Potential of molecular classification to guide fertility-sparing management among young patients with endometrial cancer
Gynecol Oncol. 2024 Feb 24;185:121-127. doi: 10.1016/j.ygyno.2024.02.020. Online ahead of print.ABSTRACTThe traditional histological classification system for endometrial carcinoma falls short in addressing the disease's molecular heterogeneity, prompting the need for alternative stratification methods. Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) has emerged as a clinically efficient tool to categorize endometrial cancers according to mismatch repair deficiency, POLE exonuclease domain mutations, and p53 expression. However, the application of this classification to fertility-sparing treatments rem...
Source: Gynecologic Oncology - February 25, 2024 Category: Cancer & Oncology Authors: Nuria Agusti Alexa Kanbergs Roni Nitecki Source Type: research
Potential of molecular classification to guide fertility-sparing management among young patients with endometrial cancer
Gynecol Oncol. 2024 Feb 24;185:121-127. doi: 10.1016/j.ygyno.2024.02.020. Online ahead of print.ABSTRACTThe traditional histological classification system for endometrial carcinoma falls short in addressing the disease's molecular heterogeneity, prompting the need for alternative stratification methods. Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) has emerged as a clinically efficient tool to categorize endometrial cancers according to mismatch repair deficiency, POLE exonuclease domain mutations, and p53 expression. However, the application of this classification to fertility-sparing treatments rem...
Source: Gynecologic Oncology - February 25, 2024 Category: Cancer & Oncology Authors: Nuria Agusti Alexa Kanbergs Roni Nitecki Source Type: research
Racial disparities in endometrial cancer: Where are we after 26 years?
CONCLUSION: Racial disparities in disease incidence and mortality in endometrial cancer rates between WAW and AAW have widened during a 26-year period of robust research, suggesting that current research alone is not enough to eliminate this disparity. Based on this rapid systematic review we have identified and analyzed the impact of causation variables on this disparity. Additionally, we have made strong and pertinent recommendations for the benefit of mitigating this escalating racial disparity.PMID:38382150 | DOI:10.1016/j.ygyno.2024.01.054 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Michael L Hicks Maya M Hicks Roland P Mathews Dineo Khabele Camille A Clare Onyinye Balogun Yolanda R Lawson Ronda Henry Tillman Raleigh Butler Cyril O Spann Groesbeck P Parham Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Incidence and risk factors of venous and arterial thromboembolic events among patients with ovarian cancer- data from a large Canadian database
CONCLUSIONS: Risk factors predictive of thrombosis in ovarian cancer patients are not consistent between ATE and VTE, thus thrombotic events should not be combined for analysis. Differential thrombosis risk assessment is needed to improve prevention strategies and guide thromboprophylaxis for these patients.PMID:38382168 | DOI:10.1016/j.ygyno.2024.02.011 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Sydney Penfound Alexandra Lukey Jessica Hodgson Wilma M Hopman Gillian E Hanley Maha Othman Source Type: research
Racial disparities in endometrial cancer: Where are we after 26 years?
CONCLUSION: Racial disparities in disease incidence and mortality in endometrial cancer rates between WAW and AAW have widened during a 26-year period of robust research, suggesting that current research alone is not enough to eliminate this disparity. Based on this rapid systematic review we have identified and analyzed the impact of causation variables on this disparity. Additionally, we have made strong and pertinent recommendations for the benefit of mitigating this escalating racial disparity.PMID:38382150 | DOI:10.1016/j.ygyno.2024.01.054 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Michael L Hicks Maya M Hicks Roland P Mathews Dineo Khabele Camille A Clare Onyinye Balogun Yolanda R Lawson Ronda Henry Tillman Raleigh Butler Cyril O Spann Groesbeck P Parham Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Incidence and risk factors of venous and arterial thromboembolic events among patients with ovarian cancer- data from a large Canadian database
CONCLUSIONS: Risk factors predictive of thrombosis in ovarian cancer patients are not consistent between ATE and VTE, thus thrombotic events should not be combined for analysis. Differential thrombosis risk assessment is needed to improve prevention strategies and guide thromboprophylaxis for these patients.PMID:38382168 | DOI:10.1016/j.ygyno.2024.02.011 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Sydney Penfound Alexandra Lukey Jessica Hodgson Wilma M Hopman Gillian E Hanley Maha Othman Source Type: research
Racial disparities in endometrial cancer: Where are we after 26 years?
CONCLUSION: Racial disparities in disease incidence and mortality in endometrial cancer rates between WAW and AAW have widened during a 26-year period of robust research, suggesting that current research alone is not enough to eliminate this disparity. Based on this rapid systematic review we have identified and analyzed the impact of causation variables on this disparity. Additionally, we have made strong and pertinent recommendations for the benefit of mitigating this escalating racial disparity.PMID:38382150 | DOI:10.1016/j.ygyno.2024.01.054 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Michael L Hicks Maya M Hicks Roland P Mathews Dineo Khabele Camille A Clare Onyinye Balogun Yolanda R Lawson Ronda Henry Tillman Raleigh Butler Cyril O Spann Groesbeck P Parham Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Incidence and risk factors of venous and arterial thromboembolic events among patients with ovarian cancer- data from a large Canadian database
CONCLUSIONS: Risk factors predictive of thrombosis in ovarian cancer patients are not consistent between ATE and VTE, thus thrombotic events should not be combined for analysis. Differential thrombosis risk assessment is needed to improve prevention strategies and guide thromboprophylaxis for these patients.PMID:38382168 | DOI:10.1016/j.ygyno.2024.02.011 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Sydney Penfound Alexandra Lukey Jessica Hodgson Wilma M Hopman Gillian E Hanley Maha Othman Source Type: research
Racial disparities in endometrial cancer: Where are we after 26 years?
CONCLUSION: Racial disparities in disease incidence and mortality in endometrial cancer rates between WAW and AAW have widened during a 26-year period of robust research, suggesting that current research alone is not enough to eliminate this disparity. Based on this rapid systematic review we have identified and analyzed the impact of causation variables on this disparity. Additionally, we have made strong and pertinent recommendations for the benefit of mitigating this escalating racial disparity.PMID:38382150 | DOI:10.1016/j.ygyno.2024.01.054 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Michael L Hicks Maya M Hicks Roland P Mathews Dineo Khabele Camille A Clare Onyinye Balogun Yolanda R Lawson Ronda Henry Tillman Raleigh Butler Cyril O Spann Groesbeck P Parham Source Type: research
Risk of borderline ovarian tumors after fertility treatment - Results from a Danish cohort of infertile women
CONCLUSIONS: No marked associations between use of fertility drugs and borderline ovarian tumors were observed. However, the cohort's relatively young age at end of follow-up emphasizes the importance of extending the follow-up period for women who have used fertility drugs.PMID:38382167 | DOI:10.1016/j.ygyno.2024.02.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Anna Kj ær Kristensen Clarissa Lima Brown Frandsen Bugge N øhr Jakob Hansen Viuff Marie Hargreave Kirsten Frederiksen Susanne K Kj ær Allan Jensen Source Type: research
Incidence and risk factors of venous and arterial thromboembolic events among patients with ovarian cancer- data from a large Canadian database
CONCLUSIONS: Risk factors predictive of thrombosis in ovarian cancer patients are not consistent between ATE and VTE, thus thrombotic events should not be combined for analysis. Differential thrombosis risk assessment is needed to improve prevention strategies and guide thromboprophylaxis for these patients.PMID:38382168 | DOI:10.1016/j.ygyno.2024.02.011 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 21, 2024 Category: Cancer & Oncology Authors: Sydney Penfound Alexandra Lukey Jessica Hodgson Wilma M Hopman Gillian E Hanley Maha Othman Source Type: research
Determination of quality of life-related health utilities for surgical complications in ovarian cancer
CONCLUSIONS: This study establishes health state utilities for surgical complications associated with ovarian cancer. These utilities can be used in future cost-effectiveness evaluations to determine quality-adjusted outcomes and may help in counseling patients during the shared decision-making process.PMID:38377761 | DOI:10.1016/j.ygyno.2024.01.041 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 20, 2024 Category: Cancer & Oncology Authors: Rudy S Suidan Charlotte C Sun Amy K Schneider Karen H Lu Sharon H Giordano Larissa A Meyer Source Type: research
