IFC Editorial Board
(Source: Experimental Hematology)
Source: Experimental Hematology - March 1, 2024 Category: Hematology Source Type: research
Biomaterials-assisted therapeutic cell production and modification in vivo
The quantity of hematopoietic stem cells (HSCs) is limited, and they are mainly stored in a special microenvironment known as the bone marrow niche1. Within this niche, HSCs maintain hematopoietic homeostasis throughout the body through self-renewal, differentiation, and proliferation. Various components of the niche, such as osteolineage cells, vascular endothelial cells, perivascular stromal cells, megakaryocytes, and the nervous system, participate in regulating HSCs2. Alongside various cells regulating HSC behavior, extracellular matrix characteristics such as matrix stiffness and concentration of bioactive factors als...
Source: Experimental Hematology - March 1, 2024 Category: Hematology Authors: Kai Dai, Jing Wang, Changsheng Liu Source Type: research
Antileukemic effect of azacitidine, a DNA methyltransferase inhibitor, on cell lines of myeloid leukemia associated with Down syndrome
Myeloid leukemia associated with Down syndrome (ML-DS) mostly develops from transient abnormal myelopoiesis (TAM), a preleukemic condition, and is associated with somatic mutations in the GATA1 gene [1 –9]. We have previously reported that genetic mutations associated with epigenetic regulators contribute to the progression of TAM to ML-DS [10,11]. Although patients with ML-DS are sensitive to cytarabine and demonstrate high event-free survival, treatment-related morbidity and mortality are high , and optimizing treatment intensity is challenging [12–16]. (Source: Experimental Hematology)
Source: Experimental Hematology - February 9, 2024 Category: Hematology Authors: Tatsuhiko Tanaka, Ko Kudo, Rika Kanezaki, Kentaro Yuzawa, Tsutomu Toki, Ryo Okuse, Akie Kobayashi, Tomohiko Sato, Takuya Kamio, Kiminori Terui, Etsuro Ito Tags: Article Source Type: research
Anti-leukemic effect of azacitidine, a DNA methyltransferase inhibitor, on cell lines of myeloid leukemia associated with Down syndrome
Myeloid leukemia associated with Down syndrome (ML-DS) mostly develops from transient abnormal myelopoiesis (TAM), a preleukemic condition, and is associated with somatic mutations in the GATA1 gene [1 –9]. We have previously reported that genetic mutations associated with epigenetic regulators contribute to the progression of TAM to ML-DS [10,11]. Although patients with ML-DS are sensitive to cytarabine and demonstrate high event-free survival, treatment-related morbidity and mortality are high , and optimizing treatment intensity is challenging [12–16]. (Source: Experimental Hematology)
Source: Experimental Hematology - February 9, 2024 Category: Hematology Authors: Tatsuhiko Tanaka, Ko Kudo, Rika Kanezaki, Kentaro Yuzawa, Tsutomu Toki, Ryo Okuse, Akie Kobayashi, Tomohiko Sato, Takuya Kamio, Kiminori Terui, Etsuro Ito Tags: Article Source Type: research
Altered erythropoiesis via JAK2 and ASXL1 mutations in myeloproliferative neoplasms
JAK2 V617F is the most frequent driver mutation found in myeloproliferative neoplasms (MPNs), in approximately 50-60% of myelofibrosis (MF)1. Mutations in additional sex combs-like 1 (ASXL1), a polycomb chromatin-binding epigenetic regulator, often co-occur with JAK2 V617F and are associated with decreased survival and increased risk of transformation to secondary acute myeloid leukemia2,3. How mutant ASXL1 contributes to the MPN disease phenotype and confers poor prognosis is not fully understood. (Source: Experimental Hematology)
Source: Experimental Hematology - February 8, 2024 Category: Hematology Authors: Taylor B. Collins, Angelo B.A. Laranjeira, Tim Kong, Mary C. Fulbright, Daniel A.C. Fisher, Christopher M. Sturgeon, Luis F.Z. Batista, Stephen T. Oh Tags: Brief Communication Source Type: research
Zeb1 maintains long-term adult hematopoietic stem cell function and extramedullary hematopoiesis
Epithelial to mesenchymal transition (EMT) is a mechanism that is utilized in the fundamental physiologic processes of embryogenesis, wound healing, and tissue development where epithelial cells reduce their cell polarity and cell adhesion properties while they acquire mesenchymal-like cell characteristics and enhanced migratory potential [1,2]. Deregulated EMT has been observed in multiple pathological settings including organ fibrosis that can cause organ failure [3], and cancer, where increased EMT mediated migratory capacity of cancer cells promotes metastasis and, therefore, therapy resistance [4]. (Source: Experimental Hematology)
Source: Experimental Hematology - February 7, 2024 Category: Hematology Authors: Alhomidi Almotiri, Ali Abdelfattah, Elis Storch, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz, Neil P. Rodrigues Tags: Article Source Type: research
A novel kit mutant rat enables hematopoietic stem cell engraftment without irradiation
Hematopoietic stem cell (HSC) engraftment, or bone marrow cell (BMC) transplantation, is a clinical procedure utilized to address various hematological disorders and certain cancers. Animal models play an essential role in unraveling the complexities of hematopoiesis, refining transplantation protocols, and advancing therapeutic strategies. Although mice have emerged as the predominant model for HSC transplantation studies owing to their well-established genetic resources1, their small size poses limitations on the number of transplanted HSCs in a single recipient. (Source: Experimental Hematology)
Source: Experimental Hematology - February 5, 2024 Category: Hematology Authors: Ryuya IIDA, Saeko ISHIDA, Jinxi WANG, Kosuke HATTORI, Kazuto YOSHIMI, Satoshi YAMAZAKI, Tomoji MASHIMO Tags: Article Source Type: research
In vivo activity of the second-generation proteasome inhibitor ixazomib against pediatric t-cell acute lymphoblastic leukemia xenografts
While overall survival rates for pediatric acute lymphoblastic leukemia (ALL) are approximately 90%, patients with relapsed T-cell ALL (T-ALL) have a particularly poor prognosis.1 Therefore, there is an urgent need to develop novel therapies that target relapsed/refractory ALL. The ubiquitin-proteasome system (UPS) maintains normal protein homeostasis and is responsible for a host of cellular processes including intracellular protein degradation, apoptosis, inflammation, and cell cycle control.2 Dysregulation of UPS-controlled processes has been linked to many cancers, rendering the UPS an attractive therapeutic target lea...
Source: Experimental Hematology - February 4, 2024 Category: Hematology Authors: Joanna Randall, Kathryn Evans, Ben Watts, Hansen J. Kosasih, Christopher M. Smith, Eric J. Earley, Stephen W. Erickson, Emily L. Jocoy, Carol J. Bult, Beverly A. Teicher, Charles E. de Bock, Malcolm A. Smith, Richard B. Lock Tags: Brief Communication Source Type: research
EV-mediated intercellular communication in acute myeloid leukemia: Transport of genetic materials in the bone marrow microenvironment
Acute myeloid leukemia (AML) is the most prevalent acute leukemia in adults. It occurs due to the proliferation of nonfunctional primitive myeloid cells in the bone marrow (BM), which further spread to other parts of the body, such as the blood, liver, spleen, and central nervous system [1]. Inadequate understanding of the pathophysiology of AML as well as the lack of specific diagnostic and therapeutic monitoring tools limit the therapeutic effect [2,3]. (Source: Experimental Hematology)
Source: Experimental Hematology - February 2, 2024 Category: Hematology Authors: Qi Zhou, Zijian Li, Yaming Xi Tags: Review Source Type: research
EV-mediated intercellular communication in AML: Transport of genetic materials in the bone marrow microenvironment
Acute myeloid leukemia (AML) is the most prevalent acute leukemia in adults. It occurs due to the proliferation of non-functional primitive myeloid cells in the bone marrow (BM), which further spreads to other parts of the body, such as the blood, liver, spleen, and central nervous system [1]. Inadequate understanding of the pathophysiology of AML, as well as the lack of specific diagnostic and therapeutic monitoring tools, limit the therapeutic effect [2,3]. (Source: Experimental Hematology)
Source: Experimental Hematology - February 2, 2024 Category: Hematology Authors: Qi Zhou, Zijian Li, Yaming Xi Tags: Review Source Type: research
IFC Editorial Board
(Source: Experimental Hematology)
Source: Experimental Hematology - February 1, 2024 Category: Hematology Source Type: research
Chromothripsis in hematologic malignancies
Cancer genomes frequently exhibit structural chromosomal rearrangements that alter both the linear order of DNA sequences and gene copy number. These structural variants span a wide spectrum of complexity from simple translocations to intricate rearrangement patterns affecting multiple chromosomes [1]. Complex chromosomal rearrangements, collectively known as chromoanagenesis (derived from the Greek chromo, meaning chromosomes, and anagenesis, meaning rebirth), are ubiquitous in cancer. Chromoanagenesis encompasses diverse phenomena, such as chromosynthesis (involving the reconstitution of chromosomes), chromoplexy (in whi...
Source: Experimental Hematology - January 31, 2024 Category: Hematology Authors: Francisco Alejandro Lagunas-Rangel Tags: Review Source Type: research
Chromothripsis in hematological malignancies
Cancer genomes frequently exhibit structural chromosomal rearrangements that alter both the linear order of DNA sequences and gene copy number. These structural variants span a wide spectrum of complexity, from simple translocations to intricate rearrangement patterns affecting multiple chromosomes [1]. Complex chromosomal rearrangements, collectively known as chromoanagenesis (derived from the Greek chromo, meaning chromosomes, and anagenesis, meaning rebirth), are ubiquitous in cancer. It encompasses diverse phenomena such as chromosynthesis (involving the reconstitution of chromosomes), chromoplexy (in which chromosomes...
Source: Experimental Hematology - January 31, 2024 Category: Hematology Authors: Francisco Alejandro Lagunas-Rangel Tags: Review Source Type: research
Minor Introns Impact on Hematopoietic Malignancies
In the central dogma of molecular biology, transcription from DNA is a pivotal process wherein messenger RNA (mRNA) serves as the key intermediate between the genetic code stored in DNA and the functional proteins. This initial step involves transcribing genetic information into precursor mRNA (pre-mRNA), which subsequently undergoes essential RNA processing steps, including 5 ′ capping, 3′ polyadenylation (poly(A) tail), pre-mRNA splicing and mRNA transport to the cytosol. The quantity and quality control of pre-mRNA is intricately regulated by various factors, including transcriptional regulators, RNA binding protein...
Source: Experimental Hematology - January 31, 2024 Category: Hematology Authors: Koutarou Nishimura, Wataru Saika, Daichi Inoue Source Type: research
Cell fate decision in erythropoiesis: Insights from multiomics studies
Erythropoiesis is an important cellular differentiation process that leads to the formation of red blood cells from hematopoietic stem cells (HSCs) [1,2]. Owing to sophisticated mouse models [3] and human ex vivo differentiation systems that recapitulate all steps of differentiation [4], erythropoiesis has been comprehensibly analyzed, which makes it an ideal model system to address outstanding questions in biology. For example, enhancers were first characterized through extensive analyses of transcription at the ß-globin locus during erythroid differentiation [5]. (Source: Experimental Hematology)
Source: Experimental Hematology - January 20, 2024 Category: Hematology Authors: Steven Tur, Carmen G. Palii, Marjorie Brand Tags: Review Source Type: research
