Effects of exercise-targeted hippocampal PDE-4 methylation on synaptic plasticity and spatial learning/memory impairments in D-galactose-induced aging rats
Exp Brain Res. 2023 Dec 5. doi: 10.1007/s00221-023-06749-9. Online ahead of print.ABSTRACTPhysical exercise reduces the effects of aging and cognitive decline by improving synaptic plasticity and spatial learning. However, the underlying neurobiological mechanisms are unclear. A total of 45 Male SPF Sprague-Dawley rats were acclimatized and then allocated into three groups, 15 in each group: the saline control (DC) group, D-gal-induced aging (DA) group, and D-gal-induced aging + exercise (DE) group. Six weeks of intraperitoneal injections of D-gal at a concentration of 100 mg/kg body weight/d was injected to establish mode...
Source: Experimental Brain Research - December 5, 2023 Category: Neuroscience Authors: Yu Jin Xue Li Changling Wei Qiongjia Yuan Source Type: research
Effects of exercise-targeted hippocampal PDE-4 methylation on synaptic plasticity and spatial learning/memory impairments in D-galactose-induced aging rats
Exp Brain Res. 2023 Dec 5. doi: 10.1007/s00221-023-06749-9. Online ahead of print.ABSTRACTPhysical exercise reduces the effects of aging and cognitive decline by improving synaptic plasticity and spatial learning. However, the underlying neurobiological mechanisms are unclear. A total of 45 Male SPF Sprague-Dawley rats were acclimatized and then allocated into three groups, 15 in each group: the saline control (DC) group, D-gal-induced aging (DA) group, and D-gal-induced aging + exercise (DE) group. Six weeks of intraperitoneal injections of D-gal at a concentration of 100 mg/kg body weight/d was injected to establish mode...
Source: Experimental Brain Research - December 5, 2023 Category: Neuroscience Authors: Yu Jin Xue Li Changling Wei Qiongjia Yuan Source Type: research
The ultrastructure of macaque mesencephalic trigeminal nucleus neurons
In this study, we explored the ultrastructure of macaque mesencephalic trigeminal nucleus neurons to determine the presence and nature of this synaptic input in a primate. We first confirmed the location of macaque mesencephalic trigeminal neurons by retrograde labeling from the masticatory muscles. Since the labeled neurons were by far the largest cells located at the edge of the periaqueductal gray, we could undertake sampling for electron microscopy based on soma size. Ultrastructurally, mesencephalic trigeminal neurons had very large somata with euchromatic nuclei that sometimes displayed deeply indented nuclear membra...
Source: Experimental Brain Research - December 1, 2023 Category: Neuroscience Authors: Niping Wang Paul J May Source Type: research
The ultrastructure of macaque mesencephalic trigeminal nucleus neurons
In this study, we explored the ultrastructure of macaque mesencephalic trigeminal nucleus neurons to determine the presence and nature of this synaptic input in a primate. We first confirmed the location of macaque mesencephalic trigeminal neurons by retrograde labeling from the masticatory muscles. Since the labeled neurons were by far the largest cells located at the edge of the periaqueductal gray, we could undertake sampling for electron microscopy based on soma size. Ultrastructurally, mesencephalic trigeminal neurons had very large somata with euchromatic nuclei that sometimes displayed deeply indented nuclear membra...
Source: Experimental Brain Research - December 1, 2023 Category: Neuroscience Authors: Niping Wang Paul J May Source Type: research
The ultrastructure of macaque mesencephalic trigeminal nucleus neurons
In this study, we explored the ultrastructure of macaque mesencephalic trigeminal nucleus neurons to determine the presence and nature of this synaptic input in a primate. We first confirmed the location of macaque mesencephalic trigeminal neurons by retrograde labeling from the masticatory muscles. Since the labeled neurons were by far the largest cells located at the edge of the periaqueductal gray, we could undertake sampling for electron microscopy based on soma size. Ultrastructurally, mesencephalic trigeminal neurons had very large somata with euchromatic nuclei that sometimes displayed deeply indented nuclear membra...
Source: Experimental Brain Research - December 1, 2023 Category: Neuroscience Authors: Niping Wang Paul J May Source Type: research
The ultrastructure of macaque mesencephalic trigeminal nucleus neurons
In this study, we explored the ultrastructure of macaque mesencephalic trigeminal nucleus neurons to determine the presence and nature of this synaptic input in a primate. We first confirmed the location of macaque mesencephalic trigeminal neurons by retrograde labeling from the masticatory muscles. Since the labeled neurons were by far the largest cells located at the edge of the periaqueductal gray, we could undertake sampling for electron microscopy based on soma size. Ultrastructurally, mesencephalic trigeminal neurons had very large somata with euchromatic nuclei that sometimes displayed deeply indented nuclear membra...
Source: Experimental Brain Research - December 1, 2023 Category: Neuroscience Authors: Niping Wang Paul J May Source Type: research
Unravelling the Parkinson's puzzle, from medications and surgery to stem cells and genes: a comprehensive review of current and future management strategies
Exp Brain Res. 2023 Nov 28. doi: 10.1007/s00221-023-06735-1. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative disorder, prevalent in the elderly population. Neuropathological hallmarks of PD include loss of dopaminergic cells in the nigro-striatal pathway and deposition of alpha-synuclein protein in the neurons and synaptic terminals, which lead to a complex presentation of motor and non-motor symptoms. This review focuses on various aspects of PD, from clinical diagnosis to currently accepted treatment options, such as pharmacological management through dopamine replacement and surgical techni...
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Krishnapriya Chandrababu Vineeth Radhakrishnan A S Anjana Rahul Rajan Unnikrishnan Sivan Syam Krishnan P S Baby Chakrapani Source Type: research
Seasickness susceptibility and the vestibular time constant: a prospective study
This study was retrospectively registered on December 7th 2022 and assigned the identifier number NCT05640258.PMID:38015244 | DOI:10.1007/s00221-023-06745-z (Source: Experimental Brain Research)
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Daniel Lagami Yoni Evgeni Gutkovich Anna Jamison Yuri Fonar Dror Tal Source Type: research
Trunk postural reactions to the force perturbation intensity and frequency during sitting astride in children with cerebral palsy
Exp Brain Res. 2023 Nov 28. doi: 10.1007/s00221-023-06744-0. Online ahead of print.ABSTRACTThe purpose of this study was to examine kinematic and neuromuscular responses of the head and body to pelvis perturbations with different intensities and frequencies during sitting astride in children with CP. Sixteen children with spastic CP (mean age 7.4 ± 2.4 years old) were recruited in this study. A custom designed cable-driven robotic horse was used to apply controlled force perturbations to the pelvis during sitting astride. Each participant was tested in four force intensity conditions (i.e., 10%, 15%, 20%, and 25% of body ...
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Shijun Yan Seoung Hoon Park Weena Dee Renee Keefer Ana-Marie Rojas William Zev Rymer Ming Wu Source Type: research
Unravelling the Parkinson's puzzle, from medications and surgery to stem cells and genes: a comprehensive review of current and future management strategies
Exp Brain Res. 2023 Nov 28. doi: 10.1007/s00221-023-06735-1. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative disorder, prevalent in the elderly population. Neuropathological hallmarks of PD include loss of dopaminergic cells in the nigro-striatal pathway and deposition of alpha-synuclein protein in the neurons and synaptic terminals, which lead to a complex presentation of motor and non-motor symptoms. This review focuses on various aspects of PD, from clinical diagnosis to currently accepted treatment options, such as pharmacological management through dopamine replacement and surgical techni...
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Krishnapriya Chandrababu Vineeth Radhakrishnan A S Anjana Rahul Rajan Unnikrishnan Sivan Syam Krishnan P S Baby Chakrapani Source Type: research
Seasickness susceptibility and the vestibular time constant: a prospective study
This study was retrospectively registered on December 7th 2022 and assigned the identifier number NCT05640258.PMID:38015244 | DOI:10.1007/s00221-023-06745-z (Source: Experimental Brain Research)
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Daniel Lagami Yoni Evgeni Gutkovich Anna Jamison Yuri Fonar Dror Tal Source Type: research
Trunk postural reactions to the force perturbation intensity and frequency during sitting astride in children with cerebral palsy
Exp Brain Res. 2023 Nov 28. doi: 10.1007/s00221-023-06744-0. Online ahead of print.ABSTRACTThe purpose of this study was to examine kinematic and neuromuscular responses of the head and body to pelvis perturbations with different intensities and frequencies during sitting astride in children with CP. Sixteen children with spastic CP (mean age 7.4 ± 2.4 years old) were recruited in this study. A custom designed cable-driven robotic horse was used to apply controlled force perturbations to the pelvis during sitting astride. Each participant was tested in four force intensity conditions (i.e., 10%, 15%, 20%, and 25% of body ...
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Shijun Yan Seoung Hoon Park Weena Dee Renee Keefer Ana-Marie Rojas William Zev Rymer Ming Wu Source Type: research
Unravelling the Parkinson's puzzle, from medications and surgery to stem cells and genes: a comprehensive review of current and future management strategies
Exp Brain Res. 2023 Nov 28. doi: 10.1007/s00221-023-06735-1. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative disorder, prevalent in the elderly population. Neuropathological hallmarks of PD include loss of dopaminergic cells in the nigro-striatal pathway and deposition of alpha-synuclein protein in the neurons and synaptic terminals, which lead to a complex presentation of motor and non-motor symptoms. This review focuses on various aspects of PD, from clinical diagnosis to currently accepted treatment options, such as pharmacological management through dopamine replacement and surgical techni...
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Krishnapriya Chandrababu Vineeth Radhakrishnan A S Anjana Rahul Rajan Unnikrishnan Sivan Syam Krishnan P S Baby Chakrapani Source Type: research
Seasickness susceptibility and the vestibular time constant: a prospective study
This study was retrospectively registered on December 7th 2022 and assigned the identifier number NCT05640258.PMID:38015244 | DOI:10.1007/s00221-023-06745-z (Source: Experimental Brain Research)
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Daniel Lagami Yoni Evgeni Gutkovich Anna Jamison Yuri Fonar Dror Tal Source Type: research
Trunk postural reactions to the force perturbation intensity and frequency during sitting astride in children with cerebral palsy
Exp Brain Res. 2023 Nov 28. doi: 10.1007/s00221-023-06744-0. Online ahead of print.ABSTRACTThe purpose of this study was to examine kinematic and neuromuscular responses of the head and body to pelvis perturbations with different intensities and frequencies during sitting astride in children with CP. Sixteen children with spastic CP (mean age 7.4 ± 2.4 years old) were recruited in this study. A custom designed cable-driven robotic horse was used to apply controlled force perturbations to the pelvis during sitting astride. Each participant was tested in four force intensity conditions (i.e., 10%, 15%, 20%, and 25% of body ...
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Shijun Yan Seoung Hoon Park Weena Dee Renee Keefer Ana-Marie Rojas William Zev Rymer Ming Wu Source Type: research
