Primary Hodgkin lymphoma: a rare manifestation in the hard palate.
We report one case of 43-year-old white female with an unusualmanifestation extranodal of primary Hodgkin lymphoma in the hard palatewith clinical aspects similar of other infections cutaneous mucosal diseases. Analyses of infectious agents resulted negative. An incisional biopsy showed lymphoplasmocitary infiltrate with presence of Hodgkin and Reed-Sternberg cells, that exhibited immunoreactivity for CD30 and Fascin and nonreactivity for CD15, CD45, CD56, CD20, CD3 and TIA1, supporting a diagnosis of classical Hodgkin lymphoma clinical stage according Ann Arbor I-A. The patient was submitted to 3 cycles of che...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Rapid recurrence and poor prognosis with altered levels of β-catenin in 3 cases of head and neck Squamous cell carcinoma patients.
We report 3 cases which had considerably higher levels of β-catenin and had rapid recurrence within 3 months, 6 months and 15 months respectively followed by very poor prognosis and death.
We speculate presence of resistant cells and higher levels of β-catenin as one of the important prognostic markers for recurrence and therapeutic resistance. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Temperature-dependent fluorescence of IRDye800CW in imaging of head and neck cancers.
Conclusions: TBR is increased with decreasing sample temperature, suggesting that the clinical exam of fluorescently labeled tissues may be improved at cooler temperatures. Our results indicate that both the rate of signal loss and the change in fluorescence with temperature observed for IRDye800CW are independent of the conjugating antibody. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Surveillance of patients with oral potentially malignant disorders using optical imaging: A case series.
Conclusion: These three cases illustrate how autofluorescence imaging can be used over time to gather additional clinical data with potential diagnostic relevance. Specifically, we observed optical changes in OPMD lesions prior to discernable clinical changes prompting the clinician to biopsy. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Neuromuscular injuries after neck surgery and radiotherapy for cancer: A systematic literature review.
Discussion
This review demonstrated that it is impossible to define the incidence of neuromuscular injuries induced by surgery and radiotherapy for head and neck cancer. Levels of evidence were low, descriptions and analyses were incomplete, patient groups were heterogeneous, and the scopes of the studies were too disparate. Easily demonstrated complications such as spinal accessory nerve injuries occupy a predominant place in the literature. Further research is required on other nerve and muscle injuries that remain poorly defined. Despite these gaps in our knowledge, the treatment sequelae can no longer be ignored or n...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Association of Ck17 and Ck 18 with clinical aggressiveness in patients with upper aerodigestive tract carcinoma.
In conclusion, our study demonstrated that positive Ck18 expression is associated with large tumor size in UADTC. Our data indicate that the expressions of Ck17 and Ck18 are associated with the lesser degree ofkeratinisationof the lesions. Finally, when we considered ITF classification, we noticeda significant association with positive Ck17 expression. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Matrix metalloproteinases (MMP-2 and MMP-9) in epithelial dysplasia, verrucous carcinoma oral squamous cell carcinoma.
Factors that represent the potential for invasion and metastasis, such as matrix metalloproteinases (MMPs), could predict prognosis of cancer. Although an important risk factor for oral cancer is the presence of epithelial dysplasia, many lesions will not progress to malignancy. Matrix metalloproteinases (MMPs) are zinc dependent proteinases capable of digesting various structural components of the extracellular matrix. Because MMPs are frequently overexpressed in Oral squamous cell carcinoma (SCC), we found that they are also overexpressed in oral dysplasias which is restricted to the epithelium though; we also found that...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Erratum to: cTNM vs. pTNM: the effect of not applying ultrasonography in the identification of cervical nodal disease.
Erratum
In 2012, Jerjes et al. reported the results of a clinical audit study of patients with head and neck cancer treated at University College London Hospitals. We would like to highlight an error noted in the second paragraph of the materials and methods section of the article. It was stated in the original article that “All applications were accompanied by multidisciplinary team recommendation, ethical approval and informed patient consent”.
As this short communication was an audit study, reporting the benefit of using ultrasonography in the diagnosis of nodal disease, no patient consenting or ethical ...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
HPV infection, GSTM1-GSTT1 genotypes, mitochondrial mutations and tobacco association with oral cancer from northeast India.
Conclusion:
We report for the first time the association of HPV infection with mtDNA mutations from India.Large-scale studies are needed to clarify an individual’s risk to tobacco-betel quid, HPV infection and to determine the pathological significance of these associated mtDNA somatic mutations. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Treatment outcomes in pT4aN0 oral squamous cell carcinoma patients without pathological risk factors.
Conclusions: pT4aN0 OSCC patients without pathological risk factors exhibit a good capacity for disease control and good survival after curative surgery alone. Postoperative radiotherapy did not provide additional benefit for locoregional disease control or survival. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Are the neck malignant melanomas different from the ones affecting the head? Clinicopathologic, dermoscopic and prognostic findings.
Conclusion: Melanomas of the neck must be distinguished from face and scalp melanomas because of younger age, different dermoscopic patterns and ex-naevo origin and better prognosis. These data should be taken into account both from an epidemiological and clinical point of view. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
CXCR4 antagonist inhibits perineural invasion of adenoid cystic carcinoma.
Conclusions
CXCR4 is highly expressed in ACC and is associated with perineural invasion. AMD3100, which can effectively diminish perineural invasion of ACC in vitro and in vivo, may have an adjuvant role in the management of ACC. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Minimally invasive procedure for reconstruction through grafting free fat placed in sternocleidomastoid muscle flap following total parotidectomy with parapharyngeal space dissection.
Conclusions: The free fat grafts in the SCM muscle flap restored facial contour and were preserved over a long period. This minimally invasive procedure is safe and easily performed. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
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(Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
A novel gas chromatography mass spectrometry-based serum screening method for oral squamous cell carcinoma.
In this study, we subjected OSCC patients’ serum samples to gas chromatography/mass spectrometry (GC/MS)-based metabolomic analysis. The serum samples of 18 OSCC patients were used as a training set. Their preoperative serum metabolite levels were compared with those of healthy volunteers. In addition, the pre- and postoperative serum metabolite levels of these patients were also compared. The serum samples collected from another 17 OSCC patients and healthy volunteers were used as a validation set. In addition, 12 patients with oral diseases other than OSCC were also used to evaluate the reliability of the extracted...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
