Sleep deprivation induces late deleterious effects in a pharmacological model of Parkinsonism
Exp Brain Res. 2024 Mar 18. doi: 10.1007/s00221-024-06811-0. Online ahead of print.ABSTRACTParkinson's disease is a degenerative, chronic and progressive disease, characterized by motor dysfunctions. Patients also exhibit non-motor symptoms, such as affective and sleep disorders. Sleep disorders can potentiate clinical and neuropathological features and lead to worse prognosis. The goal of this study was to evaluate the effects of sleep deprivation (SD) in mice submitted to a progressive pharmacological model of Parkinsonism (chronic administration with a low dose of reserpine). Male Swiss mice received 20 injections of re...
Source: Experimental Brain Research - March 19, 2024 Category: Neuroscience Authors: L B Lopes-Silva D M G Cunha A C Lima V S Bioni N Gon çalves J P F Kurita R Wuo-Silva R H Silva Source Type: research
Sleep deprivation induces late deleterious effects in a pharmacological model of Parkinsonism
Exp Brain Res. 2024 Mar 18. doi: 10.1007/s00221-024-06811-0. Online ahead of print.ABSTRACTParkinson's disease is a degenerative, chronic and progressive disease, characterized by motor dysfunctions. Patients also exhibit non-motor symptoms, such as affective and sleep disorders. Sleep disorders can potentiate clinical and neuropathological features and lead to worse prognosis. The goal of this study was to evaluate the effects of sleep deprivation (SD) in mice submitted to a progressive pharmacological model of Parkinsonism (chronic administration with a low dose of reserpine). Male Swiss mice received 20 injections of re...
Source: Experimental Brain Research - March 19, 2024 Category: Neuroscience Authors: L B Lopes-Silva D M G Cunha A C Lima V S Bioni N Gon çalves J P F Kurita R Wuo-Silva R H Silva Source Type: research
Sleep deprivation induces late deleterious effects in a pharmacological model of Parkinsonism
Exp Brain Res. 2024 Mar 18. doi: 10.1007/s00221-024-06811-0. Online ahead of print.ABSTRACTParkinson's disease is a degenerative, chronic and progressive disease, characterized by motor dysfunctions. Patients also exhibit non-motor symptoms, such as affective and sleep disorders. Sleep disorders can potentiate clinical and neuropathological features and lead to worse prognosis. The goal of this study was to evaluate the effects of sleep deprivation (SD) in mice submitted to a progressive pharmacological model of Parkinsonism (chronic administration with a low dose of reserpine). Male Swiss mice received 20 injections of re...
Source: Experimental Brain Research - March 19, 2024 Category: Neuroscience Authors: L B Lopes-Silva D M G Cunha A C Lima V S Bioni N Gon çalves J P F Kurita R Wuo-Silva R H Silva Source Type: research
Unveiling the invisible: receivers use object weight cues for grip force planning in handover actions
This study aimed to investigate whether receivers are able to correctly estimate object weight by observing the giver's kinematics. For this purpose, handover actions were performed with 20 dyads, manipulating the participant role (giver/receiver) and varying the size and weight of the object. Due to the random presentation of the object weight and the absence of visual cues, the participants were unaware of the object weight from trial to trial. Kinematics were recorded with a motion tracking system and grip forces were recorded with customized test objects. Peak grip force rates were used as a measure of anticipated obje...
Source: Experimental Brain Research - March 18, 2024 Category: Neuroscience Authors: L Kopnarski J Rudisch D F Kutz C Voelcker-Rehage Source Type: research
Inhibition of fatty acid amide hydrolase reverses aberrant prefrontal gamma oscillations in the sub-chronic PCP model for schizophrenia
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06801-2. Online ahead of print.ABSTRACTHypofunctioning of NMDA receptors, and the resulting shift in the balance between excitation and inhibition, is considered a key process in the pathophysiology of schizophrenia. One important manifestation of this phenomenon is changes in neural oscillations, those above 30 Hz (i.e., gamma-band oscillations), in particular. Although both preclinical and clinical studies observed increased gamma activity following acute administration of NMDA receptor antagonists, the relevance of this phenomenon has been recently questioned given the...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Alexandre Seillier Source Type: research
Effects of the perceived temporal distance of events on mental time travel and on its underlying brain circuits
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06806-x. Online ahead of print.ABSTRACTMental Time Travel (MTT) allows us to remember past events and imagine future ones. According to previous literature, the Temporal Distance of events affects MTT: our ability to order events worsens for close, compared to far, events. However, those studies established distances a-priori, albeit the way we perceive events' temporal distance may subjectively differ from their objective distance. Thus, in the current study, we aimed to investigate the effects of Perceived Temporal Distance (PTD) on the MTT ability and the brain areas m...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Claudia Casadio Ivan Patan é Michela Candini Fausta Lui Francesca Frassinetti Francesca Benuzzi Source Type: research
A computational model of motion sickness dynamics during passive self-motion in the dark
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06804-z. Online ahead of print.ABSTRACTPredicting the time course of motion sickness symptoms enables the evaluation of provocative stimuli and the development of countermeasures for reducing symptom severity. In pursuit of this goal, we present an Observer-driven model of motion sickness for passive motions in the dark. Constructed in two stages, this model predicts motion sickness symptoms by bridging sensory conflict (i.e., differences between actual and expected sensory signals) arising from the Observer model of spatial orientation perception (stage 1) to Oman's mode...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Aaron R Allred Torin K Clark Source Type: research
Inhibition of fatty acid amide hydrolase reverses aberrant prefrontal gamma oscillations in the sub-chronic PCP model for schizophrenia
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06801-2. Online ahead of print.ABSTRACTHypofunctioning of NMDA receptors, and the resulting shift in the balance between excitation and inhibition, is considered a key process in the pathophysiology of schizophrenia. One important manifestation of this phenomenon is changes in neural oscillations, those above 30 Hz (i.e., gamma-band oscillations), in particular. Although both preclinical and clinical studies observed increased gamma activity following acute administration of NMDA receptor antagonists, the relevance of this phenomenon has been recently questioned given the...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Alexandre Seillier Source Type: research
Effects of the perceived temporal distance of events on mental time travel and on its underlying brain circuits
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06806-x. Online ahead of print.ABSTRACTMental Time Travel (MTT) allows us to remember past events and imagine future ones. According to previous literature, the Temporal Distance of events affects MTT: our ability to order events worsens for close, compared to far, events. However, those studies established distances a-priori, albeit the way we perceive events' temporal distance may subjectively differ from their objective distance. Thus, in the current study, we aimed to investigate the effects of Perceived Temporal Distance (PTD) on the MTT ability and the brain areas m...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Claudia Casadio Ivan Patan é Michela Candini Fausta Lui Francesca Frassinetti Francesca Benuzzi Source Type: research
A computational model of motion sickness dynamics during passive self-motion in the dark
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06804-z. Online ahead of print.ABSTRACTPredicting the time course of motion sickness symptoms enables the evaluation of provocative stimuli and the development of countermeasures for reducing symptom severity. In pursuit of this goal, we present an Observer-driven model of motion sickness for passive motions in the dark. Constructed in two stages, this model predicts motion sickness symptoms by bridging sensory conflict (i.e., differences between actual and expected sensory signals) arising from the Observer model of spatial orientation perception (stage 1) to Oman's mode...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Aaron R Allred Torin K Clark Source Type: research
Inhibition of fatty acid amide hydrolase reverses aberrant prefrontal gamma oscillations in the sub-chronic PCP model for schizophrenia
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06801-2. Online ahead of print.ABSTRACTHypofunctioning of NMDA receptors, and the resulting shift in the balance between excitation and inhibition, is considered a key process in the pathophysiology of schizophrenia. One important manifestation of this phenomenon is changes in neural oscillations, those above 30 Hz (i.e., gamma-band oscillations), in particular. Although both preclinical and clinical studies observed increased gamma activity following acute administration of NMDA receptor antagonists, the relevance of this phenomenon has been recently questioned given the...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Alexandre Seillier Source Type: research
Effects of the perceived temporal distance of events on mental time travel and on its underlying brain circuits
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06806-x. Online ahead of print.ABSTRACTMental Time Travel (MTT) allows us to remember past events and imagine future ones. According to previous literature, the Temporal Distance of events affects MTT: our ability to order events worsens for close, compared to far, events. However, those studies established distances a-priori, albeit the way we perceive events' temporal distance may subjectively differ from their objective distance. Thus, in the current study, we aimed to investigate the effects of Perceived Temporal Distance (PTD) on the MTT ability and the brain areas m...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Claudia Casadio Ivan Patan é Michela Candini Fausta Lui Francesca Frassinetti Francesca Benuzzi Source Type: research
A computational model of motion sickness dynamics during passive self-motion in the dark
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06804-z. Online ahead of print.ABSTRACTPredicting the time course of motion sickness symptoms enables the evaluation of provocative stimuli and the development of countermeasures for reducing symptom severity. In pursuit of this goal, we present an Observer-driven model of motion sickness for passive motions in the dark. Constructed in two stages, this model predicts motion sickness symptoms by bridging sensory conflict (i.e., differences between actual and expected sensory signals) arising from the Observer model of spatial orientation perception (stage 1) to Oman's mode...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Aaron R Allred Torin K Clark Source Type: research
Inhibition of fatty acid amide hydrolase reverses aberrant prefrontal gamma oscillations in the sub-chronic PCP model for schizophrenia
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06801-2. Online ahead of print.ABSTRACTHypofunctioning of NMDA receptors, and the resulting shift in the balance between excitation and inhibition, is considered a key process in the pathophysiology of schizophrenia. One important manifestation of this phenomenon is changes in neural oscillations, those above 30 Hz (i.e., gamma-band oscillations), in particular. Although both preclinical and clinical studies observed increased gamma activity following acute administration of NMDA receptor antagonists, the relevance of this phenomenon has been recently questioned given the...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Alexandre Seillier Source Type: research
Effects of the perceived temporal distance of events on mental time travel and on its underlying brain circuits
Exp Brain Res. 2024 Mar 15. doi: 10.1007/s00221-024-06806-x. Online ahead of print.ABSTRACTMental Time Travel (MTT) allows us to remember past events and imagine future ones. According to previous literature, the Temporal Distance of events affects MTT: our ability to order events worsens for close, compared to far, events. However, those studies established distances a-priori, albeit the way we perceive events' temporal distance may subjectively differ from their objective distance. Thus, in the current study, we aimed to investigate the effects of Perceived Temporal Distance (PTD) on the MTT ability and the brain areas m...
Source: Experimental Brain Research - March 15, 2024 Category: Neuroscience Authors: Claudia Casadio Ivan Patan é Michela Candini Fausta Lui Francesca Frassinetti Francesca Benuzzi Source Type: research
