Pathogenesis of uterine fibroids: current understanding and future directions
Fibroids are benign uterine tumors characterized by proliferation of uterine smooth muscle cells, embedded in an abundant extracellular matrix. Their prevalence is estimated to be more than 50% in women over the age of 45 years.Fibroids represent a considerable health burden. It is time to acquire a deeper mechanistic understanding of uterine fibroid-related etiology and pathogenesis, which may help pinpoint new strategies and an individualized approach. There is a need to gather prospective data and conduct studies to compare alternative approaches and assess long-term outcomes with respect to quality of life, recurrence ...
Source: Fertility and Sterility - March 5, 2024 Category: Reproduction Medicine Authors: Marie-Madeleine DOLMANS, Felice PETRAGLIA, William H. CATHERINO, Jacques DONNEZ Tags: Views and reviews Source Type: research
Uterine fibroid-related infertility: mechanisms and management
Fibroids are a common pathology and increasingly observed in women seeking medical treatment for infertility. The longer reproductive horizon thanks to improvements in medical care and current trend for women to postpone childbearing are making fibroid-related infertility increasingly common.The aim of this review is to critically analyze: 1) The link between uterine fibroids and infertility2) Mechanisms by which uterine fibroids may impair fertility 3) Management of myoma-related infertility.The association of fibroids with infertility is a source of controversy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - March 5, 2024 Category: Reproduction Medicine Authors: Jacques DONNEZ, Hugh S. TAYLOR, Louis MARCELLIN, Marie-Madeleine DOLMANS Tags: Views and reviews Source Type: research
Advanced Robotic Surgery to the Rescue: Cerclage Placement in the Bicornuate Uterus with Cervical Insufficiency
(Source: Fertility and Sterility)
Source: Fertility and Sterility - March 1, 2024 Category: Reproduction Medicine Authors: Ariella Yazdani, Emily H. Frisch, Elliott G. Richards Tags: Reflections Source Type: research
Planned oocyte cryopreservation to preserve future reproductive potential: an Ethics Committee opinion
Planned oocyte cryopreservation is an ethically permissible procedure that may help individuals avoid future infertility. Because planned oocyte cryopreservation is new and evolving, it is essential that those considering using it be informed about the uncertainties regarding its efficacy and long-term effects. This replaces the document of the same name, last published in 2017. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 29, 2024 Category: Reproduction Medicine Authors: Ethics Committee of the American Society for Reproductive Medicine Tags: ASRM pages Source Type: research
Inclusive language and environment to welcome lesbian, gay, bisexual, transgender, queer, questioning, intersex, and asexual+ patients
Using inclusive language and creating an inclusive clinical environment to serve lesbian, gay, bisexual, transgender, queer, questioning, intersex, and asexual+ patients is vital to optimizing access to care and patient outcomes. Practical recommendations are made for increasing inclusivity in the clinic, and a glossary of current terms is included. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 29, 2024 Category: Reproduction Medicine Authors: Practice Committee of the American Society for Reproductive Medicine, American Society for Reproductive Medicine, Washington, D.C. Tags: ASRM Pages Source Type: research
Functional evidence for two distinct mechanisms of action of progesterone and selective progesterone receptor modulator on uterine leiomyomas
To study the specific mechanisms through which progesterone and selective progesterone receptor modulators impact the growth and synthesis/accumulation of the extracellular matrix in uterine leiomyomas. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 29, 2024 Category: Reproduction Medicine Authors: Gabriela Milewska, Donata Ponikwicka –Tyszko, Piotr Bernaczyk, Oana Lupu, Michal Szamatowicz, Maria Sztachelska, Agata Pilaszewicz-Puza, Mariusz Koda, Tomasz Bielawski, Monika Zbucka-Kretowska, Adam Pawelczyk, Jakub Tomaszewski, Xiangdong Li, Ilpo Huhta Tags: Reproductive science Source Type: research
Evaluating prognosis in unexplained infertility
Capsule: The conundrum of unexplained infertility indicates that conception does not occur despite normal findings of the fertility work-up. Prediction models can distinguish couples with good prospects for natural conception from couples with poor prospects, the first benefitting from expectant management and the second from immediate treatment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 26, 2024 Category: Reproduction Medicine Authors: Nicole Au, Qian Feng, Laxmi Shingshetty, Abha Maheshwari, Ben W. Mol Tags: Views and reviews Source Type: research
Unification and orificing of two functional noncommunicating uterine horns through the created neovagina using peritoneum
To demonstrate the surgical approach for M üllerian agenesis with bilateral uterine remnants containing functional endometrium. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 23, 2024 Category: Reproduction Medicine Authors: Gurkan Uncu, Isil Kasapoglu, Kiper Aslan Tags: Video Source Type: research
Ovarian hyperstimulation syndrome should be dead, we are just waiting on the obituary
In a not-so-distant past, ovarian hyperstimulation syndrome (OHSS) was the most dreadful and frequent complication of assisted reproductive technology (ART). Ovarian hyperstimulation syndrome consisted of a massive modification of vascular permeability resulting in extravasation of fluid in the so-called third space with the following two primary consequences: accumulation of fluid in the pelvic cavity and ascites formation, and hemoconcentration and reduction of the vascular volume leading to possible anuria as a result of prerenal failure and increased pressure in renal veins due ascites tension. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 23, 2024 Category: Reproduction Medicine Authors: Sean Sokteang, Paul Pirtea, James P. Toner, Dominique de Ziegler Tags: Inklings Source Type: research
Ex-vivo microscopic oncotesticular sperm extraction: step-by-step surgical technique at time of radical orchiectomy
To demonstrate the intraoperative surgical techniques required for simultaneous radical orchiectomy and microscopic oncotesticular sperm extraction (m-OncoTESE) in a step-by-step fashion. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 23, 2024 Category: Reproduction Medicine Authors: Christopher K. Villota, Sean W. Hou, Clark Judge, Scott Eggener, Gladell Paner, Omer A. Raheem Tags: Video Source Type: research
Prophecy, prediction, and prognosis – can we improve the advice we give on the chance of pregnancy and treatment options for infertility?
Diagnosis, prognosis, and treatment are three vital components of medical care, established as a principle in ancient Hippocratic medicine. When diagnostic tools and knowledge were limited and treatment options were absent, physicians spent a lot of time on prognosis using their experience, clinical history, and observations to aid the patient in assessing their future health prospects (1). When the causes of disease became more apparent and new methods of treatment emerged, prognosis received much less attention. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 23, 2024 Category: Reproduction Medicine Authors: Robert J. Norman Tags: Views and reviews Source Type: research
Effectiveness of preconception weight loss interventions on fertility in women: a systematic review and meta-analysis
Preconception weight loss interventions in women with overweight or obesity led to higher pregnancy rates compared to controls but there was no impact on live birth or miscarriage rates. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 23, 2024 Category: Reproduction Medicine Authors: Ann E. Caldwell, Anna M. Gorczyca, Andrew P. Bradford, Jacinda M. Nicklas, Robert N. Montgomery, Heather Smyth, Shannon Pretzel, Thy Nguyen, Kristen DeSanto, Celia Ernstrom, Nanette Santoro Tags: Systematic review with meta-analysis Source Type: research
Why Would Menses be Related to the Day of the Week or to the Lunar Cycle?
(Source: Fertility and Sterility)
Source: Fertility and Sterility - February 23, 2024 Category: Reproduction Medicine Authors: Beverly Reed Tags: Reflections Source Type: research
Ex-Vivo Microscopic Onco-Testicular Sperm Extraction: Step-by-Step Surgical Technique at Time of Radical Orchiectomy
To demonstrate the intraoperative surgical techniques required for a simultaneous radical orchiectomy and microscopic onco-testicular sperm extraction (m-OncoTESE) in step- by-step fashion. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 23, 2024 Category: Reproduction Medicine Authors: Christopher K. Villota, Sean W. Hou, Clark Judge, Scott Eggener, Gladell Paner, Omer A. Raheem Tags: Video Source Type: research
Unification and Orificing of Two Functional Non-Communicating Uterine Horns Through the Created Neovagina Using Peritoneum
To demonstrate the surgical approach for M üllerian agenesis with bilateral uterine remnants containing functional endometrium. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 23, 2024 Category: Reproduction Medicine Authors: Gurkan Uncu, Isil Kasapoglu, Kiper Aslan Tags: Video Source Type: research
