Collection of daily patient reported outcomes is feasible and demonstrates differential patient experience in chronic kidney disease
Discussion We successfully introduced an online, patient acceptable, iterative PROM that discriminates symptom burden, cross‐sectionally, and longitudinally. Further work will prospectively examine the predictive power of changes in PRO and more rigorously investigate the potential use of these methods to optimise patient care. (Source: Hemodialysis International)
Source: Hemodialysis International - September 11, 2016 Category: Hematology Authors: Zoe C. L. Pittman, Stephen G. John, Chris W. McIntyre Tags: Original Article Source Type: research

Indoxyl sulfate, a valuable biomaker in chronic kidney disease and dialysis
Abstract Chronic kidney disease (CKD) is an increasingly recognized disease with high global incidence and mortality. Yet, the existing diagnostic tools are not sufficient enough to predict prognosis of CKD and CKD comorbidities. Indoxyl sulfate, a typical uremic toxin, is of great importance in the development of CKD with its nephrotoxicity, cardiovascular toxicity, and bone toxicity. Some reports suggest that indoxyl sulfate directly associate with renal function loss and mortality in CKD patients. This review discusses the diagnostic value of indoxyl sulfate from its biological characteristics, pathophysiological effect...
Source: Hemodialysis International - September 11, 2016 Category: Hematology Authors: Xiao Tan, Xuesen Cao, Jianzhou Zou, Bo Shen, Xiaoyan Zhang, Zhonghua Liu, Wenlv Lv, Jie Teng, Xiaoqiang Ding Tags: Review Article Source Type: research

A meta ‐analysis of sodium profiling techniques and the impact on intradialytic hypotension
Discussion This review has shown that using stepwise profiling is more effective at reducing intra‐dialytic symptoms than other profiling methods. There was no evidence that linear profiling method was any more effective than conventional dialysis and in fact the results showed the reverse. (Source: Hemodialysis International)
Source: Hemodialysis International - September 11, 2016 Category: Hematology Authors: Nina Dunne Tags: Review Article Source Type: research

Air contamination during hemodialysis should be minimized
Abstract During preparation of the hemodialysis (HD) extracorporeal circuit (ECC) a priming solution is used to remove air from the tubes and dialyzer. Ultra sound techniques have verified micro embolic signals (MES) in the ECC that may derive from clots or gas embolies. In vitro studies could clarify that embolies of air develop within the ECC and also pass the safety systems such as air traps and enter the venous line that goes into the patient. Clinical studies have confirmed the presence of MES within the ECC that pass into the return—venous—line during conventional HD without inducing an alarm. In addition...
Source: Hemodialysis International - August 29, 2016 Category: Hematology Authors: Bernd Stegmayr Tags: Review Article Source Type: research

A case of gabapentin ‐induced rhabdomyolysis requiring renal replacement therapy
In this report, we describe a case of gabapentin‐induced rhabdomyolysis in a 32‐year‐old woman with no medical history. We also review related literature and discuss the possible mechanism and the association with other factors. This case shows that gabapentin can induce rhabdomyolysis in healthy patients and that clinicians must consider the possible association between gabapentin and rhabdomyolysis. (Source: Hemodialysis International)
Source: Hemodialysis International - July 7, 2016 Category: Hematology Authors: Min Seok Choi, Howook Jeon, Hyo Suk Kim, Bo Hyun Jang, Yoon Hee Lee, Hoon Suk Park, HyungWook Kim, Dong Chan Jin Tags: Case Report Source Type: research

Identifying and integrating patient and caregiver perspectives for clinical practice guidelines on the screening and management of infectious microorganisms in hemodialysis units
Discussion Patients and caregivers emphasized the need for guidelines to address patient education and engagement, and the psychosocial implications of communication and provision of care in the context of infectious microorganisms in hemodialysis units. Integrating patient and caregiver perspectives can help to improve the relevance of guidelines to enhance quality of care, patient experiences, and health and psychosocial outcomes. (Source: Hemodialysis International)
Source: Hemodialysis International - July 7, 2016 Category: Hematology Authors: Hilary M. Miller, Allison Tong, David J. Tunnicliffe, Denise Campbell, Jule Pinter, Robert J. Commons, Eugene Athan, Jonathan C. Craig, Nicole Gilroy, Julianne Green, Belinda Henderson, Martin Howell, Rhonda L. Stuart, Carolyn van Eps, Muh Geot Wong, Jana Tags: Original Article Source Type: research

Evaluating safety of tunneled small bore central venous catheters in chronic kidney disease population: A quality improvement initiative
Discussion TSB‐CVCs demonstrated an excellent safety profile in our study. These catheters should be preferentially utilized for arm vein preservation in advanced kidney disease. Their impact on future AVF success needs further evaluation. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Gauri Bhutani, Mireille El Ters, Walter K Kremers, Joe L Klunder, Sandra J. Taler, Amy W. Williams, Andrew H. Stockland, Marie C. Hogan Tags: Original Articles Source Type: research

The gut ‐kidney axis in chronic renal failure: A new potential target for therapy
Abstract Evidence is accumulating to consider the gut microbiome as a central player in the gut‐kidney axis. Microbiome products, such as advanced glycation end products, phenols, and indoles, are absorbed into the circulation but are cleared by normal‐functioning kidneys. These products then become toxic and contribute to the uremic load and to the progression of chronic kidney failure. In this review, we discuss the gut‐kidney interaction under the state of chronic kidney failure as well as the potential mechanisms by which a change in the gut flora (termed gut dysbiosis) in chronic kidney disease (CKD) exacerbates...
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Tawfik Khoury, Keren Tzukert, Roy Abel, Ayman Abu Rmeileh, Ronen Levi, Yaron Ilan Tags: Review Article Source Type: research

Incident diabetic foot ulcers and mortality in hemodialysis patients
(Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Pranav S. Garimella, Weiling Wang, Shu ‐Fang Lin, Jeffrey Hymes, Eduardo Lacson Tags: Letter to the Editor Source Type: research

Plasma vitamin C levels in ESRD patients and occurrence of hypochromic erythrocytes
Abstract Introduction The achievement of erythropoiesis in hemodialysis (HD) patients is typically managed with erythropoiesis‐stimulating‐agents (ESA's) and intravenous iron (IV‐iron). Using this treatment strategy, HD patients frequently show an elevated fraction of red blood cells (RBC) with hemoglobin (Hb) content per cell that is below the normal range, called hypochromic RBC. The low Hb content per RBC is the result of the clinical challenge of providing sufficient iron content to the bone marrow during erythropoiesis. Vitamin C supplements have been used to increase Hb levels in HD patients with refractory ane...
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Eric Seibert, Anja Richter, Martin K. Kuhlmann, Suxin Wang, Nathan W. Levin, Peter Kotanko, Garry J. Handelman Tags: Original Article Source Type: research

Adherence rates to ferric citrate as compared to active control in patients with end stage kidney disease on dialysis
Discussion Adherence rates to the phosphate binder, ferric citrate, were similar to adherence rates to active control. Similar adherence rates to ferric citrate are notable since tolerance to active control was an entry criteria and the study was open label. Gender, race/ethnicity, nor age influenced adherence. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Diana Jalal, Molly McFadden, Jamie P. Dwyer, Kausik Umanath, Erwin Aguilar, Yoram Yagil, Barbara Greco, Mohammed Sika, Julia B. Lewis, Tom Greene, Simin Goral Tags: Original Article Source Type: research

Phenytoin overdose treated with hemodialysis using a high cut ‐off dialyzer
We describe the case of a 52‐year‐old man who presented after having ingested an unknown quantity of phenytoin. Peak phenytoin concentration was 51.2 mg/L (therapeutic range 10–20 mg/L). Five days after admission, the patient became comatose and was intubated. Because of persistent toxic phenytoin levels and unchanged clinical status for 12 days, hemodialysis (HD) was prescribed to enhance elimination of phenytoin. HD was performed using a Gambro TheraliteTM filter (Baxter International Inc., Deerfield, USA), a high cut‐off filter that allows the removal of molecules of up to 45 kDa. Phenytoin concentration rea...
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Monique J. Cormier, Simon Desmeules, Maude St ‐Onge, Marc Ghannoum Tags: Case Report Source Type: research

Comparison of techniques for culture of dialysis water and fluid
Discussion In dialysis fluid, TSA‐48h was comparable to TGEA‐7d and R2A‐7d in identifying samples as having bacterial counts ≥50 CFU/mL. In dialysis water, TSA‐48h was comparable to R2A‐7d in identifying samples ≥50 CFU/mL, but TGEA‐7d did yield significantly more results above 50 CFU/mL. Nonetheless, the negative predictive value of a TSA‐48h result of
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Jo ‐Ann B. Maltais, Klemens B. Meyer, Meredith C. Foster Tags: Original Article Source Type: research

Plain pelvic/aorta radiographs as a simple guideline to predict vascular macro ‐calcifications; one step earlier or a late sign to best weight the enemy of coronary calcification and mortality?
(Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: George S. Georgiadis, Konstantia Kantartzi, George A. Antoniou Tags: Letter to the Editor Source Type: research

Comparison of standard forearm prosthetic loop grafts to composite semiloop forearm grafts ( “semi‐grafts”) in hemodialysis patients: A prospective study
Discussion There was a trend toward better primary and secondary patency rates for the SGs especially in the long‐term. This is a valuable option in selected patients that access surgeons and nephrologists should be aware of. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: George S. Georgiadis, George A. Antoniou, Konstantia Kantartzi, Efstratios I. Georgakarakos, Christos Argyriou, Ploumis Passadakis, Miltos K. Lazarides Tags: Original Article Source Type: research

Heparin albumin priming in a clinical setting for hemodialysis patients at risk for bleeding
Discussion HA priming minimized the risk of clotting and enabled acute IHD in vulnerable patients without increased bleeding, thus allowing completion of IHD to the same extent as for standard HD. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Malin Skagerlind, Bernd Stegmayr Tags: Original Article Source Type: research

Garenoxacin pharmacokinetics in patients undergoing maintenance hemodialysis
In this study, we attempted to ascertain the appropriate dose of GRNX in patients undergoing maintenance hemodialysis (MH) based on pharmacokinetic parameters and clinical outcomes. Methods Six male patients with infections who were undergoing MH received 200 mg GRNX once daily. Blood samples were taken before and at 1, 2, 4, 6, 12, and 24 hours after GRNX administration. Plasma GRNX concentrations were measured using high‐performance liquid chromatography. Findings The mean maximum plasma concentration (Cmax) was 3.00 ± 1.12 µg/mL, time to maximum plasma concentration (Tmax) was 3.0&...
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Togo Aoyama, Kouju Kamata, Satoshi Kishino Tags: Original Article Source Type: research

Personal Support Worker (PSW) ‐supported home hemodialysis: A paradigm shift
We describe the administrative structure of the pilot project allowing scalability and turnkey operation in the province of Ontario. Regulatory and insurance concerns were resolved and patients and staff were enthusiastic. The projected total dialysis cost, when economies of scale are met, are expected to be lower than the cost of in‐center HD. Discussion A second phase of the project is currently under way including 8 hospitals and 67 patients. If equally successful, it may have significant implications for the delivery of care for End Stage Renal Disease in Ontario and similar jurisdictions. It promises to increas...
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Andreas Pierratos, Melanie Tremblay, Gokulan Kandasamy, Graham Woodward, Peter Blake, Janet Graham, Marc Hebert, Rebecca Harvey Tags: Original Article Source Type: research

Younger black patients have a higher risk of infection mortality that is mostly non ‐dialysis related: A national study of cause‐specific mortality among U.S. maintenance dialysis patients
Abstract Introduction While it has been well documented that in the U.S., black and Hispanic dialysis patients have overall lower risks of death than white dialysis patients, little is known whether their lower risks are observed in cause‐specific deaths. Additionally, recent research reported that younger black patients have a higher risk of death, but the source is unclear. Therefore, this study examined cause‐specific deaths among US dialysis patients by race/ethnicity and age. Methods This national study included 1,255,640 incident dialysis patients between 1995 and 2010 in the United States Renal Data System. Five...
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Alison J. Yu, Keith C. Norris, Alfred K. Cheung, Guofen Yan Tags: Original Article Source Type: research

The impact of education and cooking methods on serum phosphate levels in patients on hemodialysis: 1 ‐year study
Discussion Providing additional education to hemodialysis patients on the specific cooking methods and accordingly prepared meals may decrease serum phosphate levels without significantly affecting nutritional status which may be useful in helping to prevent and treat hyperphosphatemia. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Ivica Vrdoljak, Ines Panjkota Krbav čić, Martina Bituh, Ninoslav Leko, Draško Pavlović, Tea Vrdoljak Margeta Tags: Original Article Source Type: research

Air embolism following removal of hemodialysis catheter
Discussion AE following catheter removal carries a major risk of mortality. Great awareness and attention to preventive procedures and appropriate care after development of AE seem mandatory. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Tuncay Sahutoglu, Tamer Sakaci, Nuri Baris Hasbal, Ekrem Kara, Elbis Ahbap, Mustafa Sevinc, Yener Koc, Taner Basturk, Elif Sahutoglu, Abdulkadir Unsal Tags: Original Article Source Type: research

A systematic review of the benefits and harms of dipeptidyl peptidase ‐4 inhibitor for chronic kidney disease
Discussion DPP‐4 inhibitors demonstrated beneficial effects on the glycemic control for diabetic patients with CKD without causing any additional adverse effects. However, a definitive conclusion has yet to be drawn due to serious methodological problems and a small number of studies. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Hiroyuki Kamiya Tags: Original Article Source Type: research

A systematic review of the benefits and harms of dipeptidyl peptidase‐4 inhibitor for chronic kidney disease
Discussion DPP‐4 inhibitors demonstrated beneficial effects on the glycemic control for diabetic patients with CKD without causing any additional adverse effects. However, a definitive conclusion has yet to be drawn due to serious methodological problems and a small number of studies. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Hiroyuki Kamiya Tags: Original Article Source Type: research

Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial
Abstract Introduction Pruritus is one of the frustrating skin manifestations of advanced renal failure. Many options have been used for the management of uremic pruritus (UP) such as pregabalin. There are some studies that reported beneficial effects of pregabalin in reducing UP; however, most of them did not have a comparator arm. Therefore, we designed this study to compare antipruritic effects of pregabalin with doxepin in the management of pruritus in hemodialysis patients. Methods Seventy‐two patients suffering from UP were randomly assigned to receive pregabalin (50 mg every other day) or doxepin (10 mg p...
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Nazanin Foroutan, Abbas Etminan, Naemeh Nikvarz, Mohadese Shojai Shahrokh Abadi Tags: Original Article Source Type: research

A case of gabapentin‐induced rhabdomyolysis requiring renal replacement therapy
In this report, we describe a case of gabapentin‐induced rhabdomyolysis in a 32‐year‐old woman with no medical history. We also review related literature and discuss the possible mechanism and the association with other factors. This case shows that gabapentin can induce rhabdomyolysis in healthy patients and that clinicians must consider the possible association between gabapentin and rhabdomyolysis. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Min Seok Choi, Howook Jeon, Hyo Suk Kim, Bo Hyun Jang, Yoon Hee Lee, Hoon Suk Park, HyungWook Kim, Dong Chan Jin Tags: Case Report Source Type: research

Methotrexate induced pneumatosis intestinalis under hemodialysis patient
Abstract Pneumatosis intestinalis (PI) is a rare disorder characterized by the gas within the intestinal mucosa. This is the first report methotrexate (MTX) induced PI under hemodialysis (HD) patient. A 46‐year‐old man suffered rheumatoid arthritis and underwent HD at local HD center. After the initial induction of MTX, the patient showed epigastralgia and diarrhea. He was referred to our hospital and abdominal computed tomography showed significant large intestinal edema and free intraperitoneal air consistent with PI. Physicians should aware that MTX is contraindication drug for chronic kidney disease and high‐flux...
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Akira Mima, Dai Nagahara, Kosuke Tansho Tags: Case Report Source Type: research

Chitotriosidase as a novel biomarker of early atherosclerosis in hemodialysis patients
In conclusion, this is the first report showing that serum CHIT‐1 level was related independently with carotid IMT in hemodialysis patients. This biomarker might have an unknown role in the development of atherosclerosis during uremia. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Aydın Güçlü, Mahmut Ilker Yilmaz, Turgut Tursem Tokmak, Hilmi Umut Unal, Murat Karaman, Mustafa Gezer, Ahmet Taş, İbrahim Aydin, Raziye Akçılar, Yusuf Dursun Tags: Original Article Source Type: research

Potential role of costimulatory pathways in immune dysfunction in hemodialysis patients
(Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Pasquale Esposito, Carmelo Libetta, Antonio Dal Canton Tags: INFECTIONS Source Type: research

Check the guide wire after catheter placement
(Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Krzysztof Letachowicz, Tomasz Gołębiowski, Mariusz Kusztal Tags: ACCESS Source Type: research

Issue Information ‐ TOC
(Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Tags: ISSUE INFORMATION ‐ TOC Source Type: research

Low versus high dialysate calcium concentration in alternate night nocturnal hemodialysis: A randomized controlled trial
Discussion Although dialysate calcium prescription influenced biochemical parameters it was not associated with difference in progression of VC between HC and LC groups. An important finding was the potential impact of alternate night NHD in attenuating progression of VC and inducing stabilisation of LVMI and PWV. (Source: Hemodialysis International)
Source: Hemodialysis International - June 29, 2016 Category: Hematology Authors: Rosemary Masterson, Susan Blair, Kevan R. Polkinghorne, Kenneth K. Lau, Michael Lian, Boyd J. Strauss, John G. Morgan, Peter Kerr, Nigel D. Toussaint Tags: Original Article Source Type: research

A comparison between physicians and computer algorithms for form CMS ‐2728 data reporting
Discussion Using computer algorithms showed superior identification of comorbidities for form CMS‐2728 and altered standardized mortality ratios. Adapting similar algorithms in available EMR systems may offer more thorough evaluation of comorbidities and improve quality reporting. (Source: Hemodialysis International)
Source: Hemodialysis International - June 28, 2016 Category: Hematology Authors: Mohammed Said Malas, Jay Wish, Ranjani Moorthi, Shaun Grannis, Paul Dexter, Jon Duke, Sharon Moe Tags: Original Article Source Type: research

Effect of vitamin D supplementation on endothelial dysfunction in hemodialysis patients
Abstract Introduction Patients with chronic kidney disease (CKD) commonly experience 25‐hydroxyvitamin D3 (25‐OH‐D3) deficiency, and these patients have a higher incidence of cardiovascular diseases (CVDs) due to endothelial dysfunction (ED). The aim of our study was to investigate the effect of 25‐OH‐D3 deficiency and its supplementation on ED in patients with CKD. Methods Twenty‐nine uremic patients on dialysis and 20 healthy controls were evaluated for ED by high‐resolution Doppler ultrasonography of the brachial artery. In addition, 25‐OH‐D3‐deficient patients (25‐OH‐D3 
Source: Hemodialysis International - June 28, 2016 Category: Hematology Authors: Yusuf Karakas, Garip Sahin, Furkan Ertürk Urfali, Cengiz Bal, Nevbahar Akcar Degirmenci, Basar Sirmagul Tags: Original Article Source Type: research

Long ‐term effects of angiotensin II blockade with irbesartan on inflammatory markers in hemodialysis patients: A randomized double blind placebo controlled trial (SAFIR study)
Discussion Inflammatory biomarkers were neither acutely, nor in the long‐term significantly affected by the ARB irbesartan. Our findings suggest that ARB treatment in HD patients does not offer protective anti‐inflammatory effects. (Source: Hemodialysis International)
Source: Hemodialysis International - June 26, 2016 Category: Hematology Authors: Christian D. Peters, Krista D. Kjaergaard, Claus H. Nielsen, Kent L. Christensen, Bo M. Bibby, Jens D. Jensen, Bente Jespersen Tags: Original Article Source Type: research

Maintenance of blood flow rate on dialysis with self ‐centering CentrosFLO catheter: A multicenter prospective study
Discussion The CentrosFLO catheter demonstrates long term patency with good flow rates on dialysis, which, by comparison with previous studies, shows a clinically significant improvement in blood flow rate vs. other catheters. Stable hydraulic resistance of the catheter lumens showed no evidence of tip encroachment by fibrous sheaths. (Source: Hemodialysis International)
Source: Hemodialysis International - June 26, 2016 Category: Hematology Authors: Anil K. Agarwal, Stephen R. Ash, Tags: Original Article Source Type: research

Predialysis volume overload and patient ‐reported sleep duration and quality in patients receiving hemodialysis
Discussion Hydration status was associated with self‐reported sleep duration in patients on dialysis. Future studies should prospectively examine the effects of optimizing fluid status on sleep duration and quality. (Source: Hemodialysis International)
Source: Hemodialysis International - June 26, 2016 Category: Hematology Authors: Adrian P. Abreo, Lorien S. Dalrymple, Glenn M. Chertow, George A. Kaysen, Charles A. Herzog, Kirsten L. Johansen Tags: Original Article Source Type: research

Bone ‐specific alkaline phosphatase and bone turnover in African American hemodialysis patients
Abstract Introduction Noninvasive measures of bone activity include intact parathyroid hormone (iPTH) and bone‐specific alkaline phosphatase (BSAP). Whether BSAP measurement alone or in combination with other biochemical data provides more reliable information about bone turnover than iPTH alone in African Americans on hemodialysis is unknown. Methods This cross‐sectional study aimed to determine the optimal predictor and cutoff points for BSAP, iPTH, calcium and phosphorus in classifying bone biopsy findings. Forty‐three African American hemodialysis patients were available for analysis. Biochemical data on the day ...
Source: Hemodialysis International - June 26, 2016 Category: Hematology Authors: Lenar Yessayan, Carol Moore, Mei Lu, Jerry Yee Tags: Original Article Source Type: research

Hyponatremia in patients with chronic kidney disease
Abstract Hyponatremia is a common condition encountered in clinical practice. A number of studies have associated low serum sodium levels with increased mortality in various patient populations, such as hospitalized patients and patients with various comorbid conditions; recent studies have shown that individuals with chronic kidney disease also are afflicted by hyponatremia. However, few studies have focused on patients with hemodialysis. Evidence supporting the incidence and prevalence of hyponatremia, clinical characteristics and the association with patient outcomes with hemodialysis is limited. In the present review, ...
Source: Hemodialysis International - June 26, 2016 Category: Hematology Authors: Rui Zhang, Songyan Wang, Mian Zhang, Lijuan Cui Tags: Review Article Source Type: research

Transient mediastinal mass from fluid overload
We describe the case of a 75 year old woman known for end‐stage renal disease on hemodialysis who presented with acute pulmonary edema in the context of a Non ST‐Elevation Myocardial Infarction. Chest CT imaging showed pulmonary edema, pleural effusions, and a middle mediastinum soft‐tissue mass of 4.2 × 2.5cm. Malignancy was initially suspected, however given the clinical context of fluid overload and absence of other signs of malignancy, the possibility of the mass representing soft‐tissue edema was raised. Therefore, the patient's fluid overload was treated with a progressive reduction in the dry weight us...
Source: Hemodialysis International - June 26, 2016 Category: Hematology Authors: David Massicotte‐Azarniouch, Joseph P. O'Sullivan, Edward G. Clark Tags: Case Report Source Type: research

Long‐term effects of angiotensin II blockade with irbesartan on inflammatory markers in hemodialysis patients: A randomized double blind placebo controlled trial (SAFIR study)
Discussion Inflammatory biomarkers were neither acutely, nor in the long‐term significantly affected by the ARB irbesartan. Our findings suggest that ARB treatment in HD patients does not offer protective anti‐inflammatory effects. (Source: Hemodialysis International)
Source: Hemodialysis International - June 26, 2016 Category: Hematology Authors: Christian D. Peters, Krista D. Kjaergaard, Claus H. Nielsen, Kent L. Christensen, Bo M. Bibby, Jens D. Jensen, Bente Jespersen Tags: Original Article Source Type: research

Maintenance of blood flow rate on dialysis with self‐centering CentrosFLO catheter: A multicenter prospective study
Discussion The CentrosFLO catheter demonstrates long term patency with good flow rates on dialysis, which, by comparison with previous studies, shows a clinically significant improvement in blood flow rate vs. other catheters. Stable hydraulic resistance of the catheter lumens showed no evidence of tip encroachment by fibrous sheaths. (Source: Hemodialysis International)
Source: Hemodialysis International - June 26, 2016 Category: Hematology Authors: Anil K. Agarwal, Stephen R. Ash, Tags: Original Article Source Type: research

Volkmann's ischemic contracture: An unusual complication of arterio ‐venous fistula
Abstract Native arterio‐venous fistulae (AVF) are vascular access of first choice for chronic hemodialysis. However, AVF are also associated with many adverse events like: primary or secondary failure, infection, lymphedema, stenosis, thrombosis, and ischemia of distal extremities. The most common ischemia related complications of AVF are: ischemic neuropathy and steal syndrome with its consequences like pain and peripheral necrosis. Ischemic muscle contracture is a rare complication of AVF. Herein, we are reporting a case of Volkmann's ischemic contracture developing after creation of brachiocephalic AVF. (Source: Hemod...
Source: Hemodialysis International - June 20, 2016 Category: Hematology Authors: Ajay Jaryal, Sanjay Vikrant, Preyander Thakur Tags: Case Report Source Type: research

Influence of religiosity and spiritual coping on health ‐related quality of life in Saudi haemodialysis patients
This study revealed significant findings regarding the importance of religiosity and SC on the HRQoL of the Saudi HD patients. Therefore, it has been highly recommended to integrate religiosity into the health‐care process for such patients to facilitate the achievement of overall optimum health levels. (Source: Hemodialysis International)
Source: Hemodialysis International - June 20, 2016 Category: Hematology Authors: Jonas Preposi Cruz, Paolo C. Colet, Nahed Alquwez, Ergie P. Inocian, Raid Salman Al ‐Otaibi, Sheikh Mohammed Shariful Islam Tags: Original Article Source Type: research

Reduction of carbamylated albumin by extended hemodialysis
Abstract Introduction Among conventional hemodialysis (CHD) patients, carbamylated serum albumin (C‐Alb) correlates with urea and amino acid deficiencies and is associated with mortality. We postulated that reduction of C‐Alb by intensive HD may correlate with improvements in protein metabolism and cardiac function. Methods One‐year observational study of in‐center nocturnal extended hemodialysis (EHD) patients and CHD control subjects. Thirty‐three patients receiving 4‐hour CHD who converted to 8‐hour EHD were enrolled, along with 20 controls on CHD. Serum C‐Alb, biochemistries, and cardiac MRI parameters ...
Source: Hemodialysis International - June 20, 2016 Category: Hematology Authors: Jeffrey Perl, Sahir Kalim, Ron Wald, Marc B. Goldstein, Andrew T. Yan, Nazanin Noori, Mercedeh Kiaii, Julia Wenger, Christopher Chan, Ravi I. Thadhani, S. Ananth Karumanchi, Anders H. Berg Tags: Original Article Source Type: research

Volkmann's ischemic contracture: An unusual complication of arterio‐venous fistula
Abstract Native arterio‐venous fistulae (AVF) are vascular access of first choice for chronic hemodialysis. However, AVF are also associated with many adverse events like: primary or secondary failure, infection, lymphedema, stenosis, thrombosis, and ischemia of distal extremities. The most common ischemia related complications of AVF are: ischemic neuropathy and steal syndrome with its consequences like pain and peripheral necrosis. Ischemic muscle contracture is a rare complication of AVF. Herein, we are reporting a case of Volkmann's ischemic contracture developing after creation of brachiocephalic AVF. (Source: Hemod...
Source: Hemodialysis International - June 20, 2016 Category: Hematology Authors: Ajay Jaryal, Sanjay Vikrant, Preyander Thakur Tags: Case Report Source Type: research

Influence of religiosity and spiritual coping on health‐related quality of life in Saudi haemodialysis patients
This study revealed significant findings regarding the importance of religiosity and SC on the HRQoL of the Saudi HD patients. Therefore, it has been highly recommended to integrate religiosity into the health‐care process for such patients to facilitate the achievement of overall optimum health levels. (Source: Hemodialysis International)
Source: Hemodialysis International - June 20, 2016 Category: Hematology Authors: Jonas Preposi Cruz, Paolo C. Colet, Nahed Alquwez, Ergie P. Inocian, Raid Salman Al‐Otaibi, Sheikh Mohammed Shariful Islam Tags: Original Article Source Type: research

Hemodialysis ‐induced regional left ventricular systolic dysfunction
In this study, we evaluated the prevalence and potential risk factors associated with HD‐induced LV systolic dysfunction and provide some evidences for clinical strategies. Methods We recruited 31 standard HD patients for this study from Fudan University Zhongshan hospital. Echocardiography was performed predialysis, at peak stress during HD (15 minutes prior to the end of dialysis), and 30 minutes after HD. Auto functional imaging (AFI) was used to assess the incidence and persistence of HD‐induced regional wall motion abnormalities (RWMAs). Blood samples were drawn to measure biochemical variables. Findings&emsp...
Source: Hemodialysis International - June 16, 2016 Category: Hematology Authors: Yuxin Nie, Zhen Zhang, Jianzhou Zou, Yixiu Liang, Xuesen Cao, Zhonghua Liu, Bo Shen, Xiaohong Chen, Xiaoqiang Ding Tags: Original Article Source Type: research

Efficacy of beta ‐hydroxy‐beta‐methylbutyrate supplementation in maintenance hemodialysis patients
Discussion These results do not support the efficacy of HMB to attenuate co‐morbid conditions in MHD patients. Moreover, this highlights the need for future interventions targeted at reducing pill burden and improving pill compliance in this population. (Source: Hemodialysis International)
Source: Hemodialysis International - June 13, 2016 Category: Hematology Authors: Peter J. Fitschen, Annabel Biruete, Jinny Jeong, Kenneth R. Wilund Tags: Original Article Source Type: research

Do patient ‐reported measures of symptoms and health status predict mortality in hemodialysis? An assessment of POS‐S Renal and EQ‐5D
Abstract Introduction Experience with the use of patient‐reported outcome measures such as EQ‐5D and the symptom module of the Palliative care Outcome Scale—Renal Version (POS‐S Renal) as mortality prediction tools in hemodialysis is limited. Methods A prospective survival study of people receiving hemodialysis (N = 362). The EQ‐5D and the POS‐S Renal were used to assess symptom burden and self‐rated health (with a self‐rated component). Participants were followed from instrument completion to death or study end. Competing risks survival analysis was used to evaluate associations with time...
Source: Hemodialysis International - May 14, 2016 Category: Hematology Authors: Donal J. Sexton, Aoife C. Lowney, Conall M. O'Seaghdha, Marie Murphy, Tony O'Brien, Liam F. Casserly, Regina McQuillan, William D. Plant, Joseph A. Eustace, Sinead M. Kinsella, Peter J. Conlon Tags: Original Article Source Type: research

Do patient‐reported measures of symptoms and health status predict mortality in hemodialysis? An assessment of POS‐S Renal and EQ‐5D
Abstract Introduction Experience with the use of patient‐reported outcome measures such as EQ‐5D and the symptom module of the Palliative care Outcome Scale—Renal Version (POS‐S Renal) as mortality prediction tools in hemodialysis is limited. Methods A prospective survival study of people receiving hemodialysis (N = 362). The EQ‐5D and the POS‐S Renal were used to assess symptom burden and self‐rated health (with a self‐rated component). Participants were followed from instrument completion to death or study end. Competing risks survival analysis was used to evaluate associations with time...
Source: Hemodialysis International - May 14, 2016 Category: Hematology Authors: Donal J. Sexton, Aoife C. Lowney, Conall M. O'Seaghdha, Marie Murphy, Tony O'Brien, Liam F. Casserly, Regina McQuillan, William D. Plant, Joseph A. Eustace, Sinead M. Kinsella, Peter J. Conlon Tags: Original Article Source Type: research