Preparation of mesoporous silica/hydroxyapatite loaded quercetin nanoparticles and research on its antibacterial properties
In this study, amino-functionalized mesoporous silica/hydroxyapatite nanoparticles (MSNS/HAP) with the property of acid dissociation have been prepared as a traditional Chinese medicine monomer carriers to improve the drug loading rate and antibacterial properties of antimicrobial quercetin (QUE) in vitro. The experimental results confirm that the drug loading rate of MSNs/HAP is 28.94 %, which is about 3.6 times higher than that of aminated mesoporous sililca nanoparticles (MSNs). The drug release of QUE on MSNs/HAP is pH-sensitive in phosphate buffered saline (pH=4.0-7.4). The above fabricated traditional Chinese medicin...
Source: Health Physics - April 15, 2024 Category: Physics Authors: Xuan Yi Fang Bao Siyuan Fu Yazhi Yang Yuanyuan Xu Source Type: research
Critical loss of primary implant stability in osteosynthesis locking screws under cyclic overloading
Med Eng Phys. 2024 Apr;126:104143. doi: 10.1016/j.medengphy.2024.104143. Epub 2024 Mar 4.ABSTRACTPrimary implant stability, which refers to the stability of the implant during the initial healing period is a crucial factor in determining the long-term success of the implant and lays the foundation for secondary implant stability achieved through osseointegration. Factors affecting primary stability include implant design, surgical technique, and patient-specific factors like bone quality and morphology. In vivo, the cyclic nature of anatomical loading puts osteosynthesis locking screws under dynamic loads, which can lead t...
Source: Health Physics - April 15, 2024 Category: Physics Authors: Juan D Silva-Henao Sophie Schober Dieter H Pahr Andreas G Reisinger Source Type: research
Validity and reliability of inertial measurement units used to measure motion of the lumbar spine: A systematic review of individuals with and without low back pain
Med Eng Phys. 2024 Apr;126:104146. doi: 10.1016/j.medengphy.2024.104146. Epub 2024 Mar 11.ABSTRACTLow back pain (LBP) is a leading cause of disability, resulting in aberrant movement. This movement is difficult to measure accurately in clinical practice and gold standard methods, such as optoelectronic systems involve the use of expensive laboratory equipment. Inertial measurement units (IMU) offer an alternative method of quantifying movement that is accessible in most environments. However, there is no consensus around the validity and reliability of IMUs for quantifying lumbar spine movements compared with gold standard...
Source: Health Physics - April 15, 2024 Category: Physics Authors: Frederick A McClintock Andrew J Callaway Carol J Clark Jonathan M Williams Source Type: research
Advancing fetal ultrasound diagnostics: Innovative methodologies for improved accuracy in detecting down syndrome
Med Eng Phys. 2024 Apr;126:104132. doi: 10.1016/j.medengphy.2024.104132. Epub 2024 Mar 2.ABSTRACTThis research work explores the integration of medical and information technology, particularly focusing on the use of data analytics and deep learning techniques in medical image processing. Specifically, it addresses the diagnosis and prediction of fetal conditions, including Down Syndrome (DS), through the analysis of ultrasound images. Despite existing methods in image segmentation, feature extraction, and classification, there is a pressing need to enhance diagnostic accuracy. Our research delves into a comprehensive liter...
Source: Health Physics - April 15, 2024 Category: Physics Authors: Dinesh Mavaluru Sahithya Ravali Ravula Jerlin Priya Lovelin Auguskani Santhi Muttipoll Dharmarajlu Amutha Chellathurai Jayabrabu Ramakrishnan Bharath Kumar Mamilla Mugaiahgari Nadana Ravishankar Source Type: research
First in human Phase I Clinical Trial of Stereotactic Irradiation to Achieve Lung Volume Reduction (SILVR) in Severe Emphysema
CONCLUSIONS: Stereotactic Irradiation for Lung Volume Reduction appears to be safe, with a signal for efficacy as a novel therapeutic alternative for patients with severe emphysema. SILVR may be most safe/effective in patients with lower BODE index and/or less parenchymal destruction.PMID:38615887 | DOI:10.1016/j.ijrobp.2024.03.049 (Source: Health Physics)
Source: Health Physics - April 14, 2024 Category: Physics Authors: Devanish N Kamtam Michael S Binkley Ntemena Kapula Cheyenne Sadeghi Shannon Nesbit Haiwei Henry Guo Md Joon Chang Peter G Maxim Maximilian Diehn Billy W Loo Joseph B Shrager Source Type: research
Impact of Hydrodynamic Interactions on the Kinetic Pathway of Protein Folding
Phys Rev Lett. 2024 Mar 29;132(13):138402. doi: 10.1103/PhysRevLett.132.138402.ABSTRACTProtein folding is a fundamental process critical to cellular function and human health, but it remains a grand challenge in biophysics. Hydrodynamic interaction (HI) plays a vital role in the self-organization of soft and biological materials, yet its role in protein folding is not fully understood despite folding occurring in a fluid environment. Here, we use the fluid particle dynamics method to investigate many-body hydrodynamic couplings between amino acid residues and fluid motion in the folding kinetics of a coarse-grained four-α...
Source: Health Physics - April 13, 2024 Category: Physics Authors: Jiaxing Yuan Hajime Tanaka Source Type: research
Diagnostic CT-Enabled Planning (DART): Results of a Randomized Trial in Palliative Radiation Therapy
CONCLUSION: dCT-based radiation planning substantially reduced TIC without detriment in plan deliverability or quality and had a tangible impact on patient experience with reduced patient-reported time burden.PMID:38613562 | DOI:10.1016/j.ijrobp.2024.03.005 (Source: Health Physics)
Source: Health Physics - April 13, 2024 Category: Physics Authors: Melissa O'Neil Joanna M Laba Timothy K Nguyen Michael Lock Christopher D Goodman Elizabeth Huynh Jonatan Snir Vikki Munro Jenna Alce Lidia Schrijver Sylvia Lemay Tara MacDonald Andrew Warner David A Palma Source Type: research
Simulation of time-intensity curve based on k-space filling in breast dynamic contrast-enhanced three-dimensional magnetic resonance imaging
This study elucidated the effects of a three-dimensional k-space trajectory incorporating the partial Fourier (PF) technique on a time-intensity curve (TIC) in a dynamic contrast-enhanced magnetic resonance imaging of a typical malignant breast tumor using a digital phantom. Images were obtained from the Cancer Imaging Archive Open Data for Breast Cancer, and 1-min scans with high temporal resolution were analyzed. The order of the k-space trajectory was set as Linear (sequential), Low-High (centric), PF (62.5%; Z-, Y-, and both directions), and Low-High Radial. k0 (center of the k-space) timing and TIC shape were affected...
Source: Health Physics - April 13, 2024 Category: Physics Authors: Yasuo Takatsu Tsuyoshi Ueyama Takahiro Iwasaki Tomoko Tateyama Tosiaki Miyati Source Type: research
Factorial analysis of the Brazilian-Portuguese version of the Work Ability Index, reproducibility and validity of the single item and the short version for online application
CONCLUSION: The reliability and construct and concurrent validity of the various versions of the WAI were strong to excellent in online applications. Confirmatory factor analysis demonstrated a new grouping of items for the WAI Brazilian version. However, it is necessary to be careful in the choice due to the distribution model of items in health domains and aspects of work.PMID:38613967 | DOI:10.1016/j.bjpt.2024.101060 (Source: Health Physics)
Source: Health Physics - April 13, 2024 Category: Physics Authors: Renata Lumena Altruda Pucci Anderson Martins da Silva Rosimeire Simprini Padula Source Type: research
The effect of the KNEE program for Netball players on the modified Star Excursion Balance Test - a randomized controlled trial
CONCLUSION: The KNEE program when implemented as a warm-up prior to training and match-play can improve postural control in the PM direction which is integral to Netball.PMID:38614047 | DOI:10.1016/j.ptsp.2024.03.004 (Source: Health Physics)
Source: Health Physics - April 13, 2024 Category: Physics Authors: Jane Grayson David Hillard Alanna Antcliff Cliffton Chan Elizabeth Nightingale Evangelos Pappas Source Type: research
Prospective trial of Functional Lung Avoidance Radiation Therapy for Lung Cancer: Quality of Life Report
CONCLUSION: The current work provides an innovative combination of functional avoidance and PROs and is the first report of PROs for patients treated with prospective 4DCT-ventilation functional avoidance. Approximately 30% of patients had clinically significant decline in PROs at 12 months. The study provides additional data on outcomes with 4DCT-ventilation functional avoidance.PMID:38614278 | DOI:10.1016/j.ijrobp.2024.03.046 (Source: Health Physics)
Source: Health Physics - April 13, 2024 Category: Physics Authors: Joseph Lombardo Edward Castillo Richard Castillo Ryan Miller Bernard Jones Moyed Miften Brian Kavanagh Adam Dicker Cullen Boyle Benjamin Leiby Joshua Banks Nicole L Simone Benjamin Movsas Inga Grills Thomas Guerrero Chad G Rusthoven Yevgeniy Vinogradskiy Source Type: research
Stereotactic Radiation for Ultra-Central Non-Small Cell Lung Cancer: A Safety and Efficacy Trial (SUNSET)
CONCLUSIONS: 60 Gy in 8 fractions, planned and delivered with only a moderate hotspot, has a favorable adverse event rate within the pre-specified acceptability criteria, and results in excellent control for UC tumors.PMID:38614279 | DOI:10.1016/j.ijrobp.2024.03.050 (Source: Health Physics)
Source: Health Physics - April 13, 2024 Category: Physics Authors: E Giuliani Meredith Edith Filion Sergio Faria Vijayananda Kundapur Toni Vu Thi Trinh Thuc Benjamin H Lok Srinivas Raman Houda Bahig Joanna M Laba Pencilla Lang Alexander V Louie Andrew Hope George B Rodrigues Andrea Bezjak Marie-Pierre Campeau Marie Duclo Source Type: research
The Effect of Computerized Wobble Board and Core Stabilization Exercises on Balance Performance and Exercise Capacity in Patients with Heart Failure: A Randomized Controlled Trial
CONCLUSION: CWBET and CSET programs were equally effective and safe for improving balance performance and exercise capacity in patients with HF.PMID:38614379 | DOI:10.1016/j.apmr.2024.04.003 (Source: Health Physics)
Source: Health Physics - April 13, 2024 Category: Physics Authors: Habibe Durdu Rengin Demir Melih Zeren Ertan Aydin Zeki Yuksel Gunaydin Zerrin Yigit Source Type: research
Impact of Hydrodynamic Interactions on the Kinetic Pathway of Protein Folding
Phys Rev Lett. 2024 Mar 29;132(13):138402. doi: 10.1103/PhysRevLett.132.138402.ABSTRACTProtein folding is a fundamental process critical to cellular function and human health, but it remains a grand challenge in biophysics. Hydrodynamic interaction (HI) plays a vital role in the self-organization of soft and biological materials, yet its role in protein folding is not fully understood despite folding occurring in a fluid environment. Here, we use the fluid particle dynamics method to investigate many-body hydrodynamic couplings between amino acid residues and fluid motion in the folding kinetics of a coarse-grained four-α...
Source: Health Physics - April 13, 2024 Category: Physics Authors: Jiaxing Yuan Hajime Tanaka Source Type: research
Diagnostic CT-Enabled Planning (DART): Results of a Randomized Trial in Palliative Radiation Therapy
CONCLUSION: dCT-based radiation planning substantially reduced TIC without detriment in plan deliverability or quality and had a tangible impact on patient experience with reduced patient-reported time burden.PMID:38613562 | DOI:10.1016/j.ijrobp.2024.03.005 (Source: Health Physics)
Source: Health Physics - April 13, 2024 Category: Physics Authors: Melissa O'Neil Joanna M Laba Timothy K Nguyen Michael Lock Christopher D Goodman Elizabeth Huynh Jonatan Snir Vikki Munro Jenna Alce Lidia Schrijver Sylvia Lemay Tara MacDonald Andrew Warner David A Palma Source Type: research
