The impact of nitric oxide on HER family post-translational modification and downstream signaling in cancer
The human epidermal growth factor receptor (HER) family consists of four members, activated by two families of ligands. They are known for mediating cell–cell interactions in organogenesis, and their deregulation has been associated with various cancers, including breast and esophageal cancers. In particular, aberrant epidermal growth factor receptor (EGFR) and HER2 signaling drive disease progression and result in poorer patient outcomes. Nitric oxide (NO) has been proposed as an alternative activator of the HER family and may play a role in this aberrant activation due to its ability to induce s-nitrosation and phospho...
Source: Frontiers in Physiology - March 27, 2024 Category: Physiology Source Type: research
Dose-effect of exercise intervention on heart rate variability of acclimatized young male lowlanders at 3,680 m
This study investigated whether exercise could improve the reduced HRV in an environment of high altitude. A total of 97 young, healthy male lowlanders living at 3,680 m for > 1 year were recruited.They were randomized into four groups, of which three performed-low-, moderate-, and highintensity (LI, MI, HI) aerobic exercise for four weeks, respectively. The remaining was the control group (CG) receiving no intervention. For HI, compared to other groups, heart rate (p = 0.002) was significantly decreased, while standard deviation of RR intervals (p < 0.001), SD2 of Poincaré plot (p = 0.046) and the number of success...
Source: Frontiers in Physiology - March 27, 2024 Category: Physiology Source Type: research
Exercise, weight maintenance, and nonalcoholic fatty liver disease risk: a Chinese cohort study
Conclusion: It might be more crucial to emphasize the adoption of regular moderate to high-intensity exercise for preventing NAFLD in the general population, rather than solely focusing on weight maintenance. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 26, 2024 Category: Physiology Source Type: research
Effects of chronic static stretching interventions on jumping and sprinting performance –a systematic review with multilevel meta-analysis
When improving athletic performance in sports with high-speed strength demands such as soccer, basketball, or track and field, the most common training method might be resistance training and plyometrics. Since a link between strength capacity and speed strength exists and recently published literature suggested chronic stretching routines may enhance maximum strength and hypertrophy, this review was performed to explore potential benefits on athletic performance. Based on current literature, a beneficial effect of static stretching on jumping and sprinting performance was hypothesized. A systematic literature search was c...
Source: Frontiers in Physiology - March 26, 2024 Category: Physiology Source Type: research
The importance of core strength for change of direction speed
Change of direction speed (CODS) is determined by several physical aspects, such as linear sprint speed, reactive strength and power of leg muscles. It appears that core strength may also play a role in CODS, however, its relationship to CODS remains unclear. The aim of this narrative review was to analyze the literature addressing a) the relationship between core strength and CODS and b) the effect of core strength training on CODS. This analysis revealed a significant relationship between the parameters of core strength and stability (the pressure of the activated core muscles during lower limb movement and the greatest ...
Source: Frontiers in Physiology - March 26, 2024 Category: Physiology Source Type: research
Sex-specific colonic mitochondrial dysfunction in the indomethacin-induced rat model of inflammatory bowel disease
Conclusion: Our study provides a better understanding of the role mitochondria in the development of IBD and highlights sex differences in colon mitochondrial function. It also opens an avenue for the development of strategies to re-establish normal mitochondrial function that could provide more options for preventive and therapeutic interventions for IBD. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 26, 2024 Category: Physiology Source Type: research
Expression of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in the rat submandibular gland is influenced by pre- and post-natal high-fat diet exposure
Conclusion: Exposure to HFD during pre- and post-natal periods increased GLP-1 mRNA expression in the SMGs of male rats. However, GIP expression decreased following the HFD in male newborns. Furthermore, a decreasing trend of GIP mRNA expression was observed in male newborns after HFD feeding. Sex influenced incretin hormones secretion and obesity-related conditions. HFD during pre- and post-natal periods reprograms the epigenome, contributing to subsequent disease development. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 26, 2024 Category: Physiology Source Type: research
A preliminary exploration of the regression equation for performance in amateur half-marathon runners: a perspective based on respiratory muscle function
This document presents a study on the relationship between physical characteristics, respiratory muscle capacity, and performance in amateur half-marathon runners. The aim of this study was to establish a preliminary predictive model to provide insights into training and health management for runners. Participants were recruited from the 2023 Beijing Olympic Forest Park Half-Marathon, comprising 233 individuals. Personal information including age, gender, height, weight, and other relevant factors were collected, and standardized testing methods were used to measure various parameters. Correlation analysis revealed signifi...
Source: Frontiers in Physiology - March 25, 2024 Category: Physiology Source Type: research
Monte Carlo simulation study of an in vivo four-dimensional tracking system with a diverging collimator for monitoring radiation source (Ir-192) location during brachytherapy: proof of concept and feasibility
Discussion: These results indicated that the newly designed in vivo 4D tracking system for monitoring the Ir-192 source during brachytherapy could determine the 3D position of the radiation source in real time during treatment. We conclude that the proposed positioning system has the potential to make brachytherapy more accurate and reliable. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 25, 2024 Category: Physiology Source Type: research
The interplay of maternal and offspring obesogenic diets: the impact on offspring metabolism and muscle mitochondria in an outbred mouse model
Consumption of obesogenic (OB) diets increases the prevalence of maternal obesity worldwide, causing major psychological and social burdens in women. Obesity not only impacts the mother’s health and fertility but also elevates the risk of obesity and metabolic disorders in the offspring. Family lifestyle is mostly persistent through generations, possibly contributing to the growing prevalence of obesity. We hypothesized that offspring metabolic health is dependent on both maternal and offspring diet and their interaction. We also hypothesized that the sensitivity of the offspring to the diet may be influenced by the matc...
Source: Frontiers in Physiology - March 22, 2024 Category: Physiology Source Type: research
Cardiac fibrogenesis: an immuno-metabolic perspective
Cardiac fibrosis is a major and complex pathophysiological process that ultimately culminates in cardiac dysfunction and heart failure. This phenomenon includes not only the replacement of the damaged tissue by a fibrotic scar produced by activated fibroblasts/myofibroblasts but also a spatiotemporal alteration of the structural, biochemical, and biomechanical parameters in the ventricular wall, eliciting a reactive remodeling process. Though mechanical stress, post-infarct homeostatic imbalances, and neurohormonal activation are classically attributed to cardiac fibrosis, emerging evidence that supports the roles of immun...
Source: Frontiers in Physiology - March 21, 2024 Category: Physiology Source Type: research
Data independent acquisition reveals in-depth serum proteome changes in uremic pruritus
In this study, we employed LC-MS/MS-based data-independent acquisition (DIA) mode to analyze serum samples obtained from 54 UP patients categorized as DKD-UP, HN-UP, and GN-UP (n = 18 for each subgroup), along with 18 uremic patients without pruritus (Negative) and 18 CKD patients without pruritus (CKD). Through DIA mode analysis, a total of 7075 peptides and 959 proteins were quantified. Within these, we identified four upregulated and 13 downregulated Differentially Expressed Proteins (DEPs) in DKD-UP versus Negative, five upregulated and 22 downregulated DEPs in HN-UP versus Negative, and three upregulated and 23 downre...
Source: Frontiers in Physiology - March 21, 2024 Category: Physiology Source Type: research
Changes of uterocervical angle and cervical length in early and mid-pregnancy and their value in predicting spontaneous preterm birth
Conclusion: The combination of UCA and CL has a better ability to predict preterm birth than either measurement alone. A more obtuse UCA or a shorter CL is associated with an earlier spontaneous preterm birth. The UCA increases from early to mid-pregnancy, while the CL decreases from early to mid-pregnancy. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 21, 2024 Category: Physiology Source Type: research
Corrigendum: Exosomes as a delivery tool of exercise-induced beneficial factors for the prevention and treatment of cardiovascular disease: a systematic review and meta-analysis
(Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 20, 2024 Category: Physiology Source Type: research
Causal relationship between physical activity and platelet traits: a Mendelian randomization study
Conclusion: Some types of physical activity have a causal relationship with platelet crit and platelet count. However, the types of physical activity we studied have not supported a causal relationship with mean platelet volume and platelet distribution width. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - March 20, 2024 Category: Physiology Source Type: research
