Efficacy and safety of iloprost in the treatment of pulmonary arterial hypertension: A systematic review and meta-analysis
Pulmonary arterial hypertension (PAH) is a heterogeneous disease characterized by pulmonary vascular construction and remodeling, leading to increased pulmonary vascular resistance (PVR) and elevated mean pulmonary arterial pressure (mPAP). It can induce progressive respiratory distress and right ventricular failure, resulting in premature death.1 The incidence of PAH is approximately 2.4 cases per million people annually, and its prevalence ranges from 15 to 50 cases per million individuals. Moreover, a significant mortality risk of up to 30 % within 3 years indicates a poor prognosis. (Source: Heart and Lung)
Source: Heart and Lung - November 21, 2023 Category: Intensive Care Authors: Rui Zhou, Zhifang Zhao, Jihong Liu, Miao Liu, Fei Xie Source Type: research
Ventilator hyperinflation associated with flow bias optimization in the bronchial hygiene of mechanically ventilated patients
Chest physiotherapy can be used through a variety of techniques with the aim of improving bronchial hygiene in patients admitted to the intensive care unit.1 Patients are mechanically ventilated when gas exchange must be maintained, respiratory muscle work must be relieved, oxygen consumption must be reduced, or when specific therapies must be applied.2 However, these patients also risk pulmonary secretion retention, since orotracheal intubation prevents glottal closure, which is necessary for effective coughing, and reduces mucociliary transport, resulting in a predisposition to pulmonary infection. (Source: Heart and Lung)
Source: Heart and Lung - November 20, 2023 Category: Intensive Care Authors: Guilherme Silva Bonczynski, Juliana Siqueira Novo, Alexandre Sim ões Dias, Luciane de Fraga Gomes Martins, Wagner da Silva Naue, Marcia Souza Volpe, Luiz Alberto Forgiarini Junior Source Type: research
Reduced IgG2 with thrombocytopenia predicts mortality in patients with influenza pneumonia
Seasonal influenza remains an important and lethal infectious disease among humans and is prevalent worldwide. Based on the World Health Organization (WHO) report, approximately 250,000 to 500,000 deaths are attributed to seasonal influenza annually.1 The evolution of virus causes the seasonal epidemics by immunity escape, which enhances the difficulty of prevention and treatment and more accurate prediction clinical markers are needed.2 Influenza can result in respiratory and systemic symptoms. (Source: Heart and Lung)
Source: Heart and Lung - November 18, 2023 Category: Intensive Care Authors: Wenxin Liu, Xiaomei Zhang, Dan Wang, Xiaobo Yu, Shubin Guo, Fei Teng Source Type: research
Evidence-informed development of women-focused cardiac rehabilitation education
Cardiovascular diseases (CVD) are among the leading causes of disability and are the leading cause of death worldwide in men but also – albeit less well-recognized – in women.1 Despite acute care, CVD patients – particularly women – are at much greater risk of recurrent events and death than patients without, necessitating secondary prevention.2 In recent years, there has at last been more research regarding CVD in women, such that clinicians now know more about secondary preventive treatment.3 (Source: Heart and Lung)
Source: Heart and Lung - November 18, 2023 Category: Intensive Care Authors: Gabriela Lima de Melo Ghisi, Andree-Anne Hebert, Paul Oh, Tracey Colella, Crystal Aultman, Carolina Carvalho, Rajni Nijhawan, Marie-Kristelle Ross, Sherry L. Grace Source Type: research
The year of the patient and caregiver
Heart failure persists as one of the most prevalent chronic illnesses in the United States with costs projecting to reach 70 billion by 20301. Heart failure readmission rates are high despite the ongoing advancements in treatment options including medications and device therapies. Many contributing factors lead to the complexity that make up a typical heart failure patient. Socioeconomic status, access to health care centers, race, ethnicity, gender and social support are just a few of the barriers patients must navigate. (Source: Heart and Lung)
Source: Heart and Lung - November 18, 2023 Category: Intensive Care Authors: Amy Corcoran Source Type: research
Venovenous extracorporeal membrane oxygenation for respiratory failure refractory to high frequency percussive ventilation
Lung protective ventilation (LPV) strategies minimize barotrauma and have demonstrated improvement in outcomes in acute respiratory distress syndrome (ARDS), but may fail to maintain adequate gas exchange.1 –3 Venovenous extracorporeal membrane oxygenation (VV ECMO) is commonly considered in appropriate candidates with ARDS refractory to conventional ventilation (CV) and adjuncts including neuromuscular blockade, prone positioning, and inhaled nitric oxide. However, ECMO exposes patients to numerous complications despite otherwise excellent gas exchange capabilities. (Source: Heart and Lung)
Source: Heart and Lung - November 15, 2023 Category: Intensive Care Authors: Berhane Worku, Sandi Khin, Ivan Wong, Ivancarmine Gambardella, Charles Mack, Ankur Srivastava, Monika Tukacs, Felix Khusid, Salik Malik, Sandhya Balaram, Noah Reisman, Iosif Gulkarov Source Type: research
Behavioral interventions and symptom cluster change in adults with chronic obstructive pulmonary disease and insomnia
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality.1 Over 40 % of people with COPD are estimated to have insomnia, and the presence of insomnia in people with COPD has been associated with the prevalence of other symptoms such as dyspnea, fatigue, anxiety, and depression.2,3 Although progressive respiratory symptoms of COPD predicted individuals’ daily fu nction, quality of life, and mortality, lung function measurements may not suffice to predict negative health outcomes. (Source: Heart and Lung)
Source: Heart and Lung - November 15, 2023 Category: Intensive Care Authors: Jeehye Jun, Chang Park, Cynthia Fritschi, Bilgay Balserak, Pamela Martyn-Nemeth, Samuel Kuna, Mary Kapella Source Type: research
“A friendly reminder” – Improving workflow and efficiency in a pulmonary fellows’ outpatient continuity clinic
Continuity clinic for fellowship trainees is a distinct part of the graduate medical education curriculum. This aspect of training exposes fellows to specialty-specific ambulatory practices and cultivates relationships with patients and clinic preceptors. Increasing clinical responsibilities across separate hospital systems, mounting electronic inbox tasks, and growing barriers to patient care help develop pulmonary and critical care medicine (PCCM) fellow's ability to balance inpatient practice with maintaining availability for their clinic patients. (Source: Heart and Lung)
Source: Heart and Lung - November 3, 2023 Category: Intensive Care Authors: Alan Hyslop, Roberto Swazo, Joseph P Smith Source Type: research
Effects of THE PEEP-ZEEP Maneuver in Adults Receiving Mechanical Ventilation: A Systematic Review with Meta-Analysis
Adults receiving mechanical ventilation (MV) may experience a reduction in mucus clearance, leading to a continuous accumulation of large amounts of secretions in the airways.1, 2 This could lead to impaired gas exchange, increased respiratory muscle work, and decreased blood oxygen levels, which in turn increases the risk of mechanical ventilation dependency, causing more secretions to be retained and may increase the risk of pneumonia, creating a cycle.2 –7 (Source: Heart and Lung)
Source: Heart and Lung - November 1, 2023 Category: Intensive Care Authors: Junhong Zhang, Xuling Wang, Jinfeng Xie, Li Shen, Guoxin Mo, Lixin Xie Source Type: research
Integrative review of electrocardiographic characteristics in patients with reduced, mildly reduced, and preserved heart failure
Acute heart failure (AHF) is a rapid decompensation of cardiac function. Most heart failure patients with heart failure symptoms seek treatment in the emergency department and are hospitalized for treatment.1,2 Guideline-directed medical therapy for heart failure is based on types of heart failure categorized based on left ventricular ejection fraction (LVEF). Recent guidelines recommended treatment based on types of heart failure with different cut-offs of LVEF: heart failure with reduced EF (HFrEF, ≤40%), mildly reduced EF (HFmrEF, 41-49%), and preserved EF (HFpEF,>50%). (Source: Heart and Lung)
Source: Heart and Lung - October 30, 2023 Category: Intensive Care Authors: Sunita Pokhrel Bhattarai, Robert Charles Block, Ying Xue, Darcey H Rodriguez, Rebecca G. Tucker, Mary G Carey Source Type: research
Urban Zen integrative therapy: Understanding intervention delivery adherence
Research testing complementary health interventions (CHI) generally emphasizes clinical outcomes, such as symptom management, psychological health, and well-being. Accurate and consistent measurement of CHI dose and delivery is critical to ensure the internal validity of research results. Measuring CHI dose and delivery is one element of a broader concept of treatment fidelity, which “refers to the methodological strategies used to monitor and enhance the reliability and validity of behavioral interventions”1 (p. (Source: Heart and Lung)
Source: Heart and Lung - October 28, 2023 Category: Intensive Care Authors: Tania T. Von Visger, Ji Won Shin, Mary Beth Happ Source Type: research
Factors related to pre-operative cough strength in cardiac surgical patients: a cross-sectional study
Coughing serves as an intrinsic defense mechanism, safeguarding against aspiration and facilitating the clearance of respiratory secretions.1 The evaluation of cough strength presently encompasses various methodologies such as cough peak flow (CPF), White Card Test (WCT), Semiquantitative Cough Strength Score (SCSS), ultrasonic assessment of diaphragm activity, and alterations in tracheal intubation cuff pressure.2 Among these, CPF has gained significant traction as a reliable tool for cough strength assessment due to its portability, simplicity of operation, objective data collection, and bedside application. (Source: Heart and Lung)
Source: Heart and Lung - October 25, 2023 Category: Intensive Care Authors: Yan Zhang, Zheng Lin, Yuhong Chen, Liang Hong, Xiao Shen Source Type: research
Nurse practitioner-led, virtually delivered, motivational enhancement and device support intervention to improve CPAP adherence: A feasibility randomized control trial
Obstructive sleep apnea (OSA) is the most common and costly sleep-related breathing disorder. Over 930 million people worldwide currently have OSA, and approximately 1 in 5 Americans suffer from this chronic health condition.1 The physiologic changes caused by OSA often lead to a range of distressing symptoms (e.g., excessive daytime sleepiness, depression, impairments in memory, attention, and other cognitive domains) and numerous cardiovascular, cerebrovascu lar, and metabolic comorbidities.2,3 These conditions impair social relationships, hinder work performance and safety, increase healthcare utilization, shorten lif...
Source: Heart and Lung - October 23, 2023 Category: Intensive Care Authors: Jennifer N. Miller, Kevin Kupzyk, Cheng Zheng, Chris Wichman, Sharon Schutte-Rodin, Philip Gehrman, Amy Sawyer, Ann M. Berger, Michele C. Balas Source Type: research
Cardiovascular risk trajectory and its associated factors among candidates on the waiting list for deceased-donor kidney transplantation: A longitudinal study
Cardiovascular disease (CVD) is a substantial cause of morbidity and mortality in wait-listed kidney transplantation (KT) candidates,1 constituting the most frequent cause of death within the first few months after transplantation.2 The annual incidence of fatal or nonfatal cardiovascular events in KT recipients ranges from 3.5 % to 5.0 %, exceeding the rate in the general population by 50 times.3,4 Despite the significant disease burden and risk, little is known about the prevention of CVD risk in KT candidates on the waiting list. (Source: Heart and Lung)
Source: Heart and Lung - October 21, 2023 Category: Intensive Care Authors: Hye Jin Chong, Min Kyeong Jang, Hyun Kyung Kim Source Type: research
Causal relationship between asthma and inflammatory bowel disease : A two-sample bidirectional mendelian randomization analysis
Inflammatory bowel disease (IBD) is a chronic, recurrent autoimmune disease that usually includes two closely related but heterogeneous subtypes: Crohn's disease (CD) and ulcerative colitis (UC). In recent years, the incidence of IBD has been on the rise in several countries around the world, posing a heavy burden on public health1-3. IBD can cause many complications such as intestinal perforation, bleeding, and strictures4, meanwhile, studies reported the organs affected by IBD are not limited to the intestine, with approximately 20%-50% of patients reported to have extraintestinal manifestations5, 6. (Source: Heart and Lung)
Source: Heart and Lung - October 14, 2023 Category: Intensive Care Authors: Jianxiong Lai, Bin Fang, Lirong Luo, Wenjie Xie, Yuanhui Xu, Jian Li Source Type: research
