Recent advances in t-cell lymphoid neoplasms
Mature blood cell populations are mostly derived from hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) through the progressive loss of differentiation potential and the acquisition of functional traits. These cells progressively differentiate into lymphoid and myeloid progenitors that will give rise to either T, B and NK cells (lymphoid lineage) or erythrocytes, megakaryocytes, granulocytes and monocytes/macrophages (myeloid lineage). Different phenotypical, functional and more recently genomic classification of the early hematopoietic progenitors have been widely and long studied and it is constantly evo...
Source: Experimental Hematology - December 5, 2021 Category: Hematology Authors: Anna Bigas, Juan Jos é Rodriguez-Sevilla, Lluis Espinosa, Fernando Gallardo Tags: Review Source Type: research
The regulation roles of Ca2+ in erythropoiesis: what have we learned?
Red blood cells (RBCs) are generated from hematopoietic stem and progenitor cells (HSPCs) through the step-wise process of differentiation known as erythropoiesis. According to the colony formation activity, two different erythroid progenitor cells have been functionally defined, namely early burst-forming unit erythroid cells (BFU-E) and late colony-forming unit erythroid cells (CFU-E) progenitor cells. The earliest morphologically identifiable erythroid precursor is the pro-erythroblast, which differentiates sequentially into the basophilic, poly-chromatophilic and orthochromatic erythroblast, and finally becomes reticul...
Source: Experimental Hematology - December 5, 2021 Category: Hematology Authors: Yuanzhen Zhang, Yan Xu, Shujing Zhang, Zhiyuan Lu, Yuan Li, Baobing Zhao Source Type: research
Cover 2: Editorial Board
(Source: Experimental Hematology)
Source: Experimental Hematology - December 1, 2021 Category: Hematology Source Type: research
CCL8 deficiency in the host abrogates early mortality of acute graft-versus-host disease in mice with dysregulated IL-6 expression
Acute graft-versus-host disease (aGVHD) is a major cause of mortality after allogeneic hematopoietic stem cell transplantation (HSCT)1-4. Although recent advances in prophylaxis and treatment of aGVHD have significantly improved the outcome of HSCT, the immunobiological mechanisms of aGVHD remain to be elucidated5-10. Previous studies have suggested that the pathogenesis of aGVHD involves three major steps: (1) damage of recipient tissues by treatment of underlying diseases, preceding infections, and conditioning regimens for HSCT; (2) allogeneic recognition, expansion, and migration of donor T cells; (3) tissue destructio...
Source: Experimental Hematology - November 19, 2021 Category: Hematology Authors: Keita Igarashi, Tsukasa Hori, Masaki Yamamoto, Hitoshi Sohma, Nobuhiro Suzuki, Hiroyuki Tsutsumi, Yukihiko Kawasaki, Yasuo Kokai Source Type: research
Translational research for bone marrow failure patients
Life-long function of the blood and immune systems are essential for health. Continuous blood cell production from hematopoietic stem and progenitor cells (HSPCs) within the bone marrow and other hematopoietic organs, such as the spleen, sustain hematopoietic system homeostasis [1-4]. Aberrations in hematopoiesis can result in over- or under-production of blood cells that cause a range of diseases such as leukemia, lymphoma, cytopenias and anemias. One group of particularly severe hematological diseases are the bone marrow failure syndromes [5, 6]. (Source: Experimental Hematology)
Source: Experimental Hematology - November 17, 2021 Category: Hematology Authors: Camille Malouf, Stephen J. Loughran, Adam C. Wilkinson, Akiko Shimamura, Paula R ío Tags: Perspective Source Type: research
