Conserved copper regulation of the antimicrobial isocyanide brassicicolin A in Alternaria brassicicola
Fungal Genet Biol. 2023 Sep 12:103839. doi: 10.1016/j.fgb.2023.103839. Online ahead of print.ABSTRACTPhytopathogenic Alternaria species are renown for production of toxins that contribute to virulence on host plants. Typically, these toxins belong to well-known secondary metabolite chemical classes including polyketides, non-ribosomal peptides and terpenes. However, the purported host toxin brassicicolin A produced by A. brassicicola is an isocyanide, a chemical class whose genetics and encoding gene structure is largely unknown. The chemical structure of brassicicolin A shows it to have similarity to the recently characte...
Source: Fungal Genetics and Biology - September 14, 2023 Category: Biology Authors: Nischala Nadig Sung Chul Park Jin Woo Bok Nancy P Keller Source Type: research
Conserved copper regulation of the antimicrobial isocyanide brassicicolin A in Alternaria brassicicola
Fungal Genet Biol. 2023 Sep 12:103839. doi: 10.1016/j.fgb.2023.103839. Online ahead of print.ABSTRACTPhytopathogenic Alternaria species are renown for production of toxins that contribute to virulence on host plants. Typically, these toxins belong to well-known secondary metabolite chemical classes including polyketides, non-ribosomal peptides and terpenes. However, the purported host toxin brassicicolin A produced by A. brassicicola is an isocyanide, a chemical class whose genetics and encoding gene structure is largely unknown. The chemical structure of brassicicolin A shows it to have similarity to the recently characte...
Source: Fungal Genetics and Biology - September 14, 2023 Category: Biology Authors: Nischala Nadig Sung Chul Park Jin Woo Bok Nancy P Keller Source Type: research
Conserved copper regulation of the antimicrobial isocyanide brassicicolin A in Alternaria brassicicola
Fungal Genet Biol. 2023 Sep 12:103839. doi: 10.1016/j.fgb.2023.103839. Online ahead of print.ABSTRACTPhytopathogenic Alternaria species are renown for production of toxins that contribute to virulence on host plants. Typically, these toxins belong to well-known secondary metabolite chemical classes including polyketides, non-ribosomal peptides and terpenes. However, the purported host toxin brassicicolin A produced by A. brassicicola is an isocyanide, a chemical class whose genetics and encoding gene structure is largely unknown. The chemical structure of brassicicolin A shows it to have similarity to the recently characte...
Source: Fungal Genetics and Biology - September 14, 2023 Category: Biology Authors: Nischala Nadig Sung Chul Park Jin Woo Bok Nancy P Keller Source Type: research
Update on the state of research to manage Fusarium head blight
Fungal Genet Biol. 2023 Sep 2:103829. doi: 10.1016/j.fgb.2023.103829. Online ahead of print.ABSTRACTFusarium head blight (FHB) is one of the most devastating diseases of cereal crops, causing severe reduction in yield and quality of grain worldwide. In the United States, the major causal agent of FHB is the mycotoxigenic fungus, Fusarium graminearum. The contamination of grain with mycotoxins, including deoxynivalenol and zearalenone, is a particularly serious concern due to its impact on the health of humans and livestock. For the past few decades, multidisciplinary studies have been conducted on management strategies des...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Soumya Moonjely Malaika Ebert Drew Paton-Glassbrook Zachary A Noel Ludmila Roze Rebecca Shay Tara Watkins Frances Trail Source Type: research
The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus
Fungal Genet Biol. 2023 Sep 3;169:103836. doi: 10.1016/j.fgb.2023.103836. Online ahead of print.ABSTRACTThe filamentous fungus Aspergillus flavus is a plant and human pathogen predominantly found in the soil as spores or sclerotia and is capable of producing various secondary metabolites (SM) such as the carcinogenic mycotoxin aflatoxin. Recently, we have discovered a novel nuclear chromatin binding complex (KERS) that contains the JARID1-type histone demethylase KdmB, a putative cohesion acetyl transferase EcoA, a class I type histone deacetylase RpdA and the PHD ring finger reader protein SntB in the model filamentous fu...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Betim Karahoda Brandon T Pfannenstiel Özlem Sarikaya-Bayram Zhiqiang Dong Koon Ho Wong Alastair B Fleming Nancy P Keller Özgür Bayram Source Type: research
Update on the state of research to manage Fusarium head blight
Fungal Genet Biol. 2023 Sep 2:103829. doi: 10.1016/j.fgb.2023.103829. Online ahead of print.ABSTRACTFusarium head blight (FHB) is one of the most devastating diseases of cereal crops, causing severe reduction in yield and quality of grain worldwide. In the United States, the major causal agent of FHB is the mycotoxigenic fungus, Fusarium graminearum. The contamination of grain with mycotoxins, including deoxynivalenol and zearalenone, is a particularly serious concern due to its impact on the health of humans and livestock. For the past few decades, multidisciplinary studies have been conducted on management strategies des...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Soumya Moonjely Malaika Ebert Drew Paton-Glassbrook Zachary A Noel Ludmila Roze Rebecca Shay Tara Watkins Frances Trail Source Type: research
The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus
Fungal Genet Biol. 2023 Sep 3;169:103836. doi: 10.1016/j.fgb.2023.103836. Online ahead of print.ABSTRACTThe filamentous fungus Aspergillus flavus is a plant and human pathogen predominantly found in the soil as spores or sclerotia and is capable of producing various secondary metabolites (SM) such as the carcinogenic mycotoxin aflatoxin. Recently, we have discovered a novel nuclear chromatin binding complex (KERS) that contains the JARID1-type histone demethylase KdmB, a putative cohesion acetyl transferase EcoA, a class I type histone deacetylase RpdA and the PHD ring finger reader protein SntB in the model filamentous fu...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Betim Karahoda Brandon T Pfannenstiel Özlem Sarikaya-Bayram Zhiqiang Dong Koon Ho Wong Alastair B Fleming Nancy P Keller Özgür Bayram Source Type: research
Update on the state of research to manage Fusarium head blight
Fungal Genet Biol. 2023 Sep 2:103829. doi: 10.1016/j.fgb.2023.103829. Online ahead of print.ABSTRACTFusarium head blight (FHB) is one of the most devastating diseases of cereal crops, causing severe reduction in yield and quality of grain worldwide. In the United States, the major causal agent of FHB is the mycotoxigenic fungus, Fusarium graminearum. The contamination of grain with mycotoxins, including deoxynivalenol and zearalenone, is a particularly serious concern due to its impact on the health of humans and livestock. For the past few decades, multidisciplinary studies have been conducted on management strategies des...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Soumya Moonjely Malaika Ebert Drew Paton-Glassbrook Zachary A Noel Ludmila Roze Rebecca Shay Tara Watkins Frances Trail Source Type: research
The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus
Fungal Genet Biol. 2023 Sep 3;169:103836. doi: 10.1016/j.fgb.2023.103836. Online ahead of print.ABSTRACTThe filamentous fungus Aspergillus flavus is a plant and human pathogen predominantly found in the soil as spores or sclerotia and is capable of producing various secondary metabolites (SM) such as the carcinogenic mycotoxin aflatoxin. Recently, we have discovered a novel nuclear chromatin binding complex (KERS) that contains the JARID1-type histone demethylase KdmB, a putative cohesion acetyl transferase EcoA, a class I type histone deacetylase RpdA and the PHD ring finger reader protein SntB in the model filamentous fu...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Betim Karahoda Brandon T Pfannenstiel Özlem Sarikaya-Bayram Zhiqiang Dong Koon Ho Wong Alastair B Fleming Nancy P Keller Özgür Bayram Source Type: research
Update on the state of research to manage Fusarium head blight
Fungal Genet Biol. 2023 Sep 2:103829. doi: 10.1016/j.fgb.2023.103829. Online ahead of print.ABSTRACTFusarium head blight (FHB) is one of the most devastating diseases of cereal crops, causing severe reduction in yield and quality of grain worldwide. In the United States, the major causal agent of FHB is the mycotoxigenic fungus, Fusarium graminearum. The contamination of grain with mycotoxins, including deoxynivalenol and zearalenone, is a particularly serious concern due to its impact on the health of humans and livestock. For the past few decades, multidisciplinary studies have been conducted on management strategies des...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Soumya Moonjely Malaika Ebert Drew Paton-Glassbrook Zachary A Noel Ludmila Roze Rebecca Shay Tara Watkins Frances Trail Source Type: research
The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus
Fungal Genet Biol. 2023 Sep 2:103836. doi: 10.1016/j.fgb.2023.103836. Online ahead of print.ABSTRACTThe filamentous fungus Aspergillus flavus is a plant and human pathogen predominantly found in the soil as spores or sclerotia and is capable of producing various secondary metabolites (SM) such as the carcinogenic mycotoxin aflatoxin. Recently, we have discovered a novel nuclear chromatin binding complex (KERS) that contains the JARID1-type histone demethylase KdmB, a putative cohesion acetyl transferase EcoA, a class I type histone deacetylase RpdA and the PHD ring finger reader protein SntB in the model filamentous fungus...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Betim Karahoda Brandon T Pfannenstiel Özlem Sarikaya-Bayram Zhiqiang Dong Koon Ho Wong Alastair B Fleming Nancy P Keller Özgür Bayram Source Type: research
Update on the state of research to manage Fusarium head blight
Fungal Genet Biol. 2023 Sep 2:103829. doi: 10.1016/j.fgb.2023.103829. Online ahead of print.ABSTRACTFusarium head blight (FHB) is one of the most devastating diseases of cereal crops, causing severe reduction in yield and quality of grain worldwide. In the United States, the major causal agent of FHB is the mycotoxigenic fungus, Fusarium graminearum. The contamination of grain with mycotoxins, including deoxynivalenol and zearalenone, is a particularly serious concern due to its impact on the health of humans and livestock. For the past few decades, multidisciplinary studies have been conducted on management strategies des...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Soumya Moonjely Malaika Ebert Drew Paton-Glassbrook Zachary A Noel Ludmila Roze Rebecca Shay Tara Watkins Frances Trail Source Type: research
The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus
Fungal Genet Biol. 2023 Sep 2:103836. doi: 10.1016/j.fgb.2023.103836. Online ahead of print.ABSTRACTThe filamentous fungus Aspergillus flavus is a plant and human pathogen predominantly found in the soil as spores or sclerotia and is capable of producing various secondary metabolites (SM) such as the carcinogenic mycotoxin aflatoxin. Recently, we have discovered a novel nuclear chromatin binding complex (KERS) that contains the JARID1-type histone demethylase KdmB, a putative cohesion acetyl transferase EcoA, a class I type histone deacetylase RpdA and the PHD ring finger reader protein SntB in the model filamentous fungus...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Betim Karahoda Brandon T Pfannenstiel Özlem Sarikaya-Bayram Zhiqiang Dong Koon Ho Wong Alastair B Fleming Nancy P Keller Özgür Bayram Source Type: research
Update on the state of research to manage Fusarium head blight
Fungal Genet Biol. 2023 Sep 2:103829. doi: 10.1016/j.fgb.2023.103829. Online ahead of print.ABSTRACTFusarium head blight (FHB) is one of the most devastating diseases of cereal crops, causing severe reduction in yield and quality of grain worldwide. In the United States, the major causal agent of FHB is the mycotoxigenic fungus, Fusarium graminearum. The contamination of grain with mycotoxins, including deoxynivalenol and zearalenone, is a particularly serious concern due to its impact on the health of humans and livestock. For the past few decades, multidisciplinary studies have been conducted on management strategies des...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Soumya Moonjely Malaika Ebert Drew Paton-Glassbrook Zachary A Noel Ludmila Roze Rebecca Shay Tara Watkins Frances Trail Source Type: research
The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus
Fungal Genet Biol. 2023 Sep 2:103836. doi: 10.1016/j.fgb.2023.103836. Online ahead of print.ABSTRACTThe filamentous fungus Aspergillus flavus is a plant and human pathogen predominantly found in the soil as spores or sclerotia and is capable of producing various secondary metabolites (SM) such as the carcinogenic mycotoxin aflatoxin. Recently, we have discovered a novel nuclear chromatin binding complex (KERS) that contains the JARID1-type histone demethylase KdmB, a putative cohesion acetyl transferase EcoA, a class I type histone deacetylase RpdA and the PHD ring finger reader protein SntB in the model filamentous fungus...
Source: Fungal Genetics and Biology - September 4, 2023 Category: Biology Authors: Betim Karahoda Brandon T Pfannenstiel Özlem Sarikaya-Bayram Zhiqiang Dong Koon Ho Wong Alastair B Fleming Nancy P Keller Özgür Bayram Source Type: research
