EMP1 as a Potential Biomarker in Liver Fibrosis: A Bioinformatics Analysis
In this study, we combined a publicly accessible single-cell transcriptome of human liver with microarray datasets to evaluate the cell-specific expression patterns of differentially expressed genes in the liver. We noticed that EMP1 (epithelial membrane protein 1) is significantly active not only in CCl4 (carbon tetrachloride)-treated mouse liver fibrosis but also in BDL (bile duct ligation)-induced liver fibrosis and even in human fibrotic liver tissues such as alcoholic hepatitis, NASH (nonalcoholic steatohepatitis), and advanced stage liver fibrosis. Furthermore, we demonstrated that EMP1 is a specific fibrotic gene ex...
Source: Gastroenterology Research and Practice - April 3, 2023 Category: Gastroenterology Authors: Xuchen Chen Xinliang Lv Manman Han Yexiao Hu Wanqiong Zheng Haibo Xue Zhuokai Li Kui Li Wei Tan Source Type: research

Comparison between Submucosal Tunneling Endoscopic Resection and Endoscopic Submucosal Dissection for Prepyloric Submucosal Tumors: A Case-Matched Controlled Study
CONCLUSIONS: For the treatment of prepyloric SMTs, P-STER appeared to be a more effective endoscopic technique compared with ESD, although further randomized controlled trials were warranted.PMID:36911253 | PMC:PMC9995185 | DOI:10.1155/2023/5931360 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 13, 2023 Category: Gastroenterology Authors: Wengang Zhang Jiafeng Wang Ningli Chai Enqiang Linghu Source Type: research

Monitoring a Mandatory Nonmedical Switching Policy from Originator to Biosimilar Infliximab in Patients with Inflammatory Bowel Diseases: A Population-Based Cohort Study
CONCLUSION: British Columbia's Biosimilars Initiative for nonmedical switching from originator to biosimilar infliximab for inflammatory bowel diseases was not associated with harmful impacts on medications and health services use. An increase in dose escalation was accompanied by an improvement in health status proxies.PMID:36911254 | PMC:PMC9995207 | DOI:10.1155/2023/2794220 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 13, 2023 Category: Gastroenterology Authors: Anat Fisher Jason D Kim Colin R Dormuth Source Type: research

Comparison between Submucosal Tunneling Endoscopic Resection and Endoscopic Submucosal Dissection for Prepyloric Submucosal Tumors: A Case-Matched Controlled Study
CONCLUSIONS: For the treatment of prepyloric SMTs, P-STER appeared to be a more effective endoscopic technique compared with ESD, although further randomized controlled trials were warranted.PMID:36911253 | PMC:PMC9995185 | DOI:10.1155/2023/5931360 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 13, 2023 Category: Gastroenterology Authors: Wengang Zhang Jiafeng Wang Ningli Chai Enqiang Linghu Source Type: research

Monitoring a Mandatory Nonmedical Switching Policy from Originator to Biosimilar Infliximab in Patients with Inflammatory Bowel Diseases: A Population-Based Cohort Study
CONCLUSION: British Columbia's Biosimilars Initiative for nonmedical switching from originator to biosimilar infliximab for inflammatory bowel diseases was not associated with harmful impacts on medications and health services use. An increase in dose escalation was accompanied by an improvement in health status proxies.PMID:36911254 | PMC:PMC9995207 | DOI:10.1155/2023/2794220 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 13, 2023 Category: Gastroenterology Authors: Anat Fisher Jason D Kim Colin R Dormuth Source Type: research

Comparison between Submucosal Tunneling Endoscopic Resection and Endoscopic Submucosal Dissection for Prepyloric Submucosal Tumors: A Case-Matched Controlled Study
CONCLUSIONS: For the treatment of prepyloric SMTs, P-STER appeared to be a more effective endoscopic technique compared with ESD, although further randomized controlled trials were warranted.PMID:36911253 | PMC:PMC9995185 | DOI:10.1155/2023/5931360 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 13, 2023 Category: Gastroenterology Authors: Wengang Zhang Jiafeng Wang Ningli Chai Enqiang Linghu Source Type: research