Trametinib response in heavily pretreated high-grade ovarian cancer: one step towards precision medicine
This report suggests that trametinib could be effective in high-grade serous ovarian cancer, although most of promising scientific data on this molecule have focused on low-grade ovarian cancer. Molecular profiling has gradually become part of care for patients affected by recurrent ovarian cancer, however further randomized studies are needed to prove its efficacy in everyday clinical practice. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - February 14, 2020 Category: OBGYN Source Type: research
A Clinicopathologic Study of Endometrial Cancer Metastatic to Bone: Identification of Microsatellite Instability Improves Treatment Strategies
Publication date: Available online 10 February 2020Source: Gynecologic Oncology ReportsAuthor(s): Jennifer McEachron, Carolyn Chatterton, Victoria Hastings, Constantine Gorelick, Katherine Economos, Yi-Chun Lee, Marguax J. KanisAbstractMetastasis to bone (BM) is an uncommon manifestation of advanced endometrial cancer (EC). The present study will review the clinicopathologic features of a cohort of patients with EC and BM. We conducted a multi-center retrospective review of patients with EC and BM. Demographic and clinical information was extracted from the medical records. Survival outcomes were determined using Kaplan-Me...
Source: Gynecologic Oncology Reports - February 12, 2020 Category: OBGYN Source Type: research
Results of an Abbreviated Phase II Study of AKT Inhibitor MK-2206 in the Treatment of Recurrent Platinum-Resistant High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma (NCT 01283035)
Publication date: Available online 3 February 2020Source: Gynecologic Oncology ReportsAuthor(s): Elizabeth K. Lee, Zhenying Tan-Wasielewski, Carol Aghajanian, Robert L. Coleman, Jennifer Curtis, Michelle S. Hirsch, Ursula A. Matulonis, Lewis C. Cantley, Gordon B. Mills, L. Austin Doyle, Joyce F. LiuAbstractPlatinum-resistant, recurrent, high grade epithelial ovarian carcinoma remains challenging to treat. Chemotherapy produces limited responses with modest survival benefits in the treatment of recurrent disease. In this context, targeted therapies may improve upon conventional therapies. PI3K/AKT pathway alterations are fr...
Source: Gynecologic Oncology Reports - February 4, 2020 Category: OBGYN Source Type: research
Patient Perceptions and Understanding of Obesity Related Endometrial cancer
This study demonstrates a need for patient education regarding the strong relationship between obesity and endometrial cancer risk. Patients are willing to consider weight loss interventions if they were proven to be as safe and effective as pelvic surgery in the management of endometrial cancer. (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - February 2, 2020 Category: OBGYN Source Type: research
Editorial Board
Publication date: February 2020Source: Gynecologic Oncology Reports, Volume 31Author(s): (Source: Gynecologic Oncology Reports)
Source: Gynecologic Oncology Reports - February 2, 2020 Category: OBGYN Source Type: research
