Comparative genomics and bioinformatics approaches revealed the role of CC-NBS-LRR genes under multiple stresses in passion fruit
This study lays the groundwork for future investigations aimed at enhancing the genetic composition of passion fruit to ensure robust growth and productivity in challenging environments. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - February 26, 2024 Category: Genetics & Stem Cells Source Type: research
Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics
Vascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a senescence-associated secretory phenotype macromolecular damage, and metabolic dysregulation. Vascular senescence has been demonstrated to play a key role in different vascular diseases, such as atherosclerosis, peripheral arterial disease, hypertension, stroke, diabetes, chronic venous disease, and venous ulcers. Even though cellular senescence was first described in 1961...
Source: Frontiers in Genetics - February 26, 2024 Category: Genetics & Stem Cells Source Type: research
Differentially expressed microRNAs targeting genes in key pathways in keratoconus
Conclusion: Indicated miRNAs and their target genes might be involved in KTCN pathogenesis via disruption of crucial molecular processes, including ECM organization and signal transduction. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - February 26, 2024 Category: Genetics & Stem Cells Source Type: research
Functional polymorphisms of NOS3 and GUCY1A3 affect both nitric oxide formation and association with hypertensive disorders of pregnancy
Impaired nitric oxide (NO) formation may be associated with endothelial dysfunction and increased cardiovascular disease risk in preeclampsia (PE). Functional single-nucleotide polymorphisms (SNPs) of nitric oxide synthase 3 (NOS3) (rs3918226) and guanylate cyclase 1, soluble, alpha 3 (GUCY1A3) (rs7692387) increase susceptibility to the adverse consequences due to inadequate generation of NO by the endothelium. However, no previous study has examined whether these SNPs affect NO formation in healthy pregnancy and in gestational hypertension (GH) and PE. Here, we compared the alleles and genotypes of NOS3 (rs3918226) and GU...
Source: Frontiers in Genetics - February 26, 2024 Category: Genetics & Stem Cells Source Type: research
External proficiency testing for histocompatibility and immunogenetics in today and future
The Histocompatibility and Immunogenetics laboratories provide disease association and pharmacogenetic analyses as well as the tests required for transplantation immunology and transfusion medicine. They perform Human Leukocyte Antigen (HLA) genotyping in patients/recipients and potential donor candidates for solid organ and stem cell transplants using various molecular methods, and determine mismatches. In addition, they also perform HLA antibody tests to detect anti-HLA antibodies in patients and flow cross-matches to evaluate donor-recipient compatibility. Evidence-based clinical guidelines have emphasized the importanc...
Source: Frontiers in Genetics - February 26, 2024 Category: Genetics & Stem Cells Source Type: research
Comparison of RNA-Seq and microarray in the prediction of protein expression and survival prediction
Gene expression profiling using RNA-sequencing (RNA-seq) and microarray technologies is widely used in cancer research to identify biomarkers for clinical endpoint prediction. We compared the performance of these two methods in predicting protein expression and clinical endpoints using The Cancer Genome Atlas (TCGA) datasets of lung cancer, colorectal cancer, renal cancer, breast cancer, endometrial cancer, and ovarian cancer. We calculated the correlation coefficients between gene expression measured by RNA-seq or microarray and protein expression measured by reverse phase protein array (RPPA). In addition, after selectin...
Source: Frontiers in Genetics - February 23, 2024 Category: Genetics & Stem Cells Source Type: research
DeepCBS: shedding light on the impact of mutations occurring at CTCF binding sites
In conclusion, DeepCBS is a promising method to analyze impacts of mutations occurring at CTCF binding sites on the insulator function of CTCF, with potential extensions to shed light on the effects of mutations on other functions of CTCF. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - February 23, 2024 Category: Genetics & Stem Cells Source Type: research
A maternally derived complex small supernumerary marker chromosome involving chromosomes 8 and 14: case report and review of the literature
Conclusion: This report highlights the importance of cytogenetics in diagnosis of rare genetic disorders, with impact on genetic counselling of patients and their families. There are three comparable cases in the literature involving both chromosomes 8 and 14, but with different breakpoints; the complex sSMC derived from chromosomes 8 and 14 in this case, characterized as der(14)t(8;14) (p22.3;q21)mat. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - February 23, 2024 Category: Genetics & Stem Cells Source Type: research
Genotype-by-environment interactions govern fitness changes associated with adaptive mutations in two-component response systems
Discussion: This three-step response shows that different mutations in a single gene leads to individualized phenotypes governed by unique GxE interactions that not only contribute to transcriptional divergence but also to phenotypic plasticity. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - February 23, 2024 Category: Genetics & Stem Cells Source Type: research
Comparative transcriptome and metabolome profiles of the leaf and fruits of a Xianjinfeng litchi budding mutant and its mother plant
Conclusion: These results provide the groundwork for breeding litchi for fruit and leaf traits that are useful for its taste and yield. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - February 23, 2024 Category: Genetics & Stem Cells Source Type: research
Editorial: Insights in RNA: 2022
(Source: Frontiers in Genetics)
Source: Frontiers in Genetics - February 22, 2024 Category: Genetics & Stem Cells Source Type: research
Potential causal associations of PM2.5 and osteoporosis: a two-sample mendelian randomization study
Conclusion: In contrast to most observational studies, our research did not discover a potential causal relationship between PM2.5 and the development of osteoporosis. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - February 22, 2024 Category: Genetics & Stem Cells Source Type: research
Association of sleep traits with male fertility: a two-sample Mendelian randomization study
Conclusion: This study found that chronotype affects testosterone secretion levels. However, further studies are needed to explain this mechanism. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - February 22, 2024 Category: Genetics & Stem Cells Source Type: research
Editorial: Unveiling novel aspects of SARS-CoV-2 to combat COVID-19
(Source: Frontiers in Genetics)
Source: Frontiers in Genetics - February 21, 2024 Category: Genetics & Stem Cells Source Type: research
Linkage mapping and genomic prediction of grain quality traits in tropical maize (Zea mays L.)
The suboptimal productivity of maize systems in sub-Saharan Africa (SSA) is a pressing issue, with far-reaching implications for food security, nutrition, and livelihood sustainability within the affected smallholder farming communities. Dissecting the genetic basis of grain protein, starch and oil content can increase our understanding of the governing genetic systems, improve the efficacy of future breeding schemes and optimize the end-use quality of tropical maize. Here, four bi-parental maize populations were evaluated in field trials in Kenya and genotyped with mid-density single nucleotide polymorphism (SNP) markers....
Source: Frontiers in Genetics - February 21, 2024 Category: Genetics & Stem Cells Source Type: research
