Effect of transplanted cells with CD184 and CD26 expressions and reconstitution of CD3+ lymphocyte population on long-term survival after autologous hematopoietic stem cell transplantation for multiple myeloma
Multiple myeloma (MM) is one of the most common hematological neoplasms. Its incidence is 4 per 100,000 persons [1,2]. Despite recent advances in medicine and the introduction of new drugs frequently targeting the causative mechanism, MM remains incurable. Autologous hematopoietic stem cell transplantation (auto-SCT) is still a standard procedure for responding patients with MM. Auto-SCT prolongs overall survival (OS) and progression-free survival (PFS) in patients with MM [3,4]. The median OS using modern therapies is an average of 6 years [2]. (Source: Experimental Hematology)
Source: Experimental Hematology - September 2, 2023 Category: Hematology Authors: Anna Kopinska, Ma łgorzata Krawczyk-Kuliś, Agata Wieczorkiewicz-Kabut, Anna Koclęga, Krystyna Jagoda, Joanna Dziaczkowska-Suszek, Grzegorz Helbig Tags: Original Article Source Type: research
Functional and molecular profiling of hematopoietic stem cells during regeneration
Hematopoietic stem cells (HSCs) support lifelong production of mature blood cells and need to be precisely regulated to ensure a balance between mature cellular output and long-term sustainability. While HSCs are the only hematopoietic cells that harbor both self-renewal and long-term multilineage capacity, they do not constitute a homogenous population. Subtle differences in lineage priming and reconstitution potential create a continuum of non-discrete HSC subtypes 1-4. Similarly, the differentiation of HSCs into more restricted progenitors is a gradual, rather than stepwise, process 5, 6. (Source: Experimental Hematology)
Source: Experimental Hematology - September 2, 2023 Category: Hematology Authors: Anna Rydstr öm, Tan HM Grahn, Abhishek Niroula, Els Mansell, Mark van der Garde, Maroulio Pertesi, Agatheeswaran Subramaniam, Shamit Soneji, Roman Zubarev, Tariq Enver, Björn Nilsson, Kenichi Miharada, Jonas Larsson, Stefan Karlsson Tags: Article Source Type: research
Effect of transplanted cells with CD184, CD26 expressions and reconstitution of CD3+ lymphocyte population on long-term survival after autologous hematopoietic stem cell transplantation for multiple myeloma
Multiple myeloma (MM) is one of the most common hematological neoplasms. Its incidence is 4 per 100,000 persons [1-2]. Despite recent advances in medicine and the introduction of new drugs frequently targeting the causative mechanism, MM remains incurable. Autologous hematopoietic stem cell transplantation (auto-SCT) is still a standard procedure for responding MM patients. Auto-SCT prolongs overall survival (OS) and progression-free survival (PFS) in patients with MM [3-4]. The median OS using modern therapies is an average of 6 years [2]. (Source: Experimental Hematology)
Source: Experimental Hematology - September 2, 2023 Category: Hematology Authors: Anna Kopinska, Ma łgorzata Krawczyk-Kuliś, Agata Wieczorkiewicz-Kabut, Anna Koclęga, Krystyna Jagoda, Joanna Dziaczkowska-Suszek, Grzegorz Helbig Tags: Article Source Type: research
IFC: Editorial Board
(Source: Experimental Hematology)
Source: Experimental Hematology - September 1, 2023 Category: Hematology Source Type: research
The Role of Extracellular Vesicles on the Occurrence of Clinical Complications in β-Thalassemia
Thalassemia is a heterogeneous group of hereditary quantitative hemoglobinopathies caused by partial or complete defects in the synthesis of globin chains [1]. According to the type of globin chain with defective synthesis, thalassemia is classified into α-, β-, δβ-, γδβ-, δ- and γ-thalassemia (γ-thal) types. α- and β-thal are the most common types of thalassemia, which are caused by defects in the synthesis of α-globin and β-globin chain genes, respectively [2]. The main pathophysiology of thalassemia is the decrease in the synthesis of globin chains and the imbalance of the ratio of globin chains in Hb. (So...
Source: Experimental Hematology - August 29, 2023 Category: Hematology Authors: Mehrnaz Abdolalian, Mahin Nikogouftar Zarif, Mohammadreza Javan Tags: Review Article Source Type: research
Chronic inflammation can transform the fate of normal and mutant hematopoietic stem cells
Hematopoietic stem cells (HSCs) are at the top of the blood hierarchy and are responsible for the production of all blood cells after birth [1]. They emerge during the first days of gestation (27 days after conception in humans, 10.5 days after conception in mice) on the ventral side of the aorta-gonad-mesonephros through a process called endothelial-to-hematopoietic transition, after which they migrate and expand in the fetal liver and bone marrow [2 –4]. Some HSCs remain quiescent to maintain their ability to self-renew, some duplicate, some differentiate into a specific blood cell lineage, and some migrate outside the...
Source: Experimental Hematology - August 28, 2023 Category: Hematology Authors: Jingjing Li, Camille Malouf, Linde A. Miles, Mara B. Willis, Eric M. Pietras, Katherine Y. King Tags: Review Source Type: research
Chronic inflammation can transform the fate of normal and mutant haematopoietic stem cells
Hematopoietic stem cells (HSCs) are at the top of the blood hierarchy and are responsible for the production of all blood cells after birth [1]. They emerge during the first days of gestation (27 days post-conception in humans, 10.5 days post-conception in mice) on the ventral side of the aorta-gonad-mesonephros through a process called endothelial-to-hematopoietic transition, after which they migrate and expand in the foetal liver and bone marrow [2-4]. Some HSCs remain quiescent to maintain their ability to self-renew, some duplicate, some differentiate into a specific blood cell lineage, and some migrate outside their n...
Source: Experimental Hematology - August 28, 2023 Category: Hematology Authors: Jingjing Li, Camille Malouf, Linde A. Miles, Mara B. Willis, Eric M. Pietras, Katherine Y. King Tags: Review Source Type: research
Engineered hematopoietic and immune cells derived from human pluripotent stem cells
Hematopoietic stem cells (HSCs) are crucial for the formation of functional myeloid and lymphoid cells [1 –3], and their perturbations have been linked to several hematological diseases [4–6]. Hematopoietic cell transplantation (HCT) is a widely used therapeutic strategy for treating these diseases [7,8]; however, the lack of a scalable and off-the-shelf cell source of HSCs limits their application [9–11]. In this regard, human pluripotent stem cells (hPSCs) represent a promising alternative source of transplantable HSCs and provide a unique platform for studying human hematopoiesis [11–14]. (Source: Experimental Hematology)
Source: Experimental Hematology - August 21, 2023 Category: Hematology Authors: Yun Chang, Sydney N Hummel, Juhyung Jung, Gyuhyung Jin, Qing Deng, Xiaoping Bao Tags: Review Source Type: research
Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice
Hyperactivation of JAK2 kinase is a common feature among human Ph- myeloproliferative neoplasms (MPNs),1 and has also been hypothesized as a defining feature of leukemic stem cells in acute myeloid leukemia (AML).2 Myeloid neoplasms have been found to harbor dysregulation of multiple intracellular signaling pathways, among which one of the most widespread is the NF κB signaling pathway. NFκB pathway hyperactivation has been identified in AML, myelodysplastic syndromes (MDS), chronic myeloid leukemia (CML), and MPNs. (Source: Experimental Hematology)
Source: Experimental Hematology - August 20, 2023 Category: Hematology Authors: Daniel A.C. Fisher, Angelo B.A. Laranjeira, Tim Kong, Steven C. Snyder, Kevin Shim, Mary C. Fulbright, Stephen T. Oh Tags: Article Source Type: research
A Bloody Feast —Nutritional Regulation of Hematopoiesis
In recent decades, nutrition has been recognized as one of the major keys to a healthy life. Doctors and dietitians often recommend maintaining good health by keeping a balanced diet, which includes fruits, vegetables, grains, dairy, and a source of protein to provide the body with the required vitamins and major food groups. Indeed, an unbalanced diet has been classified as a significant risk factor for medical conditions such as obesity, diabetes, and cardiovascular diseases [1 –3]. (Source: Experimental Hematology)
Source: Experimental Hematology - August 12, 2023 Category: Hematology Authors: Noga Ussishkin, Daphna Nachmani Tags: Review Source Type: research
A Bloody Feast – Nutritional Regulation of Hematopoiesis
In recent decades nutrition has been recognized as one of the major keys to a healthy life. Doctors and dietitians, often recommend to maintain good health by keeping a balanced diet, which includes fruits, vegetables, grains, dairy, and a source of protein to provide the body with the required vitamins and major food groups. Indeed, an unbalanced diet has been classified as a significant risk factor for medical conditions such as obesity, diabetes and cardiovascular diseases (1-3). (Source: Experimental Hematology)
Source: Experimental Hematology - August 12, 2023 Category: Hematology Authors: Noga Ussishkin, Daphna Nachmani Tags: Review Source Type: research
Epidemiology of Chronic Lymphocytic Leukemia in Sardinia, Italy (1974 –2003)
Chronic lymphocytic leukemia (CLL) is a multifaceted, multifactorial disease caused by the monoclonal expansion of B lymphocytes, which become unresponsive to physiological blocks of replication and accumulate in the peripheral blood, bone marrow, and secondary lymphoid organ [1]. This lymphoid malignancy typically affects elderly men, with an average age at diagnosis approximately 70 years and less than 15% of cases arising at age 60 years or earlier [2]. Monoclonal CLL lymphocytes exhibit a peculiar immunophenotype CD19-, CD23-, and CD5-positive, and low expression of CD20 and surface immunoglobulins [3]. (Source: Experimental Hematology)
Source: Experimental Hematology - August 9, 2023 Category: Hematology Authors: Giorgio Broccia, Jonathan Carter, Cansu Ozsin-Ozler, Sara De Matteis, Pierluigi Cocco Tags: Article Source Type: research
Epidemiology of chronic lymphocytic leukemia in Sardinia, Italy (1974-2003)
Chronic lymphocytic leukemia (CLL) is a multifaceted, multi-factorial disease caused by the monoclonal expansion of B lymphocytes, which become unresponsive to physiological blocks of replication and accumulate in the peripheral blood, bone marrow, and secondary lymphoid organ [1]. This lymphoid malignancy typically affects elderly men, with an average age at diagnosis around 70 and less than 15% of cases arising at age 60 or earlier [2]. Monoclonal CLL lymphocytes exhibit a peculiar immunophenotype CD19-, CD23-, and CD5- positive, and low expression of CD20 and surface immunoglobulins [3]. (Source: Experimental Hematology)
Source: Experimental Hematology - August 9, 2023 Category: Hematology Authors: Giorgio Broccia, Jonathan Carter, Cansu Ozsin-Ozler, Sara De Matteis, Pierluigi Cocco Tags: Article Source Type: research
Myeloid Hif2 α is not essential to maintain systemic iron homeostasis
Systemic iron homeostasis is tightly regulated as both excess and deficiency of iron have deleterious effects. Despite tight systemic regulation, more than one billion people worldwide suffer from iron-related disorders [1,2]. Systemic iron homeostasis requires heterotissue communication. Diet is the sole source of iron, and it is actively absorbed in the small intestine through the transporter divalent metal transporter-1 (Dmt1; gene name Slc11a2) [3,4]. Iron is stored within enterocyte in an iron storage protein, ferritin (FTN) or exported out of the cell and into the circulation through the only known mammalian iron exp...
Source: Experimental Hematology - August 8, 2023 Category: Hematology Authors: Chesta Jain, Sanjana Parmini, Wesley Huang, Sean Hannifin, Rashi Singhal, Nupur K. Das, Kyoung Eun Lee, Yatrik M. Shah Tags: Article Source Type: research
Myeloid Hif2 α is not essential to maintain systemic iron homeostasis.
Dietary consumption serves as the primary source of iron uptake, while erythropoiesis acts as a major regulator of systemic iron demand. In addition to intestinal iron absorption, macrophages play a crucial role in recycling iron from senescent red blood cells. The kidneys are responsible for the production of erythropoietin (Epo), which stimulates erythropoiesis, while the liver plays a central role in producing the iron-regulatory hormone hepcidin. The transcriptional regulator hypoxia-inducible factor (HIF)2 α has a central role in the regulation of Epo, hepcidin, and intestinal iron absorption and therefore plays a cr...
Source: Experimental Hematology - August 8, 2023 Category: Hematology Authors: Chesta Jain, Sanjana Parmini, Wesley Huang, Sean Hannifin, Rashi Singhal, Nupur K. Das, Kyoung Eun Lee, Yatrik M. Shah Tags: Article Source Type: research
