Effects of weight ‐based ultrafiltration rate limits on intradialytic hypotension in hemodialysis
Hemodialysis International,Volume 22, Issue 2, Page 270-278, April 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - June 23, 2017 Category: Hematology Authors: James L.PirkleJr , Mary E.Comeau , Carl D.Langefeld , Gregory B.Russell , Somer S.Balderston , Barry I.Freedman , John M.Burkart Source Type: research

Effects of weight ‐based ultrafiltration rate limits on intradialytic hypotension in hemodialysis
Hemodialysis International, EarlyView. (Source: Hemodialysis International)
Source: Hemodialysis International - June 23, 2017 Category: Hematology Source Type: research

Subcutaneous defibrillators for dialysis patients
Hemodialysis International,Volume 22, Issue 1, Page 4-8, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - June 23, 2017 Category: Hematology Source Type: research

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Hemodialysis International, Ahead of Print. (Source: Hemodialysis International)
Source: Hemodialysis International - June 23, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 4-8, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - June 23, 2017 Category: Hematology Source Type: research

Effects of weight ‐based ultrafiltration rate limits on intradialytic hypotension in hemodialysis
Discussion: A weight‐based UF rate limit of 13 mL/kg/h was associated with a decrease in the rate of intradialytic hypotension events among in‐center hemodialysis patients. (Source: Hemodialysis International)
Source: Hemodialysis International - June 23, 2017 Category: Hematology Authors: James L. Pirkle, Mary E. Comeau, Carl D. Langefeld, Gregory B. Russell, Somer S. Balderston, Barry I. Freedman, John M. Burkart Tags: Original Article Source Type: research

High sodium continuous veno ‐venous hemodialysis with regional citrate anticoagulation and online dialysate generation in patients with acute liver failure and cerebral edema
Hemodialysis International,Volume 22, Issue 2, Page 184-191, April 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - May 16, 2017 Category: Hematology Authors: TamimHamdi , LenarYessayan , JerryYee , BalazsSzamosfalvi Source Type: research

High sodium continuous veno ‐venous hemodialysis with regional citrate anticoagulation and online dialysate generation in patients with acute liver failure and cerebral edema
Hemodialysis International, EarlyView. (Source: Hemodialysis International)
Source: Hemodialysis International - May 16, 2017 Category: Hematology Source Type: research

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Hemodialysis International, Ahead of Print. (Source: Hemodialysis International)
Source: Hemodialysis International - May 16, 2017 Category: Hematology Source Type: research

Case of Mycobacterium mucogenicum in a home hemodialysis patient
We present a case of a patient on home hemodialysis who developed Mycobacterium mucogenicum bacteremia. While infections with this particular organism are rare, disseminated infections have been reported and have been associated with significant morbidity and mortality. Diagnosis required appropriate cultures, understanding of natural habitat of organism and complete environmental analysis including blood, dialysis sample port, reverse osmosis and incoming water supply cultures. The patient was treated successfully with systemic antibiotics, removal of central venous catheter, patient education and complete exchange of the...
Source: Hemodialysis International - May 9, 2017 Category: Hematology Authors: Miten J. Dhruve, Paul E. Bunce, Celine D'Gama, Christopher T Chan Tags: CASE REPORT Source Type: research

The deterioration in physical function of hemodialysis patients
Hemodialysis International,Volume 22, Issue 2, Page 245-253, April 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - May 5, 2017 Category: Hematology Authors: Brianna K.Sutcliffe , Paul N.Bennett , Steve F.Fraser , MohammadrezaMohebbi Source Type: research

The deterioration in physical function of hemodialysis patients
Hemodialysis International, EarlyView. (Source: Hemodialysis International)
Source: Hemodialysis International - May 5, 2017 Category: Hematology Source Type: research

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Hemodialysis International, Ahead of Print. (Source: Hemodialysis International)
Source: Hemodialysis International - May 5, 2017 Category: Hematology Source Type: research

HIF ‐prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism
Abstract A classic response to systemic hypoxia is the increase in red blood cell production. This response is controlled by the prolyl hydroxylase domain/hypoxia‐inducible factor (HIF) pathway, which regulates a broad spectrum of cellular functions. The discovery of this pathway as a key regulator of erythropoiesis has led to the development of small molecules that stimulate the production of endogenous erythropoietin and enhance iron metabolism. This review provides a concise overview of the cellular and molecular mechanisms that govern HIF‐induced erythropoietic responses and provides an update on clinical experienc...
Source: Hemodialysis International - April 27, 2017 Category: Hematology Authors: Volker H. Haase Tags: SCHOLARLY REVIEW Source Type: research

Iron and anemia in chronic kidney disease: New treatments changing old paradigms
(Source: Hemodialysis International)
Source: Hemodialysis International - April 27, 2017 Category: Hematology Authors: John T. Daugirdas Tags: PREFACE Source Type: research

Issue information
(Source: Hemodialysis International)
Source: Hemodialysis International - April 27, 2017 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Sleep apnea syndrome, inflammation and oxidative stress in hemodialysis patients
Hemodialysis International,Volume 22, Issue 2, Page 209-216, April 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - April 20, 2017 Category: Hematology Authors: OlgaNikitidou , EuphemiaDaskalopoulou , AikateriniPapagianni , VassiliosLiakopoulos , AikateriniMichalaki , FoteiniChristidou , ParaskeviArgyropoulou , DimitriosKirmizis , GeorgiosEfstratiadis , PavlosNikolaidis , MichailDani Source Type: research

Sleep apnea syndrome, inflammation and oxidative stress in hemodialysis patients
Hemodialysis International, EarlyView. (Source: Hemodialysis International)
Source: Hemodialysis International - April 20, 2017 Category: Hematology Source Type: research

Survival comparisons of intensive vs. conventional hemodialysis: Pitfalls and lessons
Hemodialysis International,Volume 22, Issue 1, Page 9-22, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - April 20, 2017 Category: Hematology Source Type: research

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Hemodialysis International, Ahead of Print. (Source: Hemodialysis International)
Source: Hemodialysis International - April 20, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 9-22, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - April 20, 2017 Category: Hematology Source Type: research

Survival comparisons of intensive vs. conventional hemodialysis: Pitfalls and lessons
Abstract The optimal dose of hemodialysis (HD) has not yet been established. As a means of better approximating the physiology of native kidney function, there has been a growing interest in intensive HD (an increase in dialysis frequency and/or duration). Although many studies have demonstrated a survival benefit with intensive dialysis, results have been conflicting. This controversy stems from the challenges of randomizing patients to conventional vs. intensive HD modalities and, therefore, the reliance on observational comparisons that have been limited by varying definitions for intensive dialysis, differences in dial...
Source: Hemodialysis International - April 20, 2017 Category: Hematology Authors: Amanda J. Miller, Jeff Perl, Karthik K. Tennankore Tags: Scholarly Review Source Type: research

Efficacy and safety of low ‐dose heparin in hemodialysis
Hemodialysis International,Volume 22, Issue 1, Page 74-81, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - April 18, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 74-81, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - April 18, 2017 Category: Hematology Source Type: research

Physical function was related to mortality in patients with chronic kidney disease and dialysis
Abstract Previous studies have shown that exercise improves aerobic capacity, muscular functioning, cardiovascular function, walking capacity, and health‐related quality of life (QOL) in patients with chronic kidney disease (CKD) and dialysis. Recently, additional studies have shown that higher physical activity contributes to survival and decreased mortality as well as physical function and QOL in patients with CKD and dialysis. Herein, we review the evidence that physical function and physical activity play an important role in mortality for patients with CKD and dialysis. During November 2016, Medline and Web of Scien...
Source: Hemodialysis International - April 18, 2017 Category: Hematology Authors: Shinichiro Morishita, Atsuhiro Tsubaki, Nobuyuki Shirai Tags: Review Article Source Type: research

Efficacy and safety of low ‐dose heparin in hemodialysis
Abstract Introduction: The dose of unfractionated heparin (UFH) administered during hemodialysis (HD) varies widely. This prospective study evaluated the safety and efficacy of UFH dose de‐escalation.Methods: Sixty‐six prevalent patients on HD receiving UFH per standard‐dose protocol (load dose [LD] 50–75 units/kg, maintenance dose [MD] 500–1000 units/hour) had heparin prescription converted to low‐dose protocol (start LD 15 units/kg and MD 500 units/hour; dose adjusted in small increments based on assessments of extracorporeal blood circuit). Coagulation parameters, dialysis adequacy, dialyzer clotting...
Source: Hemodialysis International - April 18, 2017 Category: Hematology Authors: Mariana Murea, Gregory B. Russell, Pirouz Daeihagh, Anita M. Saran, Karan Pandya, Mark Cabrera, John M. Burkart, Barry I. Freedman Tags: Original Article Source Type: research

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all ‐cause mortality in hemodialysis patients: A prospective cohort study
Hemodialysis International,Volume 22, Issue 1, Page 82-92, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - April 12, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 82-92, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - April 12, 2017 Category: Hematology Source Type: research

Iron deficiency anemia in chronic kidney disease: Uncertainties and cautions
Abstract Anemia in chronic kidney disease is common and iron deficiency is an important cause. To repair iron‐deficiency anemia, replacement of iron is needed. Iron can be replaced either by the oral route or by the intravenous route. In a meta‐analysis, 5 of the 6 trials were short‐term, 1 to 3 months, and compared to oral iron, the mean increase in hemoglobin with intravenous iron was only 0.31 g/dL. However, one of the studies included in this meta‐analysis was 6 months long and had a mean decline in hemoglobin of 0.52 g/dL associated with intravenous iron administration. Given the short duration of most of the ...
Source: Hemodialysis International - April 12, 2017 Category: Hematology Authors: Rajiv Agarwal Tags: Supplement Article Source Type: research

A single center, open ‐label, randomized, parallel group study assessing the relationship between asymptomatic bacteriuria and inflammation in maintenance hemodialysis patients
Hemodialysis International,Volume 22, Issue 1, Page 110-118, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - April 3, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 110-118, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - April 3, 2017 Category: Hematology Source Type: research

Safety of intravenous iron in hemodialysis patients
Abstract Among end‐stage renal disease patients maintained by hemodialysis, anemia has been managed primarily through erythropoiesis‐stimulating agents (ESAs) and intravenous (IV) iron. Following concerns about the cardiovascular (CV) safety of ESAs and changes in the reimbursement policies in Medicare's ESRD program, the use of IV iron has increased. IV iron supplementation promotes hemoglobin production and reduces ESA requirements, yet there exists relatively little evidence on the long‐term safety of iron supplementation in hemodialysis patients. Labile iron can induce oxidative stress and is also essential in ba...
Source: Hemodialysis International - April 3, 2017 Category: Hematology Authors: Xiaojuan Li, Abhijit V. Kshirsagar, M. Alan Brookhart Tags: Supplement Article Source Type: research

Ferric pyrophosphate citrate as an iron replacement agent for patients receiving hemodialysis
Abstract Treatment of anemia remains an integral component in the care of patients with end stage kidney disease receiving dialysis. Currently, both erythropoiesis stimulating agents and iron replacement agents remain important anemia management strategies for patients undergoing hemodialysis (HD). Ferric pyrophosphate citrate (FPC) was approved by the U.S. Food and Drug Administration in January 2015 as an iron replacement product in adult patients receiving long‐term maintenance HD. FPC is administered to patients on HD through the dialysate. Multicenter randomized, placebo‐controlled phase three clinical studies (CR...
Source: Hemodialysis International - April 3, 2017 Category: Hematology Authors: Steven Fishbane, Hitesh H. Shah Tags: Supplement Article Source Type: research

Frank Gotch
(Source: Hemodialysis International)
Source: Hemodialysis International - April 3, 2017 Category: Hematology Authors: John T. Daugirdas, Marcia L. Keen, Nathan W. Levin Tags: IN MEMORIAM Source Type: research

Issue information
(Source: Hemodialysis International)
Source: Hemodialysis International - April 3, 2017 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Gender disparity in fistula use at initiation of hemodialysis varies markedly across ESRD networks —Analysis of USRDS data
Abstract Background: Gender disparities had been noted in the care of women with end stage renal disease (ESRD) in the early 2000's, including less frequent initiation of hemodialysis utilizing a fistula but more recent data have not been examined and underlying factors have not been extensively studied.Study design: Data from the United States Renal Data System (USRDS) were examined, including 202,999 hemodialysis patients. Only those who had received prior nephrology care were included. Multiple logistic regression was used, adjusted for possible confounders, including age, race, cause of ESRD, BMI, height, history of al...
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Mariana Markell, Amarpali Brar, Dimitre G. Stefanov, Moro O. Salifu Tags: Original Article Source Type: research

Subcutaneous defibrillators for dialysis patients
This article provides the risks associated with leads of traditional defibrillators and raises awareness of the subcutaneous ICD and their benefits for hemodialysis patients. (Source: Hemodialysis International)
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Tushar J. Vachharajani, Loay Salman, Eric J. Costanzo, Sushil K. Mehandru, Mayurkumar Patel, Dawn M. Calderon, Roy O. Mathew, Mandeep S. Sidhu, Arif Asif Tags: Review Article Source Type: research

Spontaneous intercostal artery bleeding in a hemodialysis patient
We report a patient presented with swelling in his right‐side back which started immediately after scheduled hemodialysis and continued to increase in size. Contrast computed tomography scan revealed soft tissue attenuated lesion with internal enhancing dots which suggested expanding hematoma with active bleeding. Arteriography detected focal contrast extravasation from seventh ICA, and transcatheter arterial embolization was successfully done. To the best of our knowledge, this is the first report describing spontaneous bleeding of ICA in a hemodialysis patient. (Source: Hemodialysis International)
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Areum Durey, Young Sam Kim, Ah Jin Kim Tags: Case Report Source Type: research

Antithrombotic therapy in end ‐stage renal disease
Abstract The delicate balance of risk vs. benefit of using antiplatelet and antithrombotic agents in the general population is well established. The decision to use these agents in the end stage renal disease (ESRD) population remains complex and difficult. The concomitant association of a prothombotic state with high risk of bleeding in the ESRD population requires individualization and careful clinical judgment before implementing such therapy. There remains a paucity of clinical trials and lack of substantial evidence in literature for safe and effective use of antithrombotic drugs in patients with advanced chronic kidn...
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Svetha Chunduri, Jon E. Folstad, Tushar J. Vachharajani Tags: Review Article Source Type: research

High sodium continuous veno ‐venous hemodialysis with regional citrate anticoagulation and online dialysate generation in patients with acute liver failure and cerebral edema
We describe a novel approach for delivering continuous osmotherapy to patients with acute liver failure, renal failure, and cerebral edema. In comparison to standard therapy, the described modality enables precise titration of serum sodium without undesirable fluctuations in extracellular fluid volume. A particular advantage is zero delivery of citrate to this vulnerable group of patients with acute liver failure. (Source: Hemodialysis International)
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Tamim Hamdi, Lenar Yessayan, Jerry Yee, Balazs Szamosfalvi Tags: Original Article Source Type: research

Case of Mycobacterium mucogenicum in home hemodialysis patient
We present a case of a patient on home hemodialysis who developed Mycobacterium mucogenicum bacteremia. While infections with this particular organism are rare, disseminated infections have been reported and have been associated with significant morbidity and mortality. Diagnosis required appropriate cultures, understanding of natural habitat of organism and complete environmental analysis including blood, dialysis sample port, reverse osmosis and incoming water supply cultures. The patient was treated successfully with systemic antibiotics, removal of central venous catheter, patient education and complete exchange of the...
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Miten J. Dhruve, Paul E. Bunce, Celine D'Gama, Christopher T Chan Tags: Case Report Source Type: research

The deterioration in physical function of hemodialysis patients
Abstract Introduction: Physical function in people on hemodialysis deteriorates significantly, however quantification of the rate of deterioration has not been well established. The aim of this study was to examine the rate of deterioration in objective physical function among end‐stage kidney disease patients receiving hemodialysis. Methods: One hundred and ninety‐three participants (mean age 67.5 ±13.2 years, 60.6% males) receiving hemodialysis in Australia. Objective physical function was assessed via the 30‐second sit‐to‐stand and eight‐foot timed up‐and‐go at baseline, 12 and 24 weeks. Findings:...
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Brianna K. Sutcliffe, Paul N. Bennett, Steve F. Fraser, Mohammadreza Mohebbi Tags: Original Article Source Type: research

Clinical practice guidelines on iron therapy: A critical evaluation
Abstract Anemia is common among patients with chronic kidney disease (CKD) and it is managed primarily with erythropoiesis‐stimulating agents (ESA) and iron therapy. Following concerns around ESA therapy and economic constraints, IV iron is more and more administered worldwide. Several guidelines or position papers, which give indications on iron therapy in CKD patients, have been issued in Nephrology. Unfortunately, the field is characterized by a lack of evidence. As a result, the recommendations/suggestions are not uniform. There is general consensus to prescribe iron therapy to patients who are clearly iron deficient...
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Lucia Del Vecchio, Francesco Locatelli Tags: Supplement Article Source Type: research

Sleep apnea syndrome, inflammation and oxidative stress in hemodialysis patients
Abstract Introduction: Sleep apnea syndrome (SAS) is an established cardiovascular risk factor in the general population related to inflammation and oxidative stress and is very common among hemodialysis patients. Cardiovascular disease and its complications is the main cause of death among hemodialysis patients. The aim of the present study was to investigate the role of SAS in the promotion of inflammation and oxidative stress and thus in the augmentation of cardiovascular risk in hemodialysis patients.Methods: Thirty‐seven hemodialysis patients underwent an overnight full polysomnography study. The following morning b...
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Olga Nikitidou, Euphemia Daskalopoulou, Aikaterini Papagianni, Vassilios Liakopoulos, Aikaterini Michalaki, Foteini Christidou, Paraskevi Argyropoulou, Dimitrios Kirmizis, Georgios Efstratiadis, Pavlos Nikolaidis, Michail Daniilidis, Nicholas Dombros Tags: Original Article Source Type: research

Catheter ‐related fungal endocarditis caused by Candida parapsilosis in a hemodialysis patient
We reported a case of FE associated with catheter infection in a 44‐year‐old woman on HD. The risk factors and treatment strategies of FE in HD patients were discussed. (Source: Hemodialysis International)
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Ying Shu, Shaobin Yu, Ling Zha, Ping Fu, Tianlei Cui Tags: Case Report Source Type: research

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all ‐cause mortality in hemodialysis patients: A prospective cohort study
In this study, we prospectively studied the predictive value of MLR for all‐cause and cardiovascular mortality in HD patients and compared it with NLR. Methods: Patients who had been on a HD treatment for at least 6 months were enrolled. MLR was calculated by dividing the monocyte count by the lymphocyte count. Survival outcomes were estimated using the Kaplan‐Meier method and compared by the log‐rank test. Univariate and multivariate analyses were performed to evaluate the prognostic impact of MLR and other clinical factors on all‐cause and cardiovascular mortality. Results: Mortality rates for the lowest, middle,...
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Fangfang Xiang, Rongyi Chen, Xuesen Cao, Bo Shen, Zhonghua Liu, Xiao Tan, Xiaoqiang Ding, Jianzhou Zou Tags: Original Article Source Type: research

A single center, open ‐label, randomized, parallel group study assessing the relationship between asymptomatic bacteriuria and inflammation in maintenance hemodialysis patients
Discussion: Asymptomatic bacteriuria is not a modifiable risk factor for chronic inflammation in the MHD population. (Source: Hemodialysis International)
Source: Hemodialysis International - April 1, 2017 Category: Hematology Authors: Ilia Beberashvili, Evgeni Golovko, Liat Golinsky, Nedal Garra, Inna Sinuani, Leonid Feldman, Oleg Gorelik, Shai Efrati, Kobi Stav Tags: Original Article Source Type: research

Association between afebrile status and in ‐hospital mortality among adult chronic hemodialysis patients with bacteremia
Hemodialysis International,Volume 22, Issue 1, Page 119-125, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 23, 2017 Category: Hematology Source Type: research

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Hemodialysis International,Volume 22, Issue 1, Page 119-125, January 2018. (Source: Hemodialysis International)
Source: Hemodialysis International - March 23, 2017 Category: Hematology Source Type: research

Impact of iatrogenic iron overload on the course of hepatitis C in the dialysis population: A plea for caution
Abstract About 2.5% of the world population, corresponding to about 177 million individuals, are infected by hepatitis C virus (HCV), a small, single‐stranded RNA virus. The prevalence of HCV infection among dialysis patients in Japan, Europe, and North America during the 2012 to 2015 period was found to be 8.7% in the DOPPS study. Nosocomial HCV spread in hemodialysis facilities still occurs. Increased hepatic tissue iron has been shown to play a deleterious role in the course of hepatitis C, favor development of fibrosis and cirrhosis and possibly increase the risk of liver cancer in the general population. Regular los...
Source: Hemodialysis International - March 23, 2017 Category: Hematology Authors: Guy Rostoker, Nosratola D. Vaziri Tags: SCHOLARLY REVIEW Source Type: research