Investigating the tumor-immune microenvironment through extracellular vesicles from frozen patient biopsies and 3D cultures
Melanomas are highly immunogenic tumors that have been shown to activate the immune response. Nonetheless, a significant portion of melanoma cases are either unresponsive to immunotherapy or relapsed due to acquired resistance. During melanomagenesis, melanoma and immune cells undergo immunomodulatory mechanisms that aid in immune resistance and evasion. The crosstalk within melanoma microenvironment is facilitated through the secretion of soluble factors, growth factors, cytokines, and chemokines. In addition, the release and uptake of secretory vesicles known as extracellular vesicles (EVs) play a key role in shaping the...
Source: Frontiers in Immunology - May 25, 2023 Category: Allergy & Immunology Source Type: research
Prediction of mortality in pneumonia patients with connective tissue disease treated with glucocorticoids or/and immunosuppressants by machine learning
ConclusionIn this study, the nomogram developed performed well in predicting the 90-day risk of death in pneumonia patients with CTD treated with glucocorticoids or/and immunosuppressants. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 25, 2023 Category: Allergy & Immunology Source Type: research
Feeding the gut microbiome: impact on multiple sclerosis
Multiple sclerosis (MS) is a multifactorial neurological disease characterized by chronic inflammation and immune-driven demyelination of the central nervous system (CNS). The rising number of MS cases in the last decade could be partially attributed to environmental changes, among which the alteration of the gut microbiome driven by novel dietary habits is now of particular interest. The intent of this review is to describe how diet can impact the development and course of MS by feeding the gut microbiome. We discuss the role of nutrition and the gut microbiota in MS disease, describing preclinical studies on experimental...
Source: Frontiers in Immunology - May 25, 2023 Category: Allergy & Immunology Source Type: research
Prognostic immunogenic characteristics of iron pendant disease modifiers in colon cancer
ConclusionsThe model showed a superior response to immunotherapy in the high-risk group, revealing a potential relationship between iron death and tumor immunotherapy, which will provide new ideas for the treatment and prognostic assessment of colon cancer patients. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 25, 2023 Category: Allergy & Immunology Source Type: research
Crosstalk between the gut microbiota and innate lymphoid cells in intestinal mucosal immunity
The human gastrointestinal mucosa is colonized by thousands of microorganisms, which participate in a variety of physiological functions. Intestinal dysbiosis is closely associated with the pathogenesis of several human diseases. Innate lymphoid cells (ILCs), which include NK cells, ILC1s, ILC2s, ILC3s and LTi cells, are a type of innate immune cells. They are enriched in the mucosal tissues of the body, and have recently received extensive attention. The gut microbiota and its metabolites play important roles in various intestinal mucosal diseases, such as inflammatory bowel disease (IBD), allergic disease, and cancer. Th...
Source: Frontiers in Immunology - May 25, 2023 Category: Allergy & Immunology Source Type: research
Reducedhumoral response against variants of concern in childhood solid cancer patients compared to adult patients and healthy children after SARS-CoV-2 vaccination
ConclusionsThe humoral response against VOCs after the CoronaVac vaccination in CCP was moderately impaired although the vaccine was safe. Age and chemotherapy time seem to be the primary reason for poor response and low serology levels. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 25, 2023 Category: Allergy & Immunology Source Type: research
Corrigendum: Definition of the immune parameters related to COVID-19 severity
(Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 24, 2023 Category: Allergy & Immunology Source Type: research
Efficacy and safety of chimeric antigen receptor T cell therapy in relapsed/refractory diffuse large B-cell lymphoma with different HBV status: a retrospective study from a single center
ConclusionsCAR-T therapy was effective and can be used safely in r/r DLBCL with HBV infection under proper monitoring and antiviral prophylaxis. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 24, 2023 Category: Allergy & Immunology Source Type: research
Circulating sepsis-related metabolite sphinganine could protect against intestinal damage during sepsis
DiscussionThese findings highlighted the potential diagnostic value of the ML, and also provided new insight into enhanced therapy and/or preventative measures against sepsis. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 24, 2023 Category: Allergy & Immunology Source Type: research
Gut epithelial barrier dysfunction in lupus triggers a differential humoral response against gut commensals
DiscussionLupus development can cause alterations in microbiota composition, allowing specific species to colonize only the lupus gut. Eventually, these alterations and the changes in gut permeability induced by intestinal inflammation could lead to bacterial translocation. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 24, 2023 Category: Allergy & Immunology Source Type: research
Case Report: Persistent response to combination therapy of pemigatinib, chemotherapy, and immune checkpoint inhibitor in a patient with advanced intrahepatic cholangiocarcinoma
Patients with advanced intrahepatic cholangiocarcinoma (iCCA) often have a poor prognosis. Recent advancements in targeted molecular therapy and immunotherapy have been made. Herein, we report a case of advanced iCCA treated with a combination of pemigatinib (a selective FGFR inhibitor), chemotherapy, and an immune checkpoint inhibitor. A 34-year-old female was diagnosed with advanced iCCA with multiple liver masses and metastases in the peritoneum and lymph nodes. Next-generation sequencing (NGS) identified the genetic mutations. An FGFR2-BICC1 gene fusion was found in this patient. The patient was treated with pemigatini...
Source: Frontiers in Immunology - May 24, 2023 Category: Allergy & Immunology Source Type: research
Corrigendum: The impact of circadian rhythm on Bacillus Calmette-Gu érin vaccination effects on SARS-CoV-2 infections
(Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 24, 2023 Category: Allergy & Immunology Source Type: research
A case report of pulmonary hepatoid adenocarcinoma: promoting standardized diagnosis and treatment of the rare disease
ConclusionPulmonary hepatoid adenocarcinoma is a rare epithelial malignancy of primary origin in the lung with poor prognosis. Establishing the diagnosis relies mainly on the detection of hepatocellular structural morphology resembling hepatocellular carcinoma, and on clinicopathological and immunohistochemical testing to exclude diseases such as hepatocellular carcinoma. Combination treatment, mainly surgery, can prolong the survival of early-stage cases of the disease, whereas radiotherapy is mostly used for intermediate and advanced cases. Individualized treatment with molecular-targeted drugs and immunotherapy has show...
Source: Frontiers in Immunology - May 24, 2023 Category: Allergy & Immunology Source Type: research
Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma
ConclusionOverall, this study reveals that Abrine as an IDO1 inhibitor has an inhibition effect on immune escape and has a synergistic effect with the anti-PD-1 antibody on the treatment of HCC. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 24, 2023 Category: Allergy & Immunology Source Type: research
Editorial: A year in review: discussions in B cell biology
(Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 24, 2023 Category: Allergy & Immunology Source Type: research
