DPYD genotyping and 5-fluoropyrimidine toxicity: An overview of systematic reviews protocol
Farm Hosp. 2023 Dec 9:S1130-6343(23)00931-5. doi: 10.1016/j.farma.2023.11.005. Online ahead of print.ABSTRACTINTRODUCTION: The increased risk of severe and life-threatening toxicity in patients with dihydropyridine dehydrogenase deficiency, under treatment with fluoropyrimidines, has been widely studied. An up-to-date overview of systematic reviews summarizing existing literature can add value by highlighting most relevant information and supports decision-making regarding treatment in dihydropyridine dehydrogenase deficient patients. The main objective of this overview is to identify published systematic reviews on the as...
Source: Farmacia Hospitalaria - December 10, 2023 Category: Drugs & Pharmacology Authors: Sara Otero Torres Olalla Montero P érez Rosa Rodr íguez Mauriz Eduard Fort Casamartina Sandra Fontanals Mart ínez Ana Clop és Estela Source Type: research

DPYD genotyping and 5-fluoropyrimidine toxicity: An overview of systematic reviews protocol
Farm Hosp. 2023 Dec 9:S1130-6343(23)00931-5. doi: 10.1016/j.farma.2023.11.005. Online ahead of print.ABSTRACTINTRODUCTION: The increased risk of severe and life-threatening toxicity in patients with dihydropyridine dehydrogenase deficiency, under treatment with fluoropyrimidines, has been widely studied. An up-to-date overview of systematic reviews summarizing existing literature can add value by highlighting most relevant information and supports decision-making regarding treatment in dihydropyridine dehydrogenase deficient patients. The main objective of this overview is to identify published systematic reviews on the as...
Source: Farmacia Hospitalaria - December 10, 2023 Category: Drugs & Pharmacology Authors: Sara Otero Torres Olalla Montero P érez Rosa Rodr íguez Mauriz Eduard Fort Casamartina Sandra Fontanals Mart ínez Ana Clop és Estela Source Type: research

DPYD genotyping and 5-fluoropyrimidine toxicity: An overview of systematic reviews protocol
Farm Hosp. 2023 Dec 9:S1130-6343(23)00931-5. doi: 10.1016/j.farma.2023.11.005. Online ahead of print.ABSTRACTINTRODUCTION: The increased risk of severe and life-threatening toxicity in patients with dihydropyridine dehydrogenase deficiency, under treatment with fluoropyrimidines, has been widely studied. An up-to-date overview of systematic reviews summarizing existing literature can add value by highlighting most relevant information and supports decision-making regarding treatment in dihydropyridine dehydrogenase deficient patients. The main objective of this overview is to identify published systematic reviews on the as...
Source: Farmacia Hospitalaria - December 10, 2023 Category: Drugs & Pharmacology Authors: Sara Otero Torres Olalla Montero P érez Rosa Rodr íguez Mauriz Eduard Fort Casamartina Sandra Fontanals Mart ínez Ana Clop és Estela Source Type: research

DPYD genotyping and 5-fluoropyrimidine toxicity: An overview of systematic reviews protocol
Farm Hosp. 2023 Dec 9:S1130-6343(23)00931-5. doi: 10.1016/j.farma.2023.11.005. Online ahead of print.ABSTRACTINTRODUCTION: The increased risk of severe and life-threatening toxicity in patients with dihydropyridine dehydrogenase deficiency, under treatment with fluoropyrimidines, has been widely studied. An up-to-date overview of systematic reviews summarizing existing literature can add value by highlighting most relevant information and supports decision-making regarding treatment in dihydropyridine dehydrogenase deficient patients. The main objective of this overview is to identify published systematic reviews on the as...
Source: Farmacia Hospitalaria - December 10, 2023 Category: Drugs & Pharmacology Authors: Sara Otero Torres Olalla Montero P érez Rosa Rodr íguez Mauriz Eduard Fort Casamartina Sandra Fontanals Mart ínez Ana Clop és Estela Source Type: research

DPYD genotyping and 5-fluoropyrimidine toxicity: An overview of systematic reviews protocol
Farm Hosp. 2023 Dec 9:S1130-6343(23)00931-5. doi: 10.1016/j.farma.2023.11.005. Online ahead of print.ABSTRACTINTRODUCTION: The increased risk of severe and life-threatening toxicity in patients with dihydropyridine dehydrogenase deficiency, under treatment with fluoropyrimidines, has been widely studied. An up-to-date overview of systematic reviews summarizing existing literature can add value by highlighting most relevant information and supports decision-making regarding treatment in dihydropyridine dehydrogenase deficient patients. The main objective of this overview is to identify published systematic reviews on the as...
Source: Farmacia Hospitalaria - December 10, 2023 Category: Drugs & Pharmacology Authors: Sara Otero Torres Olalla Montero P érez Rosa Rodr íguez Mauriz Eduard Fort Casamartina Sandra Fontanals Mart ínez Ana Clop és Estela Source Type: research

Presence of metallic components in transdermal drug delivery systems and risk of skin burns
CONCLUSION: More than a half of the patches at the time of the study contained metals or their absence could not be confirmed by the manufacturer. However, this information was only included in 13.6% of summaries of product characteristics.PMID:38057241 | DOI:10.1016/j.farma.2023.11.003 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - December 6, 2023 Category: Drugs & Pharmacology Authors: Ana de Lorenzo-Pinto Carmen Redondo-Gal án Xandra Garc ía-González Carmen Fern ández-Álvarez Juan Andueza-Lillo Mar ía Sanjurjo-Sáez Source Type: research

[Translated article] Pharmacokinetics of eculizumab in adult and pediatric patients with atypical hemolytic uremic syndrome and C3 glomerulopathy
CONCLUSIONS: The present study reports supratherapeutic concentrations of eculizumab in patients with aHUS, and defines higher concentrations than those described in the data sheet to achieve blockade, thus encouraging the personalization of treatment with eculizumab.PMID:38057242 | DOI:10.1016/j.farma.2023.09.009 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - December 6, 2023 Category: Drugs & Pharmacology Authors: Alba Pau Parra Natalia Ramos Janire Perurena-Prieto Silvia Manrique-Rodr íguez Monica Climente Laura Garc ía Quintanilla Ángel Escolano Marta Miarons grupo PK-ECU-ORPHAR Source Type: research

Presence of metallic components in transdermal drug delivery systems and risk of skin burns
CONCLUSION: More than a half of the patches at the time of the study contained metals or their absence could not be confirmed by the manufacturer. However, this information was only included in 13.6% of summaries of product characteristics.PMID:38057241 | DOI:10.1016/j.farma.2023.11.003 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - December 6, 2023 Category: Drugs & Pharmacology Authors: Ana de Lorenzo-Pinto Carmen Redondo-Gal án Xandra Garc ía-González Carmen Fern ández-Álvarez Juan Andueza-Lillo Mar ía Sanjurjo-Sáez Source Type: research

[Translated article] Pharmacokinetics of eculizumab in adult and pediatric patients with atypical hemolytic uremic syndrome and C3 glomerulopathy
CONCLUSIONS: The present study reports supratherapeutic concentrations of eculizumab in patients with aHUS, and defines higher concentrations than those described in the data sheet to achieve blockade, thus encouraging the personalization of treatment with eculizumab.PMID:38057242 | DOI:10.1016/j.farma.2023.09.009 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - December 6, 2023 Category: Drugs & Pharmacology Authors: Alba Pau Parra Natalia Ramos Janire Perurena-Prieto Silvia Manrique-Rodr íguez Monica Climente Laura Garc ía Quintanilla Ángel Escolano Marta Miarons grupo PK-ECU-ORPHAR Source Type: research

Presence of metallic components in transdermal drug delivery systems and risk of skin burns
CONCLUSION: More than a half of the patches at the time of the study contained metals or their absence could not be confirmed by the manufacturer. However, this information was only included in 13.6% of summaries of product characteristics.PMID:38057241 | DOI:10.1016/j.farma.2023.11.003 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - December 6, 2023 Category: Drugs & Pharmacology Authors: Ana de Lorenzo-Pinto Carmen Redondo-Gal án Xandra Garc ía-González Carmen Fern ández-Álvarez Juan Andueza-Lillo Mar ía Sanjurjo-Sáez Source Type: research

[Translated article] Pharmacokinetics of eculizumab in adult and pediatric patients with atypical hemolytic uremic syndrome and C3 glomerulopathy
CONCLUSIONS: The present study reports supratherapeutic concentrations of eculizumab in patients with aHUS, and defines higher concentrations than those described in the data sheet to achieve blockade, thus encouraging the personalization of treatment with eculizumab.PMID:38057242 | DOI:10.1016/j.farma.2023.09.009 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - December 6, 2023 Category: Drugs & Pharmacology Authors: Alba Pau Parra Natalia Ramos Janire Perurena-Prieto Silvia Manrique-Rodr íguez Monica Climente Laura Garc ía Quintanilla Ángel Escolano Marta Miarons grupo PK-ECU-ORPHAR Source Type: research

Presence of metallic components in transdermal drug delivery systems and risk of skin burns
CONCLUSION: More than a half of the patches at the time of the study contained metals or their absence could not be confirmed by the manufacturer. However, this information was only included in 13.6% of summaries of product characteristics.PMID:38057241 | DOI:10.1016/j.farma.2023.11.003 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - December 6, 2023 Category: Drugs & Pharmacology Authors: Ana de Lorenzo-Pinto Carmen Redondo-Gal án Xandra Garc ía-González Carmen Fern ández-Álvarez Juan Andueza-Lillo Mar ía Sanjurjo-Sáez Source Type: research

[Translated article] Pharmacokinetics of eculizumab in adult and pediatric patients with atypical hemolytic uremic syndrome and C3 glomerulopathy
CONCLUSIONS: The present study reports supratherapeutic concentrations of eculizumab in patients with aHUS, and defines higher concentrations than those described in the data sheet to achieve blockade, thus encouraging the personalization of treatment with eculizumab.PMID:38057242 | DOI:10.1016/j.farma.2023.09.009 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - December 6, 2023 Category: Drugs & Pharmacology Authors: Alba Pau Parra Natalia Ramos Janire Perurena-Prieto Silvia Manrique-Rodr íguez Monica Climente Laura Garc ía Quintanilla Ángel Escolano Marta Miarons grupo PK-ECU-ORPHAR Source Type: research

Validated medication deprescribing instruments for patients with palliative care needs palliative care: A systematic review
CONCLUSIONS: Despite the availability of several instruments to support deprescribing in patients with palliative care needs, only one of them has undergone validation and robust assessment for effectiveness in clinical practice. The STOPPFrail tool appears to reduce the number of inappropriate medications for older people with limited life expectancy (and probably palliative care needs) and decrease the monthly costs of pharmacotherapy. Nevertheless, the impact on patient safety and humanistic outcomes remain unclear.PMID:38016841 | DOI:10.1016/j.farma.2023.08.010 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - November 28, 2023 Category: Drugs & Pharmacology Authors: Frangie Kallas de Andrade Raziel Prado Ignacio Nunes Maria Ol ívia Barboza Zanetti Ariane Cristina Barboza Zanetti M árcia Dos Santos Alan Maicon de Oliveira Andrew Carson-Stevens Leonardo R égis Leira Pereira Fabiana Rossi Varallo Source Type: research

Validated medication deprescribing instruments for patients with palliative care needs palliative care: A systematic review
CONCLUSIONS: Despite the availability of several instruments to support deprescribing in patients with palliative care needs, only one of them has undergone validation and robust assessment for effectiveness in clinical practice. The STOPPFrail tool appears to reduce the number of inappropriate medications for older people with limited life expectancy (and probably palliative care needs) and decrease the monthly costs of pharmacotherapy. Nevertheless, the impact on patient safety and humanistic outcomes remain unclear.PMID:38016841 | DOI:10.1016/j.farma.2023.08.010 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - November 28, 2023 Category: Drugs & Pharmacology Authors: Frangie Kallas de Andrade Raziel Prado Ignacio Nunes Maria Ol ívia Barboza Zanetti Ariane Cristina Barboza Zanetti M árcia Dos Santos Alan Maicon de Oliveira Andrew Carson-Stevens Leonardo R égis Leira Pereira Fabiana Rossi Varallo Source Type: research