scAAV9-VEGF alleviates symptoms of amyotrophic lateral sclerosis (ALS) mice through regulating aromatase
In conclusion, this study proved the protective effects of VEGF in the onset and development of ALS and revealed the involvement of estrogen, oxidative stress and autophagy in the VEGF-induced alleviation of ALS. Our results highlighted the potential of VEGF as a promising therapeutic agent in the treatment of ALS.PMID:37882882 | DOI:10.1007/s00221-023-06721-7 (Source: Experimental Brain Research)
Source: Experimental Brain Research - October 26, 2023 Category: Neuroscience Authors: Ying Wang Shuo Sun Jingxu Zhai Yuanyuan Liu Chaoyuan Song Cuimei Sun Qiang Li Jianqiang Liu Hong Jiang Yaling Liu Source Type: research
Long period changes of hippocampal diffusion kurtosis imaging and its correlation with cognitive dysfunction after incomplete cerebral ischemia-reperfusion in rats
This study aims to summarize the changes of functional diffusion kurtosis imaging (DKI) parameters in the bilateral hippocampal CA1 region of the hemorrhagic shock reperfusion (HSR) model of rats and their correlation with cognitive dysfunction. Adult male Sprague-Dawley rats (9-10 weeks of age, weighing 350-400 g) were randomized into the HSR group (n = 30) and the sham-operated group (Sham) (n = 30). Rats in the HSR group and the Sham group were subdivided into five time points (1, 2, 4, 8, and 12 weeks) for examination. Diffusion kurtosis imaging (DKI) was performed. Cognitive dysfunction was analyzed by the Morris Wate...
Source: Experimental Brain Research - October 25, 2023 Category: Neuroscience Authors: Lan Fu Lin-Na Guan Hongye Zuo Source Type: research
Low-load blood flow restriction reduces time-to-minimum single motor unit discharge rate
Exp Brain Res. 2023 Oct 24. doi: 10.1007/s00221-023-06720-8. Online ahead of print.ABSTRACTResistance training with low loads in combination with blood flow restriction (BFR) facilitates increases in muscle size and strength comparable with high-intensity exercise. We investigated the effects of BFR on single motor unit discharge behavior throughout a sustained low-intensity isometric contraction. Ten healthy individuals attended two experimental sessions: one with, the other without, BFR. Motor unit discharge rates from the tibialis anterior (TA) were recorded with intramuscular fine-wire electrodes throughout the duratio...
Source: Experimental Brain Research - October 24, 2023 Category: Neuroscience Authors: Timothy W Lowe Matthew S Tenan Kena Shah Lisa Griffin Source Type: research
Low-load blood flow restriction reduces time-to-minimum single motor unit discharge rate
Exp Brain Res. 2023 Oct 24. doi: 10.1007/s00221-023-06720-8. Online ahead of print.ABSTRACTResistance training with low loads in combination with blood flow restriction (BFR) facilitates increases in muscle size and strength comparable with high-intensity exercise. We investigated the effects of BFR on single motor unit discharge behavior throughout a sustained low-intensity isometric contraction. Ten healthy individuals attended two experimental sessions: one with, the other without, BFR. Motor unit discharge rates from the tibialis anterior (TA) were recorded with intramuscular fine-wire electrodes throughout the duratio...
Source: Experimental Brain Research - October 24, 2023 Category: Neuroscience Authors: Timothy W Lowe Matthew S Tenan Kena Shah Lisa Griffin Source Type: research
Space for power: feeling powerful over others' behavior affects peri-personal space representation
Exp Brain Res. 2023 Oct 21. doi: 10.1007/s00221-023-06719-1. Online ahead of print.ABSTRACTWe investigated whether and how social power affects the representation of peri-personal space (PPS). We applied a multisensory interaction task to assess PPS representation and the Personal Sense of Power Scale to assess participants' feelings of power over others' behaviors and over others' opinions. In Study 1, we probed PPS representation in a virtual social context. Participants with a higher sense of power showed a less defined differentiation between the close and far space as compared to participants with a lower sense of pow...
Source: Experimental Brain Research - October 21, 2023 Category: Neuroscience Authors: Tommaso Bertoni Maria Paola Paladino Elisa Pellencin Silvia Serino Andrea Serino Source Type: research
Space for power: feeling powerful over others' behavior affects peri-personal space representation
Exp Brain Res. 2023 Oct 21. doi: 10.1007/s00221-023-06719-1. Online ahead of print.ABSTRACTWe investigated whether and how social power affects the representation of peri-personal space (PPS). We applied a multisensory interaction task to assess PPS representation and the Personal Sense of Power Scale to assess participants' feelings of power over others' behaviors and over others' opinions. In Study 1, we probed PPS representation in a virtual social context. Participants with a higher sense of power showed a less defined differentiation between the close and far space as compared to participants with a lower sense of pow...
Source: Experimental Brain Research - October 21, 2023 Category: Neuroscience Authors: Tommaso Bertoni Maria Paola Paladino Elisa Pellencin Silvia Serino Andrea Serino Source Type: research
Space for power: feeling powerful over others' behavior affects peri-personal space representation
Exp Brain Res. 2023 Oct 21. doi: 10.1007/s00221-023-06719-1. Online ahead of print.ABSTRACTWe investigated whether and how social power affects the representation of peri-personal space (PPS). We applied a multisensory interaction task to assess PPS representation and the Personal Sense of Power Scale to assess participants' feelings of power over others' behaviors and over others' opinions. In Study 1, we probed PPS representation in a virtual social context. Participants with a higher sense of power showed a less defined differentiation between the close and far space as compared to participants with a lower sense of pow...
Source: Experimental Brain Research - October 21, 2023 Category: Neuroscience Authors: Tommaso Bertoni Maria Paola Paladino Elisa Pellencin Silvia Serino Andrea Serino Source Type: research
More implicit and more explicit motor imagery tasks for exploring the mental representation of hands and feet in action
Exp Brain Res. 2023 Oct 19. doi: 10.1007/s00221-023-06718-2. Online ahead of print.ABSTRACTThe mental representation of the body in action can be explored using motor imagery (MI) tasks. MI tasks can be allocated along a continuum going from more implicit to more explicit tasks, where the discriminant is the degree of action monitoring required to solve the tasks (which is the awareness of using the mental representation of our own body to monitor our motor imagery). Tasks based on laterality judgments, such as the Hand Laterality Task (HLT) and the Foot Laterality Task (FLT), provide an example of more implicit tasks (i.e...
Source: Experimental Brain Research - October 19, 2023 Category: Neuroscience Authors: Federico Brusa Mustafa Suphi Erden Anna Sedda Source Type: research
More implicit and more explicit motor imagery tasks for exploring the mental representation of hands and feet in action
Exp Brain Res. 2023 Oct 19. doi: 10.1007/s00221-023-06718-2. Online ahead of print.ABSTRACTThe mental representation of the body in action can be explored using motor imagery (MI) tasks. MI tasks can be allocated along a continuum going from more implicit to more explicit tasks, where the discriminant is the degree of action monitoring required to solve the tasks (which is the awareness of using the mental representation of our own body to monitor our motor imagery). Tasks based on laterality judgments, such as the Hand Laterality Task (HLT) and the Foot Laterality Task (FLT), provide an example of more implicit tasks (i.e...
Source: Experimental Brain Research - October 19, 2023 Category: Neuroscience Authors: Federico Brusa Mustafa Suphi Erden Anna Sedda Source Type: research
More implicit and more explicit motor imagery tasks for exploring the mental representation of hands and feet in action
Exp Brain Res. 2023 Oct 19. doi: 10.1007/s00221-023-06718-2. Online ahead of print.ABSTRACTThe mental representation of the body in action can be explored using motor imagery (MI) tasks. MI tasks can be allocated along a continuum going from more implicit to more explicit tasks, where the discriminant is the degree of action monitoring required to solve the tasks (which is the awareness of using the mental representation of our own body to monitor our motor imagery). Tasks based on laterality judgments, such as the Hand Laterality Task (HLT) and the Foot Laterality Task (FLT), provide an example of more implicit tasks (i.e...
Source: Experimental Brain Research - October 19, 2023 Category: Neuroscience Authors: Federico Brusa Mustafa Suphi Erden Anna Sedda Source Type: research
Recombinant human brain natriuretic peptide attenuates ischemic brain injury in mice by inhibiting oxidative stress and cell apoptosis via activation of PI3K/AKT/Nrf2/HO-1 pathway
Exp Brain Res. 2023 Oct 17. doi: 10.1007/s00221-023-06716-4. Online ahead of print.ABSTRACTIschemic stroke followed by cerebral artery occlusion is a main cause of chronic disability worldwide. Recombinant human brain natriuretic peptide (rhBNP) has been reported to alleviate sepsis-induced cognitive dysfunction and brain I/R injury. However, the function and molecular mechanisms of rhBNP in ischemic brain injury have not been clarified. For establishment of an animal model of ischemic brain injury, C57BL/6 mice were treated with middle cerebral artery occlusion (MCAO) surgery for 1 h and reperfusion for 24 h. After subcut...
Source: Experimental Brain Research - October 17, 2023 Category: Neuroscience Authors: Tong Li DaJing Su HuaWen Lu YunQing Gao YongGang Liu ShaoHua Wang YuTing Hou KeMin Qin XianTing Que XiaoPing Chen BaiLing Qin ZiJun Wang Yan Deng Source Type: research
Recombinant human brain natriuretic peptide attenuates ischemic brain injury in mice by inhibiting oxidative stress and cell apoptosis via activation of PI3K/AKT/Nrf2/HO-1 pathway
Exp Brain Res. 2023 Oct 17. doi: 10.1007/s00221-023-06716-4. Online ahead of print.ABSTRACTIschemic stroke followed by cerebral artery occlusion is a main cause of chronic disability worldwide. Recombinant human brain natriuretic peptide (rhBNP) has been reported to alleviate sepsis-induced cognitive dysfunction and brain I/R injury. However, the function and molecular mechanisms of rhBNP in ischemic brain injury have not been clarified. For establishment of an animal model of ischemic brain injury, C57BL/6 mice were treated with middle cerebral artery occlusion (MCAO) surgery for 1 h and reperfusion for 24 h. After subcut...
Source: Experimental Brain Research - October 17, 2023 Category: Neuroscience Authors: Tong Li DaJing Su HuaWen Lu YunQing Gao YongGang Liu ShaoHua Wang YuTing Hou KeMin Qin XianTing Que XiaoPing Chen BaiLing Qin ZiJun Wang Yan Deng Source Type: research
The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults
Exp Brain Res. 2023 Oct 16. doi: 10.1007/s00221-023-06717-3. Online ahead of print.ABSTRACTStroke is reported to be the second leading cause of death worldwide, among which ischemic stroke has fourfold greater incidence than intracerebral hemorrhage. Excitotoxicity induced by NMDAR plays a central role in ischemic stroke-induced neuronal death. However, intervention targeted NMDARs against ischemic stroke has failed, which may result from the complex composition of NMDARs and the dynamic changes of their subunits. In this current study, the levels of NR1, NR2A and NR2B subunits of NMDARs were observed upon different time p...
Source: Experimental Brain Research - October 16, 2023 Category: Neuroscience Authors: Bei Guo Huimeng Song Jiahui Fan Bin Wang Lingyi Chen Qiandai Hu Yanling Yin Source Type: research
Explicit effort may not influence perceptuomotor decision-making
Exp Brain Res. 2023 Oct 13. doi: 10.1007/s00221-023-06710-w. Online ahead of print.ABSTRACTMany decisions that humans make are enacted by the action system. For example, humans use reach-to-grasp movements when making perceptuomotor decisions between and obtaining fruits of varying quality from a pile. Recent work suggests that the characteristics of each action alternative may influence the decision itself-there may be a bias away from making perceptuomotor alternatives associated with high effort when participants are unaware of the effort differences between responses. The present study examined if perceptuomotor decisi...
Source: Experimental Brain Research - October 13, 2023 Category: Neuroscience Authors: Joseph X Manzone Timothy N Welsh Source Type: research
Explicit effort may not influence perceptuomotor decision-making
Exp Brain Res. 2023 Oct 13. doi: 10.1007/s00221-023-06710-w. Online ahead of print.ABSTRACTMany decisions that humans make are enacted by the action system. For example, humans use reach-to-grasp movements when making perceptuomotor decisions between and obtaining fruits of varying quality from a pile. Recent work suggests that the characteristics of each action alternative may influence the decision itself-there may be a bias away from making perceptuomotor alternatives associated with high effort when participants are unaware of the effort differences between responses. The present study examined if perceptuomotor decisi...
Source: Experimental Brain Research - October 13, 2023 Category: Neuroscience Authors: Joseph X Manzone Timothy N Welsh Source Type: research
