Tumor molecular profiling of responders and non-responders following pembrolizumab monotherapy in chemotherapy resistant advanced cervical cancer
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): N.Y.L. Ngoi, V. Heong, X.W. Lee, Y.Q. Huang, Y.L. Thian, B.A. Choo, D. Lim, Y.W. Lim, S.E. Lim, A. Ilancheran, R. Soong, D.S.P. TanAbstractOptimal treatment for advanced cervical cancer after first line chemotherapy remains undefined. Immune checkpoint inhibition with pembrolizumab, a programmed cell death protein 1(PD-1) inhibitor, is under investigation. We analyzed the micro-environmental and molecular genetic profile of tumors from 4 patients with metastatic cervical cancer treated with off-label second-line pembrolizumab in an effort t...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Using gene expression in patients with endometrial intraepithelial neoplasia to assess the risk of cancer
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): Koah Vierkoetter, Jennifer Wong, Hyeong Jun Ahn, David Shimizu, Laura Kagami, Keith TeradaAbstractPatients diagnosed with an endometrial cancer precursor lesion on biopsy may be found to have endometrial cancer at the time of subsequent surgery. The current study seeks to identify patients with endometrial intraepithelial neoplasia (EIN) on biopsy that may be harboring an occult carcinoma. Immunohistochemical stains for gene loss of expression (LOE) for 6 genes, PTEN, ARID1A, MSH6, MSH2, MLH1, and PMS2, were performed on 113 biopsy specimen...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): Liron Kogan, David Octeau, Zainab Amajoud, Jeremie Abitbol, Ido Laskov, Alex Ferenczy, Manuela Pelmus, Neta Eisenberg, Roy Kessous, Susie Lau, Amber Yasmeen, Walter H. Gotlieb, Shannon SalvadorAbstractObjectiveEvaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC).MethodsRetrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LUSI. Genes commonly implicated in carcinogenesis we...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Laparoscopic ovarian transposition prior to pelvic radiation for gynecologic cancer
This study evaluates a novel technique of laparoscopic ovarian transposition performed by Gynecologic Oncologists prior to pelvic radiation for gynecologic cancer. A retrospective review was completed of all patients that underwent laparoscopic ovarian transposition from February 2007 to June 2017 at one tertiary care cancer. The technique involves salpingectomy, followed by retroperitoneal dissection to move the ovaries lateral to the hepatic and splenic flexures of the colon. Normal ovarian function was defined by the absence of vasomotor symptoms, FSH and menstrual history (if menstruating). The radiation dose to the ov...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Human papillomavirus genotypes in Pacific Islander cervical cancer patients
ConclusionPacific Islanders referred to TAMC present with a disproportionally higher rate of regional and advanced disease. Significantly, only 28% of invasive cervical cancers in the Pacific Island population sampled could have been potentially be prevented using the available quadrivalent vaccine targeting HPV 16/18; however, 88% could be covered by the recently licensed nonavalent vaccine. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Using advanced wound care and hyperbaric oxygen to manage wound complications following treatment of vulvovaginal carcinoma
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): C. Griffiths, R.S. Howell, H. Boinpally, E. Jimenez, E. Chalas, F. Musa, S. GorensteinAbstractPostoperative management of patients with vulvar cancer is associated with a high incidence of poor wound healing and radiation -induced late tissue necrosis. This case series demonstrates the impact on wound healing with the use of hyperbaric oxygen therapy and advanced wound care following radical vulvectomy and/or radiation therapy.A retrospective case series was performed of all patients from 2016 to 2017 with lower genital cancer who underwent...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Publication rates of podium and poster abstract presentations at the 2010 and 2011 society of gynecologic oncology conferences
ConclusionsA 53% publication rate indicates that the SGO conference selection process favors research likely to be published and, thus, presumably of high quality. The overall publication rate is higher than that reported for many other biomedical conferences. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Letter to the editor regarding the manuscript entitled: “Variations in gynecologic oncology training in low (LIC) and middle income (MIC) countries (LMICs): Common efforts and challenges” by Carolyn Johnston et al. (Gyneco Oncol Rep 2017; 20: 9–14)
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): Nadia Srur-Rivero, Francisco Fuster-Alfaro, Manuel Araya-Vargas, Ana Lucrecia Araya-Fallas (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Evidence-based improvisation: Facing the challenges of cervical cancer care in Uganda
We describe the ways in which a small but dedicated group of gynecologists carefully use limited evidence and available resources creatively to provide the best possible care for their patients. We show that improvisation, albeit evidence-based, is central to the nature and success of oncology care in Africa (Livingston, 2012). We argue that a “recalibrated global response” (Farmer et al., 2010), particularly stressing the expansion of radiotherapy capabilities, could dramatically improve cancer care and outcomes for women in Uganda as well as in LMICs globally. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Extraovarian sex cord tumor with annular tubules discovered arising from a leiomyoma
ConclusionThis is the first extraovarian SCTAT in the published literature arising from a leiomyoma. Our patient had no family history and displayed no syndromic features for Peutz-Jeghers Syndrome. Ultimately, she declined genetic testing. The lack of evidence of ovarian involvement on both imaging and on intraoperative examination made localization to either ovary impossible. The patient is currently being managed with surveillance since the morbidity associated with bilateral oophorectomy in the 4th decade of life exceeds the theoretical risk of SCTAT. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Polymyositis as a presentation of advanced carcinoma of Mullerian origin: A case report and discussion
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Catherine Dieffenbach, Sara Bouberhan, Elizabeth Raynor, Meghan Shea, Fong Liu (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Advancing clinical research globally: Cervical cancer research network from Mexico
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Bryan J. Ager, Dolores Gallardo-Rincón, David Cantú de León, Adriana Chávez-Blanco, Linus Chuang, Alfonso Dueñas-González, Eva Gómez-García, Roberto Jerez, Anuja Jhingran, Mary McCormack, Linda Mileshkin, Carlos Pérez-Plasencia, Marie Plante, Andrés Poveda, David K. GaffneyAbstractCervical cancer is the fourth most common cancer in women with 85% of the mortality burden occurring in less-developed regions of the world. The Cervix Cancer Research Network (CCRN) was foun...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Ovarian microcystic stromal tumor: Radiologic-pathologic correlation
We present a case of a 66 year old female who presented for evaluation of a new cystic pelvic mass found to have ovarian microcystic stromal tumor. To our knowledge, this is one of the first reports to evaluate the radiologic features associated with this tumor. An enhanced understanding of the correlation between imaging appearance and specific histopathologic findings may aid in the early recognition of this rare neoplasm. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Adjuvant therapy after radical trachelectomy for stage I cervical cancer
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Sarah Z. Hazell, Rebecca L. Stone, Jeffrey Y. Lin, Akila N. Viswanathan (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Clear cell carcinoma of the pelvic side wall arising from endometriosis
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Lisa N. Abaid, John S. Cupp, Miles Chang, Steven R. Beanes, Bram H. GoldsteinAbstractEndometriosis is a condition wherein an ectopic layer of endometrial tissue arises in an extra-uterine location, often effecting significant pelvic pain and infertility. While very uncommon, there have been reported cases of endometriosis undergoing malignant transformation, frequently involving the ovaries and seldom in extra-gonadal regions. We recount a case depicting a 63 year-old woman who presented with an apparent inguinal hernia in 2017; she wa...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Uterine preservation in a young patient with adenosarcoma of the uterus – Case report and review of literature
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): C. Goh, X.H. Lin, P.S. Chin, Y.K. Lim (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Myasthenia as a paraneoplastic manifestation of ovarian Cancer
We describe the first case of myasthenia gravis as a possible paraneoplastic manifestation of ovarian cancer preceding its diagnosis. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Sacituzumab Govitecan (IMMU-132) in treatment-resistant uterine serous carcinoma: A case report
ConclusionSacituzumab govitecan may present a new treatment option for recurrent USC patients harboring Trop-2+ tumors resistant to chemotherapy. Clinical trials with sacituzumab govitecan are warranted. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Binimetinib (MEK162) in recurrent low-grade serous ovarian cancer resistant to chemotherapy and hormonal treatment
ConclusionBinimetinib may present a new treatment option for hormone- and chemotherapy-resistant LGSOC harboring KRAS mutations. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Serous borderline tumor with micropapillary pattern of the right ovary that developed 6 recurrences over 30 years after primary surgery
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Mari Minagawa, Mamoru Maeda, Masahito Shimauchi, Hirohisa Kishi, Shinichi TeshimaAbstractSerous borderline tumors (SBTs) are nonaggressive and have excellent prognosis. Furthermore, SBTs with micropapillary pattern (SBT-MP) are known to be associated with a higher recurrence rate, microinvasions and invasive implants compared to typical SBTs, and these characteristics have adverse effects on prognosis. Here, we report a case of SBT with micropapillary pattern (SBT-MP) that developed 6 recurrences over 30 years after primary surgery. Th...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Cervical cancer in women over 65: An analysis of screening
ConclusionsWomen over 65 make up a significant portion of women diagnosed with cervical cancer. As many as half of all cervical cancers over age 65 occur in women who get recommended screening, and some of these may be prevented or detected early if screening was extended beyond age 65. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Treatment of recurrent granulosa cell tumor with metformin and letrozole, a case report
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Shannon K. Rush, Barbara A. Goff (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Everolimus and papillomavirus lesions in female renal transplant recipient: A case report
We describe the case of a transplanted patient with high-risk HPV infection that manifested as multiple genital condylomas and abnormal Papanicolaou (Pap) smear. Her immunosuppressants were corticosteroids, cyclosporine, and azathioprine. Since gynecologic treatments to eradicate condylomas were completely unsuccessful, cyclosporine was replaced by everolimus. Soon after, condylomas disappeared, HPV status became negative, and Pap smear returned to normal and has remained normal since. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Poorly differentiated, ovarian Sertoli-Leydig cell tumor with heterologous rhabdomyosarcoma and glandular elements: Diagnosis and management of a rare neoplasm
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Charanjeet Singh, Sarfraz Ahmad, Fouad M. Hajjar, Robert W. HollowayAbstractOvarian Sertoli-Leydig cell tumors (SLCT) represent
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Myocarditis with tremelimumab plus durvalumab combination therapy for endometrial cancer: A case report
ConclusionsDurvalumab plus tremelimumab combination therapy can lead to fulminant immune-mediated myocarditis. This patient's myocarditis was amenable to treatment with high-dose intravenous steroids and mycophenolate. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Müllerian carcinosarcoma arising from atypical pelvic endometriosis
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Khalid Amin, Beatrice Brumley, Britt K. Erickson, Mahmoud A. Khalifa (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Matthew Cowan, Tara Suntum, Andrea D. Olivas, Melody Perpich, Mark A. Applebaum, Ricardo R. Lastra, S.Diane Yamada (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Prolonged intubation after robotic-assisted hysterectomy for endometrial cancer: Case reports
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Marcia A. Ciccone, Marianne S. Hom, Elise B. Morocco, Laila I. Muderspach, Koji Matsuo (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Extragastrointestinal stromal tumors of the pelvic cavity and the vagina: Two case reports and review of the literature
In this report, we present two cases of EGISTs along with a review of the literature. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Linear accelerator-based radiosurgery and hypofractionated stereotactic radiotherapy for brain metastasis secondary to gynecologic malignancies: A single institution series examining outcomes of a rare entity
Conclusion: Linear-accelerator based SRS or fSRT is safe and effective for control of local tumor growth in brain metastases secondary to gynecologic malignancies. The course of disease remains aggressive as seen by poor overall survival and distant failure rate. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Endometrial cancer in an increasingly obese population: Exploring alternative options when surgery may not cut it
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Jeanine N. Staples, Lisa Rauh, M. Sean Peach, William D. Baker, Susan C. ModesittAbstractObjectivesThe study objectives were to describe outcomes of obese patients with early endometrial cancer following primary non-surgical treatment, assess predictors of response, and estimate the increased surgical risk for these women.MethodsRetrospective chart review identified women with early stage endometrial cancer at a single institution with BMI ≥ 30 kg/m2 who did not undergo surgery as primary treatment modality due to obesity and me...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Pelvic exenteration by robotically-assisted laparoscopy: A feasibility series of 6 cases
The objective of this study was to evaluate the feasibility of pelvic exenteration with robotically assisted laparoscopy.Patients who underwent this procedure between 2015 and 2016 were included. Patients characteristics, treatment indication, intraoperative events, immediate and late complications, and histological outcomes were recorded.The data of 6 patients were analyzed. The primary cancer staging ranged from IB1 to IIB. All cases were loco-regional recurrence and 2 cases presented with with vesico-vaginal fistula. All patients had a history of pelvic irradiation. The mean operative time was 6.7 h. No complications ...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Aspirin use correlates with survival in women with clear cell ovarian cancer
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Alyssa M. Wield, Christine S. Walsh, B.J. Rimel, Ilana Cass, Beth Y. Karlan, Andrew J. LiAbstractData from colon, breast and prostate cancers suggest that aspirin users have reduced mortality. While the direct mechanism remains uncertain, aspirin can suppress the COX-dependent and independent pathways involved in tumor progression. We hypothesized that aspirin users with clear cell ovarian cancer would have improved survival outcomes.We performed a retrospective review of patients with clear cell ovarian cancer diagnosed between 1995 and...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Nivolumab use for BRCA gene mutation carriers with recurrent epithelial ovarian cancer: A case series
In conclusion, our study suggests that nivolumab monotherapy is well-tolerated and may be an effective salvage therapy for BRCA mutation carriers with recurrent epithelial ovarian, fallopian tubal, and primary peritoneal cancers. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Definitive radiation therapy for cervical cancer: Non-white race and public insurance are risk factors for delayed completion, a pilot study
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Shariska S. Petersen, Samfee Doe, Thomas BuekersAbstractThis is a pilot study to assess whether racial disparities exist in time to initiation and completion of external beam pelvic radiation therapy and brachytherapy in cervical cancers treated with definitive chemoradiation.A retrospective analysis was conducted on all cervical cancer patients treated with definitive radiotherapy between 2006 and 2016 at a single institution. Patient demographics including age, race, insurance status and stage at diagnosis were obtained. Analyses were ...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Resilience, hope and flourishing are inversely associated with burnout among members of the Society for Gynecologic Oncology
In this study we sought to: 1) determine rates of burnout and other associated indices of psychosocial distress such as alcohol and substance abuse, 2) establish the baseline performance of gynecologic oncologists on several positive psychology metrics, 3) determine if increased hope, resilience, and flourishing are associated with decreased burnout.MethodsA survey of members of the Society of Gynecologic Oncology (SGO) was conducted in spring of 2017. Participants were sent an electronic questionnaire consisting of 82 items measuring burnout, depression, substance abuse, flourishing, resilience, hope, and psychological we...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Collaborations in gynecologic oncology education and research in low- and middle- income countries: Current status, barriers and opportunities
We describe here the existing educational and research programs that are offered by major international organizations, the barriers and opportunities provided by these collaborations and hope to improve the outcomes of cervical cancer through these efforts. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Improving quality of care and timely access to radiation therapy for patients with invasive cervical cancer at the National Cancer Institute Paraguay
This report is based on site visits to NCI Paraguay by HVO volunteers in 2012, 2013, and 2016, with a follow-up report from the site in 2017. During the study period, increased access to external beam radiation and brachytherapy led to a decrease in wait time to start radiation from 2 to 3 months to 4–6 weeks. The center transitioned from 2-dimensional (2D) to 3-D planning and was able to offer concurrent chemotherapy and radiation, including brachytherapy, to patients with locally advanced cervical cancer. Based on the American Society of Clinical Oncology's resource-stratified clinical guidelines, from 2012 to ...
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

The known roots of a known problem
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Eduardo Rosenblatt (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Florid cystic endosalpingiosis with uterine preservation and successful assisted reproductive therapy
Publication date: August 2018Source: Gynecologic Oncology Reports, Volume 25Author(s): Kayla E. Nixon, J. Kenneth Schoolmeester, Jamie N. Bakkum-Gamez (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 11, 2018 Category: OBGYN Source Type: research

Radical resection of an endometrioid carcinoma arising from endometriosis in the round ligament within the right canal of Nuck: a case report and literature review
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): Yashiro Motooka, Takeshi Motohara, Ritsuo Honda, Hironori Tashiro, Yoshiki Mikami, Hidetaka Katabuchi (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research

Evidence-based improvisation: Facing the challenges of cervical cancer care in Uganda
We describe the ways in which a small but dedicated group of gynecologists carefully use limited evidence and available resources creatively to provide the best possible care for their patients. We show that improvisation, albeit evidence-based, is central to the nature and success of oncology care in Africa (Livingston, 2012). We argue that a “recalibrated global response” (Farmer et al., 2010), particularly stressing the expansion of radiotherapy capabilities, could dramatically improve cancer care and outcomes for women in Uganda as well as in LMICs globally. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research

Editorial Board
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research

Primary small cell ovarian cancer of pulmonary type: A case report
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): Emmanouil Kalampokas, Vijay Sharma, Tanja Gagliardi, Fiona Payne, Mahalakshmi GurumurthyAbstractBackgroundPrimary small cell ovarian cancer of pulmonary type (SCCOPT) is a rare aggressive ovarian tumour with an incidence of
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research

A persistent mass: A case of aggressive Angiomyxoma of the vulva
We present a case of aggressive angiomyxoma of the vulva. The patient presented with a persistent, enlarging vulvar mass, initially misdiagnosed as a Bartholin gland cyst. The patient underwent wide local excision, which resulted in total resection of the mass. Final pathology was consistent with aggressive angiomyxoma, a rare soft tissue tumor with a predilection for the female pelvis. Though rare, it is important to consider in the differential diagnosis of a pelvic mass, given the locally aggressive nature of this tumor and propensity for recurrence. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research

Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer
We report a case of TLS following chemotherapy for a recurrent uterine serous carcinoma. In this case, we speculated that the cause of death might be a pulmonary tumor embolism caused by TLS. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research

Oncofertility in the setting of advanced cervical cancer - A case report
ConclusionsFertility options may exist for patients even in the setting of metastatic cervical cancer. Early involvement of a reproductive endocrinologist is imperative. This case emphasizes the importance of cross-specialty communication. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research

Saddle pulmonary embolus resulting in cardiovascular collapse requiring extracorporeal membrane oxygenation in a postoperative patient with endometrial cancer
ConclusionSaddle pulmonary embolus is a potentially catastrophic and fatal postoperative complication. This case demonstrates a successful implementation of directed thrombolysis, veno-arterial extracorporeal membrane oxygenation and multidisciplinary management in a case of postoperative saddle pulmonary embolus.PrécisWe report a case of an endometrial cancer patient who sustained a massive postoperative pulmonary embolus and was successfully resuscitated using extracorporeal membrane oxygenation. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research

Malignant peritoneal mesothelioma in a woman with bilateral ovarian serous borderline tumour: Potential interactions between the two diseases
We report a case of a 59-year-old woman with peritoneal malignant mesothelioma and no previous exposure to asbestos with a diagnosis of bilateral ovarian serous borderline tumour with peritoneal implants one year before. We discuss the histopathological and immunohistochemical findings to explain possible and potential interactions between the two diseases. To our knowledge, the association of both serous borderline ovarian tumour and malignant peritoneal mesothelioma has never been described before in the same woman and in such a tight temporal connection. This finding raises numerous issues about the origin of the two tu...
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research

Advanced ovarian cancer treated in pregnancy and detected by cell-free DNA aneuploidy screening
Publication date: May 2018Source: Gynecologic Oncology Reports, Volume 24Author(s): Christina N. Cordeiro Mitchell, Tricia Murdock, Amanda N. Fader, Rebecca L. Stone (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - July 5, 2018 Category: OBGYN Source Type: research