient. This technique enables extending fistula patency and improves cost efficiency. (Source: Hemodialysis International)
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Ant ónio Norton de Matos, Clemente Neves Sousa, Paulo Almeida, Paulo Teles, Luís Loureiro, Gabriela Teixeira, Duarte Rego, Sérgio Teixeira Tags: Case Report Source Type: research

Sticking to the script: A curious case of confusion in an ESRD patient
Abstract A 60‐year‐old male Dialysis patient presented with altered mental status and Hypertensive Urgency. He had a significant lesion noted on his glans penis. He was treated for infection and hypertension with expectant management, without significant improvement in his mental acuity. Laboratory and radiologic workup were unrevealing for the etiology. Upon detailed review it was noted he had recently been given Acyclovir for a presumed Herpes Simplex Virus infection. He had been prescribed what is considered correct dosing for an ESRD patient. An Acyclovir level was obtained and urgent Dialysis was undertaken, presu...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Barry R. Gorlitsky, John T. Herion Tags: Case Report Source Type: research

Time ‐extended local rtPA infiltration for acutely thrombosed hemodialysis fistulas
Conclusion The modified L&W technique with prolonged local rtPA reaction times is a safe and effective declotting procedure. The need for TCP was not increased and therefore comparable to the standard technique. (Source: Hemodialysis International)
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Susanne Regus, Werner Lang, Marco Heinz, Ulrich Rother, Alexander Meyer, Veronika Alm ási‐Sperling, Michael Uder, Axel Schmid Tags: Original Article Source Type: research

Symptoms among patients receiving in ‐center hemodialysis: A qualitative study
Discussion The major symptoms attributed to HD treatment by participants were cramping, fatigue, depression, and itching. Greater attention by health care providers to the most common and bothersome symptoms could positively impact daily life for HD patients. (Source: Hemodialysis International)
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Kim J. Cox, Mark B. Parshall, Stephen H. A. Hernandez, Sanah Z. Parvez, Mark L. Unruh Tags: Original Article Source Type: research

Treatment of a soft tissue calcification in a patient receiving peritoneal dialysis
We describe a case of a massive soft tissue calcification in the right gluteal region in a peritoneal dialysis patient. The patient had severe pain and were disabled. The treatment was converted to an intensive hemodialysis regimen with a minimal calcium load and high dose of cinacalcet. During the treatment, the calcification diminished rapidly from a diameter of 26.6 to 2.9 cm, and the patient symptoms were relieved, leaving the patient with no pain or restriction in mobilization. (Source: Hemodialysis International)
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Kristine Lindhard, Bo Broberg, Henrik Groenberg, Henrik Post Hansen Tags: Case Report Source Type: research

Recent advances in CKD and ESRD: A literature update
Abstract The past year has seen interesting publications in the fields of chronic kidney disease and end stage renal disease. This review highlights some of these important papers and places their findings in the context of clinical care. (Source: Hemodialysis International)
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Tushar Chopra, Mitchell H. Rosner Tags: Scholarly Review Source Type: research

Changes in urine volume and serum albumin in incident hemodialysis patients
Abstract Introduction Hypoalbuminemia is a predictor of poor outcomes in dialysis patients. Among hemodialysis patients, there has not been prior study of whether residual kidney function or decline over time impacts serum albumin levels. We hypothesized that a decline in residual kidney function is associated with an increase in serum albumin levels among incident hemodialysis patients.Methods In a large national cohort of 38,504 patients who initiated hemodialysis during 1/2007‐12/2011, we examined the association of residual kidney function, ascertained by urine volume and renal urea clearance, with changes in serum a...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Rieko Eriguchi, Yoshitsugu Obi, Connie M. Rhee, Jason A. Chou, Amanda R. Tortorici, Anna T. Mathew, Taehee Kim, Melissa Soohoo, Elani Streja, Csaba P. Kovesdy, Kamyar Kalantar ‐Zadeh Tags: Original Article Source Type: research

Dialytic hemodynamics are associated with changes in gait speed
Abstract Introduction Functional impairment and reduced mobility are prevalent in patients on chronic hemodialysis (HD). The impact of HD on physical performance and mobility needs evaluation.Methods We measured gait speed in a cohort of chronic HD patients both pre and post an HD session. We collected demographic and laboratory data and dialytic hemodynamic parameters for the HD session. Participants completed the Falls Efficacy Scale International (FES‐I) survey to assess concern for falling. We used linear regression analysis to tests for associations between our predictor variables of intra‐dialytic hemodynamic cha...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Dawn F. Wolfgram, Zubin Lathara, Aniko Szabo, Jeff Whittle Tags: Original Article Source Type: research

Vascular imaging for hemodialysis vascular access planning
Abstract Introduction Central venous catheters (CVC) increase risks associated with hemodialysis (HD), but may be necessary until an arteriovenous fistula (AVF) or graft (AVG) is achieved. The impact of vascular imaging on achievement of working AVF and AVG has not been firmly established. Methods Retrospective cohort of patients initiating HD with CVC in 2010–2011, classified by exposure to venography or Doppler vein mapping, and followed through December 31, 2012. Standard and time‐dependent Cox models were used to determine hazard ratios (HRs) of death, working AVF, and any AVF or AVG. Logistic regress...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Rita L. McGill, Robin Ruthazer, Eduardo Lacson, Klemens B. Meyer, Dana C. Miskulin, Daniel E. Weiner Tags: Original Article Source Type: research

Bioimpedance monitoring of cellular hydration during hemodialysis therapy
Discussion These results suggest that an extensive fluid shift into the cells may take place during HD. The present research may contribute to a better understanding of how factors that influence fluid redistribution may affect an ESRD patient during dialysis. In light of this finding, it is concluded that the rate of vascular refill is jointly determined with the rate of “cellular refill” and the transfer of fluid from the intertitial compartment into the intravascular space. (Source: Hemodialysis International)
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Leslie D. Montgomery, Richard W. Montgomery, Wayne A. Gerth, Susie Q. Lew, Michael D. Klein, Julian M. Stewart, Marvin S. Medow, Manuel T. Velasquez Tags: Original Article Source Type: research

Effects of end ‐stage renal disease and dialysis modalities on blood ammonia level
Abstract Introduction Uremia results in a characteristic breath odor (uremic fetor) which is largely due to its high ammonia content. Earlier studies have shown a strong correlation between breath ammonia and blood urea levels and a 10‐fold reduction in breath ammonia after hemodialysis in patients with chronic kidney disease. Potential sources of breath ammonia include: (i) local ammonia production from hydrolysis of urea in the oropharyngeal and respiratory tracts by bacterial flora, and (ii) release of circulating blood ammonia by the lungs. While the effects of uremia and hemodialysis on breath ammonia are well known...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Nosratola D. Vaziri, Mahyar Khazaeli, Ane C. F. Nunes, Kevin T. Harley, Hyder Said, Omeed Alipour, Wei Ling Lau, Madeleine V. Pahl Tags: Original Article Source Type: research

Hemodialysis practice patterns in the Russia Dialysis Outcomes and Practice Patterns Study (DOPPS), with international comparisons
We examined treatment patterns for 481 prevalent HD patients in 20 Russian facilities, and compared them to contemporary data for 8512 patients from 311 facilities in seven European countries, Japan, and North America. Data were collected according to the uniform methodology of the Dialysis Outcomes and Practice Patterns Study, phase 5. Findings Compared to other regions, Russian patients were younger (mean age 53.4 years), had a lower percent of males (52.5%), higher arteriovenous fistula use (89.7%), and longer treatment time (mean: 252 minutes, SD: 37 minutes). Mean single pool Kt/V was 1.49 (SD 0.58). Prescription of d...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Boris Bikbov, Brian Bieber, Anton Andrusev, Natalia Tomilina, Alexander Zemchenkov, Junhui Zhao, Friedrich Port, Bruce Robinson, Ronald Pisoni Tags: Original Article Source Type: research

Home hemodialysis associated infection —The “Achilles' Heel” of intensive hemodialysis
Abstract Home hemodialysis (HHD) is emerging as an important alternate renal replacement therapy. Although there are multiple clinical advantages with HHD, concerns surrounding increased risks of infection in this group of patients remain a major barrier to its implementation. In contrast to conventional hemodialysis, infection related complication represents the major morbidity in this mode of renal replacement therapy. Vascular access related infection is an important cause of infection in this population. Use of central vein catheters and buttonhole cannulation in HHD are important modifiable risk factors for HHD associ...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Clara K. Poon, Christopher T. Chan Tags: Scholarly Review Source Type: research

Hyperprolactinemia in end ‐stage renal disease and effects of frequent hemodialysis
Discussion Serum prolactin concentrations were elevated in the large majority of patients with ESRD, but were not associated with several measures of health status. Circulating prolactin levels also do not appear to decrease in response to more frequent hemodialysis over a one‐year period. (Source: Hemodialysis International)
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Joan C. Lo, Gerald J. Beck, George A. Kaysen, Christopher T. Chan, Alan S. Kliger, Michael V. Rocco, Glenn M. Chertow, Tags: Original Article Source Type: research

Re ‐evaluation of re‐hospitalization and rehabilitation in renal research
Discussion Prior research has likely provided inaccurate estimates of 30‐day readmissions in patients undergoing dialysis. In the absence of data on specific facility types particularly when using data prior to 2012, future researchers could employ our method to more accurately characterize 30‐day readmission rates and associated outcomes in patients with end‐stage renal disease. (Source: Hemodialysis International)
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Eugene Lin, Manjula Kurella Tamura, Maria E. Montez ‐Rath, Glenn M. Chertow Tags: Original Article Source Type: research

Dialysate bicarbonate variation in maintenance hemodiafiltration patients: Impact on serum bicarbonate, intradialytic hypotension and interdialytic weight gain
Abstract Introduction The dialysate bicarbonate (DB) influences the acid‐base balance in dialysis patients. Very low and high serum bicarbonate (SB) have been related with a higher mortality. Acid‐base balance also has been associated with hemodynamic effects in these patients. The trial aim was to compare the effect of DB concentration variation on SB levels in maintenance hemodiafiltration (HDF) patients and the effect on intradialytic hypotension and interdialytic weight gain. Methods  A prospective study, with 9 months of follow‐up, involving 93 patients, divided in two groups: group 1 and group 2 with a DB ...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: M árcio Viegas, Cristina Cândido, Joana Felgueiras, José Clemente, Sara Barros, Rostislav Farbota, Filipa Vera, Antero Matos, Francisco Sousa Tags: Original Article Source Type: research

Recurrent heparin ‐induced thrombocytopenia due to heparin rinsing before priming the machine in a hemodialysis patient: A case report
Abstract Heparin has remained the most commonly used anticoagulant for patients undergoing hemodialysis. It is usually safe to use but can have severe adverse effects in some cases. Heparin‐induced thrombocytopenia (HIT) is a life‐threatening complication of exposure to heparin. It results from an autoantibody directed against endogenous platelet factor 4 (PF4) in complex with heparin, which activates platelets and can cause catastrophic arterial and venous thromboses. Here, we present the case of an 80‐year‐old woman with a recent diagnosis of chronic renal failure who developed acute HIT (platelet count nadir, 15...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Jin Han Lim, Kyung Pyo Kang, Sik Lee, Sung Kwang Park, Won Kim Tags: Case Report Source Type: research

A combination of corticosteroid, sirolimus, and intradialytic parenteral nutrition in encapsulating peritoneal sclerosis: Case report and literature review
Abstract Encapsulating peritoneal sclerosis (EPS) is a rare complication of peritoneal dialysis that carries a high morbidity and mortality. Although its pathogenesis is still not clear, the “two hit theory” suggests that long term deterioration of the peritoneum combined with intraperitoneal inflammation is needed in the pathogenesis of EPS. To date, there is no proven effective therapy with an absence of randomized controlled trials. Individual case reports and small case series have reported on the use of tamoxifen and corticosteroids for medical management of EPS. Here, we present the first case of EPS trea...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Alexandre Minetto Brabo, Nayrana Soares Do Carmo Reis, Pasqual Barretti, Daniela Ponce Tags: Review Article Source Type: research

Usefulness of assisted procedures for arteriovenous fistula maturation without compromising access patency
Abstract Introduction To increase the rate of arteriovenous fistula (AVF) use, assisted procedures for immature AVF have been strenuously performed. However, this is controversial in that an AVF matured by these assisted procedures may require more frequent intervention to maintain its patency, and have decreased long‐term patency. Methods Eighty four AVFs that were matured with assisted maturation procedures and 266 AVFs that matured spontaneously without intervention, created between November 2009 and March 2013 from the hemodialysis (HD) vascular access (VA) cohort, were compared retrospectively and we also investigat...
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Hoon Suk Park, Youn Hee Lee, Hyung Wook Kim, Jun Hyun Baik, Yong Sung Won, Cheol Whee Park, Young Ok Kim, Chul Woo Yang, Dong Chan Jin Tags: Original Article Source Type: research

Coronary artery calcification in Korean patients with incident dialysis
Discussion CAC was frequent in patients with incident dialysis, and multiple regression analysis showed that only age was significantly associated with the CAC score. In addition, L‐spine radiography could be a helpful modality for diagnosing CAC in patients with incident dialysis. (Source: Hemodialysis International)
Source: Hemodialysis International - September 30, 2016 Category: Hematology Authors: Eunjin Bae, Eun Yong Seong, Byoung ‐Geun Han, Dong Ki Kim, Chun Soo Lim, Shin‐Wook Kang, Cheol Whee Park, Chan‐Duck Kim, Byung Chul Shin, Sung Gyun Kim, Wookyung Chung, Jae Yoon Park, Joo Yeon Lee, Yon Su Kim Tags: Original Article Source Type: research

C reactive protein and depressive symptoms in haemodialysis patients: A questionable association
Abstract Introduction Patients with advanced chronic kidney disease (CKD) on haemodialysis (HD) may have increased C reactive protein (CRP) values and depressive symptoms. There is debate about the strength and nature of previously reported associations. We investigated these issues in a cohort of patients on HD.Methods We screened for depressive symptoms using two valadiated depression screening tools: the Beck Depression Inventory‐II (BDI‐II), Patient Health Questionnaire (PHQ‐9). Demographic and clinical correlates of depression symptoms were eveluated in adjusted linear and logistic regression models, which inclu...
Source: Hemodialysis International - September 28, 2016 Category: Hematology Authors: Joseph Chilcot, Karin Friedli, Ayman Guirguis, David Wellsted, Ken Farrington, Andrew Davenport Tags: Original Article Source Type: research

Impact of serum and dialysates obtained from chronic hemodialysis patients maintained on high cut ‐off membranes on inflammation profile in human THP‐1 monocytes
In this study, we tested the influence of serum and dialysates obtained from patients maintained on High cut‐off or High flux membranes on the inflammation profile of THP‐1 monocytes.Methods THP‐1 monocytes were treated with serum or dialysates obtained from patients maintained on High cut‐off and High flux membranes within a randomized crossover pilot trial. Serum‐treated cells were subjected to qPCR analyses with TaqMan probes specific for IL6, TNFa, osteopontin and osteocalcin, and transcriptional screening with Inflammatory Array. Apoptosis assay was performed flow cytometrically with 7‐AAD and Annexin V st...
Source: Hemodialysis International - September 27, 2016 Category: Hematology Authors: Bogusz Trojanowicz, Christof Ulrich, Roman Fiedler, Markus Storr, Torsten Boehler, Peter Martus, Michael Pawlak, Marcus A. Glomb, Christian Henning, Markus Templin, Kristin Werner, Daniel Zickler, Kevin Willy, Ralf Schindler, Matthias Girndt Tags: Original Article Source Type: research

C reactive protein and depressive symptoms in hemodialysis patients: A questionable association
Abstract Introduction: Patients with advanced chronic kidney disease (CKD) on haemodialysis (HD) may have increased C reactive protein (CRP) values and depressive symptoms. There is debate about the strength and nature of previously reported associations. We investigated these issues in a cohort of patients on HD.Methods: We screened for depressive symptoms using two valadiated depression screening tools: the Beck Depression Inventory‐II (BDI‐II), Patient Health Questionnaire (PHQ‐9). Demographic and clinical correlates of depression symptoms were eveluated in adjusted linear and logistic regression models, which inc...
Source: Hemodialysis International - September 27, 2016 Category: Hematology Authors: Joseph Chilcot, Karin Friedli, Ayman Guirguis, David Wellsted, Ken Farrington, Andrew Davenport Tags: ORIGINAL ARTICLE Source Type: research

In tandem extracorporeal therapies during hemodialysis in pediatric patients
We describe the successful treatment of a pediatric transplant patient with simultaneous intermittent hemodialysis and therapeutic plasma exchange (TPE). The patient presented with kidney graft failure. He had life threatening electrolyte disturbances and fluid overload due to antibody‐mediated rejection. Therefore, he was in need of both emergent kidney replacement therapy and TPE. Both extracorporeal circuits were set up, established, and maintained safely and effectively without difficulty or alarms. Running intermittent hemodialysis and TPE simultaneously significantly reduced therapy time, allowed both needed therap...
Source: Hemodialysis International - September 25, 2016 Category: Hematology Authors: Amy E. McAlister, Kira Geile, Carmen M. Halabi, T. KEEFE Davis Tags: CASE REPORT Source Type: research

Role of isolated ultrafiltration in the management of chronic refractory and acute decompensated heart failure
Abstract Chronic congestive heart failure (CHF) and acute decompensated heart failure (ADHF) refractory to medical therapy represent therapeutic challenges. In such patients, attempts to reduce pulmonary and systemic congestion frequently produce deterioration of renal function. In studies of patients with chronic severe CHF refractory to medical therapy (including loop diuretics), isolated ultrafiltration was frequently able to relieve congestive symptoms by precise removal of extracellular water and sodium, and in some cases was able to restore responsiveness to loop diuretics. Randomized controlled trials comparing isol...
Source: Hemodialysis International - September 25, 2016 Category: Hematology Authors: Mayank K. MITTAL, Natraj KATTA, Martin A. ALPERT Tags: REVIEW ARTICLE Source Type: research

Blood pressure targets for hemodialysis patients: Aspirational or practical?
Abstract Whereas there is strong relationship between high blood pressure and increased overall and cardiovascular mortality for the general population, observational studies in hemodialysis patients have reported a “U” shaped relationship between pre‐hemodialysis blood pressure recordings and patient survival. Previous attempts to introduce pre and post‐hemodialysis blood pressure targets were associated with an increased frequency of intra‐dialytic hypotension, itself an independent risk factor for mortality. Conversely, meta‐analyses of trials of antihypertensive medications in hemodialysis patients,...
Source: Hemodialysis International - September 25, 2016 Category: Hematology Authors: Andrew Davenport Tags: REVIEW ARTICLE Source Type: research

Comparisons of amino acids, body constituents and antioxidative response between long ‐time HD and normal HD
Conclusion These observations indicate the beneficial effects of in long‐time HD in improving oxidative stress in patients. (Source: Hemodialysis International)
Source: Hemodialysis International - September 25, 2016 Category: Hematology Authors: Akira Torigoe, Emiko Sato, Takefumi Mori, Norio Ieiri, Chika Takahashi, Yoko Ishida, Osamu Hotta, Sadayoshi Ito Tags: ORIGINAL ARTICLE Source Type: research

Impact of vascular access intervention therapy on cardiac load in hemodialysis patients
We examined the factors associated with cardiac load in hemodialysis patients undergoing VAIVT by measuring levels of α human atrial natriuretic polypeptide (hANP) and brain natriuretic peptide (BNP) before and after VAIVT. Data were extracted on hemodialysis patients who underwent measurements of αhANP and BNP in before and after VAIVT at our facility and related facilities between February 2014 and December 2014. Nineteeen patients (median age, 73.0 [66.5–80.5] years; male, 52.6%; 36.8% with diabetes; median duration of dialysis treatment, 50.0 [21–109] months) were enrolled in this study. Flow vo...
Source: Hemodialysis International - September 25, 2016 Category: Hematology Authors: Takayuki Adachi, Tsutomu Sakurada, Takanori Otowa, Keita Uehara, Shina Sueki, Shigeki Kojima, Nagayuki Kaneshiro, Katsuomi Matsui, Tadahisa Tomohiro, Yugo Shibagaki Tags: ORIGINAL ARTICLE Source Type: research

Reducing blood stream infection in patients on hemodialysis: Incorporating patient engagement into a quality improvement activity
Abstract Introduction Infection in our immunocompromised patients is the second leading cause of death, according to the Centers for Disease Control and Prevention (CDC). In an effort to improve quality of care, engage patients in their own care, and reduce morbidity and mortality secondary to infection, the Network designed a joint quality improvement/patient engagement activity to decrease bloodstream infection (BSI) rates. Methods Dialysis facilities were ranked utilizing 2014 National Healthcare Safety Network (NHSN) data. Selection included 20% of Network 13 facilities (n = 58) with the highest BSI rates...
Source: Hemodialysis International - September 25, 2016 Category: Hematology Authors: Lynda K. Ball, Cheryl A. George, Linda Duval, Niloufar “Nellie” F. Hedrick Tags: ORIGINAL ARTICLE Source Type: research

Reliability of delivered dialysate sodium concentration
Conclusion It is assumed when setting a dialysate sodium concentration that this sodium concentration is delivered. However we found that the dialysate sodium concentration delivered was greater than that set, despite the dialysis machines reporting a conductivity measurement in keeping with a lower sodium dialysate. Trials of lowered dialysate sodium therefore need to measure dialysate sodium concentrations to ensure what has been set is delivered. (Source: Hemodialysis International)
Source: Hemodialysis International - September 25, 2016 Category: Hematology Authors: Nasirul J Ekbal, Anne Consalus, Jahm Persaud, Andrew Davenport Tags: ORIGINAL ARTICLE Source Type: research

Preface
(Source: Hemodialysis International)
Source: Hemodialysis International - September 25, 2016 Category: Hematology Authors: Madhukar Misra Tags: PREFACE Source Type: research

Three cases of spontaneous lumbar artery rupture in hemodialysis patients
Abstract We encountered three cases of retroperitoneal hematoma caused by spontaneous lumbar artery rupture, a rare vascular complication. At the time of retroperitoneal hematoma, two patients were on anticoagulant/antiplatelet therapy. One patient was not taking any anticoagulant/antiplatelet agents but was receiving hemodialysis treatment with heparin. Lumbar artery rupture was successfully controlled by transcatheter arterial embolization in all patients, but one patient developed multiple organ failure and died. We suggest that spontaneous lumbar artery rupture may occur in patients being treated with maintenance hemod...
Source: Hemodialysis International - September 25, 2016 Category: Hematology Authors: Na Kyoung Hwang, Harin Rhee, Il Young Kim, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Chang Won Kim, Sang Heon Song Tags: Case Report Source Type: research

The CLOCK trial, a double ‐blinded randomized controlled trial: Trisodium citrate 30% and minocycline 3 mg/mL plus EDTA 30 mg/mL are effective and safe for catheter patency maintenance among CKD 5D patients on hemodialysis
Abstract Introduction Poor blood flow rate (PF) is highly prevalent among CKD 5D patients with long‐term central venous catheters. Heparin catheter lock solutions are commonly used to maintain catheter patency, however the incidence of PF remains high. The purpose of the CLOCK Trial was to evaluate two catheter lock solutions on reduction of PF incidence. Methods Seventy‐five CKD 5D patients on high‐efficiency hemodialysis at the Integrated Centre of Nephrology (Guarulhos, Brazil) were randomized 1:1:1 to receive a lock solution combining minocycline 3 mg/mL with the anticoagulant/chelation agent EDTA 30 mg/mL (M‐E...
Source: Hemodialysis International - September 25, 2016 Category: Hematology Authors: Marcus V. S. Jo ão Luiz, Cristoforo Sacavone, Carmen Tzanno Tags: Original Article Source Type: research

Indoxyl sulfate, a valuable biomarker in chronic kidney disease and dialysis
Abstract Chronic kidney disease (CKD) is an increasingly recognized disease with high global incidence and mortality. Yet, the existing diagnostic tools are not sufficient enough to predict prognosis of CKD and CKD comorbidities. Indoxyl sulfate, a typical uremic toxin, is of great importance in the development of CKD with its nephrotoxicity, cardiovascular toxicity, and bone toxicity. Some reports suggest that indoxyl sulfate directly associate with renal function loss and mortality in CKD patients. This review discusses the diagnostic value of indoxyl sulfate from its biological characteristics, pathophysiological effect...
Source: Hemodialysis International - September 11, 2016 Category: Hematology Authors: Xiao Tan, Xuesen Cao, Jianzhou Zou, Bo Shen, Xiaoyan Zhang, Zhonghua Liu, Wenlv Lv, Jie Teng, Xiaoqiang Ding Tags: Review Article Source Type: research

Utility of 18 F ‐FDG PET/CT scan to diagnose the etiology of fever of unknown origin in patients on dialysis
In this study, we used 18 F‐FDG PET/CT scan whole body survey for detection of hidden infection, in patients on dialysis, labelled as FUO. Methods In this retrospective study, 20 patients of end stage renal disease on dialysis were investigated for the cause of FUO using 18F‐FDG PET/CT scan. All these patients satisfied the definition of FUO as defined by Petersdorf and Beeson. Any focal abnormal site of increased FDG concentration detected by PET/CT, either a solitary or multiple lesions was documented and at least one of the detected abnormal sites of radio tracer concentration was further examined for histopathology...
Source: Hemodialysis International - September 11, 2016 Category: Hematology Authors: Kalawat Tek Chand, Krishna Kishore Chennu, Lakshmi Amancharla Yadagiri, Ranadheer Manthri Gupta, Ram Rapur, Siva Kumar Vishnubotla Tags: Original Article Source Type: research