Developmental expression patterns of fosl genes in Xenopus tropicalis
Publication date: Available online 21 May 2019Source: Gene Expression PatternsAuthor(s): Xiao-Fang Guo, Zhou Zhang, Li Zheng, Yi-Min Zhou, Hai-Yan Wu, Chi-Qian Liang, Hui Zhao, Dong-Qing Cai, Xu-Feng QiAbstractFos-like antigens (Fosl) including Fosl1 and Fosl2 exclusively heterodimerize with Jun members to form AP-1 complex, thereby participating in various cellular progresses including cell cycle regulation. However, expression patterns of these two genes during embryonic development remains largely unknown. In the present study, both temporal and spatial expression patterns of fosl1 and fosl2 were examined during embryon...
Source: Gene Expression Patterns - May 22, 2019 Category: Genetics & Stem Cells Source Type: research
Altered levels of hsromega lncRNAs further enhance ras signaling during ectopically activated ras induced R7 differentiation in Drosophila
Publication date: Available online 13 May 2019Source: Gene Expression PatternsAuthor(s): Mukulika Ray, Gunjan Singh, Subhash C. LakhotiaAbstractWe exploited the high Ras activity induced differentiation of supernumerary R7 cells in Drosophila eyes to examine if hsrω lncRNAs influence active Ras signaling. Surprisingly, either down- or up-regulation of hsrω lncRNAs in sev-GAL4>RasV12 expressing eye discs resulted in complete pupal lethality and substantially greater increase in R7 photoreceptor number at the expense of cone cells. Enhanced nuclear p-MAPK and presence of sev-GAL4 driven RasV12 bound RafRBDFLAG in cells not...
Source: Gene Expression Patterns - May 13, 2019 Category: Genetics & Stem Cells Source Type: research
Editorial Board
Publication date: June 2019Source: Gene Expression Patterns, Volume 32Author(s): (Source: Gene Expression Patterns)
Source: Gene Expression Patterns - May 13, 2019 Category: Genetics & Stem Cells Source Type: research
Spatio-temporal expression profile of sirtuins during aging of the annual fish Nothobranchius furzeri
Publication date: Available online 7 May 2019Source: Gene Expression PatternsAuthor(s): Julijan Kabiljo, Christina Murko, Oliver Pusch, Gordin ZupkovitzAbstractThe founding member of the sirtuin family, yeast Sir2, was the first evolutionarily conserved gene to be identified as a regulator of longevity. Sirtuins constitute a protein family of metabolic sensors, translating changes in NAD + levels into adaptive responses, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan. In mammals the sirtuin family comprises seven proteins, SIRT1-SIRT7, which vary in ...
Source: Gene Expression Patterns - May 8, 2019 Category: Genetics & Stem Cells Source Type: research
Evolution and expression of the zebrafish unc119 paralogues indicates a conserved role in cilia
Publication date: Available online 2 May 2019Source: Gene Expression PatternsAuthor(s): Francesca Jean, David PilgrimAbstractUNC119 proteins are required for ciliary trafficking in a process called lipidated protein intraflagellar targeting (LIFT) or through vesicle transport. However, although unc119 has been studied in a variety of contexts, either organismal constraints or genetic redundancy has largely restricted their study in ciliary contexts. One possible solution for this is to use the zebrafish, however, the unc119 genes have not been well described in this species. In our study, we show in a condensed species tre...
Source: Gene Expression Patterns - May 3, 2019 Category: Genetics & Stem Cells Source Type: research
Bmp signaling in molar cusp formation
Publication date: Available online 11 April 2019Source: Gene Expression PatternsAuthor(s): Fumiya Meguro, Thantrira Porntaveetus, Maiko Kawasaki, Katsushige Kawasaki, Akane Yamada, Yoshito Kakihara, Makio Saeki, Koichi Tabeta, John A. Kessler, Takeyasu Maeda, Atsushi OhazamaAbstractTooth cusp is a crucial structure, since the shape of the molar tooth is determined by number, shape, and size of the cusp. Bone morphogenetic protein (Bmp) signaling is known to play a critical role in tooth development, including in initiation. However, it remains unclear whether Bmp signaling is also involved in cusp formation. To address thi...
Source: Gene Expression Patterns - April 11, 2019 Category: Genetics & Stem Cells Source Type: research
Expression analysis of the aquaporins during zebrafish embryonic development
Publication date: Available online 2 April 2019Source: Gene Expression PatternsAuthor(s): Yinyin Qin, Shiping Wang, Xuchu Duan, Dong LiuAbstractThe aquaporins are integral membrane proteins from a larger family of major intrinsic protein (MIP) that form pores in the membrane of cells. These proteins selectively transport water and other small uncharged solutes across cell plasma membranes. The organization of water within cells and tissues is fundamental to life, and the aquaporins play an important role in serving as the plumbing system for cells. As many as thirteen mammalian AQPs have been characterized, which have been...
Source: Gene Expression Patterns - April 4, 2019 Category: Genetics & Stem Cells Source Type: research
Identification of regulatory elements recapitulating early expression of L-plastin in the zebrafish enveloping layer and embryonic periderm
Publication date: Available online 30 March 2019Source: Gene Expression PatternsAuthor(s): Emily A. Baumgartner, Zachary J. Compton, Spencer Evans, J. Topczewski, Elizabeth E. LeClairAbstractWe have cloned and characterized an intronic fragment of zebrafish lymphocyte cytosolic protein 1 (lcp1, also called L-plastin) that drives expression to the zebrafish enveloping layer (EVL). L-plastin is a calcium-dependent actin-bundling protein belonging to the plastin/fimbrin family of proteins, and is necessary for the proper migration and attachment of several adult cell types, including leukocytes and osteoclasts. Unexpectedly, ...
Source: Gene Expression Patterns - March 31, 2019 Category: Genetics & Stem Cells Source Type: research
Spatiotemporal expression pattern of Sjfz7 and its expression comparison with other frizzled family genes in developmental stages of Schistosoma japonicum
Publication date: Available online 6 March 2019Source: Gene Expression PatternsAuthor(s): Zhongxue Ye, Jingxiu Xu, Xingang Feng, Yingying Jia, Zhiqiang Fu, Yang Hong, Hao Li, Ke Lu, Jiaojiao Lin, Mingxin Song, Liqun Wang, Chunxiu YuanAbstractWnts are secreted signaling molecules that are implicated in a variety of growth-related processes. Frizzled proteins have been identified as receptors for Wnt ligands in vertebrates and invertebrates, but a functional role for dioecious flatworm Frizzleds has not been determined. To evaluate the endogenous role of Frizzled proteins during development, we have identified and characteri...
Source: Gene Expression Patterns - March 8, 2019 Category: Genetics & Stem Cells Source Type: research
GTP binding protein 10 is a member of the OBG family of proteins and is differentially expressed in the early Xenopus embryo
Publication date: Available online 1 March 2019Source: Gene Expression PatternsAuthor(s): Razhan Jerry, Jessica Sullivan-Brown, Michael D. Yoder (Source: Gene Expression Patterns)
Source: Gene Expression Patterns - March 4, 2019 Category: Genetics & Stem Cells Source Type: research
Evolution of the Rho guanine nucleotide exchange factors Kalirin and Trio and their gene expression in Xenopus development
Publication date: Available online 4 March 2019Source: Gene Expression PatternsAuthor(s): Marie-Claire Kratzer, Laura England, David Apel, Monika Hassel, Annette BorchersAbstractGuanine nucleotide exchange factors (GEFs) activate Rho GTPases by accelerating their GDP/GTP exchange. Trio and its paralog Kalirin (Kalrn) are unique members of the Rho-GEFs that harbor three catalytic domains: two functional GEF domains and a serine/threonine kinase domain. The N-terminal GEF domain activates Rac1 and RhoG GTPases, while the C-terminal GEF domain acts specifically on RhoA. Trio and Kalrn have an evolutionary conserved function i...
Source: Gene Expression Patterns - March 4, 2019 Category: Genetics & Stem Cells Source Type: research
An in situ hybridization study of MMP-2, -9, -13, -14, TIMP-1, and -2 mRNA in fetal mouse mandibular condylar cartilage as compared with limb bud cartilage
Publication date: Available online 27 February 2019Source: Gene Expression PatternsAuthor(s): Masato Takahashi, Kaoru Fujikawa, Randilini Angammana, Shunichi ShibataAbstractThe main purpose of this in situ hybridization study was to investigate MMPs and TIMPs mRNA expression in developing mandibular condylar cartilage and limb bud cartilage. At E14.0, MMP-2, -14, TIMP-1 and -2 mRNAs were expressed in the periosteum of mandibular bone, and in the condylar anlage. At E15.0 MMP-2, -14, TIMP-1 and -2 mRNAs were expressed in the perichondrium of newly formed condylar cartilage and the periosteum of developing bone collar, where...
Source: Gene Expression Patterns - February 27, 2019 Category: Genetics & Stem Cells Source Type: research
Expression of the heparin-binding growth factors Midkine and pleiotrophin during ocular development
In this study, we demonstrate by section in situ hybridization, the spatiotemporal expression of MDK and PTN during ocular development in chick and mouse. We show that MDK and PTN are expressed in dynamic patterns that overlap in a few non-neuronal tissues in the anterior eye and in neuronal cell layers of the posterior eye. We show that the expression patterns of MDK and PTN are only conserved in a few tissues in chick and mouse but they overlap with the expression of some of their receptors LRP1, RPTPZ, ALK, NOTCH2, ITGβ1, SDC1, and SDC3. The dynamic expression patterns of MDK, PTN and their receptors suggest that they ...
Source: Gene Expression Patterns - February 27, 2019 Category: Genetics & Stem Cells Source Type: research
Editorial Board
Publication date: January 2019Source: Gene Expression Patterns, Volume 31Author(s): (Source: Gene Expression Patterns)
Source: Gene Expression Patterns - February 13, 2019 Category: Genetics & Stem Cells Source Type: research
Regionalized nervous system in Hydra and the mechanism of its development
In this study we show how it is formed and maintained, focusing on the neuropeptide Hym-176 gene and its paralogs. First, we demonstrate that four axially localized neuron subsets that express different combination of the neuropeptide Hym-176 gene and its paralogs cover almost an entire body, forming a regionalized nervous system in Hydra. Second, we show that positional information governed by the Wnt signaling pathway plays a key role in determining the regional specificity of the neuron subsets as is the case in bilaterians. Finally, we demonstrated two basic mechanisms, regionally restricted new differentiation and phe...
Source: Gene Expression Patterns - January 23, 2019 Category: Genetics & Stem Cells Source Type: research
