Calculation of a conversion factor for estimating the glycolytic contribution in exercise from post-exercise blood lactate concentration
Conclusion: These results generally support the use of a common conversion factor to calculate the glycolytic contribution from post-exercise blood lactate concentrations. However, there is some inter-individual variability in the conversion factor. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 24, 2024 Category: Physiology Source Type: research
Intracardiac electrophysiology to characterize susceptibility to ventricular arrhythmias in murine models
In this study, we provide detailed information on PES in mice, including catheter positioning, stimulation protocols, intracardiac and surface ECG interpretation and we reveal a higher susceptibility of two mouse lines to experience triggered ventricular arrhythmias, when compared to control mice.Discussion: Overall, this technique allows to characterize arrhythmias and provides results in phenotyping 2 arrhythmogenic-disease murine models. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 23, 2024 Category: Physiology Source Type: research
Skin temperature influence on transcutaneous carbon dioxide (CO2) conductivity and skin blood flow in healthy human subjects at the arm and wrist
Conclusion: these results are extremely encouraging for the development of next-generation tcpCO2 sensors. Indeed, the moderate increase (× 2) in skin conductivity from NH to 44°C tends to indicate that heating the skin is not critical from a response time point of view, i.e. little to no skin heating would only result in a doubled sensor response time in the worst case, compared to a maximal heating at 44°C. Crucially, a skin temperature within the 35–38°C range already sharply increases the skin blood flow, suggesting that tcpCO2 correlates well with the arterial paCO2 even at such low skin temperatures. These two ...
Source: Frontiers in Physiology - January 23, 2024 Category: Physiology Source Type: research
Effects of whole-body vibration training on physical function, activities of daily living, and quality of life in patients with stroke: a systematic review and meta-analysis
Conclusion: Our findings indicate that WBVT may serve as a viable adjunct therapy for stroke patients to alleviate spasticity and enhance motor and balance functions. Variable frequency and side-alternating vibration appear to be crucial factors influencing the therapeutic effects of WBVT on these dysfunctions. Nonetheless, WBVT did not show significant effects on gait, ADL, or QOL in stroke patients.Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42022384319) (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 23, 2024 Category: Physiology Source Type: research
Effects of acute bouts of evening resistance or endurance exercises on sleep EEG and salivary cortisol
This study underlines significant modifications of sleep quality and quantity after both moderate evening endurance and resistance exercises. Still, these effects cannot be considered as deleterious. In contrast to the resistance exercise, endurance exercise led to an increase in sleep EEG activity associated with hyperarousal during sleep and higher cortisol levels, suggesting an hyperarousal effect of endurance exercise performed in the evening. These results align with previous warning about the arousal effects of evening exercise but do not support the notion of deleterious effects on sleep. While these results provide...
Source: Frontiers in Physiology - January 23, 2024 Category: Physiology Source Type: research
Using dropout based active learning and surrogate models in the inverse viscoelastic parameter identification of human brain tissue
Inverse mechanical parameter identification enables the characterization of ultrasoft materials, for which it is difficult to achieve homogeneous deformation states. However, this usually involves high computational costs that are mainly determined by the complexity of the forward model. While simulation methods like finite element models can capture nearly arbitrary geometries and implement involved constitutive equations, they are also computationally expensive. Machine learning models, such as neural networks, can help mitigate this problem when they are used as surrogate models replacing the complex high fidelity model...
Source: Frontiers in Physiology - January 23, 2024 Category: Physiology Source Type: research
Mindful breathing as an effective technique in the management of hypertension
Discussion: Mindful breathing for 15 min a day, at a rate of 6 breaths per minute is effective in lowering blood pressure, and has both an immediate, and a short term effect (over several days). This large scale study demonstrates that device guided mindful breathing with a consumer wearable for 15 min a day is effective in lowering blood pressure, and a helpful complement to the standard of care. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 23, 2024 Category: Physiology Source Type: research
Timing of diuretic administration effects on urine volume in hospitalized patients
Discussion: Time-of-day of medication administration may be a factor associated with increased medication efficiency. Randomized controlled trials should be conducted to quantify the relative effect of modifiable factors, such as time of medication administration, that may affect short- and longer-term outcomes. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 23, 2024 Category: Physiology Source Type: research
β2-Adrenoceptors activation regulates muscle trophic-related genes following acute resistance exercise in mice
This study investigated the effects of the β2-ARs blockade on the acute molecular responses induced by a single bout of RE in rodent skeletal muscles. Male C57BL6/J mice were subjected to a single bout of progressive RE (until exhaustion) on a vertical ladder under β2-AR blockade with ICI 118,551 (ICI; 10 mg kg-1, i. p.), or vehicle (sterile saline; 0.9%, i. p.), and the gene expression was analyzed in gastrocnemius (GAS) muscles by qPCR. We demonstrated that a single bout of RE acutely increased the circulating levels of stress-associated hormones norepinephrine (NE) and corticosterone (CORT), as well as the muscle ph...
Source: Frontiers in Physiology - January 22, 2024 Category: Physiology Source Type: research
Cardiorespiratory and metabolic consequences of detraining in endurance athletes
Conclusion: There is a dearth of data investigating the detraining effects of training reduction/cessation among endurance athletes. Delving deeper into this topic may be useful for professionals and researchers to identify the optimal strategies to minimize these effects. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 22, 2024 Category: Physiology Source Type: research
Phenotyping of light-activated neurons in the mouse SCN based on the expression of FOS and EGR1
Discussion: Our analysis revealed cell-specific differences in light responsiveness between different peptidergic and Ngb-expressing neurons in different compartments of the mouse SCN, indicating that light activates diverse neuronal networks in the SCN, some of which participate in photoentrainment. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 22, 2024 Category: Physiology Source Type: research
Advances in metabolic reprogramming of renal tubular epithelial cells in sepsis-associated acute kidney injury
We present various intervention targets that could facilitate the recovery of oxidative phosphorylation-centric metabolism. These novel insights and strategies aim to transform the clinical prevention and treatment landscape of sepsis-associated acute kidney injury, with a focus on metabolic mechanisms. This investigation could provide valuable insights for clinicians aiming to enhance patient outcomes in the context of sepsis-associated acute kidney injury. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 19, 2024 Category: Physiology Source Type: research
Bone resorption by osteoclasts involves fine tuning of RHOA activity by its microtubule-associated exchange factor GEF-H1
We report here that actin ring disorganization upon microtubule depolymerization is mediated by the activation of the RHOA-ROCK signaling pathway. We next show the involvement of GEF-H1, one of RHOA guanine exchange factor highly expressed in osteoclasts, which has the particularity of being negatively regulated by sequestration on microtubules. Using a CRISPR/Cas9-mediated GEF-H1 knock-down osteoclast model, we demonstrate that RHOA activation upon microtubule depolymerization is mediated by GEF-H1 release. Interestingly, although lower levels of GEF-H1 did not impact sealing zone formation in the presence of an intact mi...
Source: Frontiers in Physiology - January 19, 2024 Category: Physiology Source Type: research
A hemodynamic analysis of energy loss in abdominal aortic aneurysm using three-dimension idealized model
Conclusion: Collectively, increases in aneurysm diameter, curvature, and eccentricity all raise mean flow EL and turbulent flow EL, which may aggravate the damage and disturbance of flow in aneurysm. In addition, it can be inferred by conventional parameters (TAWSS, OSI, RRT and ECAP) that the increase of aneurysm diameter may raise the risk of thrombosis, whereas the curvature and eccentricity appeared to have a protective effect against thrombosis. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 19, 2024 Category: Physiology Source Type: research
Effects of beta-blockers use on mortality of patients with acute respiratory distress syndrome: a retrospective cohort study
Conclusion: The findings suggest a potential association between beta-blocker usage and reduced mortality in critically ill patients with ARDS. However, further validation of this observation is needed through randomized controlled trials. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - January 19, 2024 Category: Physiology Source Type: research
