Alcohol dehydrogenase 1 is a tubular mitophagy-dependent apoptosis inhibitor against septic acute kidney injury
Exp Cell Res. 2023 Oct 6:113804. doi: 10.1016/j.yexcr.2023.113804. Online ahead of print.ABSTRACTAlcohol dehydrogenase 1 (ADH1) is an alcohol-oxidizing enzyme with poorlydefined biology. Here we report that ADH1 is highly expressed in kidneys of mice with lethal endotoxemia and is transcriptionally upregulated in tubular cells by lipopolysaccharide (LPS) stimuli through TLR4/NF-κB cascade. The Adh1 knockout (Adh1KO) mice with lethal endotoxemia displayed increased susceptibility to acute kidney injury (AKI) but not systemic inflammatory response. Adh1KO mice develop more severe tubular cell apoptosis in comparison to Adh1...
Source: Experimental Cell Research - October 8, 2023 Category: Cytology Authors: Yang Zheng Juan-Juan Cai Xue Yang Zi-Qiang Shao Jing-Quan Liu Xiang-Hong Yang Ren-Hua Sun Bang-Chuan Hu Shi-Jing Mo Lan-Juan Li Source Type: research

Alcohol dehydrogenase 1 is a tubular mitophagy-dependent apoptosis inhibitor against septic acute kidney injury
Exp Cell Res. 2023 Oct 6:113804. doi: 10.1016/j.yexcr.2023.113804. Online ahead of print.ABSTRACTAlcohol dehydrogenase 1 (ADH1) is an alcohol-oxidizing enzyme with poorlydefined biology. Here we report that ADH1 is highly expressed in kidneys of mice with lethal endotoxemia and is transcriptionally upregulated in tubular cells by lipopolysaccharide (LPS) stimuli through TLR4/NF-κB cascade. The Adh1 knockout (Adh1KO) mice with lethal endotoxemia displayed increased susceptibility to acute kidney injury (AKI) but not systemic inflammatory response. Adh1KO mice develop more severe tubular cell apoptosis in comparison to Adh1...
Source: Experimental Cell Research - October 8, 2023 Category: Cytology Authors: Yang Zheng Juan-Juan Cai Xue Yang Zi-Qiang Shao Jing-Quan Liu Xiang-Hong Yang Ren-Hua Sun Bang-Chuan Hu Shi-Jing Mo Lan-Juan Li Source Type: research

Alcohol dehydrogenase 1 is a tubular mitophagy-dependent apoptosis inhibitor against septic acute kidney injury
Exp Cell Res. 2023 Oct 6:113804. doi: 10.1016/j.yexcr.2023.113804. Online ahead of print.ABSTRACTAlcohol dehydrogenase 1 (ADH1) is an alcohol-oxidizing enzyme with poorlydefined biology. Here we report that ADH1 is highly expressed in kidneys of mice with lethal endotoxemia and is transcriptionally upregulated in tubular cells by lipopolysaccharide (LPS) stimuli through TLR4/NF-κB cascade. The Adh1 knockout (Adh1KO) mice with lethal endotoxemia displayed increased susceptibility to acute kidney injury (AKI) but not systemic inflammatory response. Adh1KO mice develop more severe tubular cell apoptosis in comparison to Adh1...
Source: Experimental Cell Research - October 8, 2023 Category: Cytology Authors: Yang Zheng Juan-Juan Cai Xue Yang Zi-Qiang Shao Jing-Quan Liu Xiang-Hong Yang Ren-Hua Sun Bang-Chuan Hu Shi-Jing Mo Lan-Juan Li Source Type: research

RING induces cell cycle arrest and apoptosis in human breast cancer cells by regulating the HSF1/MT2A axis
In conclusion, RING1 suppressed the transcriptional activation of MT2A induced by HSF1 by facilitating the ubiquitination degradation of HSF1, resulting in cell cycle arrest and apoptosis in BC cells.PMID:37797799 | DOI:10.1016/j.yexcr.2023.113795 (Source: Experimental Cell Research)
Source: Experimental Cell Research - October 5, 2023 Category: Cytology Authors: Di Liu Yize Guo Qin Du Yuxuan Zhu Ya Guo Source Type: research

RING induces cell cycle arrest and apoptosis in human breast cancer cells by regulating the HSF1/MT2A axis
In conclusion, RING1 suppressed the transcriptional activation of MT2A induced by HSF1 by facilitating the ubiquitination degradation of HSF1, resulting in cell cycle arrest and apoptosis in BC cells.PMID:37797799 | DOI:10.1016/j.yexcr.2023.113795 (Source: Experimental Cell Research)
Source: Experimental Cell Research - October 5, 2023 Category: Cytology Authors: Di Liu Yize Guo Qin Du Yuxuan Zhu Ya Guo Source Type: research

RING induces cell cycle arrest and apoptosis in human breast cancer cells by regulating the HSF1/MT2A axis
In conclusion, RING1 suppressed the transcriptional activation of MT2A induced by HSF1 by facilitating the ubiquitination degradation of HSF1, resulting in cell cycle arrest and apoptosis in BC cells.PMID:37797799 | DOI:10.1016/j.yexcr.2023.113795 (Source: Experimental Cell Research)
Source: Experimental Cell Research - October 5, 2023 Category: Cytology Authors: Di Liu Yize Guo Qin Du Yuxuan Zhu Ya Guo Source Type: research

Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt pathway and activating the p53 signaling
In conclusion, our results indicate that ZNF24 inhibits 5-FU resistance of CRC cells by suppressing the Wnt pathway and activating p53 signaling, which offers a potential strategy for managing chemoresistance in CRC.PMID:37774763 | DOI:10.1016/j.yexcr.2023.113796 (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 29, 2023 Category: Cytology Authors: Fanqi Meng Chunlong Ai Guoqiang Yan Guangyi Wang Source Type: research

Autophagy reduces aortic calcification in diabetic mice by reducing matrix vesicle body-mediated IL-1 β release
In conclusion, our results suggested that MVBs could carry IL-1β out of cells and induce VC in normal VSMCs, and these processes could be counteracted by autophagy. These results suggested that MVB-mediated IL-1β release may be an effective target for treating vascular calcification.PMID:37774764 | DOI:10.1016/j.yexcr.2023.113803 (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 29, 2023 Category: Cytology Authors: Xiaolei Sun Yang Zheng Linzhuo Xie Yuanqun Zhou Runyu Liu Yarong Ma Ming Zhao Yong Liu Source Type: research

Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt pathway and activating the p53 signaling
In conclusion, our results indicate that ZNF24 inhibits 5-FU resistance of CRC cells by suppressing the Wnt pathway and activating p53 signaling, which offers a potential strategy for managing chemoresistance in CRC.PMID:37774763 | DOI:10.1016/j.yexcr.2023.113796 (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 29, 2023 Category: Cytology Authors: Fanqi Meng Chunlong Ai Guoqiang Yan Guangyi Wang Source Type: research

Autophagy reduces aortic calcification in diabetic mice by reducing matrix vesicle body-mediated IL-1 β release
In conclusion, our results suggested that MVBs could carry IL-1β out of cells and induce VC in normal VSMCs, and these processes could be counteracted by autophagy. These results suggested that MVB-mediated IL-1β release may be an effective target for treating vascular calcification.PMID:37774764 | DOI:10.1016/j.yexcr.2023.113803 (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 29, 2023 Category: Cytology Authors: Xiaolei Sun Yang Zheng Linzhuo Xie Yuanqun Zhou Runyu Liu Yarong Ma Ming Zhao Yong Liu Source Type: research

Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt pathway and activating the p53 signaling
In conclusion, our results indicate that ZNF24 inhibits 5-FU resistance of CRC cells by suppressing the Wnt pathway and activating p53 signaling, which offers a potential strategy for managing chemoresistance in CRC.PMID:37774763 | DOI:10.1016/j.yexcr.2023.113796 (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 29, 2023 Category: Cytology Authors: Fanqi Meng Chunlong Ai Guoqiang Yan Guangyi Wang Source Type: research

Autophagy reduces aortic calcification in diabetic mice by reducing matrix vesicle body-mediated IL-1 β release
In conclusion, our results suggested that MVBs could carry IL-1β out of cells and induce VC in normal VSMCs, and these processes could be counteracted by autophagy. These results suggested that MVB-mediated IL-1β release may be an effective target for treating vascular calcification.PMID:37774764 | DOI:10.1016/j.yexcr.2023.113803 (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 29, 2023 Category: Cytology Authors: Xiaolei Sun Yang Zheng Linzhuo Xie Yuanqun Zhou Runyu Liu Yarong Ma Ming Zhao Yong Liu Source Type: research

Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt pathway and activating the p53 signaling
In conclusion, our results indicate that ZNF24 inhibits 5-FU resistance of CRC cells by suppressing the Wnt pathway and activating p53 signaling, which offers a potential strategy for managing chemoresistance in CRC.PMID:37774763 | DOI:10.1016/j.yexcr.2023.113796 (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 29, 2023 Category: Cytology Authors: Fanqi Meng Chunlong Ai Guoqiang Yan Guangyi Wang Source Type: research

Autophagy reduces aortic calcification in diabetic mice by reducing matrix vesicle body-mediated IL-1 β release
In conclusion, our results suggested that MVBs could carry IL-1β out of cells and induce VC in normal VSMCs, and these processes could be counteracted by autophagy. These results suggested that MVB-mediated IL-1β release may be an effective target for treating vascular calcification.PMID:37774764 | DOI:10.1016/j.yexcr.2023.113803 (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 29, 2023 Category: Cytology Authors: Xiaolei Sun Yang Zheng Linzhuo Xie Yuanqun Zhou Runyu Liu Yarong Ma Ming Zhao Yong Liu Source Type: research

Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt pathway and activating the p53 signaling
In conclusion, our results indicate that ZNF24 inhibits 5-FU resistance of CRC cells by suppressing the Wnt pathway and activating p53 signaling, which offers a potential strategy for managing chemoresistance in CRC.PMID:37774763 | DOI:10.1016/j.yexcr.2023.113796 (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 29, 2023 Category: Cytology Authors: Fanqi Meng Chunlong Ai Guoqiang Yan Guangyi Wang Source Type: research