Identification and functional analysis of ovarian lncRNAs during different egg laying periods in Taihe Black-Bone Chickens
This study randomly selected ovarian tissues from 12 chickens for RNA-seq. Four chickens were selected for each period, including the early laying period (102 days, Pre), the peak laying period (203 days, Peak), and the late laying period (394 days, Late). Based on our previous study of mRNA expression profiles in the same ovarian tissue, we identified three differentially expressed lncRNAs (DE lncRNAs) at different periods and searched for their cis- and trans-target genes to draw an lncRNA-mRNA network.Results and discussion: In three groups of ovarian tissues, we identified 136 DE lncRNAs, with 8 showing specific exp...
Source: Frontiers in Physiology - February 15, 2024 Category: Physiology Source Type: research
Editorial: Physiological education: preparing for the future
(Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 15, 2024 Category: Physiology Source Type: research
An artificial intelligence-based bone age assessment model for Han and Tibetan children
Conclusion: EVG-BANet can accurately predict the bone age (BA) for both Han children and Tibetan children living in the Tibetan Plateau with limited healthcare facilities. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 15, 2024 Category: Physiology Source Type: research
Alteration in the number, morphology, function, and metabolism of erythrocytes in high-altitude polycythemia
Conclusion: In model rats, an HAPC-related erythrocyte increase was associated with enhanced bone marrow hematopoietic function and reduced erythrocyte apoptosis, whereas numerous abnormal erythrocytes, increased EOF, and reduced hemolysis resistance were associated with erythrocyte metabolism. CD73/adenosine/S1P/2,3-BPG and eENT1/adenosine/BPGM/2,3-BPG metabolic pathways in erythrocytes were activated in HAPC rats, facilitating oxygen release. These findings further reveal the intrinsic HAPC mechanism and forms a basis for future development of preventive and therapeutic strategies for HAPC. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 15, 2024 Category: Physiology Source Type: research
Volume loss during muscle reinnervation surgery is correlated with reduced CMAP amplitude but not reduced force output in a rat hindlimb model
Discussion: The results from our rat model of MR suggests that tissue electrophysiology (CMAPs) and kinesiology (force production) may recover on different time scales, with volumetric muscle loss at the time of MR surgery not significantly reducing functional outcome measurements for the DMTs after 100 days of reinnervation. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 15, 2024 Category: Physiology Source Type: research
Knockdown of ANGPTL2 promotes left ventricular systolic dysfunction by upregulation of NOX4 in mice
Conclusion: Together, these data reveal that the absence of ANGPTL2 induces an upregulation of cardiac NOX4 that contributes to oxidative stress and LV dysfunction. By interacting and repressing cardiac NOX4, ANGPTL2 could play a new beneficial role in the maintenance of cardiac redox homeostasis and function. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 15, 2024 Category: Physiology Source Type: research
Assessment of intracranial aneurysm rupture risk using a point cloud-based deep learning model
Conclusion: The point cloud, as a 3D visualization technique for intracranial aneurysms, can effectively capture the spatial contour and morphological aspects of aneurysms. More structural features between the aneurysm and its parent vessels can be exposed by keeping a portion of the parent vessels, enhancing the model’s performance. The point cloud-based deep learning model exhibited good performance in predicting rupture risk while also facing challenges in generalizability. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 15, 2024 Category: Physiology Source Type: research
Proteomic analyses of urinary exosomes identify novel potential biomarkers for early diagnosis of sickle cell nephropathy, a sex-based study
Sickle cell nephropathy (SCN) is a leading cause of morbidity and mortality in sickle cell disease (SCD). Early intervention is crucial for mitigating its effects. However, current diagnostic methods rely on generic tests and may not detect SCN until irreversible renal damage occurs. Therefore, specific biomarkers for early diagnosis of SCN are needed. Urinary exosomes, membrane-bound vesicles secreted by renal podocytes and epithelial cells, contain both common and cell type-specific membrane and cytosolic proteins, reflecting the physiologic and pathophysiologic states of the kidney. Using proteomics, we analyzed the pro...
Source: Frontiers in Physiology - February 15, 2024 Category: Physiology Source Type: research
Individually optimized estimation of energy expenditure in rescue workers using a tri-axial accelerometer and heart rate monitor
Conclusion: The use of wearables provided a reasonable estimation of energy expenditure for physical workers with heavy equipment. The application of our approach to disaster relief and rescue operations can provide important insights into nutrition and healthcare management. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 15, 2024 Category: Physiology Source Type: research
Differential responses of selectively bred mussels (Perna canaliculus) to heat stress —survival, immunology, gene expression and microbiome diversity
This study aimed to identify general biomarkers of heat stress in P. canaliculus and to assess whether responses differed between genetically distinct selectively bred mussels. We exposed three families of selectively bred mussels (families A, B and C) to three seawater temperature regimes in the laboratory: 1) a “control” treatment (ambient 12°C), 2) a 26°C heat challenge with a subsequent recovery period, and 3) a sustained 26°C heat challenge with no recovery. We investigated whether the survival, immune response (hemocyte concentration and viability, oxidative stress and total antioxidant capacity), hemocyte gen...
Source: Frontiers in Physiology - February 15, 2024 Category: Physiology Source Type: research
Editorial: Cold, heat and hypoxia as a medical tool: the use in a healthy and diseased population
(Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 14, 2024 Category: Physiology Source Type: research
Comparison of pectoralis major muscle satellite cell assay methods: an opinion paper
(Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 14, 2024 Category: Physiology Source Type: research
GLP-2 regulation of intestinal lipid handling
Lipid handling in the intestine is important for maintaining energy homeostasis and overall health. Mishandling of lipids in the intestine contributes to dyslipidemia and atherosclerotic cardiovascular diseases. Despite advances in this field over the past few decades, significant gaps remain. The gut hormone glucagon-like peptide-2 (GLP-2) has been shown to play pleotropic roles in the regulation of lipid handling in the intestine. Of note, GLP-2 exhibits unique actions on post-prandial lipid absorption and post-absorptive release of intestinally stored lipids. This review aims to summarize current knowledge in how GLP-2 ...
Source: Frontiers in Physiology - February 14, 2024 Category: Physiology Source Type: research
An observational study ascertaining the prevalence of bullae and blebs in young, healthy adults and its possible implications for scuba diving
This study aims to ascertain the prevalence of bullae in young and healthy adults.Methods: This single-center cross-sectional observational study re-assessed the CT scans of adults (aged 18—40) performed for a clinical suspicion for pulmonary embolism, from 1 January 2016 to 1 March 2020. Presence of bullae was recorded in an electronic database. Chi-square and Fisher exact tests were used for statistical analyses. Additionally, a multivariate logistic regression analysis was performed to study the independent predictive value of identified risk factors.Results: A total of 1,014 cases were identified, of which 836 could ...
Source: Frontiers in Physiology - February 14, 2024 Category: Physiology Source Type: research
Higher perfusion pressure and pump flow during cardiopulmonary bypass are beneficial for kidney function –a single-centre prospective study
Conclusion: Maintaining MAP > 90 mmHg during the CPB positively impacts intraoperative and postoperative kidney function. It significantly reduces renal hypoperfusion during the procedure compared to MAP < 70 mmHg. MAP > 90 mmHg is safe for the central nervous system, and preliminary results suggest that it may have a beneficial impact on the incidence of postoperative delirium. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 14, 2024 Category: Physiology Source Type: research
