Gynecologic and Obstetric Investigation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nodal assessment in Endometrial Atypical Hyperplasia.
Conclusion: The overall risk of nodal metastases in preoperative AH patients was low. Conversely, 9.9% of the preoperative AH patients belonged to the intermediate or high-risk group for EC at the final histological examination. Preoperative cancer risk factors would identify AH patients for whom nodal staging could be suggested. (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - July 6, 2022 Category: OBGYN Source Type: research

Hypoxia promotes extravillous trophoblast cell invasion through the hypoxia-inducible factor urokinase-type plasminogen activator receptor pathway.
Conclusions: The low oxygen-regulated early events of EVT invasion may be mediated by the HIF-1α-uPAR pathway. (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - July 4, 2022 Category: OBGYN Source Type: research

Screening for Low-Tract Genital Infections in Women with Threatened Preterm Labor: Which Role?
Conclusions: There is no evidence that the search for vaginal or urinary infections in women admitted for threatened preterm labor is helpful to identify those at increased risk of preterm birth. Although several studies have explored the role of screening for bacterial vaginosis in asymptomatic women and some studies evaluated vaginal or urinary infections in women with preterm birth, none of them focused on the possible role of microbiological specimens as a predictive tool in women admitted for threatened PTL. No association was found in our study, but prospective randomized controlled trials are required to confirm the...
Source: Gynecologic and Obstetric Investigation - June 22, 2022 Category: OBGYN Source Type: research

Screening for low-tract genital infections in women with threatened preterm labour. Which role?
Objectives: to evaluate the possible relationship between cultural specimens and preterm birth in women admitted for threatened preterm labour. Preterm birth is the leading cause of neonatal mortality and antenatal hospitalization: several risk factors including intrauterine infections have been identified but its real causes remain poorly understood. Design: retrospective, multicentre, cohort study including 250 women admitted for threatened preterm labour. Methods, Participants/Materials, Setting: all women admitted for threatened Preterm Labour, i.e. presenting with cervical changes and uterine activity before 37 weeks...
Source: Gynecologic and Obstetric Investigation - June 22, 2022 Category: OBGYN Source Type: research

Does Maternal SARS-CoV-2 Infection or SARS-CoV-2 Vaccination trigger an Inflammatory Response in The Fetus? A Prospective Cohort Study
Conclusion: Neither IL-6 nor CRP indicated increased inflammation in the cord blood of newborns of vaccinated or SARS-CoV-2 infected mothers when the newborn was not infected. (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - June 21, 2022 Category: OBGYN Source Type: research

Transvaginal versus port-site specimen retrieval after laparoscopic myomectomy: a systematic review and meta-analysis
Conclusion: TVSR and PSSR after LM showed comparable results for operative time and surgery-related complications. However, the need of post-operative rescue analgesics was lower in women who underwent TVSR. (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - June 21, 2022 Category: OBGYN Source Type: research

Ultrasound-targeted microbubble destruction-mediated miR-1228 downregulation suppresses tumor proliferation, migration, and invasion of cervical cancer cells
Conclusions: These results indicated that the delivery of UTMD-mediated miR-1228 inhibitor might be a potential therapeutic method for the treatment of cervical cancer through suppressing cellular activities. (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - June 21, 2022 Category: OBGYN Source Type: research

Long Noncoding RNA Brain Cytoplasmic RNA 1 Induces Cisplatin-Resistance of Cervical Cancer Cells by Sponging MicroRNA-330-5p and Upregulating High-Mobility Group Box 3
Conclusions: BCYRN1 knockdown could disrupt the DDP-resistance of CC cells through upregulating miR-330-5p to suppress HMGB3 mRNA level.Gynecol Obstet Invest (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - June 15, 2022 Category: OBGYN Source Type: research

Long non-coding RNA brain cytoplasmic RNA 1 induces cisplatin-resistance of cervical cancer cells by sponging microRNA-330-5p and upregulating high-mobility group box 3
Conclusions: BCYRN1 knockdown could disrupt DDP-resistance of CC cells through upregulating miR-330-5p to suppress HMGB3 mRNA level. (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - June 15, 2022 Category: OBGYN Source Type: research

Tissue Factor Pathway Inhibitor 2: A Novel Biomarker for Predicting Asymptomatic Venous Thromboembolism in Patients with Epithelial Ovarian Cancer
Conclusion: The combination of D-dimer and TFPI2 may be useful to safely exclude VTE and select patients at high risk of VTE.Gynecol Obstet Invest (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - May 25, 2022 Category: OBGYN Source Type: research

Erratum
Gynecol Obstet Invest (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - May 24, 2022 Category: OBGYN Source Type: research

Plasmatic circRNAs Panel to Predict the Risk of Macrosomia in Women with Gestational Diabetes Mellitus
Conclusion: The circRNA_1030, circRNA_23658, circRNA_0009049, and circRNA_32231 might be the potential biomarkers for predicting the GDM and macrosomia during the perinatal period.Gynecol Obstet Invest (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - May 23, 2022 Category: OBGYN Source Type: research

Cervical versus utero-ovarian ligament injection of the tracer for the pelvic sentinel lymph node mapping in gynecologic oncology: a prospective observational study.
Objective: In gynecologic oncology, the consolidated injection site for the pelvic sentinel lymph node mapping is the cervix. However, in apparent early-stage ovarian cancer, current trials map the pelvic area injecting the tracers in the utero-ovarian ligament. A different injection site is proposed based on a possible different lymphatic ovarian drainage through the utero-ovarian ligament and uterus and consequently a different pelvic sentinel lymph node mapping than the cervix; however, this was never proven. On that basis, this study aimed to investigate whether injecting the tracer in the utero-ovarian ligament map th...
Source: Gynecologic and Obstetric Investigation - May 18, 2022 Category: OBGYN Source Type: research

A SARS-CoV-2 Delta variant case manifesting as extensive placental infection and fetal transmission
Conclusion. We report with strong probability the first SARS-CoV-2 Delta variant transplacental transmission. Placental cells exhibited extensive apoptosis, senescence, and ferroptosis after SARS-CoV-2 Delta infection (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - May 6, 2022 Category: OBGYN Source Type: research

Implementing a Universal Cervical Length Screening Program in a Large Hospital System: It Takes Some Time to Achieve Consistent Results
Conclusions: During the first 6 months after implementation of a universal CL screening program, there was greater variation in CL measurements, lower acceptance for TV US, and a higher number of women diagnosed with a CL ≤25 mm, as compared to subsequent epochs. After the first 6 months, these metrics improved and remained stable. Most operators improved their performance over time; however, there were a few with a low success rate for TV-CL and others who systematically over- or underestimate CL measurements. (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - March 30, 2022 Category: OBGYN Source Type: research