Corticomuscular cross-recurrence analysis reveals between-limb differences in motor control among individuals with ACL reconstruction
Exp Brain Res. 2023 Dec 13. doi: 10.1007/s00221-023-06751-1. Online ahead of print.ABSTRACTSurgical reconstruction of the anterior cruciate ligament (ACL) and subsequent physical therapy can help athletes return to competition; however, re-injury rates remain disproportionately high due, in part, to lingering biomechanical and neurological factors that are not fully addressed during rehabilitation. Prior reports indicate that individuals exhibit altered electrical activity in both brain and muscle after ACL reconstruction (ACLR). In this investigation, we aimed to extend existing approaches by introducing a novel non-linea...
Source: Experimental Brain Research - December 13, 2023 Category: Neuroscience Authors: Christopher D Riehm Scott Bonnette Justin L Rush Jed A Diekfuss Moein Koohestani Gregory D Myer Grant E Norte David A Sherman Source Type: research
Visuomotor tracking strategies in children: associations with neurodevelopmental symptoms
Exp Brain Res. 2023 Dec 11. doi: 10.1007/s00221-023-06752-0. Online ahead of print.ABSTRACTChildren with neurodevelopmental disorders (NDDs) often display motor problems that may impact their daily lives. Studying specific motor characteristics related to spatiotemporal control may inform us about the mechanisms underlying their challenges. Fifty-eight children with varying neurodevelopmental symptoms load (median age: 5.6 years, range: 2.7-12.5 years) performed an interactive tablet-based tracking task. By investigating digit touch errors relative to the target's movement direction, we found that a load of neurodevelopmen...
Source: Experimental Brain Research - December 11, 2023 Category: Neuroscience Authors: Max Thorsson Martyna A Galazka Mats Johnson Jakob Åsberg Johnels Nouchine Hadjikhani Source Type: research
Visuomotor tracking strategies in children: associations with neurodevelopmental symptoms
Exp Brain Res. 2023 Dec 11. doi: 10.1007/s00221-023-06752-0. Online ahead of print.ABSTRACTChildren with neurodevelopmental disorders (NDDs) often display motor problems that may impact their daily lives. Studying specific motor characteristics related to spatiotemporal control may inform us about the mechanisms underlying their challenges. Fifty-eight children with varying neurodevelopmental symptoms load (median age: 5.6 years, range: 2.7-12.5 years) performed an interactive tablet-based tracking task. By investigating digit touch errors relative to the target's movement direction, we found that a load of neurodevelopmen...
Source: Experimental Brain Research - December 11, 2023 Category: Neuroscience Authors: Max Thorsson Martyna A Galazka Mats Johnson Jakob Åsberg Johnels Nouchine Hadjikhani Source Type: research
Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats
Exp Brain Res. 2023 Dec 7. doi: 10.1007/s00221-023-06750-2. Online ahead of print.ABSTRACTDepression is a common non-motor symptom in Parkinson's disease (PD) that includes anhedonia and impacts quality of life but is not effectively treated with conventional antidepressants clinically. Vagus nerve stimulation improves treatment-resistant depression in the general population, but research about its antidepressant efficacy in PD is limited. Here, we administered peripheral non-invasive focused ultrasound to hemiparkinsonian ('PD') and non-parkinsonian (sham) rats to mimic vagus nerve stimulation and assessed its antidepress...
Source: Experimental Brain Research - December 7, 2023 Category: Neuroscience Authors: Rachael A Herlihy Francisco Alicandri Hudy Berger Huda Rehman Yifan Kao Kainat Akhtar Elizabeth Dybas Emily Mahoney-Rafferty Kassie Von Stein Raven Kirby Angela Tawfik Rachel Skumurski Paul J Feustel Eric S Molho Damian S Shin Source Type: research
Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats
Exp Brain Res. 2023 Dec 7. doi: 10.1007/s00221-023-06750-2. Online ahead of print.ABSTRACTDepression is a common non-motor symptom in Parkinson's disease (PD) that includes anhedonia and impacts quality of life but is not effectively treated with conventional antidepressants clinically. Vagus nerve stimulation improves treatment-resistant depression in the general population, but research about its antidepressant efficacy in PD is limited. Here, we administered peripheral non-invasive focused ultrasound to hemiparkinsonian ('PD') and non-parkinsonian (sham) rats to mimic vagus nerve stimulation and assessed its antidepress...
Source: Experimental Brain Research - December 7, 2023 Category: Neuroscience Authors: Rachael A Herlihy Francisco Alicandri Hudy Berger Huda Rehman Yifan Kao Kainat Akhtar Elizabeth Dybas Emily Mahoney-Rafferty Kassie Von Stein Raven Kirby Angela Tawfik Rachel Skumurski Paul J Feustel Eric S Molho Damian S Shin Source Type: research
Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats
Exp Brain Res. 2023 Dec 7. doi: 10.1007/s00221-023-06750-2. Online ahead of print.ABSTRACTDepression is a common non-motor symptom in Parkinson's disease (PD) that includes anhedonia and impacts quality of life but is not effectively treated with conventional antidepressants clinically. Vagus nerve stimulation improves treatment-resistant depression in the general population, but research about its antidepressant efficacy in PD is limited. Here, we administered peripheral non-invasive focused ultrasound to hemiparkinsonian ('PD') and non-parkinsonian (sham) rats to mimic vagus nerve stimulation and assessed its antidepress...
Source: Experimental Brain Research - December 7, 2023 Category: Neuroscience Authors: Rachael A Herlihy Francisco Alicandri Hudy Berger Huda Rehman Yifan Kao Kainat Akhtar Elizabeth Dybas Emily Mahoney-Rafferty Kassie Von Stein Raven Kirby Angela Tawfik Rachel Skumurski Paul J Feustel Eric S Molho Damian S Shin Source Type: research
Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats
Exp Brain Res. 2023 Dec 7. doi: 10.1007/s00221-023-06750-2. Online ahead of print.ABSTRACTDepression is a common non-motor symptom in Parkinson's disease (PD) that includes anhedonia and impacts quality of life but is not effectively treated with conventional antidepressants clinically. Vagus nerve stimulation improves treatment-resistant depression in the general population, but research about its antidepressant efficacy in PD is limited. Here, we administered peripheral non-invasive focused ultrasound to hemiparkinsonian ('PD') and non-parkinsonian (sham) rats to mimic vagus nerve stimulation and assessed its antidepress...
Source: Experimental Brain Research - December 7, 2023 Category: Neuroscience Authors: Rachael A Herlihy Francisco Alicandri Hudy Berger Huda Rehman Yifan Kao Kainat Akhtar Elizabeth Dybas Emily Mahoney-Rafferty Kassie Von Stein Raven Kirby Angela Tawfik Rachel Skumurski Paul J Feustel Eric S Molho Damian S Shin Source Type: research
Effects of exercise-targeted hippocampal PDE-4 methylation on synaptic plasticity and spatial learning/memory impairments in D-galactose-induced aging rats
Exp Brain Res. 2023 Dec 5. doi: 10.1007/s00221-023-06749-9. Online ahead of print.ABSTRACTPhysical exercise reduces the effects of aging and cognitive decline by improving synaptic plasticity and spatial learning. However, the underlying neurobiological mechanisms are unclear. A total of 45 Male SPF Sprague-Dawley rats were acclimatized and then allocated into three groups, 15 in each group: the saline control (DC) group, D-gal-induced aging (DA) group, and D-gal-induced aging + exercise (DE) group. Six weeks of intraperitoneal injections of D-gal at a concentration of 100 mg/kg body weight/d was injected to establish mode...
Source: Experimental Brain Research - December 5, 2023 Category: Neuroscience Authors: Yu Jin Xue Li Changling Wei Qiongjia Yuan Source Type: research
Effects of exercise-targeted hippocampal PDE-4 methylation on synaptic plasticity and spatial learning/memory impairments in D-galactose-induced aging rats
Exp Brain Res. 2023 Dec 5. doi: 10.1007/s00221-023-06749-9. Online ahead of print.ABSTRACTPhysical exercise reduces the effects of aging and cognitive decline by improving synaptic plasticity and spatial learning. However, the underlying neurobiological mechanisms are unclear. A total of 45 Male SPF Sprague-Dawley rats were acclimatized and then allocated into three groups, 15 in each group: the saline control (DC) group, D-gal-induced aging (DA) group, and D-gal-induced aging + exercise (DE) group. Six weeks of intraperitoneal injections of D-gal at a concentration of 100 mg/kg body weight/d was injected to establish mode...
Source: Experimental Brain Research - December 5, 2023 Category: Neuroscience Authors: Yu Jin Xue Li Changling Wei Qiongjia Yuan Source Type: research
The ultrastructure of macaque mesencephalic trigeminal nucleus neurons
In this study, we explored the ultrastructure of macaque mesencephalic trigeminal nucleus neurons to determine the presence and nature of this synaptic input in a primate. We first confirmed the location of macaque mesencephalic trigeminal neurons by retrograde labeling from the masticatory muscles. Since the labeled neurons were by far the largest cells located at the edge of the periaqueductal gray, we could undertake sampling for electron microscopy based on soma size. Ultrastructurally, mesencephalic trigeminal neurons had very large somata with euchromatic nuclei that sometimes displayed deeply indented nuclear membra...
Source: Experimental Brain Research - December 1, 2023 Category: Neuroscience Authors: Niping Wang Paul J May Source Type: research
The ultrastructure of macaque mesencephalic trigeminal nucleus neurons
In this study, we explored the ultrastructure of macaque mesencephalic trigeminal nucleus neurons to determine the presence and nature of this synaptic input in a primate. We first confirmed the location of macaque mesencephalic trigeminal neurons by retrograde labeling from the masticatory muscles. Since the labeled neurons were by far the largest cells located at the edge of the periaqueductal gray, we could undertake sampling for electron microscopy based on soma size. Ultrastructurally, mesencephalic trigeminal neurons had very large somata with euchromatic nuclei that sometimes displayed deeply indented nuclear membra...
Source: Experimental Brain Research - December 1, 2023 Category: Neuroscience Authors: Niping Wang Paul J May Source Type: research
The ultrastructure of macaque mesencephalic trigeminal nucleus neurons
In this study, we explored the ultrastructure of macaque mesencephalic trigeminal nucleus neurons to determine the presence and nature of this synaptic input in a primate. We first confirmed the location of macaque mesencephalic trigeminal neurons by retrograde labeling from the masticatory muscles. Since the labeled neurons were by far the largest cells located at the edge of the periaqueductal gray, we could undertake sampling for electron microscopy based on soma size. Ultrastructurally, mesencephalic trigeminal neurons had very large somata with euchromatic nuclei that sometimes displayed deeply indented nuclear membra...
Source: Experimental Brain Research - December 1, 2023 Category: Neuroscience Authors: Niping Wang Paul J May Source Type: research
The ultrastructure of macaque mesencephalic trigeminal nucleus neurons
In this study, we explored the ultrastructure of macaque mesencephalic trigeminal nucleus neurons to determine the presence and nature of this synaptic input in a primate. We first confirmed the location of macaque mesencephalic trigeminal neurons by retrograde labeling from the masticatory muscles. Since the labeled neurons were by far the largest cells located at the edge of the periaqueductal gray, we could undertake sampling for electron microscopy based on soma size. Ultrastructurally, mesencephalic trigeminal neurons had very large somata with euchromatic nuclei that sometimes displayed deeply indented nuclear membra...
Source: Experimental Brain Research - December 1, 2023 Category: Neuroscience Authors: Niping Wang Paul J May Source Type: research
Unravelling the Parkinson's puzzle, from medications and surgery to stem cells and genes: a comprehensive review of current and future management strategies
Exp Brain Res. 2023 Nov 28. doi: 10.1007/s00221-023-06735-1. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative disorder, prevalent in the elderly population. Neuropathological hallmarks of PD include loss of dopaminergic cells in the nigro-striatal pathway and deposition of alpha-synuclein protein in the neurons and synaptic terminals, which lead to a complex presentation of motor and non-motor symptoms. This review focuses on various aspects of PD, from clinical diagnosis to currently accepted treatment options, such as pharmacological management through dopamine replacement and surgical techni...
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Krishnapriya Chandrababu Vineeth Radhakrishnan A S Anjana Rahul Rajan Unnikrishnan Sivan Syam Krishnan P S Baby Chakrapani Source Type: research
Seasickness susceptibility and the vestibular time constant: a prospective study
This study was retrospectively registered on December 7th 2022 and assigned the identifier number NCT05640258.PMID:38015244 | DOI:10.1007/s00221-023-06745-z (Source: Experimental Brain Research)
Source: Experimental Brain Research - November 28, 2023 Category: Neuroscience Authors: Daniel Lagami Yoni Evgeni Gutkovich Anna Jamison Yuri Fonar Dror Tal Source Type: research
