Expert Opinion on Investigational Drugs This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Novel carbonic anhydrase inhibitors for the treatment of < em > Helicobacter pylori < /em > infection
Expert Opin Investig Drugs. 2024 Mar 22. doi: 10.1080/13543784.2024.2334714. Online ahead of print.ABSTRACTINTRODUCTION: Helicobacter pylori, the causative agent of peptic ulcer, gastritis and gastric cancer encodes two carbonic anhydrases (CA, EC 4.2.1.1) belonging to the α- and β-class (HpCAα/β), which have been validated as antibacterial drug targets. Acetazolamide and ethoxzolamide were also clinically used for the management of peptic ulcer.AREAS COVERED: Sulfonamides were the most investigated HpCAα/β compounds, with several low nanomolar inhibitors indentified, some of which also crystallized as adducts with H...
Source: Expert Opinion on Investigational Drugs - March 22, 2024 Category: Drugs & Pharmacology Authors: Claudiu T Supuran Source Type: research