Expression of hypoxia inducible factor-1 alpha (HIF-1 & #945;) in oral squamous cell carcinoma and its correlation with neoangiogenesis and 3-year survival from the disease.
Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. OSCC falls into a larger category known as head and neck squamous cell carcinomas (HNSCCs). This collection constitutes all squamous cell carcinomas of the oral cavity, larynx, pharynx and oesophagus of which OSCC is the most common. Cancer cells involve morphological cellular transformation, dysregulation of apoptosis, uncontrolled cellular proliferation, invasion, angiogenesis, and metastasis. Also, one of the hallmarks of cancer is the elevated uptake of glucose even under normal oxygen conditions, known as aerobic glycolysis or the & ldq...
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Iatrogenic Horner ’s syndrome with abducent nerve paralysis after cervical schwannoma excision.
Horner & rsquo;s syndrome usually occurs after surgical intervention around carotid artery. A complete intracranial course of abducent nerve prevents its injury during neck surgery. We encountered an unusual complication in a 31-year-old female who underwent schwannoma excision under general anaesthesia. Patient developed Horner & rsquo;s syndrome and lateral rectus palsy in immediate post-operative period. Post-operative investigations did not reveal any abnormality in abducent nerve. Patient was managed conservatively and improved. We believe that either both neural injuries occurred independently or cautery may ...
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Primary non-Hodgkin ’s B cell lymphoma of the thyroid gland: A rare entity.
The clinical and pathologic spectrum of lymphoproliferative disorders affecting the thyroid gland is diverse. The aim of the article is to present a case of primary malignant lymphoma of thyroid, which is relatively uncommon representing less than 5% of all thyroid malignancies. The majority of thyroid lymphomas are diffuse large cell of B-cell origin. A 65 year female   presented with diffuse enlargement of thyroid gland since 20 days. There was no pain or difficulty in swallowing. Cytological findings were suggestive of malignant round cell tumor with closest resemblance to non- Hodgkins lymphoma. On trucut biop...
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Rapid recurrence and poor prognosis with altered levels of & #946;-catenin in 3 cases of head and neck Squamous cell carcinoma patients.
We report 3 cases which had considerably higher levels of & beta;-catenin and had rapid recurrence within 3 months, 6 months and 15 months respectively followed by very poor prognosis and death. We speculate presence of resistant cells and higher levels of & beta;-catenin as one of the important prognostic markers for recurrence and therapeutic resistance. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Expression of Epstein-Barr virus-encoded BamH1 –a rightward transcript 7 microRNA in nasopharyngeal carcinoma cells modulates the responsiveness to irradiation treatment.
  Introduction Nasopharyngeal carcinoma is highly sensitive to irradiation treatment. Expression of Epstein-Barr virus gene products affects the radiosensitivity of these cancer cells. In this paper, the association between the Epstein-Barr virus-encoded BamH1-a rightward transcript 7 microRNA (e bv-miR-BART7) and the effects on irradiation sensitivity was explored. Methods Ebv-miR-BART7 expression level in the tissue was quantified using real-time quantitative polymerase chain reaction. The radiosensitivity of nasopharyngeal carcinoma cells with ebv-miR-BART7 expression was evaluated by colony formation ...
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Efficacy and toxicity of radiotherapy for Graves ’ ophthalmopathy: the University of Athens experience.
Conclusion:Orbital radiotherapy for Graves & rsquo; disease is a well-established treatment option, even if patients have failed previously with other treatment modalities such as corticosteroids and surgical decompression. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Integrin & #945;v & #946;6 as a novel marker for diagnosis and metastatic potential of thyroid carcinoma.
In conclusion, the detection of & alpha;v & beta;6 expression may help to improve diagnostic accuracy and predict metastatic potential for thyroid carcinomas. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Identification of high-risk human papillomaviruse (HPV-16 & 18) infection by multiplex PCR (MPX-PCR) and its expression in oral sub mucous fibrosis and oral squamous cell carcinoma.
This study concluded that multiplex PCR (MPX-PCR) could be helpful for quick screening of HR-HPVs and it is highly convenient, simple and cost-effective tool for large scale multi-institutional study for developing countries. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

High HIF-1 & #945; expression genotypes increase odds ratio of oral cancer.
Conclusions: In conclusion, ou r study demonstrated that the T and A alleles of C1772T and G1790A polymorphisms of the HIF-1 & alpha; gene increased the risk of ED and OSCC. C1772T and G1790A polymorphisms of the HIF-1 & alpha; gene had differing patterns of allelic imbalance in the precancerous lesions and subsequent carcinoma, suggesting a complex genetic pattern of progression from dysplasia to carcinoma. These findings suggest an additional role for HIF-1 & alpha; in OSCC development. Further studies are necessary to elucidate the HIF-1 & alpha; pathway in carcinogenesis, which would facilitate the deve...
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Re-irradiation in Head & Neck cases using IMRT technique: a retrospective study with toxicity and survival report.
Conclusion: The IMRT technique allows the re-irradiation with safety and tolerated toxicity. However, future prospective studies of these approaches with much more patients are warranted. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

High hypoxia-inducible factor-1 & #945; expression genotype associated with Eastern Cooperative Oncology Group performance in head and neck squamous cell carcinoma.
Conclusions: In conclusion, our study demonstrated that the C1772T and polymorphism of the HIF-1 & alpha; gene are associated with poor ECOG-PS. Our data suggests that the presence of the TT genotype in HNSCC individuals might contribute to the higher clinical aggressiveness of malignant disease. Such findings may have implications for interruptions in the disease process and modifications in treatment regiments. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Cred é A, Locher M, Bredell M. Tongue cancer in young patients: case report of a 26-year-old patient. Head Neck Oncol. 2012 May 14;4(1):20.
This article presents the case of a 26-year-old woman with tongue cancer. The median age at the diagnosis of the tongue & rsquo;s cancer is 61 & thinsp;years. Only approximately 2% of patients are diagnosed before the age of 35. Case presentation Our patient survived acute myeloid leukemia (AML) before her second year. She had been having recurrent, poorly healing aphtae on the right side of the tongue for a period of months before the symptoms of the tongue cancer appeared. As a treatment a partial glossectomy was con ducted on the right side and a neck dissection of levels I-III. Than a reconstruction of the...
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Shen WQ, Cheng KJ, Bao YY, Zhou SH, Yao HT. Expression of Glut-1, HIF-1 & #945;, PI3K and p-Akt in a case of ceruminous adenoma. Head Neck Oncol. 2012 May 2;4(1):18.
Conclusions Ceruminous adenoma of the EAC is a rare tumour. The treatment of choice is wide local excision with clear margins. To our knowledge, this is the first report of Glut-1 expression and the PI3K/Akt pathway in ceruminous adenoma of the EAC. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Gon çalves JJ, Rocha AM. A decision support system for quality of life in head and neck oncology patients. Head Neck Oncol. 2012 Feb 16;4:3.
Conclusions The possibility of representing graphically useful results that physician needs to analyze in the appointment, immediately after the answer collection, in an useful time, makes this QoL assessment platform a diagnosis instrument ready to be used routinely in clinical practice. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Gerber S, Gengler C, Gr ätz KW, Kruse AL. The impact of frozen sections on final surgical margins in squamous cell carcinoma of the oral cavity and lips: a retrospective analysis over an 11 years period. Head Neck Oncol. 2011 Dec 30;3:56.
Conclusions Our data suggests that intraoperative FS in SCC can be useful in selected case s. However it is not advisable as a routine approach. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Kim K, Amonkar MM, H ögberg D, Kasteng F. Economic burden of resected squamous cell carcinoma of the head and neck in an incident cohort of patients in the UK. Head Neck Oncol. 2011 Oct 28;3:47.
Conclusions In the UK, SCCHN patients after surgical resection needed considerable healthcare resources and incurred substantial costs. Study findings might provide a useful source for clinicians and decision makers in understanding the economic burden of managing SCCHN in the UK and also sugge sts a need for new therapies that could improve outcomes and reduce the disease burden. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Wiskirska-Wo & #378;nica B, Leszczy & #324;ska M, Swidzi & #324;ski, Czerniejewska H, Jackowska J, Witold S. Voice estimation in patients after reconstructive subtotal laryngectomy. Head Neck Oncol. 2011 Oct 26;3:46.
Conclusions The perceptual voice estimation revealed a good phonation result in only 3 cases after using surgery with the Calearo method as well as the best results of MPT. The VHI reflected severe voice handicap in 2 patients (26 to 40 poin ts). No statistically significant differences were observed between the values of the acoustic parameters in MDVP analysis after following operation -CHEP, Calearo, Sedlacek. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Cordella C, Luebbers HT, Rivelli V, Gr ätz KW, Kruse AL. An evaluation of the preoperative hemoglobin level as a prognostic factor for oral squamous cell carcinoma. Head Neck Oncol. 2011 Aug 15;3:35.
Conclusion Our data suggests that an Hb of below 11 g/dl contributes to and is an indicator for a poor prognosis. Consequently, pre-treatment Hb corrections may significantly improve outcome, but further investigations, including blood transfusion/application of erythropoietin due to tumor anem ia, independent of intraoperative blood-loss are necessary to ascertain their role in an improved survival. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Eckardt AM, Kokem üller H, Tavassol F, Gellrich NC. Reconstruction of oral mucosal defects using the nasolabial flap: clinical experience with 22 patients. Head Neck Oncol. 2011 May 23;3:28.
Conclusions The nasolabial flap is a valuable alternative for reconstruction of smaller defects of the oral cavity in particular in older and medically compromised patients. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Schwager K, Villa A, R ösli C, Neri D, Rösli-Khabas M, Moser G. A comparative immunofluorescence analysis of three clinical-stage antibodies in head and neck cancer. Head Neck Oncol. 2011 May 8;3:25.
Conclusions These results suggests that an individualized treatment procedure (e.g., choice of L19, F8 or F 16 based on immuno-PET or immunofluorescence procedure) may represent the most logical avenue for offering the best possible antibody to any given patient. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Rana M, Warraich R, Kokem üller H, Lemound J, Essig H, Tavassol F, Eckardt A, Gellrich NC. Reconstruction of mandibular defects - clinical retrospective research over a 10-year period -. Head Neck Oncol. 2011 Apr 28;3:23.
Conclusion Based on this study, autogenous bone grafts are a reliable treatment modality for the reconstruction of mandibular bone defects with predic table aesthetic and functional outcomes. As the free vascularized fibular flap has the least resorption and failure rate, it should be the first choice for most cases of mandiblular reconstruction. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Moser S, Beer M, Damerau G, L übbers HT, Grätz KW, Kruse AL. A case report of metastasis of malignant mesothelioma to the oral gingiva. Head Neck Oncol. 2011 Apr 22;3:21.
Conclusion This article highlights the importance of biopsy and histopathological diagnosis of oral lesions especially in case of a malignant history. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Peltonen JK, V ähäkangas KH, Helppi HM, Bloigu R, Pääkkö P, Turpeenniemi-Hujanen T. Specific TP53 mutations predict aggressive phenotype in head and neck squamous cell carcinoma: a retrospective archival study. Head Neck Oncol. 2011 Apr 22;3:20.
Conclusions These data indicate that a TP53 mutation in L2, L3 or LSH is worth pursuing as a marker for predicting prognosis and response to radiation among HNSCC patients. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Rivelli V, Luebbers HT, Weber FE, Cordella C, Gr ätz KW, Kruse AL. Screening recurrence and lymph node metastases in head and neck cancer: the role of computer tomography in follow-up. Head Neck Oncol. 2011 Mar 25;3:18.
Conclusion Routine CT for follow-up is still indicated for detecting lymph node metastases as well as local recurrence. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Kom ínek P, Stárek I, Geierová M, Matoušek P, Zeleník K. Phosphaturic mesenchymal tumour of the sinonasal area: case report and review of the literature. Head Neck Oncol. 2011 Mar 16;3:16.
Conclusion PMT is rare in the sinonasal region, it can be rarely observed without the signs of osteomalacia. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Kruse AL, Luebbers HT, Gr ätz KW. Evaluation of white blood cell count as a possible prognostic marker for oral cancer. Head Neck Oncol. 2011 Feb 27;3:13.
Conclusion In conclusion, our findings demonstrate that elevated WBC count does not seem to be a predictor fo r recurrence or for further metastases. Further research is recommended to investigate the WBC count in precancerous lesions and in HPV positive patients with oral SCC. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Kruse AL, Luebbers HT, Obwegeser JA, Bredell M, Gr ätz KW. Evaluation of the pectoralis major flap for reconstructive head and neck surgery. Head Neck Oncol. 2011 Feb 27;3:12.
Conclusion The PMMF is a flap for huge defects in head and neck reconstructive surgery, in particular when a bulky flap is needed in order to cover the carotid artery or reconstructive surgery, but the complication rate should not be underestimated in particular after radiotherapy. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Tavassol F, Starke OF, Kokem üller H, Wegener G, Müller-Tavassol CC, Gellrich NC, Eckardt A. Prognostic significance of heat shock protein 70 (HSP70) in patients with oral cancer. Head Neck Oncol. 2011 Feb 23;3:10.
Conclusions The survival of patients suffering from T2 tumors with positive HSP70 expression was 8 times higher than that for patients with negative HSP70 expression, suggesting that T1-T2 tumors of OSCC with low expression of HSP70 require more radical treatment. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

St Guily JL, Clavel C, Oka ïs C, Prétet JL, Beby-Defaux A, Agius G, Birembaut P, Jacquard AC, Léocmach Y, Soubeyrand B, Riethmuller D, Denis F, Mougin C. Human papillomavirus genotype distribution in tonsil cancers. Head Neck Oncol. 2011 Feb 7;3(1):6.
Conclusions Our results indicate that HPV is common in tonsil carcinomas and emphasize the predominant role of HPV 16. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Silveira AP, Gon çalves J, Sequeira T, Ribeiro C, Lopes C, Monteiro E,Pimentel FL. Geriatric oncology: comparing health related quality of life in head and neck cancer patients. Head Neck Oncol. 2011 Jan 13;3:3.
Conclusions Geriatric oncology assessments signalize age-independent indicators t hat might guide oncologic geriatric care optimization. Decision-making in geriatric oncology must be based on tumour characteristics and chronological age but also on performance status evaluation, co-morbidity, and patient reported outcomes assessment. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Peltonen JK, Helppi HM, P ääkkö P, Turpeenniemi-Hujanen T, Vähäkangas KH. p53 in head and neck cancer: functional consequences and environmental implications of TP53 mutations. Head Neck Oncol. 2010 Dec 15;2:36.
Conclusions Our study contributes to the knowledge of cumulative chemical exposure and p53 aberrations in head and neck cancer, an area where literature is scarce. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Jensen AD, Bergmann ZP, Garcia-Huttenlocher H, Freier K, Debus J, M ünter MW. Cetuximab and radiation for primary and recurrent squamous cell carcinoma of the head and neck (SCCHN) in the elderly and multi-morbid patient: a single-centre experience. Head Neck Oncol. 2010 Nov 26;2:34.
Conclusion RIT is a feasible treatment option for elderly and multi-morbid patients with promising therapeutic activity. Long-term disease control can also be achieved in patients receiving RIT for re-irradiation. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Silveira AP, Gon çalves J, Sequeira T, Ribeiro C, Lopes C, Monteiro E, Pimentel FL. Patient reported outcomes in head and neck cancer: selecting instruments for quality of life integration in clinical protocols. Head Neck Oncol. 2010 Oct 31;2:32.
Conclusions This study emphases the importance in selecting the appropriate tool as a critical success factor in implementing routine Health Related Quality of Life assessment in clinical practice. This decision assumes particularly importance when utilization of results in real time and integr ation into clinical protocols are considered. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Kruse AL, Bredell M, Luebbers HT, Gr ätz KW. Head and neck cancer in the elderly: a retrospective study over 10 years (1999 - 2008). Head Neck Oncol. 2010 Oct 5;2:25.
Conclusion The group of patients with head and neck cancer who were older than 70 years was characterized by a higher portion of female patients, a higher number of maxillary carcinomas, and a higher prevalence of pre vious second cancer. Making decisions in cancer therapy for elderly patients is challenging. Patients suffering from operable head and neck cancer should be treated with curative intent and with regard to quality of life if a careful assessment of comorbidities is performed preoperatively. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Kruse AL, Bredell M, Gr ätz KW. Oral squamous cell carcinoma in non-smoking and non-drinking patients. Head Neck Oncol. 2010 Oct 4;2:24.
Conclusion The group of patients with no tobacco and alcohol use tends toward a higher proportion of females, a higher proportion of patien ts over 70 years, and a higher number of oral maxillary SCC. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

St Guily JL, Borget I, Vainchtock A, R émy V, Takizawa C. Head and neck cancers in France: an analysis of the hospital medical information system (PMSI) database. Head Neck Oncol. 2010 Sep 1;2:22.
Conclusion Even without taking into account the rehabilitation costs, the hospital burden of H & amp;N cancers is considerable. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Kruse AL, Luebbers HT, Gr ätz KW. C-reactive protein levels: a prognostic marker for patients with head and neck cancer? Head Neck Oncol. 2010 Aug 2;2:21.
Conclusion Our findings do not appear to support a correlation between preoperative CRP levels and development of recurrence or metastases. In further studies, CRP levels in precancerous lesions and in Human Papilloma Virus (HPV) positive patients with ora l squamous cell carcinoma (SCC) should be studied. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Scholz M, Parvin R, Thissen J, L öhnert C, Harders A, Blaeser K. Skull base approaches in neurosurgery. Head Neck Oncol. 2010 Jul 5;2:16.
The skull base surgery is one of the most demanding surgeries. There are different structures that can be injured easily, by operating in the skull base. It is very important for the neurosurgeon to choose the right approach in order to reach the lesion without harming the other intact structures. Due to the pioneering work of Cushing, Hirsch, Yasargil, Krause, Dandy and other dedicated neurosurgeons, it is possible to address the tumor and other lesions in the anterior, the mid-line and the posterior cranial base. With the transsphenoidal, the frontolateral, the pterional and the lateral suboccipital approach nearly every...
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

HPV & head and neck cancer: a descriptive update.
The incidence of head and neck squamous cell carcinoma (HNSCC) has been gradually increasing over the last three decades. Recent data have now attributed a viral aetiology to a subset of head and neck cancers. Several studies indicate that oral human papillomavirus (HPV) infection is likely to be sexually acquired. The dominance of HPV 16 in HPV+ HNSCC is even greater than that seen in cervical carcinoma of total worldwide cases. Strong evidence suggests that HPV+ status is an important prognostic factor associated with a favourable outcome in head and neck cancers. Approximately 30 to 40% of HNSCC patients with present wi...
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Identification of potential therapeutic targets in human head & neck squamous cell carcinoma.
Conclusion Five genes and their products may serve as a diagnostic biomarker or therapeutic target for HNSCC. While additional work is needed to elucidate the biological significance of these proteins, CD24 and CD74 expressed only in small proportion of cells indicating tumor heterogeneity and subtypes of tumor initiating cells (CD24+/CD44+) present in HNSCC. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Head & neck optical diagnostics: vision of the future of surgery.
Review paper and Proceedings of the Inaugural Meeting of the Head and Neck Optical Diagnostics Society (HNODS) on March 14th 2009 at University College London. The aim of our research must be to provide breakthrough translational research which can be applied clinically in the immediate rather than the near future. We are fortunate that this is indeed a possibility and may fundamentally change current clinical and surgical practice to improve our patients & #39; lives. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Head & Neck Oncology: purpose, scope and goals-charting the future.
For many years now there has been a growing frustration with the statistics of head and neck cancer. Despite the many advances in diagnosis and therapy, there has been little change in the prognosis for most cancers of the head and neck in the last 50 years, so what is the point of yet another journal? Well, it is not all bad news. Declaration   (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment.
Head & amp; Neck Cancer (HNC) represents the sixth most common malignancy worldwide and it is historically linked to well-known behavioural risk factors, i.e., tobacco smoking and/or the alcohol consumption. Recently, substantial evidence has been mounting that Human Papillomavirus (HPV) infection is playing an increasing important role in oral cancer. Because of the attention and clamor surrounding oral HPV infection and related cancers, as well as the use of HPV prophylactic vaccines, in this invited perspective the authors raise some questions and review some controversial issues on HPV infection and its role in HNC...
Source: Head and Neck Oncology - July 21, 2016 Category: Cancer & Oncology Source Type: research

Bone reconstruction and optic functional restoration after fronto-orbital fibrous dysplasia resection.
The article has been forwarded to the production team. The processing may take few weeks. Then the proof will be forwarded to the corresponding author. The final PDF and HTML files will be uploaded when the corrections to the proof are returned by the corresponding author. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

Immunoprofile of primary gingival angiosarcoma: A case report and review of the literature.
The angiosarcoma of the oral cavity is extremely rare, with only a few such cases reported in the literature. We used a case of primary gingival angiosarcoma arising in maxilla as an opportunity to review the clinicopathological and immunohistochemical profile of this tumor in the oral cavity. A 59-years-old man had a fibrous mass involving the gingival and alveolar mucosa in the maxillary left molar region associated with extensive bone destruction. A biopsy was performed and the tumor was histopathologically diagnosed as angiosarcoma. Whereas that early diagnosis is crucial and that the definitive diagnosis of angiosarco...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

Management of oral carcinoma in a patient with severe trimus using a novel approach.
Trismus is often present in patients diagnosed with oral malignancy. Trismus is a debilitating condition and is treated adequately with release of fibrosis and interposition of vascularised tissue to provide long term improvement in mouth opening. Treatment of an oral cancer in a patient with trismus becomes challenging because of difficult access and further deterioration of mouth opening following treatment of the malignancy. Herein we describe the planning of access and management of oral carcinoma with severe trismus using nasolabial flaps. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

Bilateral dentigerous cyst in non-syndromic patient: Case report and review of literature.
The objective of this work is to report a case of bilateral dentigerous cyst in the anterior region of the maxilla in a  43 years-old woman referred to the oral and maxillofacial surgery department, Dentistry Faculty of Bauru, University of São Paulo with absence of the upper canine teeth. Radiographic examination showed the teeth impacted maxillary cuspids and two unilocular radiolucent  independent. Incisional biopsy was performed and the diagnosis of lesions was of dentigerous cyst. The proposed treatment was surgical enucleation of the cyst and the removal of impacted teeth under general anesthesia. Th...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

Assessment of voice related quality of life and its correlation with socioeconomic status after total laryngectomy.
Conclusion- VHI and V-RQOL scores in our series were superior to other studies due to major population with lower socioeconomic status and better social support which exists in our society. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

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(Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

Human papilloma virus in head and neck carcinoma: Experience from a regional cancer center in Gujarat.
Aim: We investigated the etiological role of HPVs in patients with head and neck cancers and aimed to study its detection tumor tissues taken cancer patients.Methods: 100 patients with malignancies of buccal mucosa, tongue and right maxilla were included in the study. Tumor biopsy was taken for histopathology and molecular studies for by multiplex PCR. Results: Out of 100 head and neck cancers, 81 % were males and 19 % females, 69% belonged to age>50 yrs and 31 % were 50yrs of age and, old heavy drinkers and heavy smokers. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research