Association between afebrile status and in ‐hospital mortality among adult chronic hemodialysis patients with bacteremia
Conclusions: An afebrile status in HD patients with bacteremia is associated with higher in‐hospital mortality. Blood culture and empirical antibiotic administration, irrespective of the fever status, should be considered in HD patients with a CRP ≥ 5 mg/dL. (Source: Hemodialysis International)
Source: Hemodialysis International - March 23, 2017 Category: Hematology Authors: Wonhak Kim, So Mi Kim, Hoon Yu, Mun Jang, Seung Don Baek, Soon Bae Kim Tags: Original Article Source Type: research

HFE gene mutations are not risk factors for iron overload in European hemodialysis patients
(Source: Hemodialysis International)
Source: Hemodialysis International - March 23, 2017 Category: Hematology Authors: Guy Rostoker, Mireille Griuncelli, Yves Cohen Tags: Letter to the Editor Source Type: research

Role of hepcidin ‐ferroportin axis in the pathophysiology, diagnosis, and treatment of anemia of chronic inflammation
Abstract Anemia of chronic inflammation (ACI) is a frequently diagnosed anemia and portends an independently increased morbidity and poor outcome associated with multiple underlying diseases. The pathophysiology of ACI is multifactorial, resulting from the effects of inflammatory cytokines which both directly and indirectly suppress erythropoiesis. Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL‐6, lead to hepcidin‐induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis. The role of hepcidin‐ferroportin axis i...
Source: Hemodialysis International - March 22, 2017 Category: Hematology Authors: Arielle L. Langer, Yelena Z. Ginzburg Tags: SCHOLARLY REVIEW Source Type: research

Role of hepcidin ‐ferroportin axis in the pathophysiology, diagnosis, and treatment in anemia of chronic inflammation
Abstract Anemia of chronic inflammation (ACI) is a frequently diagnosed anemia and portends an independently increased morbidity and poor outcome associated with multiple underlying diseases. The pathophysiology of ACI is multifactorial, resulting from the effects of inflammatory cytokines which both directly and indirectly suppress erythropoiesis. Recent advances in molecular understanding of iron metabolism provide strong evidence that immune mediators, such as IL‐6, lead to hepcidin‐induced hypoferremia, iron sequestration, and decreased iron availability for erythropoiesis. The role of hepcidin‐ferroportin axis i...
Source: Hemodialysis International - March 22, 2017 Category: Hematology Authors: Arielle L. Langer, Yelena Z. Ginzburg Tags: Supplement Article Source Type: research

Oral iron supplementation: Potential implications for the gut microbiome and metabolome in patients with CKD
Abstract Patients with chronic kidney disease (CKD) and loss of kidney function are at increased risk for morbidity and mortality. The risks of CKD are attributed to “uremia,” an increased concentration of uremic retention solutes (toxins) in the plasma. Recently, a colo‐renal axis became clearly apparent and uremia has been associated with an altered gut microbiome composition and metabolism. There is a high prevalence of anemia in patients with CKD, for which patients are often treated with oral or intravenous iron. Recent in vivo and in vitro studies have reported adverse effects of oral iron supplementati...
Source: Hemodialysis International - March 22, 2017 Category: Hematology Authors: Guus A. M. Kortman, Dorien Reijnders, Dorine W. Swinkels Tags: Supplement Article Source Type: research

Markers of iron status in chronic kidney disease
Abstract Anemia is one of the main comorbidities related to chronic kidney disease (CKD). Until the advent of erythropoiesis stimulating agents (ESA), endogenous erythropoietin deficiency has been thought to be the main culprit of anemia in CKD patients. The use of ESAs has shed new light on the physiology of CKD anemia, where iron homeostasis plays an increasingly important role. Disorders of iron homeostasis occurring in CKD turn the anemia management in those patients into a complex multifactorial therapeutic task, where ESA and Iron dose must be properly balanced to achieve the desired outcome without exposing the pati...
Source: Hemodialysis International - March 22, 2017 Category: Hematology Authors: Adam E. Gaweda Tags: Supplement Article Source Type: research

HFE mutations and iron in hemodialysis patients
Discussion: although data must be confirmed in larger prospective studies, this favorable shift in iron metabolism balance possibly results in reduced mortality, in particular because of cardiovascular and infective diseases. Further genetic studies may offer a valuable tool to test these hypotheses and guide personalized clinical management and the research of new therapies. (Source: Hemodialysis International)
Source: Hemodialysis International - March 14, 2017 Category: Hematology Authors: Luca Valenti, Serena Pelusi Tags: Supplement Article Source Type: research

Predictors of post ‐hospitalization recovery of renal function among patients with acute kidney injury requiring dialysis
Hemodialysis International,Volume 22, Issue 1, Page 66-73, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 13, 2017 Category: Hematology Source Type: research

Safety of arteriovenous fistulae and grafts for continuous renal replacement therapy: The Michigan experience
Hemodialysis International,Volume 22, Issue 1, Page 50-55, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 13, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 66-73, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 13, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 50-55, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 13, 2017 Category: Hematology Source Type: research

Predictors of post ‐hospitalization recovery of renal function among patients with acute kidney injury requiring dialysis
Discussion: A significant proportion of AKI survivors will recover renal function following discharge. Outpatient intradialytic factors may influence subsequent renal function recovery. (Source: Hemodialysis International)
Source: Hemodialysis International - March 12, 2017 Category: Hematology Authors: Russell Pajewski, Patrick Gipson, Michael Heung Tags: Original Article Source Type: research

Sex differences in vascular dysfunction and cardiovascular outcomes: The cardiac, endothelial function, and arterial stiffness in ESRD (CERES) study
Hemodialysis International,Volume 22, Issue 1, Page 93-102, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 8, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 93-102, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 8, 2017 Category: Hematology Source Type: research

Iatrogenic hypernatremia in hemodialysis patients: A result of erroneous online conductivity monitor and conductivity meter reading
We present two cases of symptomatic hypernatremia which manifested as increased thirst, excessive weight gain and worsening hypertension in HD patients. The hypernatremia was caused by a combination of errors in online conductivity reading and a faulty hand held conductivity meter. Symptoms were relieved in both patients after replacement of the dialysis machine. (Source: Hemodialysis International)
Source: Hemodialysis International - March 8, 2017 Category: Hematology Authors: Chamberlain I. Obialo, Smitha John, Khalid Bashir Tags: CASE REPORT Source Type: research

Sex differences in vascular dysfunction and cardiovascular outcomes: The cardiac, endothelial function, and arterial stiffness in ESRD (CERES) study
Abstract Introduction: Recent studies suggest that women with end‐stage renal disease (ESRD) may have higher rates of mortality than men, but it is unknown whether sex differences in vascular function explain this disparity. The cardiac, endothelial function, and arterial stiffness in ESRD (CERES) study is an ongoing, prospective observational study designed to investigate vascular function, myocardial injury, and cardiovascular outcomes in ESRD. Methods: Among 200 CERES participants (34% women), we evaluated arterial wave reflections as augmentation index normalized to a heart rate of 75 (AIx75), arterial stiffness as p...
Source: Hemodialysis International - March 7, 2017 Category: Hematology Authors: Isabella Guajardo, Amrita Ayer, Alexander D. Johnson, Peter Ganz, Claire Mills, Catherine Donovan, Rebecca Scherzer, Sanjiv J. Shah, Carmen A. Peralta, Ruth F. Dubin Tags: Original Article Source Type: research

Sertraline can reduce uremic pruritus in hemodialysis patient: A double blind randomized clinical trial from Southern Iran
Hemodialysis International,Volume 22, Issue 1, Page 103-109, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 6, 2017 Category: Hematology Source Type: research

Impact of arteriovenous fistula cannulation on the quality of dialysis
Hemodialysis International,Volume 22, Issue 1, Page 45-49, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 6, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 103-109, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 6, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 45-49, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 6, 2017 Category: Hematology Source Type: research

Sertraline can reduce uremic pruritus in hemodialysis patient: A double blind randomized clinical trial from Southern Iran
Abstract Introduction: Uremic pruritus is an undesirable complication of end stage renal disease (ESRD). In spite of introduction of many treatments for this complication, it has no certain cure. The aim of this study was to assess sertraline effect on uremic pruritus. Methods: In the present clinical trial study, we randomly divided our patients into two groups; trial group that received sertraline and control group that consumed placebo. We measured the severity of pruritus by two scoring systems (visual analogue scale and DUO) at the beginning and during the study with a‐2‐week interval. Data were analyzed by SPSS 1...
Source: Hemodialysis International - March 6, 2017 Category: Hematology Authors: Maryam Pakfetrat, Leila Malekmakan, Noushin Hashemi, Taraneh Tadayon Tags: Original Article Source Type: research

Impact of arteriovenous fistula cannulation on the quality of dialysis
Discussion: Because no significant difference was found between the two techniques, the direction of insertion of needles should be decided upon on a case‐by‐case basis depending on the anatomy of the AVF and the feasibility of the puncture. (Source: Hemodialysis International)
Source: Hemodialysis International - March 5, 2017 Category: Hematology Authors: Michelle Elias, Erika Nnang ‐Obada, Bernard Charpentier, Antoine Durrbach, Severine Beaudreuil Tags: Original Article Source Type: research

Assessment of intradialysis calcium mass balance by a single pool variable ‐volume calcium kinetic model
Hemodialysis International,Volume 22, Issue 1, Page 126-135, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - February 5, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 126-135, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - February 5, 2017 Category: Hematology Source Type: research

Assessment of intradialysis calcium mass balance by a single pool variable ‐volume calcium kinetic model
Discussion: The proposed single pool variable‐volume Calcium kinetic model is adequate for prediction and quantification of intradialysis calcium mass balance, it can evaluate the eventual calcium transfer outside the extracellular pool in clinical practice. (Source: Hemodialysis International)
Source: Hemodialysis International - February 5, 2017 Category: Hematology Authors: Salvatore di Filippo, Fabio Carfagna, Vincenzo la Milia, Antonio Bellasi, Giustina Casagrande, Camilla Bianchi, Domenico Vito, Maria Laura Costantino, Giuseppe Rombol à, Claudio Minoretti, Carlo Schönholzer, Giuseppe Pontoriero, Francesco Locatelli Tags: Original Article Source Type: research

Hypoproteinemia as a prognostic risk factor for arteriovenous fistula failure
Hemodialysis International,Volume 22, Issue 1, Page 37-44, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - January 29, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 37-44, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - January 29, 2017 Category: Hematology Source Type: research

Hemodialysis Abstracts from the 37th Annual Dialysis Conference March 11 –14, 2017 Long Beach, California
(Source: Hemodialysis International)
Source: Hemodialysis International - January 24, 2017 Category: Hematology Tags: CONFERENCE ABSTRACTS Source Type: research

2016 List of Reviewers
(Source: Hemodialysis International)
Source: Hemodialysis International - January 24, 2017 Category: Hematology Tags: 2016 LIST OF REVIEWERS Source Type: research

Correction
(Source: Hemodialysis International)
Source: Hemodialysis International - January 24, 2017 Category: Hematology Tags: CORRECTION Source Type: research

Issue information
(Source: Hemodialysis International)
Source: Hemodialysis International - January 24, 2017 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Psychosocial aspects of children and families treated with hemodialysis
Discussion: The assessment of QoL in pediatric patients would allow for the earliest possible identification of their nonsomatic problems and irregularities. This could, consequently, contribute to improving QoL in both children with chronic kidney disease and their families. (Source: Hemodialysis International)
Source: Hemodialysis International - January 22, 2017 Category: Hematology Authors: Anna Medy ńska, Danuta Zwolińska, Ryszard Grenda, Monika Miklaszewska, Maria Szczepańska, Agnieszka Urzykowska, Katarzyna Zachwieja, Katarzyna Kiliś‐Pstrusińska Tags: Original Article Source Type: research

Biomarkers upon discontinuation of renal replacement therapy predict 60 ‐day survival and renal recovery in critically ill patients with acute kidney injury
Hemodialysis International,Volume 22, Issue 1, Page 56-65, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - January 11, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 56-65, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - January 11, 2017 Category: Hematology Source Type: research

Life threatening nutritional deficiencies in a dialysis patient
We describe a case report of a patient with ESRD recently started on outpatient maintenance hemodialysis, who presented with life threatening muscular weakness with respiratory failure requiring prolonged mechanical ventilation. On initial workup, it was unclear what the cause of her weakness was, however, further investigations showed undetectable phosphorous levels as well as very low levels of trace elements. Replacement of these compounds to normal levels led to marked improvement in the clinical picture. On further evaluation, the patient was also found to be profoundly depressed with poor appetite even prior to initi...
Source: Hemodialysis International - January 10, 2017 Category: Hematology Authors: Fahad Aziz, Kunal Chaudhary Tags: Case Report Source Type: research

Ethanol combined with heparin as a locking solution for the prevention of catheter related blood stream infections in hemodialysis patients: A prospective randomized study
Discussion Locking of NTCs in HD patients with ethanol 70% + unfractionated heparin reduces CRBSI rates without increasing the thrombotic episodes. (Source: Hemodialysis International)
Source: Hemodialysis International - January 10, 2017 Category: Hematology Authors: Sofia Sofroniadou, Ioanna Revela, Alexandros Kouloubinis, Ioanna Makriniotou, Sinodi Zerbala, Despina Smirloglou, Petros Kalocheretis, Apostolos Drouzas, George Samonis, Christos Iatrou Tags: Original Article Source Type: research

Hyperparathyroidism caused by distant pulmonary lesions and parathyromatosis after ethanol injection/parathyroidectomy for secondary hyperparathyroidism
Abstract Secondary hyperparathyroidism (SHPT) treatment includes parathyroidectomy and percutaneous ethanol injection therapy (PEIT), which are invasive procedures. The condition in which benign hyperfunctioning parathyroid tissue is distributed throughout the neck and mediastinum is termed parathyromatosis. Here, we present the case of a 51‐year‐old woman who began hemodialysis in 1986 due to chronic kidney disease of unknown etiology and developed SHPT in 1999. She underwent 6 rounds of PEIT followed by total a parathyroidectomy with partial forearm autotransplantation. Between 2011 and 2013, surgeons removed several...
Source: Hemodialysis International - January 10, 2017 Category: Hematology Authors: Michio Nakamura, Kiho Tanaka, Takeshi Fujii Tags: Case Report Source Type: research

Coronal mode ultrasound guided hemodialysis cannulation: A pilot randomized comparison with standard cannulation technique
Hemodialysis International,Volume 22, Issue 1, Page 23-30, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - January 9, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 23-30, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - January 9, 2017 Category: Hematology Source Type: research

Native arteriovenous fistula placement in three patients after implantation of a left ventricular assist device with non ‐pulsatile blood flow
We present three patients who received successful arteriovenous fistulae placement after left ventricular assist device implantation with assisted long term patency. (Source: Hemodialysis International)
Source: Hemodialysis International - January 8, 2017 Category: Hematology Authors: Johannes F. Schaefers, Christian Ertmer Tags: Case Report Source Type: research

Coronal mode ultrasound guided hemodialysis cannulation: A pilot randomized comparison with standard cannulation technique
Abstract Background Infiltrations from cannulation result in significant morbidity including loss of hemodialysis (HD) vascular access (VA). Cannulation is dependent on personnel skill and VA characteristics. Surface marking of VA lacks real‐time information and traditional ultrasound (US) devices are large, expensive, requiring skilled operators. Sonic Window© (Analogic Ultrasound, Peabody, MA, USA) is a coronal mode ultrasound device (CMUD) approved for VA cannulation. Methods Single center randomized, prospective pilot study comparing handheld US‐guided cannulation of new arteriovenous fistula (AVF) to standard...
Source: Hemodialysis International - January 8, 2017 Category: Hematology Authors: Lalathaksha Kumbar, Vivek Soi, Elizabeth Adams, Cheryl Brown Deacon, Mohamed Zidan, Jerry Yee Tags: Original Article Source Type: research

Time ‐extended local rtPA infiltration for acutely thrombosed hemodialysis fistulas
Hemodialysis International,Volume 22, Issue 1, Page 31-36, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - January 3, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 31-36, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - January 3, 2017 Category: Hematology Source Type: research

The available intravenous iron formulations: History, efficacy, and toxicology
Abstract A number of intravenous iron formulations have been developed over the past 65 years which rely on dextran or other compounds to prevent uncontrolled release of free iron to the circulation. High molecular weight dextran was associated with a number of serious adverse reactions and was removed from markets worldwide in 2009. The preponderance of published evidence suggests that the formulations of parenteral iron currently available in the United States, including low molecular weight iron dextran, are all safe and effective and there are no major, clinically important differences among them in terms of either eff...
Source: Hemodialysis International - January 1, 2017 Category: Hematology Authors: Michael Auerbach, Iain Macdougall Tags: Supplement Article Source Type: research

Impact of iatrogenic iron overload on the course of hepatitis C in dialysis population: A plea for caution
Abstract About 2.5% of the world population, corresponding to about 177 million individuals, are infected by hepatitis C virus (HCV), a small, single‐stranded RNA virus. The prevalence of HCV infection among dialysis patients in Japan, Europe, and North America during the 2012 to 2015 period was found to be 8.7% in the DOPPS study. Nosocomial HCV spread in hemodialysis facilities still occurs. Increased hepatic tissue iron has been shown to play a deleterious role in the course of hepatitis C, favor development of fibrosis and cirrhosis and possibly increase the risk of liver cancer in the general population. Regular los...
Source: Hemodialysis International - January 1, 2017 Category: Hematology Authors: Guy Rostoker, Nosratola D. Vaziri Tags: Supplement Article Source Type: research

Diagnosing and preventing iron overload
Abstract Absolute or functional iron (Fe) deficiency is an important determinant of anemia in hemodialysis patients and parenteral Fe is routinely used to treat this condition in conjunction with erythropoiesis stimulating agents. While restoration of hemoglobin toward the target range is a good outcome of Fe replacement, it is well known that Fe overload and toxicity may be adverse consequences of this therapy. Dialysis clinical practice guidelines recommend tailoring Fe therapy based on transferrin saturation and serum ferritin levels. Unfortunately, serum Fe markers may not accurately reflect the amount of Fe in the bod...
Source: Hemodialysis International - January 1, 2017 Category: Hematology Authors: Ganesh Ramanathan, John K. Olynyk, Paolo Ferrari Tags: Supplement Article Source Type: research

Thyroid function in end stage renal disease and effects of frequent hemodialysis
Discussion: Among patients receiving hemodialysis without overt hyper/hypothyroidism or thyroid hormone treatment, thyroid indices were not associated with multiple measures of health status and were not significantly altered with increased dialysis frequency. (Source: Hemodialysis International)
Source: Hemodialysis International - December 31, 2016 Category: Hematology Authors: Joan C. Lo, Gerald J. Beck, George A. Kaysen, Christopher T. Chan, Alan S. Kliger, Michael V. Rocco, Minwei Li, Glenn M. Chertow, Tags: Original Article Source Type: research

Overview of iron metabolism in health and disease
Abstract Iron is an essential element for numerous fundamental biologic processes, but excess iron is toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney disease and iron administration is a mainstay of anemia management in many patients. This review provides an overview of the essential role of iron in biology, the regulation of systemic and cellular iron homeostasis, how imbalances in iron homeostasis contribute to disease, and the implications for chronic kidney disease patients. (Source: Hemodialysis International)
Source: Hemodialysis International - December 31, 2016 Category: Hematology Authors: Som Dev, Jodie L. Babitt Tags: Supplement Article Source Type: research

Safety of arteriovenous fistulae and grafts for continuous renal replacement therapy: The Michigan experience
Discussion: In our experience, use of AVF/AVG for CRRT can be performed with a low serious complication rate and low risk of access loss, potentially avoiding catheter‐related complications. (Source: Hemodialysis International)
Source: Hemodialysis International - December 31, 2016 Category: Hematology Authors: Anas Al Rifai, Nidhi Sukul, Robert Wonnacott, Michael Heung Tags: Original Article Source Type: research

Iatrogenic hypernatremia in hemodialysis patients: A result erroneous online conductivity monitor and conductivity meter reading
We present two cases of symptomatic hypernatremia which manifested as increased thirst, excessive weight gain and worsening hypertension in HD patients. The hypernatremia was caused by a combination of errors in online conductivity reading and a faulty hand held conductivity meter. Symptoms were relieved in both patients after replacement of the dialysis machine. (Source: Hemodialysis International)
Source: Hemodialysis International - December 31, 2016 Category: Hematology Authors: Chamberlain I. Obialo, Smitha John, Khalid Bashir Tags: Case Report Source Type: research