Abnormal prenatal brain development in Chiari II malformation
DiscussionWe conclude that regional brain development should be taken into consideration when evaluating prenatal brain development in fetuses with Chiari II. (Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - April 17, 2023 Category: Neurology Source Type: research
Spatiotemporal dynamics of the development of mouse olfactory system from prenatal to postnatal period
DiscussionOverall, the present study laid the groundwork for a better understanding of the spatial and temporal developmental events of the olfactory system. (Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - April 11, 2023 Category: Neurology Source Type: research
On the other end of the line: Extracellular vesicle-mediated communication in glaucoma
In the last decade, extracellular vesicles (EVs) have emerged as a promising field of research due to their ability to participate in cell-to-cell communication via the transfer of their very diverse and complex cargo. The latter reflects the nature and physiological state of the cell of origin and, as such, EVs may not only play a pivotal role in the cellular events that culminate into disease, but also hold great potential as drug delivery vehicles and biomarkers. Yet, their role in glaucoma, the leading cause of irreversible blindness worldwide, has not been fully studied. Here, we provide an overview of the different E...
Source: Frontiers in Neuroanatomy - April 11, 2023 Category: Neurology Source Type: research
Editorial: Understanding retinal remodeling: Retinal alterations and therapeutic implications
(Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - April 5, 2023 Category: Neurology Source Type: research
Structural plasticity of the axon initial segment in rat hippocampal granule cells following high frequency stimulation and LTP induction
The axon initial segment (AIS) is the site of action potential initiation and important for the integration of synaptic input. Length and localization of the AIS are dynamic, modulated by afferent activity and contribute to the homeostatic control of neuronal excitability. Synaptopodin is a plasticity-related protein expressed by the majority of telencephalic neurons. It is required for the formation of cisternal organelles within the AIS and an excellent marker to identify these enigmatic organelles at the light microscopic level. Here we applied 2 h of high frequency stimulation of the medial perforant path in rats in vi...
Source: Frontiers in Neuroanatomy - April 5, 2023 Category: Neurology Source Type: research
Ex vivo, in situ perfusion protocol for human brain fixation compatible with microscopy, MRI techniques, and anatomical studies
We describe the compatibility of the method proposed for intravascular fixation of the human brain and fixation of the donor’s body for anatomical purposes. Thus, body donor programs can provide human brain tissue, while the remainder of the body can also be fixed for anatomical studies. Therefore, this method of human brain fixation through the carotid system optimizes the procurement of human brain tissue, allowing a greater understanding of human neurological diseases, while benefiting anatomy departments by making the remainder of the body available for teaching purposes. (Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - March 23, 2023 Category: Neurology Source Type: research
Corrigendum: The olfactory tract: Basis for future evolution in response to rapidly changing ecological niches
(Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - March 23, 2023 Category: Neurology Source Type: research
A preliminary study of diffusion tensor imaging in root entry zone of primary trigeminal neuralgia
ConclusionQuantitative variables derived from DTI in REZ had significantly different profiles between PTN patients and HCs, which were associated with VAS situation and the disease course of PTN. The comprehensive index established on DTI variables were of great potential to reveal the microstructure changes in PTN patients and predict the therapeutic effect. (Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - March 22, 2023 Category: Neurology Source Type: research
Spatiotemporal microvascular changes following contusive spinal cord injury
Microvascular integrity is disrupted following spinal cord injury (SCI) by both primary and secondary insults. Changes to neuronal structures are well documented, but little is known about how the capillaries change and recover following injury. Spatiotemporal morphological information is required to explore potential treatments targeting the microvasculature post-SCI to improve functional recovery. Sprague-Dawley rats were given a T10 moderate/severe (200 kDyn) contusion injury and were perfuse-fixed at days 2, 5, 15, and 45 post-injury. Unbiased stereology following immunohistochemistry in four areas (ventral and dorsal ...
Source: Frontiers in Neuroanatomy - March 21, 2023 Category: Neurology Source Type: research
3D electron microscopy and volume-based bouton sorting reveal the selectivity of inputs onto geniculate relay cell and interneuron dendrite segments
ConclusionThe results underlie differences in network properties of synaptic inputs from distinct origins on geniculate cell types. (Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - March 17, 2023 Category: Neurology Source Type: research
The L1 cell adhesion molecule constrains dendritic spine density in pyramidal neurons of the mouse cerebral cortex
This study provides insight into the molecular mechanism of spine regulation and underscores the potential for this adhesion molecule to regulate cognitive and other L1-related functions that are abnormal in the L1 syndrome. (Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - March 16, 2023 Category: Neurology Source Type: research
Comparing the effects of transcranial alternating current and temporal interference (tTIS) electric stimulation through whole-brain mapping of c-Fos immunoreactivity
The analysis of the topography of brain neuromodulation following transcranial alternating current (AC) stimulation is relevant for defining strategies directed to specific nuclei stimulation in patients. Among the different procedures of AC stimulation, temporal interference (tTIS) is a novel method for non-invasive neuromodulation of specific deep brain targets. However, little information is currently available about its tissue effects and its activation topography in in vivo animal models. After a single session (30 min, 0.12 mA) of transcranial alternate current (2,000 Hz; ES/AC group) or tTIS (2,000/2,010 Hz; Es/tTIS...
Source: Frontiers in Neuroanatomy - March 13, 2023 Category: Neurology Source Type: research
Suppression of neuronal apoptosis and glial activation with modulation of Nrf2/HO-1 and NF-kB signaling by curcumin in streptozotocin-induced diabetic spinal cord central neuropathy
DiscussionCurcumin could suppress diabetic spinal cord central neuropathy, glial activation, and neuronal apoptosis with the regulation of Nrf2/HO-1 and NF-kB signaling. (Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - March 9, 2023 Category: Neurology Source Type: research
Molecular identity of the lateral lemniscus nuclei in the adult mouse brain
In conclusion, the LLN are characterized by specific molecular profiles that reflect their rostrocaudal organization into the three constituent nuclei. This molecular regionalization may be involved in the etiology of some hearing disorders, in accordance with previous functional studies of these genes. (Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - March 9, 2023 Category: Neurology Source Type: research
Loss of M üller cell glutamine synthetase immunoreactivity is associated with neuronal changes in late-stage retinal degeneration
ConclusionThese findings further support a strong interplay between glia-neuronal alterations in late-stage degeneration and highlight a need for future studies and consideration in intervention development. (Source: Frontiers in Neuroanatomy)
Source: Frontiers in Neuroanatomy - March 7, 2023 Category: Neurology Source Type: research
