Risk factor analysis and nomogram construction in patients with distant metastatic prostate cancer at different PSA levels: a study based on the SEER database
CONCLUSIONS: We found different independent prognostic factors for different PSA levels in patients with distant metastatic PCa. A new nomogram was constructed to predict OS and CSS in patients, which helps in clinical-assisted decision-making.PMID:38567600 | DOI:10.26355/eurrev_202403_35744 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: H-D Li S-Q Fan F Qin S-T Zhao S-P Kong J-G Ma Source Type: research

Comparison of intravesical chemotherapy regimens after radical nephroureterectomy for upper tract urothelial carcinoma and analysis of risk factors for postoperative recurrence
CONCLUSIONS: Epirubicin and gemcitabine reduced the occurrence of bladder cancer and effectively inhibited tumor angiogenesis after radical nephroureterectomy for UTUC. The tumor location, number of lesions, tumor stage, preoperative ureteral examination, and preoperative history of bladder cancer were risk factors for postoperative bladder cancer.PMID:38567601 | DOI:10.26355/eurrev_202403_35745 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: S-C Jiang Y-G Liao J Luo D Hu Y-D Wang K He Source Type: research

Comparison of urinary incontinence following three different prostate apex disconnection techniques in transurethral thulium laser prostatectomy
CONCLUSIONS: The incidence of urinary incontinence following transurethral thulium laser prostatectomy was lower with semi-separation and pre-separation compared to post-separation.PMID:38567602 | DOI:10.26355/eurrev_202403_35746 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: X-B Meng Y Li Z-H Gao C-J Wang Y-M Gu Source Type: research

Zonulin: can it be used as a marker for preterm labor?
CONCLUSIONS: In conclusion, serum zonulin levels were not useful as a marker for predicting preterm labor. However, examining large-scale studies about the relationship between PROM and zonulin is still needed.PMID:38567603 | DOI:10.26355/eurrev_202403_35747 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: S E Tekg ündüz Source Type: research

Analysis of risk factors affecting the prognosis of patients with sepsis and construction of nomogram prediction model
CONCLUSIONS: Nine clinical variables have been found to be independent risk factors for death in septic patients. The prediction model established based on this has good accuracy, discrimination, and consistency in predicting the prognosis of sepsis patients.PMID:38567604 | DOI:10.26355/eurrev_202403_35748 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: S-H Cui C-Y Liang Y-F Hao Source Type: research

High triglyceride-glucose index is associated with low postoperative satisfaction in patients with posterior instrumented lumbar fusion
CONCLUSIONS: In patients who underwent posterior lumbar instrumentation and fusion surgery, a high preoperative TyG index may predict poor postoperative ODI and PF scores, indicating lower patient satisfaction.PMID:38567605 | DOI:10.26355/eurrev_202403_35750 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: V K ıyak Source Type: research

The CRISPR-Cas9 induced CCR5 Δ32 mutation as a potent gene therapy methodology for resistance to HIV-1 variant: a review
Eur Rev Med Pharmacol Sci. 2024 Mar;28(6):2430-2463. doi: 10.26355/eurrev_202403_35751.ABSTRACTHuman Immunodeficiency Virus (HIV) has continuously been the greatest epidemic for humanity over a period spanning almost five decades. With no specific cure or treatment available to date despite extensive research, the C-C Chemokine Receptor 5, Delta 32 (CCR5 Δ32) allele genetic point mutation plays an imperative role in the prevention of acquired immunodeficiency syndrome (AIDS). This comprehensive study aims to review the induction of the homozygous recessive deletion genotype using the Clustered Regularly Interspaced Short ...
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: M Saifullah O Laghzaoui H Ozyahyalar A Irfan Source Type: research

Association of SOD1 gene variants (50 bp Ins/Del, rs4817415, rs2070424, rs1041740, rs17880135) with plasma protein levels in vitiligo patients and their analysis in silico
CONCLUSIONS: Information regarding the pathogenesis of vitiligo helps recognize risk factors and identify the relationship of diagnostic markers of cell damage inherent to the disease. This will help improve aspects of prevention and the choice of treatment alternatives appropriate to each case.PMID:38567607 | DOI:10.26355/eurrev_202403_35752 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: B C G ómez-Meda G M Z úñiga-González L D Ba ñuelos-Díaz M P Oceguera-Angel A Galindo-G ómez M G S ánchez-Parada A F Garibaldi-R íos B M Torres-Mendoza A L Zamora-Perez J I Delgado-Saucedo M G M árquez-Rosales M P Gallegos-Arreola Source Type: research

Effects of different doses of remimazolam on hemodynamics during general anesthesia in patients with septic shock
CONCLUSIONS: Remimazolam is safe and effective for inducing general anesthesia in patients with septic shock. Low, medium, and high doses of remimazolam can maintain a stable hemodynamic state, and the recovery of hepatic and renal function is certain to depend on the dose.PMID:38567608 | DOI:10.26355/eurrev_202403_35755 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: Q-C Dai J-L Zhao X-Y Miao R Wang Z Hui Source Type: research

Effect of intravenous and topical laryngeal lidocaine on sore throat after extubation: a prospective randomized controlled study
CONCLUSIONS: Both topical laryngeal lidocaine and intravenous lidocaine before intubation have positive effects on preventing sore throat. Topical laryngeal route was superior to intravenous route. Chictr.org.cn ID: ChiCTR2100042442.PMID:38567609 | DOI:10.26355/eurrev_202403_35756 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: J Lin W-D Wang Q-Y Yang Y-L Wen J-H Yang W-Q Fan Y-B Zuo Source Type: research

Dexmedetomidine protects the uterus against ischemia-reperfusion injury in rats
CONCLUSIONS: In our study, it has been documented that dexmedetomidine protects the uterine tissue against ischemia-reperfusion injury.PMID:38567610 | DOI:10.26355/eurrev_202403_35757 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: V K ölükçü M G ürler Balta H Tapar T Karaman S Karaman V Unsal F Gevrek M Katar Source Type: research

Development and validation of a comprehensive model to predict complications after hepatectomy
CONCLUSIONS: We developed an accurate and practical scoring system based on preoperative and early postoperative data to predict poor outcomes after hepatectomy. Further external validation on larger series could lead to the integration of such a tool in the routine clinical practice to support patients' management and early warning during ICU stay.GRAPHICAL ABSTRACT: https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-NEW-2.pdf.PMID:38567611 | DOI:10.26355/eurrev_202403_35758 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: R Gaspari F Ardito P C Pafundi A W Avolio P Aceto E Adducci M Pallocchi E Parente L Sollazzi M Antonelli F Giuliante Source Type: research

Potential acetylcholinesterase inhibitors to treat Alzheimer's disease
CONCLUSIONS: This study found that Z-9 (Fluoroquinolones) and TBAF-6 (benzimidazole-benzothiazole) compounds improve behavioral and biochemical parameters, thus treating neurodegenerative disorders effectively.PMID:38567612 | DOI:10.26355/eurrev_202403_35759 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: A Saud V Krishnaraju A Taha K Kalpana V Malarkodi S Durgaramani V Vinoth Prabhu F A Saleh S Ezhilarasan Source Type: research

Effects of adenosine triphosphate, Lacidipine, and Benidipine on 5-fluorouracil-induced kidney damage in rats
CONCLUSIONS: It may be possible to prevent nephrotoxicity by adding ATP + Benidipine or ATP to 5-FU treatment.PMID:38567613 | DOI:10.26355/eurrev_202403_35760 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: T Dagel D Altuner B Suleyman R Mammadov S Bulut T Bal Tastan M Gulaboglu H Suleyman Source Type: research

A comparative perspective on brucellar, pyogenic, and tuberculous spondylodiscitis
CONCLUSIONS: Weight loss, painless palpation, involved thoracic spine, psoas abscess, and neurologic deficit are symptoms favoring tuberculous spondylodiscitis. History of spine surgery, high fever, skin erythema, and paraspinal abscess are findings in favor of pyogenic spondylodiscitis. Rural living, sweating, and involved lumbar spine are symptoms that indicate brucellar spondylodiscitis. These symptoms can be used to distinguish the types of spondylodiscitis.PMID:38567614 | DOI:10.26355/eurrev_202403_35761 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: A I Baran M Celik Y Arslan S Incecik I Binici M Toprak M Sunnetcioglu Source Type: research