Issue Information
Counting on Death – Quantitative aspects of Bcl‐2 family regulation, reviewed by Thomas Brunner, Annika Hantusch and Markus Rehm (pp. 4124–4138). (Source: FEBS Journal)
Source: FEBS Journal - November 19, 2018 Category: Research Tags: Issue Cover & Information Source Type: research
Table of Contents
The FEBS Journal, Volume 285, Issue 22, Page 4311-4311, November 2018. (Source: FEBS Journal)
Source: FEBS Journal - November 19, 2018 Category: Research Tags: Table of Contents Source Type: research
Increased oxidative stress and CaMKII activity contribute to electro ‐mechanical defects in cardiomyocytes from a murine model of Huntington's disease
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 19, 2018 Category: Research Authors: Julliane Vasconcelos Joviano ‐Santos,
Artur Santos‐Miranda,
Ana Flávia Machado Botelho,
Itamar Couto Guedes de Jesus,
Jéssica Neves Andrade,
Tatiane de Oliveira Barreto,
Matheus Proença S. Magalhães‐Gomes,
Priscila Aparecida Costa Valadã Tags: Original Article Source Type: research
Cryo ‐EM is uncovering the mechanism of eukaryotic protein N‐glycosylation
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 19, 2018 Category: Research Authors: Lin Bai,
Huilin Li Tags: Structural Snapshot Source Type: research
Issue Information
Counting on Death – Quantitative aspects of Bcl‐2 family regulation, reviewed by Thomas Brunner, Annika Hantusch and Markus Rehm (pp. 4124–4138). (Source: FEBS Journal)
Source: FEBS Journal - November 19, 2018 Category: Research Tags: Issue Cover & Information Source Type: research
Table of Contents
The FEBS Journal, Volume 285, Issue 22, Page 4311-4311, November 2018. (Source: FEBS Journal)
Source: FEBS Journal - November 19, 2018 Category: Research Tags: Table of Contents Source Type: research
Increased oxidative stress and CaMKII activity contribute to electro ‐mechanical defects in cardiomyocytes from a murine model of Huntington's disease
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 19, 2018 Category: Research Authors: Julliane Vasconcelos Joviano ‐Santos,
Artur Santos‐Miranda,
Ana Flávia Machado Botelho,
Itamar Couto Guedes de Jesus,
Jéssica Neves Andrade,
Tatiane de Oliveira Barreto,
Matheus Proença S. Magalhães‐Gomes,
Priscila Aparecida Costa Valadã Tags: Original Article Source Type: research
2 ‐Deoxy‐D‐glucose has distinct and cell line‐specific effects on the survival of different cancer cells upon antitumor drug treatment
Suppression of glycolysis by 2 ‐deoxy‐D‐glucose (2‐DG) stimulates apoptosis in SK‐N‐BE(2), but attenuates in HCT116 cells. In both cell lines 2‐DG stimulates stress of endoplasmic reticulum (ER), which ends up in apoptosis in SK‐N‐BE(2) but in autophagy in HCT116 cells. Prevention of ER stress by mannose attenua tes apoptosis in SK‐N‐BE(2) cells, and reverses suppression of apoptosis in HCT116 cells. The dependence of tumors on glycolysis for ATP generation offers a rationale for therapeutic strategies aimed at selective inhibition of the glycolytic pathway. Analysis of tumor cell responses to antican...
Source: FEBS Journal - November 17, 2018 Category: Research Authors: Polina Maximchik,
Alibek Abdrakhmanov,
Evgeniya Inozemtseva,
Pyotr A. Tyurin ‐Kuzmin,
Boris Zhivotovsky,
Vladimir Gogvadze Tags: Original Article Source Type: research
The intrinsically disordered nature of the peroxisomal protein translocation machinery
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 16, 2018 Category: Research Authors: Aurora Barros ‐Barbosa,
Tony A. Rodrigues,
Maria J. Ferreira,
Ana G. Pedrosa,
Nélson R. Teixeira,
Tânia Francisco,
Jorge E. Azevedo Tags: Viewpoint Source Type: research
Crystal Structures of VIM ‐1 Complexes Explain Active Site Heterogeneity in VIM‐Class Metallo‐β‐Lactamases
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 15, 2018 Category: Research Authors: Ramya Salimraj,
Philip Hinchliffe,
Magda Kosmopoulou,
Jonathan M. Tyrrell,
J ürgen Brem,
Sander S. van Berkel,
Anil Verma,
Raymond J. Owens,
Michael A. McDonough,
Timothy R. Walsh,
Christopher J. Schofield,
James Spencer Tags: Original Article Source Type: research
Cooperativity in proton sensing by PIP aquaporins
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 15, 2018 Category: Research Authors: Victoria Vitali,
Cintia Jozefkowicz,
Agustina Canessa Fortuna,
Gabriela Soto,
F. Luis Gonzalez Flecha,
Karina Alleva Tags: Original Article Source Type: research
Phosphomimetic ‐mediated in vitro rescue of hypertrophic cardiomyopathy linked to R58Q mutation in myosin regulatory light chain
This study focuses on the arginine to glutamine (R58Q) substitution in the human ventricular RLC (MYL2 gene), linked to malignant hypertrophic cardiomyopathy in humans and causing severe functional abnormalities in transgenic R58Q mice, inclu ding inhibition of cardiac RLC phosphorylation. Using a phosphomimic recombinant RLC variant where the phosphorylation site Ser‐15 was substituted with an aspartic acid (S15D) and placed in the background of R58Q, we aimed to assess whether we could rescue/mitigate R58Q‐induced structural/functi onal abnormalitiesin vitro. We show rescue of several R58Q ‐exerted adverse phenotyp...
Source: FEBS Journal - November 15, 2018 Category: Research Authors: Sunil Yadav,
Katarzyna Kazmierczak,
Jingsheng Liang,
Yoel H. Sitbon,
Danuta Szczesna ‐Cordary Tags: Original Article Source Type: research
Discovery and analysis of a novel ‐type serine biosynthetic enzyme, phosphoserine phosphatase in Thermus thermophilus
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - November 15, 2018 Category: Research Authors: Yoko Chiba,
Ayako Yoshida,
Shigeru Shimamura,
Masafumi Kameya,
Takeo Tomita,
Makoto Nishiyama,
Ken Takai Tags: Original Article Source Type: research
