Assessing awareness in severe Alzheimer ’s disease
There is an urgent need to understand the nature of awareness in people with severe Alzheimer’s disease (AD) to ensure effective person-centered care. Objective biomarkers of awareness validated in other clinical groups (e.g., anesthesia, minimally conscious states) offer an opportunity to investigate awareness in people with severe AD. In this article we demonstrate the feasibility of using Transcranial magnetic stimulation (TMS) combined with EEG, event related potentials (ERPs) and fMRI to assess awareness in severe AD. TMS-EEG was performed in six healthy older controls and three people with severe AD. The perturbati...
Source: Frontiers in Human Neuroscience - February 1, 2023 Category: Neuroscience Source Type: research

Detection of epileptic seizures through EEG signals using entropy features and ensemble learning
IntroductionEpilepsy is a disorder of the central nervous system that is often accompanied by recurrent seizures. World health organization (WHO) estimated that more than 50 million people worldwide suffer from epilepsy. Although electroencephalogram (EEG) signals contain vital physiological and pathological information of brain and they are a prominent medical tool for detecting epileptic seizures, visual interpretation of such tools is time-consuming. Since early diagnosis of epilepsy is essential to control seizures, we present a new method using data mining and machine learning techniques to diagnose epileptic seizures...
Source: Frontiers in Human Neuroscience - February 1, 2023 Category: Neuroscience Source Type: research

Editorial: Understanding emotions using brain imaging and stimulation techniques
(Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - January 31, 2023 Category: Neuroscience Source Type: research

Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation
The deep brain stimulation (DBS) Think Tank X was held on August 17–19, 2022 in Orlando FL. The session organizers and moderators were all women with the theme women in neuromodulation. Dr. Helen Mayberg from Mt. Sinai, NY was the keynote speaker. She discussed milestones and her experiences in developing depression DBS. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers (from industry and academia) can freely discuss current and emerging DBS technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank X sp...
Source: Frontiers in Human Neuroscience - January 27, 2023 Category: Neuroscience Source Type: research

A study based on functional near-infrared spectroscopy: Cortical responses to music interventions in patients with myofascial pain syndrome
ConclusionThis study combines objective assessment indicators and subjective scale assessments to demonstrate that appropriate music interventions can be effective in helping to relieve pain to some extent. The analgesic mechanisms between relevant brain regions under music intervention were explored in depth. New insights into effective analgesic methods and quantitative assessment of pain conditions are presented. (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - January 27, 2023 Category: Neuroscience Source Type: research

Case report: A novel approach of closed-loop brain stimulation combined with robot gait training in post-stroke gait disturbance
Most post-stroke patients have long-lasting gait disturbances that reduce their daily activities. They often show impaired hip and knee joint flexion and ankle dorsiflexion of the lower limbs during the swing phase of gait, which is controlled by the corticospinal tract from the primary motor cortex (M1). Recently, we reported that gait-synchronized closed-loop brain stimulation targeting swing phase-related activity in the affected M1 can improve gait function in post-stroke patients. Subsequently, a gait-training robot (Orthobot®) was developed that could assist lower-limb joint movements during the swing phase of gait....
Source: Frontiers in Human Neuroscience - January 27, 2023 Category: Neuroscience Source Type: research

The classification of brain network for major depressive disorder patients based on deep graph convolutional neural network
DiscussionBased on a large, multi-site dataset from MDD patients, the results expressed that DGCNN is not an extremely accurate method for MDD diagnosis. However, there is an improvement over previous methods with our goal of better understanding brain function and ultimately providing a biomarker or diagnostic capability for MDD diagnosis. (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - January 26, 2023 Category: Neuroscience Source Type: research

The Topo-Speech sensory substitution system as a method of conveying spatial information to the blind and vision impaired
This study evaluates the Topo-Speech algorithm in the blind and visually impaired. The system provides spatial information about the external world by applying sensory substitution alongside symbolic representations in a manner that corresponds with the unique way our brains acquire and process information. This is done by conveying spatial information, customarily acquired through vision, through the auditory channel, in a combination of sensory (auditory) features and symbolic language (named/spoken) features. The Topo-Speech sweeps the visual scene or image and represents objects’ identity by employing naming in a spo...
Source: Frontiers in Human Neuroscience - January 26, 2023 Category: Neuroscience Source Type: research

Efficient suppression of parkinsonian beta oscillations in a closed-loop model of deep brain stimulation with amplitude modulation
DiscussionEfficient models of closed-loop stimulation may contribute to the clinical development of optimized aDBS techniques designed to reduce potential stimulation-induced side effects of cDBS in PD patients while leading to a better therapeutic outcome. (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - January 26, 2023 Category: Neuroscience Source Type: research

Positive changes to written language following phonological treatment in logopenic variant primary progressive aphasia: Case report
Phonological impairment contributes to deficits in repetition and spoken naming in logopenic variant Primary Progressive Aphasia (lvPPA), but weakened phonology can also affect written language skills. In this experimental case report, we demonstrate phonological text agraphia in a 71-year-old woman in the early stages of lvPPA that undermined her ability to write meaningful, grammatical sentences. We investigated the therapeutic value of a rigorous treatment protocol to strengthen phonological manipulation skills coupled with transcranial direct current stimulation (tDCS). Intervention took place 5 days a week for 2 weeks...
Source: Frontiers in Human Neuroscience - January 25, 2023 Category: Neuroscience Source Type: research

Temporal attention affects contrast response function by response gain
Orienting attention to a specific point in time has been shown to improve the contrast sensitivity at the attended time point and impair it earlier or later. This phenomenon could be explained by temporal attention increasing the effective contrast of the target presented at the attended time point which leads to changes in contrast psychometric function by contrast gain. Another explanation is that temporal attention multiplicatively amplifies the amplitude of behavioral or neural response to contrast, resulting in alterations in contrast psychometric function by response gain. To explore the underlying mechanism, we adop...
Source: Frontiers in Human Neuroscience - January 25, 2023 Category: Neuroscience Source Type: research

Association between intensity or accumulating pattern of physical activity and executive function in community-dwelling older adults: A cross-sectional study with compositional data analysis
ConclusionLPA was positively associated with inhibitory control, and this association was stronger in bouts of LPA than in sporadic LPA. Moreover, reducing the time spent in SB or sleep and increasing the time spent in LPA, especially long-bout LPA, could be important measures for managing inhibitory control in late life. Future large longitudinal and intervention studies are needed to confirm these associations and reveal the causality and underlying mechanisms. (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - January 25, 2023 Category: Neuroscience Source Type: research

The contribution of coherence field theory to a model of consciousness: electric currents, EM fields, and EM radiation in the brain
A paradigm in neuroscience is developing which views resonance as the phenomenon responsible for consciousness. Much progress is being made in the investigation of how resonance as oscillating flows within the brain’s electric field might result in production of mind from matter. But it’s mostly unknown how vibrations among features of matter such as nanoscale atomic structures and photonic waves may participate in forming the basic substance of first-person consciousness, meaning percepts such as colors, textures, sounds, thoughts, feelings et cetera. Initial evidence at the leading edge of quantum biology suggests th...
Source: Frontiers in Human Neuroscience - January 24, 2023 Category: Neuroscience Source Type: research

Editorial: Normalization of human social and emotional dysfunction using noninvasive brain modulation approaches: From proof-of-concept to clinical studies
(Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - January 24, 2023 Category: Neuroscience Source Type: research

Editorial: Recording and modulating neural activity in neurodegenerative diseases: Pathophysiological and therapeutic implications
(Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - January 24, 2023 Category: Neuroscience Source Type: research